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001-es BibID:	BIBFORM128075
035-os BibID:	(Scopus)85205446113 (WoS)001322175600005
Első szerző:	Clemens Béla (neurológus)
Cím:	Kombinált epilepszia generalizált és fokális rohamokkal / Clemens, Béla; Dömötör, Johanna
Dátum:	2024
ISSN:	0019-1442
Megjegyzések:	Background and purpose: Combined epilepsy (with generalized and focal seizures) is a recently accepted and yet underreported epilepsy type. We intended to review the literature of combined epilepsy and to report the individual findings of the 31 combined epilepsy patients in our database. Thereafter, we investigated the characteristics of the patients at the group level. Methods: The individual findings of the 31 patients were tabulated. We characterized the group with special reference to epidemiology, timing and the sequence of generalized and focal seizures, family history of seizures and severity of the electro-clinical phenotype. The variables were compared to those of the generalized epilepsy and the focal epilepsy groups of our database. We carried out statistical analyses by the two-sided Fishers's exact test and the Kruskal-Wallis and post-hoc Dunn tests. Results: The prevalence of combined epilepsy was 1.56% within the total sample of the classifiable epilepsy patients. Females were affected more often than males (67.7% and 32.3%, respectively). Statistically significant associations emerged firstly between the "short interval" subgroup (where the generalized and focal seizures occurred with short time difference) and the lack of other cerebral abnormality, and secondly between the "long interval" subgroup (where 4 to 37 years elapsed between the occurrence of the two seizure types) and the presence of other brain abnormality (p = 0.02). The proportion of patients with positive family history of seizures was greater in the combined epilepsy- than in the generalized epilepsy group (p = 0.03) and the focal epilepsy group (p < 0.0001) of the database. The electro-clinical phenotype of the absence seizures showed more atypical findings (indicating poor prognosis) in combined epilepsy than in the generalized absence epilepsy patients of the database (p < 0,0001). Despite dissimilar patient selection and study design, our main findings were in accord with those of prior studies. The dissection of the combined epilepsy group into the "long interval" and "short interval" subgroups was a novel approach that highlighted the dissimilar pathogenetic and clinical correlates of each. Conclusion: The case reports might facilitate the spread of information about combined epilepsy in the medical community. Analyses of the patients at the group level resulted in clinically useful pieces of evidence.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban folyóiratcikk case reports combined epilepsy group level analysis
Megjelenés:	Ideggyógyászati Szemle. - 77 : 9-10 (2024), p. 329-338. -
További szerzők:	Dömötör Johanna (1982-) (neurológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM078543
035-os BibID:	(WOS)000491345500004 (Scopus)85064507740 (PMID)30957464
Első szerző:	Dömötör Johanna (neurológus)
Cím:	EEG-based connectivity in patients with partial seizures with and without generalization / Johanna Dömötör, Béla Clemens, Miklós Emri, Szilvia Puskás, István Fekete
Dátum:	2019
ISSN:	0019-1442 2498-6208
Megjegyzések:	Objective ? to investigate the neurophysiological basis of secondary generalization of partial epileptic seizures. Patients and methods ? inter-ictal, resting-state EEG functional connectivity (EEGfC) was evaluated and compared: patients with exclusively simple partial seizures (sp group) were compared to patients with simple partial and secondary generalized seizures (spsg group); patients with exclusively complex partial seizures (cp group) were compared to patients with cp and secondary generalized seizures (cpsg group); the collapsed sp+cp group (spcp) was compared to those who had exclusively secondary generalized seizures (sg group). EEGfC was computed from 21-channel waking EEG. 3 minutes of waking EEG background activity was analyzed by the LORETA Source Correlation (LSC) software. Current source density time series were computed for 23 pre-defined cortical regions (ROI) in each hemisphere, for the 1-25 Hz very narrow bands (1 Hz bandwidth). Thereafter Pearson correlation coefficients were calculated between all pairs of ROI time series in the same hemisphere. Z-scored correlation coefficients were compared at the group level (t-tests and correction for multiple comparisons by local false discovery rate, FDR). Results ? Statistically significant (corrected p<0.05) EEGfC differences emerged at specific frequencies (spsg > sg; cpsg > cp), and at many frequencies (sg > spcp). The findings indicated increased coupling between motor cortices and several non-motor areas in patients with partial and sg seizures as compared to patients with partial seizures and no sg seizures. Further findings suggested increased coupling between medial parietal-occipital areas (structural core of the cortex) and lateral hemispheric areas. Conclusion ? increased inter-ictal EEGfC is associated with habitual occurrence of secondary generalized seizures.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk epilepsy partial seizures secondary generalization EEG functional connectivity
Megjelenés:	Ideggyógyászati Szemle. - 72 : 3-4 (2019), p. 99-109. -
További szerzők:	Clemens Béla (1950-) (neurológus) Emri Miklós (1962-) (fizikus) Puskás Szilvia (1979-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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