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001-es BibID:	BIBFORM068033
Első szerző:	Chen, Ji-Qing
Cím:	Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjogren's syndrome / Chen Ji-Qing, Zilahi Erika, Papp Gábor, Sipka Sándor, Zeher Margit
Dátum:	2017
Megjegyzések:	AIM:The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS).METHOD:We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction.RESULTS:We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients.CONCLUSION:This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban microRNA-155 primary Sjögren's syndrome suppressor of cytokine signaling 1
Megjelenés:	International Journal of Rheumatic Diseases 20 : 5 (2017), p. 609-613. -
További szerzők:	Zilahi Erika (1964-) (molekuláris biológus) Papp Gábor (1984-) (belgyógyász) Sipka Sándor (1945-) (laboratóriumi szakorvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:	K 101470 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP
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001-es BibID:	BIBFORM123985
035-os BibID:	(scopus)85193061304 (wos)001221758000001
Első szerző:	Shumnalieva, Russka
Cím:	Characteristics of emerging new autoimmune diseases after COVID-19 vaccination : A sub-study by the COVAD group / Shumnalieva Russka, Ravichandran Naveen, Hannah Jennifer, Javaid Mahnoor, Darooka Naitica, Roy Debaditya, Gonzalez Daniel E., Velikova Tsvetelina, Milchert Marcin, Kuwana Masataka, Joshi Mrudula, Gracia-Ramos Abraham Edgar, Boyd Peter, Yaadav Praggya, Cheng Karen, Kobert Linda, Cavagna Lorenzo, Sen Parikshit, Day Jessica, Makol Ashima, Gutiérrez Carlos Enrique Toro, Caballero-Uribe Carlo V., Saha Sreoshy, Parodis Ioannis, Dey Dzifa, Nikiphorou Elena, Distler Oliver, Kadam Esha, Tan Ai Lyn, Shinjo Samuel Katsuyuki, Ziade Nelly, Knitza Johannes, Chinoy Hector, Aggarwal Rohit, Agarwal Vikas, Gupta Latika, COVAD Study Group
Dátum:	2024
ISSN:	1756-1841
Megjegyzések:	Background Despite the overall safety and efficacy of COVID-19 vaccinations, rare cases of systemic autoimmune diseases (SAIDs) have been reported post-vaccination. This study used a global survey to analyze SAIDs in susceptible individuals' post-vaccination. Methods A cross-sectional study was conducted among participants with self-reported new-onset SAIDs using the COVID-19 Vaccination in Autoimmune Diseases (COVAD) 2 study dataset?a validated, patient-reported e-survey?to analyze the long-term safety of COVID-19 vaccines. Baseline characteristics of patients with new-onset SAIDs and vaccinated healthy controls (HCs) were compared after propensity score matching based on age and sex in a 1:4 ratio. Results Of 16?750 individuals, 74 (median age 52?years, 79.9% females, and 76.7% Caucasians) had new-onset SAID post-vaccination, mainly idiopathic inflammatory myopathies (IIMs) (n?=?23, 31.51%), arthritis (n?=?15; 20.53%), and polymyalgia rheumatica (PMR) (n?=?12, 16.40%). Higher odds of new-onset SAIDs were noted among Caucasians (OR?=?5.3; 95% CI?=?2.9?9.7; p?<?.001) and Moderna vaccine recipients (OR?=?2.7; 95% CI?=?1.3?5.3; p?=?.004). New-onset SAIDs were associated with AID multimorbidity (OR?=?1.4; 95% CI?=?1.1?1.7; p?<?.001), mental health disorders (OR?=?1.6; 95% CI?=?1.3?1.9; p?<?.001), and mixed race (OR?=?2.2; 95% CI?=?1.2?4.2; p?=?.010), where those aged >60?years (OR?=?0.6; 95% CI?=?0.4?0.8; p?=?.007) and from high/medium human development index (HDI) countries (compared to very high HDI) reported fewer events than HCs. Conclusion This study reports a low occurrence of new-onset SAIDs following COVID-19 vaccination, primarily IIMs, PMR, and inflammatory arthritis. Identified risk factors included pre-existing AID multimorbidity, mental health diseases, and mixed race. Revaccination was well tolerated by most patients; therefore, we recommend continuing COVID-19 vaccination in the general population. However, long-term studies are needed to understand the autoimmune phenomena arising post-vaccination.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal of Rheumatic Diseases. - 27 : 5 (2024), p. 1-11. -
További szerzők:	Ravichandran, Naveen Hannah, Jennifer Javaid, Mahnoor Darooka, Naitica Roy, Debaditya Gonzalez, Daniel E. Velikova, Tsvetelina Milchert, Marcin Kuwana, Masataka Joshi, Mrudula Gracia-Ramos, Abraham Edgar Boyd, Peter Yaadav, Praggya Cheng, Karen Kobert, Linda Cavagna, Lorenzo Sen, Parikshit Day, Jessica Makol, Ashima Gutiérrez, Carlos-Enrique Toro Caballero-Uribe, Carlo Vinicio Saha, Sreoshy Parodis, Ioannis Dey, Dzifa Nikiphorou, Elena (reumatológus) Distler, Oliver Kadam, Esha Tan, Ai Lyn Shinjo, Samuel Katsuyuki Ziade, Nelly Knitza, Johannes Chinoy, Hector Aggarwal, Rohit Agarwal, Vikas Gupta, Latika Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) COVAD Study Group
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001-es BibID:	BIBFORM071723
Első szerző:	Sipka Sándor (laboratóriumi szakorvos)
Cím:	Down-regulation of increased TRAF6 expression in the peripheral mononuclear cells of patients with primary Sjögren's syndrome by an EBV-EBER1-specific synthetic single-stranded complementary DNA molecule / Sipka Sándor, Zilahi Erika, Papp Gábor, Chen Ji-Qing, Nagy Andrea, Hegyi Katalin, Kónya József, Zeher Margit
Dátum:	2017
ISSN:	1756-1841
Megjegyzések:	AIM:We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogren's syndrome (pSS) patients. Recently, the expression of EBV encoded. RNA (EBER) was published in the B cells of salivary glands of in pSS. In the present study, we applied an EBV-EBER1 specific synthetic single stranded complementary DNA molecule (EBV-EBER1-cDNA) to test whether any EBER1 related effect exists also in PBMCs of pSS patients.METHODS:In the PBMCs of pSS patients and healthy controls, we investigated in vitro the effects of a synthetic single stranded EBV-EBER1-cDNA molecule, synthetic double-stranded (ds)RNA polyinosinic-polycytidylic acid [poly (I:C)] and polyadenylic acid potassium salt poly-adenylic acid [poly-(A)] on the expression of TRAF6 gene tested by qRTPCR. The release of interferon -? was detected by ELISA.RESULTS:EBV-EBER1-cDNA resulted in a significant reduction in the expression of TRAF6 in the cells of patients, but in the healthy controls not, whereas the treatments with poly (I:C) and poly-(A) could not reduce the TRAF6 over-expression. No release of EBER1 could be observed in the culture supernatants of patients with pSS. Only the treatment with poly (I:C) resulted in a significant increase of interferon -? release, and only in the heathy controls. No release of EBER1 molecules took place during the culturing of cells. EBV-EBER- cDNA acted functionally on the cells of patients only.CONCLUSION:These findings give a further evidence of the linkage between EBV and pSS, furthermore, they show the possible role of EBV-EBER1 in the induction of increased TRAF6 expression in the peripheral B cells of Sjögren's patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Journal of Rheumatic Diseases 20 : 5 (2017), p. 614-621. -
További szerzők:	Zilahi Erika (1964-) (molekuláris biológus) Papp Gábor (1984-) (belgyógyász) Chen, Ji-Qing Nagy Andrea (1958-) (csecsemő és gyermekgyógyász, neonatológus) Dull Katalin (1983-) (molekuláris biológus, genetikus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:	K 71833 OTKA K 101470 OTKA
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