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001-es BibID:	BIBFORM089448
035-os BibID:	(WoS)000517028300002 (Scopus)85081028160
Első szerző:	Crlikova, Hana
Cím:	Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand / Hana Crlikova, Hana Kostrhunova, Jitka Pracharova, Máté Kozsup, Sándor Nagy, Péter Buglyó, Viktor Brabec,Jana Kasparkova
Dátum:	2020
ISSN:	0949-8257
Megjegyzések:	The adverse side efects and acquired resistance associated with the clinical application of traditional platinum-based anticancer drugs have forced investigation of alternative transition metal-based compounds and their cytostatic properties. Over the last years, the anticancer potential of cobalt complexes has been extensively studied, and in-depth analyses of their mode of action have been conducted. In this work, we present antiproliferative activity against human cancer cells of the dinuclear Co(III) complexes bearing the quinizarin ligand and tris(2aminoethyl)amine (tren, compound 1) or tris(2-pyridylmethyl)amine (tpa, compound 2) co-ligands. To contribute the understanding mechanisms of biological action of these compounds, their association with DNA in the cells, DNA binding in cell-free media, and DNA cleavage capability were investigated in detail. The results demonstrate that both complexes interact with DNA in tumor cells. However, their mechanism of antiproliferative action is diferent, and this diference is mirrored by distinct antiproliferative activity. The antiproliferative efect of 1 is connected with its ability to intercalate into DNA and subsequently to inhibit activities of DNA processing enzymes. In contrast, the total antiproliferative efciency of 2, thanks to its redox properties, appears to be connected with its ability to form radicals and, consequently, with the ability of 2 to cleave DNA. Hence, the fndings presented in this study may signifcantly contribute to understanding the antitumor potential of cobalt complexes.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Biological Inorganic Chemistry. - 25 : 2 (2020), p. 339-350. -
További szerzők:	Kostrhunova, Hana Pracharova, Jitka Kozsup Máté (1992-) (Okleveles vegyész) Nagy Sándor (1993-) (vegyész) Buglyó Péter (1965-) (vegyész) Brabec, Viktor Kasparkova, Jana
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP OTKA-112317 OTKA ÚNKP-19-3-I-DE-45 Egyéb ÚNKP-19-3-I-DE-56 Egyéb
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001-es BibID:	BIBFORM103444
035-os BibID:	(Wos)000501026900008 (Scopus)85070294803
Első szerző:	Cukierman, Daphne Schneider
Cím:	Impact of pyridine-2-carboxaldehyde-derived aroylhydrazones on the copper-catalyzed oxidation of the M112A PrP103-112 mutant fragment / Daphne S. Cukierman, Nikolett Bodnár, Beatriz N. Evangelista, Lajos Nagy, Csilla Kállay, Nicolás A. Rey
Dátum:	2019
ISSN:	0949-8257
Megjegyzések:	Misfolded prion protein (PrPSc) is known for its role in fatal neurodegenerative conditions, such as Creutzfeldt-Jakob disease. PrP fragments and their mutants represent important tools in the investigation of the neurotoxic mechanisms and in the evaluation of new compounds that can interfere with the processes involved in neuronal death. Metal-catalyzed oxidation of PrP has been implicated as a trigger for the conformational changes in protein structure, which, in turn, lead to misfolding. Targeting redox-active biometals copper and iron is relevant in the context of protection against the oxidation of biomolecules and the generation of oxidative stress, observed in several conditions and considered an event that might promote sporadic prion diseases as well as other neurodegenerative disorders. In this context, ortho-pyridine aroylhydrazones are of interest, as they can act as moderate tridentate ligands towards divalent metal ions such as copper(II). In the present work, we explore the potentiality of this chemical class as peptide protecting agents against the deleterious metal-catalyzed oxidation in the M112A mutant fragment of human PrP, which mimics relevant structural features that may play an important role in the neurotoxicity observed in prion pathologies. The compounds inhere studied, especially HPCFur, showed an improved stability in aqueous solution compared to our patented lead hydrazone INHHQ, displaying a very interesting protective effect toward the oxidation of methionine and histidine, processes that are related to both physiological and pathological aging.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aroylhydrazones Human prion protein Copper(II) Methionine oxidation Oxidative stress
Megjelenés:	Journal Of Biological Inorganic Chemistry. - 24 : 8 (2019), p. 1231-1244. -
További szerzők:	Bodnár Nikolett (1994-) (vegyész) Evangelista, Beatriz N. Nagy Lajos (1979-) (vegyész) Kállay Csilla (1978-) (vegyész) Rey, Nicolas Adrian
Pályázati támogatás:	NKFI-115480 Egyéb NKFI-128783 Egyéb GINOP-2.3.2-15-2016-00008 GINOP UNKP-18-4 Egyéb
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