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001-es BibID:	BIBFORM123185
035-os BibID:	(Scopus)85201523429 (WoS)001293598800001
Első szerző:	Fésüs Adina (gyógyszerész)
Cím:	The effect of the antibiotic stewardship program (ASP) on community-acquired pneumonia (CAP) : a before-after study / Adina Fésüs, Phiona Baluku, Éva Sipos, Sándor Somodi, Enikő Berczi-Kun, István Lekli, Ildikó Bácskay, Ria Benkő, Attila Vaskó
Dátum:	2024
Megjegyzések:	Background: Community-acquired pneumonia (CAP) is one of the leading causes of death worldwide. Antibiotic stewardship program (ASP) has been implemented to improve rational and responsible antibiotic use by encouraging guideline adherence. Objective: This retrospective observational before?after study aimed to evaluate whether the ASP may improve guideline adherence, antibiotic exposure, and clinical outcomes in patients hospitalized due to CAP in Hungary. Methods: The study was conducted at a pulmonology department of a tertiary care medical center in Hungary. The ASP implementation consisted of written and published guidelines available to all professionals, continuous supervision, and counseling services on antibiotic therapies at an individual level, with the aim of ensuring compliance with CAP guidelines. Overall guideline adherence (agent selection, route of administration, and dose), clinical outcomes (length of stay and 30-day mortality), antibiotic exposure, and direct costs were compared between the two periods. Fisher's exact test and t-test were applied to compare categorical and continuous variables, respectively. P-values below 0.05 were defined as significant. Results: Significant improvement in overall CAP guideline adherence (30.2%), sequential therapy (10.5%), and a significant reduction in the total duration of antibiotic therapy (13.5%) were observed. Guideline non-adherent combination therapies with metronidazole decreased significantly by 28.1%. Antibiotic exposure decreased by 7.2%, leading to a significant decrease in direct costs (23.6%). Moreover, the ASP had benefits for clinical outcomes, and length of stay decreased by 13.5%. Conclusion: The ASP may play an important role in optimizing empirical antibiotic therapy in CAP having a sustained long-term effect.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk community-acquired pneumonia hospitalized patients empirical antibiotic therapy antibiotic stewardship clinical outcomes intervention
Megjelenés:	Frontiers in Pharmacology. - 15 (2024), p. 1-12. -
További szerzők:	Baluku, Phiona Sipos Éva (1989-) (gyógyszerész) Somodi Sándor (1977-) (belgyógyász) Berczi-Kun Enikő Lekli István (1981-) (gyógyszerész) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Benkő Ria Vaskó Attila (1976-) (tüdőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM089609
035-os BibID:	(scopus)85085356296 (wos)000537225700001
Első szerző:	Tósaki Árpád (kísérletes farmakológus, gyógyszerész)
Cím:	ArrhythmoGenoPharmacoTherapy / Arpad Tosaki
Dátum:	2020
ISSN:	1663-9812
Megjegyzések:	This review is focusing on the understanding of various factors and components governing and controlling the occurrence of ventricular arrhythmias including (i) the role of various ion channel-related changes in the action potential (AP), (ii) electrocardiograms (ECGs), (iii) some important arrhythmogenic mediators of reperfusion, and pharmacological approaches to their attenuation. The transmembrane potential in myocardial cells is depending on the cellular concentrations of several ions including sodium, calcium, and potassium on both sides of the cell membrane and active or inactive stages of ion channels. The movements of Na+, K+, and Ca2+ via cell membranes produce various currents that provoke AP, determining the cardiac cycle and heart function. A specific channel has its own type of gate, and it is opening and closing under specific transmembrane voltage, ionic, or metabolic conditions. APs of sinoatrial (SA) node, atrioventricular (AV) node, and Purkinje cells determine the pacemaker activity (depolarization phase 4) of the heart, leading to the surface manifestation, registration, and evaluation of ECG waves in both animal models and humans. AP and ECG changes are key factors in arrhythmogenesis, and the analysis of these changes serve for the clarification of the mechanisms of antiarrhythmic drugs. The classification of antiarrhythmic drugs may be based on their electrophysiological properties emphasizing the connection between basic electrophysiological activities and antiarrhythmic properties. The review also summarizes some important mechanisms of ventricular arrhythmias in the ischemic/reperfused myocardium and permits an assessment of antiarrhythmic potential of drugs used for pharmacotherapy under experimental and clinical conditions.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk genetics ischemia-reperfusion electrocardiogram (ECG) arrhythmia < cardiovascular therapy action potential (AP)
Megjelenés:	Frontiers in Pharmacology. - 11 (2020), p. 1-19. -
Pályázati támogatás:	NKFIH-K-124719 egyéb GINOP-2.3.2-15-2016-00043 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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