Találati lista | Tudóstér

001-es BibID:	BIBFORM050363
035-os BibID:	PMID:23677439
Első szerző:	Klára Tamás
Cím:	Albumin-coated structural lyophilized bone allografts : a clinical report of 10 cases / Tamás Klára, Lajos Csönge, Gábor Janositz, Zoltán Csernátony, Zsombor Lacza
Dátum:	2014
ISSN:	1389-9333 1573-6814
Megjegyzések:	Bone replacement and the use of bone supplementary biological substances have become widespread in clinical practice. Although autografts have excellent properties, their limited availability, difficulties with shaping and donor site morbidity have made allografts a viable and increasingly preferred alternative. The main drawback of allografts is that the preparation destroys osteogenic cells and results in denaturation of osteoinductive proteins. Serum albumin is a well-known constituent of stem cell culture media and we found that lyophilizing albumin onto bone allografts markedly improves stem-cell attachment and bone healing in animal models thus replacing some of the osteoinductive potential. As a first step in the clinical introduction of albumin coated grafts, we aimed to test surgical handling and early incorporation in aseptic revision arthroplasty in humans. We selected patients who needed large structural allografts and the current operation was the last attempt at preserving a moving joint. In a series of 10 cases of hip and knee revision surgery we did not experience any drawbacks of the albumin-coated grafts during handling and implantation. Twelve months radiographic and SPECT-CT follow-up showed that the graft was well received by the host and active remodelling was observed. The lack of graft-related complications and the good 1-year results indicate that controlled trials may be initiated in more common bone grafting indications where long-term effectiveness can be evaluated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Cell and Tissue Banking. - 15 : 1 (2014), p. 89-97. -
További szerzők:	Csönge Lajos (Győr) Janositz Gábor Csernátony Zoltán (1959-2023) (ortopéd sebész, traumatológus) Lacza Zsombor
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM135066
Első szerző:	Lukács Miklós Ágoston (orvos)
Cím:	Management of corneal allograft rejection in post-penetrating keratoplasty patients : a retrospective analysis / Lukács Miklós Ágoston, Fodor Mariann, Módis László
Dátum:	2026
ISSN:	1573-6814
Megjegyzések:	To evaluate the treatment success and reversal rate of corneal allograft rejections in post-penetrating keratoplasty patients. Retrospective cohort study was performed in post-penetrating keratoplasty patients treated for corneal allograft rejection between September 2015 and August 2024 in a tertiary eye center in Debrecen, Hungary. Indication of keratoplasty, onset of the allograft rejection, best corrected visual acuity (BCVA), corneal transparency on slit lamp examination and applied treatment were recorded. In our institution's patient registry, 68 allograft rejection episodes were found. Before the rejection, all grafts were completely transparent. The rejection episodes occurred median 21 months after surgery. Diagnosis and treatment took place median 5 days after the onset of symptoms. Allograft rejection could be successfully reversed in 48 of the total 68 cases (70.6%). Treatment was adjusted individually and all patients received local treatment; 16 received only local and 52 received combined systemic and local corticosteroids resulting in a similar rejection reversal rate (13/16 vs. 35/52; p?=?0.359). Comparing first (47) and repeat grafts (21), there were no significant differences between the treatment success rate (33/47 vs. 15/21; P?=?1.000) and the frequency of combined local-plus-systemic treatment (34/47 vs. 18/21; p?=?0.355). Before the rejection episodes, BCVA was 0.40???0.30, which decreased following the rejection (0.28???0.28; p?<?0.001). This reduction in BCVA was observed in successfully treated cases as well (0.44???0.28 vs. 0.38???0.27; p?=?0.008). Our dexamethasone-based local treatment demonstrated similar effectiveness in reversing corneal allograft rejections in patients underwent penetrating keratoplasty compared to data on prednisolone by other studies. However, systemic steroid augmentation might be needed more frequently when using topical dexamethasone.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cell and Tissue Banking. - 27 : 1 (2026), p. 1-7. -
További szerzők:	Fodor Mariann (1975-) (szemész) Módis László (1964-) (szemész szakorvos, kontaktológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: