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1.

001-es BibID:BIBFORM013150
Első szerző:Barta Zsolt (belgyógyász, gasztroenterológus)
Cím:Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD) / Zsolt Barta, Gabor G. Szabo, Geza Bruckner, Gyula Szegedi
Dátum:2001
ISSN:1234-1010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lipoid pneumonia
Megjelenés:Medical Science Monitor. - 7 : 1 (2001), p. 134-136. -
További szerzők:Szabó G. Gábor Bruckner Géza Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
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2.

001-es BibID:BIBFORM095934
Első szerző:Buglyó Gergely (genetikus)
Cím:miRNA Profiling of Hungarian Regressive Wilms' Tumor Formalin-Fixed Paraffin-Embedded (FFPE) Samples by Quantitative Real-Time Polymerase Chain Reaction (RT-PCR) / Gergely Buglyó, Zsófia Magyar, Éva Romicsné Görbe, Rita Bánusz, Monika Csóka, Tamás Micsik, Márta Mezei, Jaxi Ayman Shawky Yani, Péter Varga, Zoltán Sápi, Bálint Nagy
Dátum:2021
ISSN:1643-3750
Megjegyzések:Background: Wilms' tumor is a common renal malignancy of early childhood with a generally favorable prognosis depending upon histological subtype. It is becoming increasingly clear that differences in miRNA (microRNA) expression signature represent important clues helping us predict a tumor's response to chemotherapy. In our study, we aimed to reveal miRNAs deregulated in regressive Wilms' tumors from FFPE (formalin-fixed, paraffin-embedded) samples, also showing whether such samples are reliable miRNA sources in Wilms' tumor. Material/Methods: Samples from 8 Hungarian patients (3 males, 5 females, aged 1 to 7 years) were analyzed by qRT-PCR (quantitative real-time PCR). A PCR array was used in a pilot experiment, and selected miRNAs (miR-128-3p, miR-184, miR-194-5p, miR-203a) were studied in the rest of the samples using individual primers. Results: miR-194-5p was underexpressed in all tumor samples. miR-184 and miR-203a were underexpressed in 7 cases, the exception being a case with a high ratio of necrotic blastemal tissue. Results obtained with miR-1283p are difficult to interpret due to varying directions of expression changes. Conclusions: We conclude that a downregulation of miR-184, miR-194-5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample. In most of our FFPE samples aged up to 9 years, RNA extraction provided miRNA with quantity and quality sufficient for qRT-PCR-based analysis, emphasizing the relevance of pathological archives as miRNA sources in future studies.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
MIRN184 microRNA Human
MIRN194 microRNAHuman
MIRN203 Human
microRNA
Real-Time Polymerase Chain Reaction
Wilms Tumor
Megjelenés:Medical Science Monitor. - 27 (2021), p. e932731-1-e932731-9. -
További szerzők:Magyar Zsófia Görbe Éva Bánusz Rita Csóka Mónika Micsik Tamás Mezei Márta Yani, Jaxi Ayman Shawky Varga Péter (szülész-nőgyógyász) Sápi Zoltán Nagy Bálint (1956-) (molekuláris genetikus)
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3.

001-es BibID:BIBFORM009907
Első szerző:Constantin Tamás
Cím:Prevalence of antiphospholipis and antinuclear antibodies in chiledren with epilepsy / Constantin T., Kálovics T., Ponyi A., Nagy E., Sallai K., Szabó L., Garami M., Müller J., Gergely P., Dankó K., Fekete G., Kálmánchey R.
Dátum:2009
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Science Monitor. - 15 : 4 (2009), p. 164-169. -
További szerzők:Kálovics Tamás Ponyi Andrea Nagy Eszter (Budapest) Sallai Krisztina Szabó Léna Garami Miklós Müller Judit Gergely Péter (Budapest) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Fekete György Kálmánchey Rozália
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4.

001-es BibID:BIBFORM030064
Első szerző:Jermendy György
Cím:Persistence of initial oral antidiabetic treatment in patients with type 2 diabetes mellitus / György Jermendy, István Wittmann, László Nagy, Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, Lajos Katona, György Paragh, István Karádi, Béla Merkely
Dátum:2012
ISSN:1234-1010
Megjegyzések:BACKGROUND: Adequate persistence of oral antidiabetic treatment is highly important to achieve proper glycemic control in patients with type 2 diabetes. The aim of this study was to evaluate the persistence of initial treatment with metformin and/or sulphonylureas in patients with type 2 diabetes. MATERIAL/METHODS: The study was performed among diabetic patients (n=256,384) who were with newly prescribed oral antidiabetic drugs (metformin and/or sulphonylureas) between 2007 and 2009. For making comparison, patients with newly prescribed statin or clopidogrel therapy (with and without percutaneous coronary intervention) were investigated. The database of the Hungarian National Health Insurance Fund Administration was used. RESULTS: The 1-year persistence of initial treatment with metformin, sulphonylureas or metformin/sulphonylurea combination was 47.7%, 45.4% and 55.8%, respectively, which was significantly better than the persistence of statin therapy (26.3%) but worse than that of clopidogrel therapy in patients undergoing coronary intervention (73.2%). Within the sulphonylurea group there was a tendency of better persistence of treatment with the "modified-release" tablets at 12 months compared to the conventional sulphonylureas (47.8 vs. 42.2%). The persistence of therapy using metformin 1000 mg - 60 tablets was significantly better (60.4%) at 12 months than that of other forms of metformin therapy with lower doses and smaller boxes (with fewer tablets) analyzed together (47.7%). CONCLUSIONS: The persistence of initial treatment with metformin and/or sulphonylureas is far from optimal. Better diabetic care and continuous patient education should be encouraged to achieve higher persistence of oral antidiabetic treatment in patients with type 2 diabetes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Science Monitor 18 : 2 (2012), p. CR72-77. -
További szerzők:Wittmann István Nagy László (Budapest) Kiss Zoltán (Budapest) Rokszin György Abonyi-Tóth Zsolt Katona Lajos Paragh György (1953-) (belgyógyász) Karádi István (1952-) (belgyógyász, kardiológus) Merkely Béla (1965-) (orvos)
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5.

001-es BibID:BIBFORM017942
035-os BibID:PMID: 21709636
Első szerző:Kiss Levente
Cím:Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress / Levente Kiss, Rita Benkő, Endre Kovács, Tamás Szerafin, Katalin Módis, Csaba Szabó, Zsombor Lacza
Dátum:2011
ISSN:1234-1010
Megjegyzések:BACKGROUND: The internal thoracic artery (ITA) is the first choice for myocardial revascularization, but atherosclerotic lesions and perioperative vasospasm may still limit its functionality. Oxidative stress via the peroxynitrite - poly-(ADP-ribose) polymerase (PARP) cascade plays an important role in the pathogenesis of impaired vascular tone via endothelial injury. We aimed to investigate and describe the histology, PARP activation and functionality of ITA grafts and to assess the possible beneficial effect of PARP-inhibition. MATERIAL/METHODS: ITA specimens from 47 patients (26 men, mean age 66.2 ± 1.7 years) who underwent coronary bypass surgery were processed for histological and immunohistochemical studies for oxidative stress and PARP activation, and were functionally tested with acetylcholine (ACh) and sodium nitroprusside (SNP) with or without PARP inhibition. RESULTS: The sections showed atherosclerotic alterations and oxidative and nitrosative stress were evidenced by positive 3-nitrotyrosine, 4-hydroxynonenal and PAR stainings. Functionally, 88.1% reacted to K-Krebs, 68.7% exhibited contraction after 1 mikroM phenylephrine, 29.9% exhibited relaxation to 30 mikroM Ach, and all precontracted segments relaxed to 30 mikroM SNP. High amplitude vasomotion was observed in 47.8% of the segments, which could be abolished by the application of 10 mikroM SNP.Incubation of the preparations with PJ34 did not improve endothelium-dependent vasodilation. CONCLUSIONS: ITA grafts are severely damaged both morphologically and functionally in patients undergoing coronary artery bypass surgery, but PARP inhibition cannot improve their functional characteristics. The topical use of SNP to the ITA during the operation may improve vascular functions by dilating the vessels and eliminating the eventual spasmic vasomotion
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Science Monitor 17 : 7 (2011), p. CR411-CR416. -
További szerzők:Benkő Rita Kovács Endre Szerafin Tamás (1960-) (szívsebész, mellkassebész) Módis Katalin Szabó Csaba Lacza Zsombor
Pályázati támogatás:TÁMOP-4.2.2-08/1/KMR-2008-0004
TÁMOP
TÁMOP-4.2.1/B-09/1/KMR-2010-0001
TÁMOP
PD 83803
OTKA
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6.

001-es BibID:BIBFORM063750
Első szerző:Márk László (belgyógyász, kardiológus)
Cím:Oral Anticoagulant Therapy and Bleeding Events with Vitamin K Antagonists in Patients with Atrial Fibrillation in a Hungarian County Hospital / Laszlo Mark, Győző Dani, Robert Vendrey, György Paragh, Andras Katona
Dátum:2015
ISSN:1643-3750
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Science Monitor 21 (2015), p. 518-525. -
További szerzők:Dani Győző Vendrey Róbert Paragh György (1953-) (belgyógyász) Katona András
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7.

001-es BibID:BIBFORM121263
035-os BibID:(Scopus)85189304810 (WoS)001239808300001
Első szerző:Papp János György (Miskolc)
Cím:New Computerized Planning Algorithm and Clinical Testing of Optimized Nuss Bar Design for Patients with Pectus Excavatum / János György Papp, Ákos Kiss, Krisztián Balogh, László Kostyál, Imre Tóth, Tibor Gáll, Péter Vajda, Tamás F. Molnár, István Papp, László Szabó, Árpád B. Palotás
Dátum:2024
ISSN:1643-3750
Megjegyzések:Background: Computer-aided design (CAD) has been used in the Nuss procedure to determine the bar length and shape. Despite computer aid, the shape and design remain quite intuitive. We tested a new algorithm to determine the optimal bar shape. Material/Methods: The normal sterno-vertebral distance was defined on computed tomography (CT) scans of patients without pectus excavatum (PEx) at the same level where the deepest depression was found on CT scans of 97 patients with PEx. Four points were marked on the CT scan of 60 patients with PEx at the deepest deformity: P1: edge of the vertebra; P2: edge of the deformity; P3: the expected contact point of the bar and the rib; and P4: the expected end of the bar. The algorithm generated 3 circles upon these points, and the fusion of the arcs drew the line of the ideal bar. Corrected and normal sterno-vertebral distance values were compared with the Mann-Whitney U test. Ten bars were bent manually guided by a 1: 1 printout of the designed bar and were implanted in 10 adolescents. Results: The shortest sterno-vertebral distance was 3 cm below the intermammillary line in PEx patients. The normal mean sterno-vertebral distance at this level was 10.16?1.35 cm in non-PEx patients. The mean virtually corrected sterno-vertebral distance was 10.28?1.27 cm. No significant difference was found (P=0.44). The bars were seamless and were successfully implanted. No bar needed adjustment, the operation time was shorter, and the patient satisfaction score was 9.4/10. Conclusions: With our new algorithm, an optimal Nuss bar can be designed. ? Med Sci Monit, 2024
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Computer-Aided Design of Custom-Made Nuss Bar
CT-Based Geometric Correction Algorithm
Individual Implant
Mathematical Model
Nuss Procedure
Pectus Excavatum
Python Software
Thoracic Deformity
Megjelenés:Medical Science Monitor. - 30 (2024), p. 1-10. -
További szerzők:Kiss Ákos Balogh Krisztián Kostyál László (1974-) (radiológus) Tóth Imre Gáll Tibor (1969-) (egészségügyi menedzser) Vajda Péter Molnár Tamás F. (Pécs) Papp István Szabó László Palotás Árpád B.
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8.

001-es BibID:BIBFORM117953
035-os BibID:(Scopus)85180132858
Első szerző:Pham, Anh
Cím:Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma : a Retrospective Study of 46 Patients / Pham Anh, Garai Ildiko, Árpád Kovács, Dér Ádám, Szanto Erika, Hascsi Zsolt, Bátyi Ferenc, Berényi Ervin, Pham Thong Minh
Dátum:2024
ISSN:1643-3750
Megjegyzések:Background: Positron emission tomography/computed tomography (PET/CT) using fluorodeoxyglucose (FDG) is essential in oncology for precise tumor delineation. This study evaluated FDG PET/CT's impact on therapeutic decisions in head and neck cancer, comparing metabolic tumor volumes (MTV) measured by different methods with radiotherapy targets, crucial for treatment planning and patient outcomes. Material/Methods: We retrospectively analyzed 46 patients with histologically confirmed head and neck cancer who underwent FDG PET/CT examination before radiotherapy. The mean age was 62 years (46-78 years). Then, we calculated MTV of the primary tumor or local recurrence using a local threshold of 41% of the standard uptake volume (SUV) corrected for lean body mass (SULmax) of the lesion and absolute threshold of SUV 2.5. Descriptive analysis of the recruited patients was assessed based on the clinical database (Medsol). Results: The study included 45 patients with squamous carcinoma and 1 with sarcoid cell carcinoma. PET/CT examination led to therapeutic decision changes in 11 cases. No significant difference was found in median values of Gross Tumor Volume (GTV) and MTV absolute (p=0.130). However, significant differences were observed in MTV local, MTV absolute, and GTV median values (p<0.001), with both MTVs showing significant correlation with GTV (p<0.01), especially MTV absolute (r=0.886). Conclusions: FDG PET/CT examination prior to radiotherapy significantly influences therapeutic decisions in head and neck cancer patients. Based on our findings, the absolute threshold method (SUV: 2.5) appears to be an effective approach for calculating MTV for radiotherapy planning purposes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Head and Neck Neoplasms
Positron Emission Tomography Computed Tomography
Radiotherapy Planning, Computer-Assisted
Radiotherapy
Carcinoma, Squamous Cell
Positron-Emission Tomography
Megjelenés:Medical Science Monitor. - 30 (2024), p. 1-7. -
További szerzők:Garai Ildikó (1966-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Dér Ádám Szántó Erika (1985-) (orvos) Hascsi Zsolt Bátyi Ferenc Berényi Ervin (1964-) (radiológus) Pham, Thong Minh
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9.

001-es BibID:BIBFORM078208
Első szerző:Surányi Éva (szemész)
Cím:Alport Patients without Classic Ocular Symptoms Have Smaller Lens Diameter / Suranyi Eva, Nagy Valeria, Berta Andras, Matyus Janos, Szalai Eszter, Ujhelyi Bernadett, Meleg Judit, Damjanovich Judit
Dátum:2019
ISSN:1643-3750
Megjegyzések:Background: The aim of this study was to present ophthalmological findings regarding Alport syndrome and report refractometry data and to present possible early signs of the syndrome. Material/Methods: Seven patients suffering from Alport syndrome were referred to the Department of Ophthalmology at the University of Debrecen between January 1st, 2014, and December 31st, 2015. All patients underwent slit lamp evaluation and dilated fundus biomicroscopy, with special attention paid to lenticonus and retinal changes. IOL Master, Pentacam HR, and ultrasound biomicroscopy were performed to assess keratometry, corneal thickness, anterior chamber depth, lens size, and axial length data. Results: One patient out of seven had ocular symptoms. Posterior polymorphous corneal dystrophy (PPMD) and dotand-fleck retinopathy were seen. Meanwhile, although keratoconus was not proven, remarkable astigmatism with high myopia was detected. The other six patients were found to have a significantly smaller lens diameter (an average of 7.82?0.66 mm, p=0.035) compared to normal controls (an average of 8.65?0.46 mm). Lenses also tended to be thicker in Alport patients (3.48?0.19 mm) compared to controls (3.4?0.2 mm), although the difference was not significant (p=0.394). The power of the lens also showed a significant difference (p=0.026), with Alport patients having lower lens power. Conclusions: Alport syndrome patients without classical ophthalmological findings have smaller crystalline lens diameter and lower lens power. These signs may support the diagnosis of Alport syndrome. Ophthalmologists should not only seek for the known classic signs, but also the parameters of the crystalline lens, especially if genetic testing is not available.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cornea
Microscopy
Acoustic
Nephritis
Hereditary
Megjelenés:Medical Science Monitor. - 25 (2019), p. 2274-2277. -
További szerzők:Nagy Valéria (1962-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Mátyus János (1957-) (belgyógyász, nephrológus) Szalai Eszter (1984-) (orvos) Ujhelyi Bernadett (1981-) (szemész) Meleg Judit Damjanovich Judit (1963-) (szemész)
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10.

001-es BibID:BIBFORM014289
Első szerző:Virág László (biokémikus, sejtbiológus, farmakológus)
Cím:Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma / Virag, L., Bai, P., Bak, I., Pacher, P., Mabley, J. G., Liaudet, L., Bakondi, E., Gergely, P., Kollai, M., Szabo, C.
Dátum:2004
ISSN:0891-5849 (Print)
Megjegyzések:Poly(ADP-ribose) polymerase-1 (PARP-1), a monomeric nuclear enzyme present in eukaryotes, plays a role in cell death, inflammatory mediator expression, and mononuclear cell recruitment in various experimental models of inflammation and reperfusion injury. Part of the molecular mechanism of this function involves the regulation of cytokine and chemokine production. Since chemokines are principal regulators of mononuclear and polymorphonuclear cell trafficking in asthma, we investigated the possibility whether PARP modulates chemokine production and cell recruitment in a murine model of asthma. MATERIAL/METHODS: We studied ovalbumin-sensitized mice challenged with a single dose of ovalbumin. RESULTS: PARP inhibition with the phenanthridinone-based PARP inhibitor PJ34 suppressed inflammatory cell migration. These effects were associated with downregulation of the CC chemokine MIP-1alpha, but not the CXC chemokine MIP-2. The production of TNF- alpha and IL-12, but not IL-5 or IL-13, was also suppressed by PARP inhibition. CONCLUSIONS: Our results demonstrate the pathogenetic role of PARP activation in a murine model of asthma. PARP selectively regulates the production of certain chemokines and cytokines in this experimental model, which may be responsible for some of the observed protective effects seen in the current murine asthma model.Matrix metalloproteinase (MMP) activation contributes to the development of various pathophysiological conditions, including dilated cardiomyopathy, congestive heart failure, and reperfusion injury. Increased oxidative and nitrosative stress have been implicated in the activation of MMPs and also in the cardiotoxicity of doxorubicin (DOX), a commonly used antitumor agent. Thus, we hypothesized that MMP activation occurs in DOX-induced cardiotoxicity. Male Balb/c mice received a single injection of DOX (25 mg/kg i.p.) and were sacrificed 12 h, 1, 2, 3 and 4 days later. Hearts and aortae were harvested for MMP zymography. DOX induced time-dependent activation of MMPs both in the heart and in the aortic tissue with an earlier onset in the latter. These results demonstrate that MMP activation is an early event in DOX-induced cardiotoxicity and raises the possibility that MMP inhibitors may influence the outcome of this severe complication.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Asthma/ drug therapy
Bronchoalveolar Lavage
Catalysis
Cell Death
Cell Movement
Chemokine CXCL2
Chemokines/metabolism
Cytokines/metabolism
Disease Models, Animal
Down-Regulation
Enzyme Inhibitors/ pharmacology
Interleukin-10/metabolism
Interleukin-12/metabolism
Interleukin-13/metabolism
Interleukin-5/metabolism
Leukocytes, Mononuclear/metabolism
Lung/pathology
Male
Mice
Mice, Inbred BALB C
Ovalbumin/metabolism/pharmacology
Peroxidase/metabolism
Poly(ADP-ribose) Polymerases/ antagonists & inhibitors
Time Factors
Tumor Necrosis Factor-alpha/metabolism
Antineoplastic Agents/toxicity
Biological Markers/analysis
Cardiomyopathy, Dilated/chemically induced/enzymology
Doxorubicin/ toxicity
Enzyme Activation
Heart/ drug effects
Heart Failure/chemically induced
Matrix Metalloproteinases/ metabolism
Models, Animal
Myocardium/enzymology/ pathology
Reperfusion Injury/chemically induced/enzymology
Acute Disease
Catalysis/drug effects
Chronic Disease
Creatine Kinase/blood
Enzyme Inhibitors/pharmacology
Heart/ drug effects/physiopathology
Heart Failure/ chemically induced/physiopathology/prevention & control
L-Lactate Dehydrogenase/blood
Metalloporphyrins/ pharmacology
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide Synthase/antagonists & inhibitors/genetics/metabolism
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Oxidative Stress/drug effects/genetics
Peroxynitrous Acid/ metabolism
Survival Rate
Antibiotics, Antineoplastic
Creatine Kinase/metabolism
Doxorubicin
Enzyme Activation/drug effects
Heart Failure/ chemically induced/pathology/physiopathology
Hemodynamics/drug effects
L-Lactate Dehydrogenase/metabolism
Metalloendopeptidases/metabolism
Poly(ADP-ribose) Polymerases/ genetics/ metabolism
Survival Analysis
Ventricular Function, Left/genetics
Apoptosis
Benzamides/ pharmacology
Caspases/metabolism
Cells, Cultured
DNA Damage/drug effects
DNA Fragmentation/drug effects
Enzyme Activation/drug effects/physiology
Mitochondria/ drug effects
Nitrates
Nitrites/toxicity
Nitrogen Oxides/ toxicity
Poly(ADP-ribose) Polymerases/ antagonists & inhibitors/metabolism
Protective Agents/ pharmacology
Thymus Gland/cytology/ drug effects
Tyrosine
külföldön készült közlemény
Megjelenés:Medical Science Monitor. - 10 : 3 (2004), p. BR77-83. -
További szerzők:Bai Péter (1976-) (biokémikus) Bak István (1975-) (vegyész, analitikus, farmakológus) Pacher Pál Mabley, Jon G. Liaudet, Lucas Bakondi Edina (1975-) (biokémikus, vegyész) Gergely Pál (1947-) (biokémikus) Kollai, M. Szabó Csaba
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