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1.

001-es BibID:BIBFORM129405
Első szerző:Alibrahem, Walaa
Cím:Potential of Carbon Nanodots (CNDs) in Cancer Treatment / Walaa Alibrahem, Nihad Kharrat Helu, Csaba Oláh, József Prokisch
Dátum:2025
ISSN:2079-4991
Megjegyzések:Carbon Nanodots (CNDs) are characterized by their nanoscale size (<10 nm), biocompatibility, stability, ?uorescence, and photoluminescence, making them a promising candidate for cancer therapy. The difference in the methods of synthesis of CNDs, whether top-down or bottom-up, affects the formation, visual, and surface characteristics of CNDs, which are crucial for their biomedical and pharmaceutical applications. The urgent need for innovative therapeutic strategies from CNDs is due to the limitations and barriers posed by conventional therapies including drug resistance and cytotoxicity. Nano-loaded chemotherapy treatments are highly effective and can enhance the solubility and targeted delivery of chemotherapeutic agents, generate reactive oxygen species (ROS) to induce cancer cell cytotoxicity, and regulate intracellular signaling pathways. Their ability to be designed for cellular uptake and exact intracellular localization further improves their therapeutic potential. In addition to working on drug delivery, CNDs are highlighted for their dual functionality in imaging and therapy, which allows real-time observing of treatment ef?cacy. Despite the development of these treatments and the promising results for the future, challenges still exist in cancer treatment.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
carbon nanodots
cancer
drug delivery
fluorescence
biocompatibility
cytotoxicity
cellular uptake
Megjelenés:Nanomaterials. - 15 : 7 (2025), p. 1-16. -
További szerzők:Helu, Nihad Kharrat (1992-) (PhD hallgató) Oláh Csaba (1972-) (idegsebész) Prokisch József (1966-) (vegyész)
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2.

001-es BibID:BIBFORM135190
Első szerző:Ferroudj, Aya (animal science)
Cím:Applications of Nano-Selenium in the Poultry Industry: An Overview / Aya Ferroudj, Hassan El-Ramady, József Prokisch
Dátum:2026
ISSN:2079-4991
Megjegyzések:Nanotechnology has emerged as a transformative tool in animal production, offering novel strategies to enhance productivity, health, and product quality. Among trace elements, selenium (Se) plays an essential role in antioxidant defence, immune regulation, and redox balance through its incorporation into selenoproteins. Selenium nanoparticles (SeNPs), synthesized via chemical, physical, or biological methods, have shown superior bioavailability, stability, and lower toxicity compared to traditional organic and inorganic selenium forms. This review explores the synthesis, physicochemical properties, and metabolic fate of SeNPs, emphasizing their advantages in poultry production systems. In poultry, SeNPs exhibit potent antioxidant and anti-stress effects by enhancing the activity of glutathione peroxidase, superoxide dismutase, and thioredoxin reductase, thereby mitigating lipid peroxidation and oxidative tissue damage. Their immunomodulatory effects are linked to improved lymphocyte proliferation, cytokine regulation, and increased immunoglobulin levels under normal and stress conditions. SeNP supplementation has been associated with enhanced growth performance, feed efficiency, carcass quality, and reproductive outcomes in broilers, layers, and quails. Furthermore, selenium nanoparticles have demonstrated therapeutic potential in preventing or alleviating chronic diseases such as cancer, diabetes, cardiovascular dysfunction, and neurodegenerative disorders. SeNPs also serve as biofortification agents, increasing selenium deposition in poultry meat and eggs, thus improving their nutritional value for human consumption. However, selenium's narrow safety margin requires careful dose optimization to avoid potential toxicity. This review highlights the multifaceted benefits of selenium nanoparticles in poultry nutrition and health, while underscoring the need for further studies on grey SeNPs, long-term safety, and regulatory frameworks. Integrating SeNPs into poultry production represents a promising strategy to bridge animal health, food security, and public nutrition.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
selenium
nanoparticles
cancer
glutathione peroxidase
Japanese quails
antioxidant
oxidative stress
growth
poultry industry
feed to food
one health
Megjelenés:Nanomaterials. - 16 : 2 (2026), p.1-24. -
További szerzők:El-Ramady, Hassan (1969-) (agrármérnök) Prokisch József (1966-) (vegyész)
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3.

001-es BibID:BIBFORM130374
035-os BibID:(Scopus)105007865285 (WoS)001509542900001
Első szerző:Ferroudj, Aya (animal science)
Cím:Comparative Study of Red and Grey Selenium Nanoparticles on Organ-Specific Selenium Deposition and Growth Performance in Japanese Quails / Aya Ferroudj, Arjun Muthu, Daniella Sári, Gréta Törős, Áron Beni, Levente Czeglédi, Renáta Knop, Hassan El Ramady, József Prokisch
Dátum:2025
ISSN:2079-4991
Megjegyzések:Selenium (Se) is an essential trace element required for various physiological functions in agriculture. Nanotechnology is applied to produce selenium nanoparticles (SeNPs) that offer new advantages, enhancing their bioavailability and reducing toxicity. To further improve the stability of Se nanoelements in the poultry industry, the grey form of Se was recently offered as a potential alternative. However, its impact on bioaccessibility, metabolism, and overall animal efficiency remains undetermined. This study investigates the impact of red and grey SeNPs on Se content in the liver, blood cellular fraction (BCF), kidney, testis, and eyes, as well as the feed intake (FI) and growth performance, of adult Japanese quails. Adult quails were randomly assigned to five groups: a control (C0) and four groups receiving either red or grey Se nanoparticles (SeNPs) at 0.05 or 0.5 mg/kg, in addition to the basal diet which already contained 0.042 mg/kg Se from the premix, resulting in total Se contents of approximately 0.092 and 0.542 mg/kg in the treatment groups (T1?T4), with four replicates per group. The growth performance of quails fed with nano-Se-supplemented diets showed significant variation across groups (p < 0.05), with body weight differing by up to 20% between the highest performing group (T2) and the lowest (T1). FI showed no significant differences across groups. The results indicated that Se accumulation differed significantly between treatments. The selenium levels in the liver increased in a dose-dependent manner, with the highest accumulation observed in T4 (0.5 mg/kg grey SeNPs), at 42% above control levels. This pattern suggests that the liver is a primary organ for selenium storage and metabolism. The greatest Se content in BCFs was recorded in the groups that received grey selenium (T3 and T4) and red selenium at high concentrations (T2), while the group given red selenium at low concentrations (T1) and the control (C0) had the lowest Se accumulation. In the kidney tissues and testis, the Se content exhibited no significant differences between the treated groups and the control. The observed variations in the eye and breast muscle Se content among treatment groups reflect the differences in selenium bioavailability, metabolism, and tissue-specific regulatory mechanisms. These findings demonstrate that grey SeNPs can significantly elevate Se bioavailability in quails, particularly in target organs, and enhance the growth performance without notable changes in feed intake. This highlights the potential of SeNPs in enhancing quail nutrition, although further research is needed to establish optimal dosing strategies for safe, effective use.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
selenium
nanoparticles
amorphous
crystallin
avian
bioavailability
tissue
quail
growth
Megjelenés:Nanomaterials. - 15 : 11 (2025), p. 1-14. -
További szerzők:Muthu, Arjun (1996-) (Ph.D. student) Sári Daniella (1991-) (dietetikus, élelmiszer mérnök, mezőgazdasági mérnök) Seresné Törős Gréta (1991-) (élelmiszerbiztonsági- és minőségi mérnök) Béni Áron (1978-) (vegyész) Czeglédi Levente (1977-) (agrármérnök) Knop Renáta (1983-) (állatorvos) El-Ramady, Hassan (1969-) (agrármérnök) Prokisch József (1966-) (vegyész)
Pályázati támogatás:DETKA
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4.

001-es BibID:BIBFORM131705
035-os BibID:(Scopus)105013117635 (WoS)001551083200001
Első szerző:Muthu, Arjun (Ph.D. student)
Cím:Green Synthesised Carbon Nanodots Using the Maillard Reaction for the Rapid Detection of Elemental Selenium in Water and Carbonated Beverages / Arjun Muthu, Duyen H. H. Nguyen, Aya Ferroudj, József Prokisch, Hassan El-Ramady, Chaima Neji, Áron Béni
Dátum:2025
ISSN:2079-4991
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nanomaterials. - 15 : 15 (2025), p. 1-16. -
További szerzők:Nguyen, Huu Huong Duyen (1995-) (Food Science) Ferroudj, Aya (1999-) (animal science) Prokisch József (1966-) (vegyész) El-Ramady, Hassan (1969-) (agrármérnök) Neji, Chaima (1990-) (agrártudományok) Béni Áron (1978-) (vegyész)
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5.

001-es BibID:BIBFORM129906
035-os BibID:(WoS)001496756900001
Első szerző:Nguyen, Huu Huong Duyen (Food Science)
Cím:Carbon Nanodots-Based Sensors : A Promising Tool for Detecting and Monitoring Toxic Compounds / Nguyen, Duyen H. H.; Muthu, Arjun; Elsakhawy, Tamer; Sheta, Mohamed H.; Abdalla, Neama; El-Ramady, Hassan; Prokisch, József
Dátum:2025
ISSN:2079-4991
Megjegyzések:The increasing prevalence of toxic compounds in food, agriculture, and the environment presents a critical challenge to public health and ecological sustainability. Carbon nanodots (CNDs), with their excellent photoluminescence, biocompatibility, and ease of functionalization, have emerged as highly promising materials for developing advanced sensors that target hazardous substances. This review provides a comprehensive overview of the synthesis, functionalization, and sensing mechanisms of CND-based sensors, highlighting their versatile application in detecting toxic compounds such as heavy metals, pesticides, mycotoxins, and emerging contaminants. The article outlines recent advancements in fluorescence, electrochemical, and colorimetric detection strategies and presents key case studies that illustrate the successful application of CNDs in real-world monitoring scenarios. Furthermore, it addresses the challenges associated with reproducibility, scalability, selectivity, and sensor stability and explores future directions for integrating CNDs with smart and sustainable technologies. This review emphasizes the transformative potential of CNDs in achieving rapid, cost-effective, and environmentally friendly toxin detection solutions across multiple domains.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nanomaterials. - 15 : 10 (2025), p. 1-27. -
További szerzők:Muthu, Arjun (1996-) (Ph.D. student) Elsakhawy, Tamer Sheta, Mohamed Abdalla, Neama El-Ramady, Hassan (1969-) (agrármérnök) Prokisch József (1966-) (vegyész)
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6.

001-es BibID:BIBFORM123021
035-os BibID:(WoS)001286893700001 (Scopus)85200775830
Első szerző:Prokisch József (vegyész)
Cím:Carbon Nanodot-Microbe-Plant Nexus in Agroecosystem and Antimicrobial Applications / József Prokisch, Duyen H. H. Nguyen, Arjun Muthu, Aya Ferroudj, Abhishek Singh, Shreni Agrawal, Vishnu D. Rajput, Karen Ghazaryan, Hassan El-Ramady, Mahendra Rai
Dátum:2024
ISSN:2079-4991
Megjegyzések:The intensive applications of nanomaterials in the agroecosystem led to the creation of sev-eral environmental problems. More efforts are needed to discover new insights in the nanomaterial-microbe-plant nexus. This relationship has several dimensions, which may include the transport ofnanomaterials to different plant organs, the nanotoxicity to soil microbes and plants, and differentpossible regulations. This review focuses on the challenges and prospects of the nanomaterial-microbe-plant nexus under agroecosystem conditions. The previous nano-forms were selected in thisstudy because of the rare, published articles on such nanomaterials. Under the study`s nexus, moreinsights on the carbon nanodot-microbe-plant nexus were discussed along with the role of the newfrontier in nano-tellurium-microbe nexus. Transport of nanomaterials to different plant organs underpossible applications, and translocation of these nanoparticles besides their expected nanotoxicity tosoil microbes will be also reported in the current study. Nanotoxicity to soil microbes and plants wasinvestigated by taking account of morpho-physiological, molecular, and biochemical concerns. Thisstudy highlights the regulations of nanotoxicity with a focus on risk and challenges at the ecologicallevel and their risks to human health, along with the scientific and organizational levels. This studyopens many windows in such studies nexus which are needed in the near future.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
soil-plant-microbe nexus
microbiomes
rhizosphere
microbe-microbe nexus
nanoparticles
nanotoxicity
Megjelenés:Nanomaterials. - 14 : 15 (2024), p. 1-37. -
További szerzők:Nguyen, Huu Huong Duyen (1995-) (Food Science) Muthu, Arjun (1996-) (Ph.D. student) Ferroudj, Aya (1999-) (animal science) Singh, Abhishek Agrawal, Shreni Rajput, Vishnu D. Ghazaryan, Karen El-Ramady, Hassan (1969-) (agrármérnök) Rai, Mahendra
Pályázati támogatás:2020-1.1.2-PIACI-KFI-2020-00100
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7.

001-es BibID:BIBFORM123003
035-os BibID:(WoS)001287205900001 (Scopus)85200784612
Első szerző:Prokisch József (vegyész)
Cím:Biological Nano-Agrochemicals for Crop Production as an Emerging Way to Address Heat and Associated Stresses / József Prokisch, Aya Ferroudj, Safa Labidi, Hassan El-Ramady, Eric C. Brevik
Dátum:2024
ISSN:2079-4991
Megjegyzések:Climate change is a global problem facing all aspects of the agricultural sector. Heat stress due to increasing atmospheric temperature is one of the most common climate change impacts on agriculture. Heat stress has direct effects on crop production, along with indirect effects through associated problems such as drought, salinity, and pathogenic stresses. Approaches reported to be effective to mitigate heat stress include nano-management. Nano-agrochemicals such as nanofertilizers and nanopesticides are emerging approaches that have shown promise against heat stress, particularly biogenic nano-sources. Nanomaterials are favorable for crop production due to their low toxicity and eco-friendly action. This review focuses on the different stresses associated with heat stress and their impacts on crop production. Nano-management of crops under heat stress, including the application of biogenic nanofertilizers and nanopesticides, are discussed. The potential and limitations of these biogenic nano-agrochemicals are reviewed. Potential nanotoxicity problems need more investigation at the local, national, and global levels, as well as additional studies into biogenic nano-agrochemicals and their effects on soil, plant, and microbial properties and processes.
Tárgyszavak:Agrártudományok Növénytermesztési és kertészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
climate change
nanofertilizers
nanopesticides
drought stress
salinity stress
nano-management
nanotoxicity
Megjelenés:Nanomaterials. - 14 : 15 (2024), p. 1-24. -
További szerzők:Ferroudj, Aya (1999-) (animal science) Labidi, Safa (1997-) (Food scientist/engineer) El-Ramady, Hassan (1969-) (agrármérnök) Brevik, Eric C.
Pályázati támogatás:Stipendium Hungaricum Scholarship Program
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8.

001-es BibID:BIBFORM120565
035-os BibID:(Scopus)85191739747 (WoS)001210754400001
Első szerző:Sári Daniella (dietetikus, élelmiszer mérnök, mezőgazdasági mérnök)
Cím:Tellurium and Nano-Tellurium : Medicine or Poison? / Daniella Sári, Aya Ferroudj, Dávid Semsey, Hassan El-Ramady, Eric C. Brevik, József Prokisch
Dátum:2024
ISSN:2079-4991
Megjegyzések:Tellurium (Te) is the heaviest stable chalcogen and is a rare element in Earth's crust (one to five ppb). It was discovered in gold ore from mines in Kleinschlatten near the present-day city of Zlatna, Romania. Industrial and other applications of Te focus on its inorganic forms. Tellurium can be toxic to animals and humans at low doses. Chronic tellurium poisoning endangers the kidney, liver, and nervous system. However, Te can be effective against bacteria and is able to destroy cancer cells. Tellurium can also be used to develop redox modulators and enzyme inhibitors. Soluble salts that contain Te had a role as therapeutic and antimicrobial agents before the advent of antibiotics. The pharmaceutical use of Te is not widespread due to the narrow margin between bene?cial and toxic doses, but there are differences between the measure of toxicity based on the Te form. Nano-tellurium (Te-NPs) has several applications: it can act as an adsorptive agent to remove pollutants, and it can be used in antibacterial coating, photo-catalysis for the degradation of dyes, and conductive electronic materials. Nano-sized Te particles are the most promising and can be produced in both chemical and biological ways. Safety assessments are essential to determine the potential risks and benefits of using Te compounds in various applications. Future challenges and directions in developing nano-materials, nano-alloys, and nano-structures based on Te are still open to debate.
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
nano-medicine
nano-toxicity
medicinal attributes
therapeutics
antimicrobial agents
Megjelenés:Nanomaterials. - 14 : 8 (2024), p. 1-24. -
További szerzők:Ferroudj, Aya (1999-) (animal science) Semsey Dávid (1994-) (élelmiszeripari technológia-, és termékfejlesztő mérnök) El-Ramady, Hassan (1969-) (agrármérnök) Brevik, Eric C. Prokisch József (1966-) (vegyész)
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9.

001-es BibID:BIBFORM129528
035-os BibID:(WoS)001474431300001 (Scopus)105003596816
Első szerző:Semsey Dávid (élelmiszeripari technológia-, és termékfejlesztő mérnök)
Cím:Analysis of fluorescent carbon nanodots synthesized from spices through thermal processes treatment / David Semsey, Duyen H. H. Nguyen, Gréta Törős, Vivien Papp, János Pénzes, Tamás Vida, Áron Béni, Mahendra Rai, József Prokisch
Dátum:2025
ISSN:2079-4991
Megjegyzések:Spices contain abundant essential oils and active compounds, which can be difficult to introduce into living cells due to their apolar, lipophilic nature. Carbon nanoparticles, produced through the Maillard reaction during food heat treatment, are small enough to enter cells easily. This study explores how thermal processing affects the formation of carbon nanodots (CNDs) in spices, revealing that higher temperatures boost CND synthesis, thus enhancing bioavailability and biological effectiveness. Interestingly, turmeric and black pepper enriched with CNDs notably influenced yeast fermentation, with an overall increase in antioxidant capacity, especially in turmeric and chili pepper. However, excessive heat occasionally reduced antioxidant activity, suggesting the breakdown of sensitive compounds. These findings highlight the potential of CND-enriched spices for health and nutrition applications.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
carbon dots
foods
cell integrity
Maillard reaction
heat treatment
Megjelenés:Nanomaterials. - 15 : 8 (2025), p. 1-16. -
További szerzők:Nguyen, Huu Huong Duyen (1995-) (Food Science) Seresné Törős Gréta (1991-) (élelmiszerbiztonsági- és minőségi mérnök) Papp Vivien Anna (1997-) (tanszéki mérnök) Pénzes János Vida Tamás Béni Áron (1978-) (vegyész) Rai, Mahendra Prokisch József (1966-) (vegyész)
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10.

001-es BibID:BIBFORM122518
035-os BibID:(WoS)001266590600001 (Scopus)85198406234
Első szerző:Semsey Dávid (élelmiszeripari technológia-, és termékfejlesztő mérnök)
Cím:Analysis of Fluorescent Carbon Nanodot Formation during Pretzel Production / Dávid Semsey, Duyen H. H. Nguyen, Gréta Törős, Arjun Muthu, Safa Labidi, Hassan El-Ramady, Áron Béni, Mahendra Rai, Prokisch József
Dátum:2024
ISSN:2079-4991
Megjegyzések:Baked pretzels are a popular choice for a quick snack, easily identifiable by their classictwisted shape, glossy exterior, and small salt crystals sprinkled on top, making them a standout snack.However, it is not commonly known that compounds with fluorescent properties can be formedduring their production. Carbon nanodots (CNDs) with an average size of 3.5 nm were isolated andidentified in bakery products. This study delved into the formation of CNDs in pretzel productionusing a fractional factorial experimental design. The research revealed that the baking temperaturehad the most significant impact on the concentration of CNDs, followed by the concentration ofNaOH in the immersion solution, and then the baking time. This study highlights the unique role ofthe NaOH immersion step, which is not typically present in bread-making processes, in facilitating theformation of CNDs. This discovery highlights the strong correlation between the formation of CNDsand the heat treatment process. Monitoring and controlling these factors is crucial for regulating theconcentration of CNDs in pretzel production and understanding nanoparticle formation in processedfoods for food safety.
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
carbon dots
bakery
Maillard reaction
baking
factorial design
Megjelenés:Nanomaterials. - 14 : 13 (2024), p. 1-11. -
További szerzők:Nguyen, Huu Huong Duyen (1995-) (Food Science) Seresné Törős Gréta (1991-) (élelmiszerbiztonsági- és minőségi mérnök) Muthu, Arjun (1996-) (Ph.D. student) Labidi, Safa (1997-) (Food scientist/engineer) El-Ramady, Hassan (1969-) (agrármérnök) Béni Áron (1978-) (vegyész) Rai, Mahendra Prokisch József (1966-) (vegyész)
Pályázati támogatás:KDP-2023
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