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001-es BibID:	BIBFORM120329
035-os BibID:	(Scopus)85123905165 (WoS)000748312400001
Első szerző:	Dérfalvy Beáta
Cím:	Joint involvement, disease activity and quality of life in pediatric Crohn`s disease - a cross-sectional study / Beata Derfalvi, Kriszta Katinka Boros, Doloresz Szabo, Gabor Bozsaki, Aron Cseh, Gabor Rudas, Katalin Eszter Muller, Gabor Veres
Dátum:	2022
ISSN:	1546-0096
Megjegyzések:	Background: Few published data describe how joint involvement, the most prevalent extraintestinal manifestation, affects quality of life (QoL) of children with Crohn's disease (CD). Arthritis and arthralgia rates in pediatric CD patients are reportedly 3?24% and 17?22%, respectively, but studies on pre-emptive and systematic screening of joint involvement with detailed musculoskeletal rheumatological exam are lacking. More detailed data collection on joint involvement improves our understanding of how arthropathy relates to disease activity and QoL measured by the Pediatric CD Activity Index (PCDAI) and IMPACT-III questionnaire. Our study aims were to assess joint involvement in pediatric CD and correlate it with the PCDAI and IMPACT-III. Methods: In this cross-sectional, observational study, a pediatric gastroenterologist assessed consecutively-seen pediatric CD patients at a tertiary care center. Patients were screened for prevalence of current and previous arthropathy, including arthritis, enthesitis and arthralgia. A single experienced pediatric rheumatologist evaluated detailed musculoskeletal history, joint status, and modified Juvenile Arthritis Multidimensional Assessment Reports (JAMAR). PCDAI, IMPACT-III, sacroiliac MRI, and HLA-B27 genetic testing were also completed. Results: A total of 82 (male:female, 1.2:1; age, 13.7 ? 3.2 years) patients were involved in this study. Mean disease duration at time of study was 21.6 ? 21 months; eight of the patients were newly-diagnosed. Of the 82 patients, 29 (35%) had evidence of arthritis; for 24 of those, this was revealed by physical exam during cross-sectional screening, and by prior documentation for the remaining five patients. Joint examination confirmed active arthritis in 8/24 (33%), active enthesitis in 1/24 (4%), and evidence of previous arthritis in 15/24 (62.5%) patients. Hip (41%) and knee (38%) joints were most commonly affected. Cumulative incidence of arthralgia was 48% (39/82), and 46% (18/39) of those patients had only arthralgia without arthritis, usually affecting the knee. Axial involvement was present in 10/82 (12%) patients. Joint involvement correlated with more severe CD disease activity, specifically higher PCDAI and lower IMPACT-III scores, and increased requirement for infliximab treatment. Sacroiliitis and HLA-B27 positivity were insignificant factors in this cohort. Conclusions: When a rheumatologist performed the assessment, joint involvement in pediatric CD was more prevalent than previously reported, in this cross-sectional study. Arthritis was associated with more severe CD disease activity and lower QoL.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Pediatric Crohn's disease Joint involvement Quality of life Arthritis Arthralgia Pediatric Crohn's disease activity index
Megjelenés:	Pediatric Rheumatology. - 20 : 1 (2022), p. 1-9. -
További szerzők:	Boros Kriszta Szabó Dolóresz Bozsáki Gábor Cseh Áron Rudas Gábor Müller Katalin Eszter Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
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001-es BibID:	BIBFORM083049
Első szerző:	Nagy Arnold
Cím:	The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children : a meta-analysis / Nagy Arnold, Mátrai Péter, Hegyi Péter, Alizadeh Hussain, Bajor Judit, Czopf László, Gyöngyi Zoltán, Kiss Zoltán, Márta Katalin, Simon Mária, Szilágyi Ágnes Lilla, Veres Gábor, Mosdósi Bernadett
Dátum:	2019
ISSN:	1546-0096
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pediatric Rheumatology. - 17 : 4 (2019), p. 1-11. -
További szerzők:	Mátrai Péter Hegyi Péter Jenő (belgyógyász) Alizadeh, Hussain Bajor Judit Czopf László Gyöngyi Zoltán Kiss Zoltán Márta Katalin Simon Mária Szilágyi Ágnes Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Mosdósi Bernadett
Pályázati támogatás:	3.6.3-VEKOP-16-2017-00009 EFOP 2.3.2-15-2016-00048 GINOP
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