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001-es BibID:BIBFORM114415
035-os BibID:(scopus)85165665880 (wos)001037011600032
Első szerző:Csámer Loránd (biomechanika, mérnök)
Cím:Custom-made 3D printing-based cranioplasty using a silicone mould and PMMA / Csámer Loránd, Csernátony Zoltán, Novák László, Kővári Viktor Zsolt, Kovács Ágnes Éva, Soósné Horváth Hajnalka, Manó, Sándor
Dátum:2023
ISSN:2045-2322
Megjegyzések:All types of cranioplasty techniques restore the morphology of the skull and affect patient aesthetics. Safe and easy techniques are required to enhance patients' recovery and the rehabilitation process. We propose a new method of cranioplasty. The 3-dimensional (3D) reconstruction of a thin-layer computed tomography (CT) scan of the skull was used to reflect the intact side onto the defect and subtract the overlapping points from one another. In this way, a 3D model of the planned implant can be built in the required shape and size. The precise fit of the implant can be checked by printing the defective part of the skull in case it can be modified. A sterilisable silicone mould based on the finalized model was created afterwards. Polymethyl methacrylate implants were prepared directly in an aseptic environment in the operating room during surgery. Between 2005 and 2020, we performed 54 cranioplasties on 52 patients whose craniotomies were performed previously for indications of traumatic brain injury, stroke or tumour surgeries. No technical problems were noted during the operations. In 2 cases, septic complications that occurred were not connected to the technique itself, and the implants were removed and later replaced. Our proposed technique based on 3D-printed individual silicone moulds is a reliable, safe, easily reproducible and low-cost method to repair different skull defects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 13 : 1 (2023), p. 1-15. -
További szerzők:Csernátony Zoltán (1959-2023) (ortopéd sebész, traumatológus) Novák László (1964-) (idegsebész) Kővári Viktor Zsolt (1979-) (idegsebész) Kovács Ágnes Éva (1993-) (mérnök) Soósné Horváth Hajnalka (1982-) (mérnök) Manó Sándor (1977-) (gépészmérnök, számítógépes tervezőmérnök)
Pályázati támogatás:OTKA-113180
OTKA
GINOP-2.3.2-15-2016-00022
GINOP
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2.

001-es BibID:BIBFORM106124
035-os BibID:(WoS)000969800000033 (Scopus)85144248767
Első szerző:Fehér Ádám (orvos, biofizikus)
Cím:Mapping the functional expression of auxiliary subunits of KCa1.1 in glioblastoma / Fehér Ádám, Pethő Zoltán, Szántó G. Tibor, Klekner Álmos, Tajti Gábor, Batta Gyula, Hortobágyi Tibor, Varga Zoltán, Albrecht Schwab, Panyi György
Dátum:2022
ISSN:2045-2322
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 12 : 1 (2022), p. 1-14. -
További szerzők:Pethő Zoltán (1989-) (orvos) Szántó György Tibor (1952-) Klekner Álmos (1970-) (idegsebész) Tajti Gábor (1988-) (gyógyszerész, biofizikus, sejtbiológus) Batta Gyula (1979-) (biológus) Hortobágyi Tibor (1965-) (patológus) Varga Zoltán (1969-) (biofizikus, szakfordító) Schwab, Albrecht Panyi György (1966-) (biofizikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM135358
035-os BibID:(scopus)105030628891
Első szerző:Szántó Dorottya (aneszteziológus, intenzív terápiás szakorvos)
Cím:Impact of vitamin D deficiency on clinical outcomes in non-traumatic subarachnoid hemorrhage : a single-center prospective cohort study / Szántó Dorottya, Fülesdi Béla, Simon Lili, Novák László, Kappelmayer János, Molnár Csilla
Dátum:2026
ISSN:2045-2322
Megjegyzések:Background and Purpose: There is growing evidence that neuroinflammation and systemic inflammatory response following SAH have a major effect on patients' outcomes. We hypothesized that due to the immunomodulating and neuroprotective properties, Vitamin D deficiency may contribute to unfavorable outcome in SAH patients. Methods: Consecutive patients admitted with acute non-traumatic SAH were prospectively included. Within 24 h of admission, serum 25(OH)vitamin D levels were measured. During the first 21 days after SAH, inflammatory markers were closely monitored, the development of any infectious complication was noted, and the onset of cerebral vasospasm was evaluated using transcranial color-coded Doppler. New ischemic lesions on follow-up computed tomography imaging were also documented. Patients' outcomes were assessed according to the modified Rankin Scale (mRS) and the Barthel's Index on days 14, 30, and 90. Results: Onehundred fifteen patients were included, of whom 61 were vitamin D deficient (VDD, serum vitamin D<50 nmol/L) and 54 were vitamin D sufficient (VDS, serum vitamin D?50 nmol/L). The incidence of new ischemic lesions was significantly higher in the VDD group (VDD: 68.63% vs. VDS: 40.74%, p=0.008). The VDD group also had higher peaks in inflammatory markers and a tendency of higher incidence of infections (VDD: 42.62% vs. VDS: 24.07%, p=0.057). A poor outcome, as defined by the mRS, was significantly more frequent among VDD patients (on day 90: VDD, 61.02% vs. VDS, 35.19%, p = 0.011). Conclusions: Our findings raise the potential harmful effects of D hypovitaminosis among patients with SAH. Vitamin D deficiency may contribute to greater inflammatory response and increased risk of secondary ischemia, infections, and poor clinical outcomes. Further studies will show whether low vitamin D levels measured at admission are the consequence of SAH severity or whether pre-ictus hypovitaminosis also plays a role in determining the worse prognosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Vitamin D
Subarachnoid Hemorrhage
Inflammation
Brain Ischemia
Neuroprotection
Infections
Megjelenés:Scientific Reports. - 16 (2026), p. 1-12. -
További szerzők:Fülesdi Béla (1961-) (aneszteziológus) Simon Lilla (1983-) (szemész) Novák László (1964-) (idegsebész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Molnár Csilla (1962-) (aneszteziológus)
Pályázati támogatás:HUN-REN-DE Cerebrovascular Research Group
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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