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001-es BibID:	BIBFORM132164
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	Association of HDL-C and its subfraction profile with heart rate response to exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Seres Ildikó, Paragh György, Ádány Róza, Pikó Péter
Dátum:	2025
ISSN:	0021-9150
Megjegyzések:	Background and Aims: High-density lipoproteins (HDL) are a heterogeneous group of plasma molecules that can be divided into subfractions based on their characteristics. Although HDL subfractions vary widely in size, density, and function, their association with cardiovascular outcomes remains complex and partly unknown. Heart rate response to physical activity (HRR) is a well-known indicator of individual cardiovascular fitness. The present study aimed to investigate the association between HRR and HDL subfraction profile in 304 individuals from the Hungarian population. Methods: HDL was divided into ten subfractions using the Lipoprint HDL? system. The YMCA 3-minute step test was used to assess the individual HRR by measuring the heart rate at four-time points: before the exercise (resting HR - HRrest), immediately (HRexe), 5 minutes (HR5min) and 10 minutes (HR10min) after exercise. In addition, acute HRR (?HR) was calculated (HRexe-HRrest). Multiple linear regression was used to examine the association between HDL subfraction profile and HRR. Results: The distribution of HDL-3 (BHRexe=-1.26, p =0.020; BHR5min=-0.70, p=0.048; B?HR=-1.21, p=0.035), HDL-4 (BHRexe=-1.86, p=0.040; BHR5min=-0.92, p=0.048; B?HR=-1.88, p=0.030), and HDL-5 (BHRexe=-3.34, p=0.017; BHR5min=-1.84, p=0.041; B?HR=-3.32, p=0.037) showed a significant negative association, whereas HDL-7 (BHRexe=2.64, p=0.025; BHR5min=1.37, p=0.045; B?HR=2.41, p=0.034), HDL-8 (BHRexe=2.87, p =0.030; BHR5min=1.70, p=0.035; B?HR=2.48, p=0.035), HDL-9 (BHRexe=3.10, p =0.010; BHR5min=2.18, p=0.013; B?HR=3.04, p=0.045), and HDL-10 (BHRexe=0.95, p =0.035; BHR5min=0.67, p=0.020; B?HR=0.71, p=0.049) were positively associated with HRR. However, there was no significant change in the concentration of HDL-C and its subfractions in mmol/L in relation to HRR. Conclusions: Our results suggest that a more optimal (smaller) heart rate change in response to physical activity is associated with a more favourable distribution of the HDL subfraction profile, i.e. a significant increase in the proportion of smaller HDL subfractions and a decrease in the proportion of larger subfractions. In contrast, no significant quantitative changes were observed in HDL-C and its subfractions.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk HDL Cardiovascular risk heart rate response to exercise HDL-C subfraction profile Cardiorespiratory fitness Lipid profile
Megjelenés:	Atherosclerosis. - 407 : Suppl. (2025), p. 57. -
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
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