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001-es BibID:	BIBFORM126872
035-os BibID:	(WoS)001395884300001
Első szerző:	Galgóczi Erika (biológus)
Cím:	Stimulation of Piezo1 Mechanosensitive Channels Inhibits Adipogenesis in Thyroid Eye Disease / Galgoczi Erika, Orsos Istvan, Molnar Zsanett, Ujhelyi Bernadett, Steiber Zita, Szabo Laszlo, Dienes Beatrix, Csernoch Laszlo, Nagy Endre V, Katko Monika
Dátum:	2025
ISSN:	0021-972X
Megjegyzések:	Context: Increased orbital tissue volume due to matrix expansion, orbital fibroblast (OF) proliferation, and adipocyte differentiation are the hallmarks of thyroid eye disease (TED). Their combination with the presence of hyaluronan-bound excess water in the constrains of the bony orbit results in increased intraorbital pressure. High intraorbital pressure, along with changes in the mechanical properties of orbital tissues, may lead to the activation of mechanosensitive receptors. The expression and role of the Piezo1 mechanoreceptor has not been investigated in TED. Objective: We aimed to verify the expression of Piezo1 in OFs, and to study the effect of in vitro Piezo1 activation by its synthetic agonist Yoda1 on adipocyte differentiation. Methods: OF cultures established using orbital connective tissues from patients with TED and controls were studied in the presence or absence of adipogenic stimuli. Piezo1 expression was confirmed by Western Blot and immunofluorescent imaging, and its function was verified by intracellular Ca2+ measurement. Adipogenic differentiation was characterized using Oil Red O staining for lipid accumulation, real-time polymerase chain reaction for gene and Western blot for protein expressions indicative in adipogenesis. Results: OFs express functional Piezo1 channels. Differentiation into adipocytes is inherent to TED OFs. Piezo1 activation by Yoda1 inhibits the expressions of early (CEBP?, CEBP?) and main (PPAR?, CEBP?) transcription factors, and the terminal marker FABP4 during adipogenesis, resulting in markedly lower intracytoplasmic lipid accumulation. Conclusion: Piezo1 channels are expressed and functional in OFs. Modeling orbital pressure by in vitro Piezo1 activation reduces de novo adipogenesis of OFs derived from TED orbits.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk orbital fibroblasts adipogenesis Piezo1 Yoda1 PPAR gamma Graves orbitopathy
Megjelenés:	Journal Of Clinical Endocrinology & Metabolism. - 110 : 9 (2025), p. 2584-2594. -
További szerzők:	Orsós István (1999-) (molekuláris biológus) Molnár Zsanett (1982-) (analitikus) Ujhelyi Bernadett (1981-) (szemész) Steiber Zita (1977-) (orvos, szemész) Szabó László (1994-) (molekuláris biológus) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Csernoch László (1961-) (élettanász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Katkó Mónika (1980-) (biológus)
Pályázati támogatás:	OTKA-143464 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM063667
Első szerző:	Galgóczi Erika (biológus)
Cím:	Cell density dependent stimulation of PAI-1 and hyaluronan synthesis by TGF-[béta] in orbital fibroblasts / Erika Galgoczi, Florence Jeney, Annamaria Gazdag, Annamaria Erdei, Monika Katko, Domonkos M. Nagy, Bernadett Ujhelyi, Zita Steiber, Ferenc Gyory, Eszter Berta, Endre V. Nagy
Dátum:	2016
ISSN:	0022-0795
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Endocrinology 229 : 2 (2016), p. 187-196. -
További szerzők:	Jeney Florence Gazdag Annamária (1979-) (belgyógyász) Erdei Annamária (1976-) (belgyógyász) Katkó Mónika (1980-) (biológus) M. Nagy Domonkos Ujhelyi Bernadett (1981-) (szemész) Steiber Zita (1977-) (orvos, szemész) Győry Ferenc (1969-) (kardiológus) Berta Eszter (1980-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Pályázati támogatás:	K105733 OTKA TÁMOP-4.2.2.B-15/1/KONV-2015-0001 TÁMOP ÁOK Bridging Fund Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030314
Első szerző:	Nagy Endre V. (belgyógyász, endokrinológus)
Cím:	Graves' ophthalmopathy : eye muscle involvement in patients with diplopia / Endre V. Nagy, Judit Toth, Ildiko Kaldi, Judit Damjanovich, Emese Mezosi, Agota Lenkey, Laszlo Toth, Jeno Szabo, Zsolt Karanyi, Andras Leovey
Dátum:	2000
Megjegyzések:	Background: Diplopia identifies patients with eye muscle involvement in Graves' ophthalmopathy (GO).Objective: To identify clinical parameters that could eliminate the need for magnetic resonance imaging(MRI) to assess the activity of inflammation in the eye muscles of GO patients with diplopia.Methods: In 43 patients with GO with recently developed diplopia, orbital ultrasound and MRI wereperformed. Muscle diameters and MRI T2 relaxation times were measured, and the amount of orbitalconnective tissue was calculated from MRI scans and compared with ultrasound readings, diplopiagrades, degree of protrusion, ocular pressure, tear production, antibody levels and hormonalparameters of thyroid function.Results: No correlation was found between diameters of 233 extraocular muscles measured by MRIand by ultrasound. For each of the four muscles, there was a diameter above which ultrasound wasalways unreliable. MRI data were used in further analysis. Of the muscles examined, the inferiorrectuses were the most frequently enlarged ? at least one, in 93% of cases. Medial, lateral and superiorrectuses were enlarged in 59%, 37% and 34% of the orbits respectively. The pattern of muscleinvolvement of the two orbits tended to be symmetric (r?0.49, P?0.003), particularly for the medialrectuses (r?0.90, P?0.000). Proptosis correlated with the sum of the muscle diameters for a giveneye (right eye: r?0.54, P?0.003; left eye: r?0.57, P?0.001), but it failed to correlate with theamount of orbital connective tissue. In 53% of the patients, normal T2 relaxation times were found inall eight muscles. There was only a weak correlation between muscle thickness and T2 relaxation time(r?0.49, P?0.003), indicating that muscle enlargement alone is not a sign of disease activity. Theseverity of diplopia was independent of T2 relaxation time. The amount of orbital connective tissueshowed a negative correlation with the greatest T2 relaxation time for a given eye (r? ?0.52,P?0.004); this suggests that disease types exist that have predominant muscle involvement andpredominant connective tissue expansion. No correlation between connective tissue expansion andproptosis, diplopia grade, muscle thickness or disease duration was found ? that is, connective tissueexpansion is not a major factor in diplopia. Both muscle and connective tissue findings wereindependent of thyroid function.Conclusion: Ultrasound and MRI eye muscle diameter readings do not correlate, because of the inherentinaccuracy of orbital ultrasound. Muscle enlargement alone does not mean oedematous swelling andactive disease. Neither ultrasound, nor any combination of 11 clinical and laboratory parametersprovided the degree of information on muscles and connective tissue that was obtainable by MRI. Inunclear cases of recently developed diplopia, before orbital decompression surgery, in the case oftreatment failure or if, for any other reason, imaging is needed in GO, MRI is the method of choice.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal of Endocrinology. - 142 : 6 (2000), p. 591-597. -
További szerzők:	Tóth Judit Káldi Ildikó (szemész) Damjanovich Judit (1963-) (szemész) Mezősi Emese Lenkey Ágota (1944-) (biológus) Tóth László (1957-) (fül-orr-gégész) Szabó Jenő (belgyógyász, endocrinologus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Leövey András (1926-2019) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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