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001-es BibID:	BIBFORM134831
Első szerző:	Achenef, Gashew Mequanint (animal science)
Cím:	Arginine shapes growth and mTOR pathway gene expression in Japanese quails (Coturnix japonica) / Mequanint Gashew, Gebrehaweria K. Reda, Fadella Nur Almira, Eman Moustafa Abdelbary, Doha Mohamad Khalifeh, Sawadi F. Ndunguru, Gabriella Gulyás, Renáta Knop, Brigitta Csernus, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi
Dátum:	2025
ISSN:	2045-2322
Megjegyzések:	Arginine is a crucial amino acid that regulates growth, metabolism, and cellular homeostasis through nutrient-sensing pathways such as the mechanistic target of rapamycin (mTOR). However, the mechanisms by which dietary arginine modulates mTOR signalling and associated gene networks during early development remain poorly understood in birds. Here, we tested the effects of dietary arginine levels (low, control, and high) on body mass, gene expression, and gene network connectivity in Japanese quail chicks (Coturnix japonica). Using 153 birds over a 14-day experiment, we show that post-hatch arginine restriction significantly impairs growth in both sexes, while gene expression and gene network connectivity responses to arginine availability are strongly sex-specific. Arginine supplementation in females led to coordinated upregulation of growth-related genes (IGF1, GHR), translation regulators (EIF4EBP1), lipid metabolism genes (FASN, FABP1), and oxidative defence (SOD2). In contrast, males showed more limited changes, primarily involving MTOR and autophagy-related gene ATG5. Gene network analysis revealed enhanced connectivity and centrality in females under arginine supplementation, suggesting a more extensive gene interaction response, while males showed sparser networks under restriction, with MTOR and IGF1 emerging as key regulatory hubs. These findings provide novel insights into the sensitivity of developing birds to early nutritional conditions and suggest that the mechanisms underlying growth, gene expression, and gene networking can differ between the sexes, even without sex differences in phenotypic traits. Our results highlight the importance of considering sex-specific gene regulatory architectures when evaluating nutritional effects on vertebrate development.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Amino acid gene expression growth poultry mechanistic target of rapamycin
Megjelenés:	Scientific Reports. - [Epub ahead of print] (2025), p. 1-25. -
További szerzők:	Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Almira, Fadella Nur (1994-) (animal scientist) AbdElbary, Eman (1991-) (animal science) Khalifeh, Doha Mohamad (1998-) (animal science) Ndunguru, Sawadi Fransisco (1980-) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
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001-es BibID:	BIBFORM118839
035-os BibID:	(WoS)001174529200010 (Scopus)85185693265
Első szerző:	Lugata, James Kachungwa (Ph.D hallgató)
Cím:	In ovo feeding of methionine affects antioxidant status and growth-related gene expression of TETRA SL and Hungarian indigenous chicks / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Gabriella Gulyás, Renáta Knop, János Oláh, Levente Czeglédi, Csaba Szabó
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Methionine (Met) plays a substantial role in poultry due to its involvement in several pathways, including enhancing antioxidant status and improving growth performance and health status. This study examined how in ovo feeding of Met affects hatching performance, antioxidant status, and hepatic gene expression related to growth and immunity in the TETRA-SL LL hybrid (TSL) commercial layer and Hungarian partridge colored hen (HPC) indigenous genotypes. The eggs were injected with saline, DL-Met, and L-Met on 17.5 days of embryonic development. The results showed that the in ovo feeding of DL-Met significantly increased the hatching weight and ferric reducing the ability of the plasma (FRAP) compared with L-Met. The in ovo feeding of either Met source enhanced the liver health and function and hepatic antioxidant status of the chicks. The genotype`s differences were significant; the TSL genotype had better hatching weight, an antioxidant defense system, and downregulated growth-related gene expression than the HPC genotype. In ovo feeding of either Met source enhanced the chicks' health status and antioxidant status, and DL-Met improved the hatching weight of the chicks more than L-Met. Genotype differences were significantly evident in the responses of growth performance, antioxidant status, blood biochemical parameters, and gene expression to Met sources.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Czeglédi Levente (1977-) (agrármérnök) Szabó Csaba (1968-) (agrármérnök)
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001-es BibID:	BIBFORM122386
035-os BibID:	(WoS)001239529900108 (Scopus)85195180757
Első szerző:	Reda, Gebrehaweria Kidane (Animal Sceince)
Cím:	Author Correction : Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails / Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus, Renáta Knop , James K. Lugata , Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Correction to: Scientific Reports https://doi.org/10.1038/s41598-024-58487-9, published online 09 April 2024 The original version of this Article contained an error in the Data Availability section where, "All data generated or analysed during this study are included in this published article [and its Supplementary Information files]. Upon acceptance of the manuscript, the datasets will be uploaded into a public repository." now reads: "All data analysed during this study are included in this published article on its Supplementary Information files.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok hozzászólás folyóiratcikk mammalian target of rapamycin
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) (Author Correction) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
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001-es BibID:	BIBFORM120370
035-os BibID:	(WoS)001199822700036 (Scopus)85189879690
Első szerző:	Reda, Gebrehaweria Kidane (Animal Sceince)
Cím:	Dietary restriction reveals sex-specifc expression of the mTOR pathway genes in Japanese quails / Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus, Renáta Knop, James K. Lugata, Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Limited resources affect an organism's physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K139021 OTKA
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