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001-es BibID:	BIBFORM129354
035-os BibID:	(Scopus)105001697986 (wos)001513361800013
Első szerző:	Kapitány Anikó (molekuláris biológus)
Cím:	Chronological maturation of the skin immune barrier is topographically different / Anikó Kapitány, Lilla Soltész, Vivien Stercel, Lilla Szabó, Orsolya Somogyi, Eszter Anna Janka, Viktória Nagy, Szilárd Póliska, Krisztián Gáspár, Zoltán Hendrik, Dániel Törőcsik, Zsolt Dajnoki, Andrea Szegedi
Dátum:	2025
ISSN:	1933-0219 1935-3456
Megjegyzések:	dult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical immune differences in other age groups are limited. This study aimed to explore the chronological maturation of the immune barrier in various skin regions. A TaqMan low-density array and immunohistochemical and immunofluorescence detection of various immune cells and mediators in sebaceous gland-rich (SGR) and gland-poor (GP) healthy skin were performed in children, adolescents, and adults. The maturation of SGR skin showed a general upward trend in the mRNA levels of most Th17-related molecules with a significant increase in IL-1B from childhood to adulthood, but with only a slight elevation between childhood and adolescence. In addition, T cell, Treg, dendritic cell (DC) counts, as well as the levels of several Th17-related proteins (IL-17, IL-10, IL-23, CCL20, S100A8, sfTSLP, LCN2), increased significantly with age. In GP skin, AHR mRNA levels decreased, while Th17-related protein levels increased, although only moderately. When comparing the two regions, SGR and GP skin were similar in childhood, with differences emerging in adolescence and becoming significant in adulthood, particularly in the IL-17 pathway, mainly produced by Th17 cells. Our results show a similarly directed maturation process in GP and SGR regions, with more pronounced development of the SGR skin immune barrier (with more immune cell infiltration and cytokine production) during and after the adolescence. This is likely to be related to the significant changes in the chemical and microbiota barriers of the SGR skin during adolescence, and may explain the high incidence of inflammatory skin diseases on the SGR skin of adolescents, highlighting the need for targeted skin care in this region.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bőrrégiók gyerekkor
Megjelenés:	Mucosal Immunology. - 18 : 3 (2025), p. 730-741. -
További szerzők:	Soltész Lilla (1994-) (orvos) Stercel Vivien (1994-) (gyermeksebész) Szabó Lilla (1993-) (molekuláris biológus) Somogyi Orsolya (1992-) (klinikai laboratóriumi kutató) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Nagy Viktória (1993-) (biotechnológia msc) Póliska Szilárd (1978-) (biológus) Gáspár Krisztián (1974-) (bőrgyógyász) Hendrik Zoltán (1986-) (patológus) Töröcsik Dániel (1979-) (bőrgyógyász) Dajnoki Zsolt (1985-) (molekuláris biológus) Szegedi Andrea (1964-) (bőrgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM082977
035-os BibID:	(WoS)000453593000019 (Scopus)85054365983
Első szerző:	Moreira, Thais Garcias
Cím:	CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells / T. G. Moreira, L. S. Horta, A. C. Gomes-Santos, R. P. Oliveira, N. M. G. P. Queiroz, D. Mangani, B. Daniel, A. T. Vieira, S. Liu, A. M. Rodrigues, D. A. Gomes, G. Gabriely, E. Ferreira, H. L. Weiner, R. M. Rezende, L. Nagy, A. M. C. Faria
Dátum:	2019
ISSN:	1933-0219 1935-3456
Megjegyzések:	Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-γ and modulate metabolic and immune functions. Despite the worldwide use of CLA dietary supplementation, strong scientific evidence for its proposed beneficial actions are missing. We found that CLA-supplemented diet reduced mucosal damage and inflammatory infiltrate in the dextran sodium sulfate (DSS)-induced colitis model. Conditional deletion of PPAR-γ in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-γ-dependent mechanism mediated by macrophages. However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-β via PPAR-γ activation. Accordingly, either macrophage-specific deletion of PPAR-γ or in vivo neutralization of latency-associated peptide (LAP, a membrane-bound TGF-β)-expressing cells abrogated the protumorigenic effect of CLA. Thus, the anti-inflammatory properties of CLA are associated with prevention of colitis but also with development of colorectal cancer.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Mucosal Immunology. - 12 : 1 (2019), p. 188-199. -
További szerzők:	Horta, Laila Sampaio Gomes-Santos, Ana Cristina Oliveira, R. P. Queiroz, N. M. G. P. Mangani, D. Dániel Bence (1987-) (molekuláris biológus) Vieira, A. T. Liu, S. Rodrigues, A. M. Gomes, D. A. Gabriely, G. Ferreira, E. Weiner, H. L. Rezende, Rafael Machado Nagy L. Faria, Ana Maria Caetano
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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