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001-es BibID:	BIBFORM135271
035-os BibID:	(wos)001670630800001
Első szerző:	Szabó László (molekuláris biológus)
Cím:	The Beneficial Effects of Marine Plant-Derived Compounds on the Musculoskeletal System / Szabó László, Gere Áron, Kovács Zsigmond Máté, Bazsó Tamás, Dienes Beatrix
Dátum:	2026
ISSN:	1661-6596 1422-0067
Megjegyzések:	The skeletal muscle system is particularly susceptible to degenerative and inflammatory processes that threaten mobility, quality of life, and systemic health. Marine plants, including brown, red, and green algae, are valuable yet understudied sources of bioactive compounds with therapeutic potential against skeletal muscle inflammation and degeneration. This narrative review provides the first overview of polyphenols, polysaccharides, carotenoids, and multiminerals derived from marine plants, with a particular focus on their effects on skeletal muscle, bone, and joint tissues. It highlights both the therapeutic potential and the limitations of marine plant-derived bioactive compounds in the musculoskeletal system. The compounds discussed, such as phlorotannins, ulvan, fucoidan, carotenoids, spirulina derivatives, and Aquamin, modulate key signaling pathways, including NF-?B, JAK/STAT3, and the NLRP3 inflammasome. Among these, MAPK emerges as the most consistently affected axis across all compound classes, leading to a reduction in TNF-?, IL-1?, IL-6, and oxidative stress markers. These bioactive compounds have been shown in both in vitro and in vivo models to reduce muscle catabolism, enhance osteoblast differentiation and mineralization, and reduce cartilage inflammation. Despite favorable safety, biocompatibility, and biodegradability profiles, current evidence shows that systemic applications significantly dominate over local delivery, highlighting the untapped potential of localized delivery strategies. Overall, this narrative review underscores the growing importance of marine plant-derived bioactives as promising natural agents for maintaining musculoskeletal integrity and alleviating degenerative disorders.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk marine plant derivatives anti-inflammatory effects musculoskeletal system muscle atrophy osteoarthritis
Megjelenés:	International Journal Of Molecular Sciences. - 27 : 2 (2026), p. 1-21. -
További szerzők:	Gere Áron Kovács Zsigmond Máté (1995-) (orvos) Bazsó Tamás (1974-) (ortopéd sebész) Dienes Beatrix (1972-) (élettanász, molekuláris biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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