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1.

001-es BibID:BIBFORM120487
035-os BibID:(Scopus)85141989280 (WoS)000906297800001
Első szerző:Ablonczy László
Cím:Assessment of Quality of Life in Children With Pulmonary Hypertension Using Parent and Self-report Questionnaires / Laszlo Ablonczy, Zita Mayer, Orsolya Somoskövi, Andrea Berkes, Orsolya Csenteri, Eva Kis, György S. Reusz
Dátum:2022
ISSN:0041-1345
Megjegyzések:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevation of pulmonary vascular resistance and right ventricular failure. By using advanced therapies to reduce mortality, clinicians focus on improving functional status and quality of life (QOL). The aim of our study was to assess health-related QOL of pediatric patients with PAH. Parents of all children (aged 2-18 years) and patients aged 5-18 years with an appropriate level of intellectual development completed general and cardiac-specific validated surveys (Pediatric Quality of Life Inventory 4.0 and Pediatric Quality of Life Inventory 3.0, respectively). Demographic and clinical information was collected to grade disease severity. Twenty-five children were enrolled, yielding 25 parent reports and 15 patient self-reports. The PAH group had significantly lower scores than healthy children in all domains. Patients with World Health Organization Functional Class I had significantly higher parent proxy scores in School Functioning (P = .029) and in Heart Problems and Symptoms domain (P = .014) Patients with tricuspid annular plane systolic excursion below ?2 z score showed impairment in each parent proxy general domain and in the Cognitive Problems score of the Cardiac module (P = .006). In conclusion the QOL of patients with PAH was impaired in every domain compared with healthy children. Patients with reduced right ventricle systolic function showed significantly lower QOL in all core domains. These results point to the need for psychosocial rehabilitation in addition to somatic care to improve the QOL in this severely ill population.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Child
Humans
Hypertension, Pulmonary
Proxy
Quality of Life
Self Report
Surveys and Questionnaires
Megjelenés:Transplantation Proceedings. - 54 : 9 (2022), p. 2598-2602. -
További szerzők:Mayer Zita Somoskövi Orsolya Berkes Andrea (1973-) (csecsemő- és gyermekgyógyász) Csenteri Orsolya Karola (1987-) (népegészségügyi ellenőr, rehabilitációs szakember) Kis Éva Reusz György
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2.

001-es BibID:BIBFORM106202
035-os BibID:(WOS)000906505300001 (Scopus)85145501296 (Pubmed)36605210
Első szerző:Abolhassani, Hassan
Cím:Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021 / Hassan Abolhassani, Tadej Avcin, Nerin Bahceciler, Dmitry Balashov, Zsuzsanna Bata, Mihaela Bataneant, Mikhail Belevtsev, Ewa Bernatowska, Judit Bidlo, Péter Blazsó, Bertrand Boisson, Mikhail Bolkov, Anastasia Bondarenko, Oksana Boyarchuk, Anna Bundschu, Jean-Laurent Casanova, Liudmyla Chernishova, Peter Ciznar, Ildikó Csürke, Melinda Erdős, Henriette Farkas, Daria S. Fomina, Nermeen Galal, Vera Goda, Sukru Nail Guner, Péter Hauser, Natalya I. Ilyina, Teona Iremadze, Sevan Iritsyan, Vlora Ismaili-Jaha, Milos Jesenak, Jadranka Kelecic, Sevgi Keles, Gerhard Kindle, Irina V. Kondratenko, Larysa Kostyuchenko, Elena Kovzel, Gergely Kriván, Georgina Kuli-Lito, Gábor Kumánovics, Natalja Kurjane, Elena A. Latysheva, Tatiana V. Latysheva, István Lázár, Gasper Markelj, Maja Markovic, László Maródi, Vafa Mammadova, Márta Medvecz, Noémi Miltner, Kristina Mironska, Fred Modell, Vicki Modell, Bernadett Mosdósi, Anna A. Mukhina, Marianna Murdjeva, Györgyi Műzes, Umida Nabieva, Gulnara Nasrullayeva, Elissaveta Naumova, Kálmán Nagy, Beáta Onozó, Bubusaira Orozbekova, Malgorzata Pac, Karaman Pagava, Alexander N. Pampura, Srdjan Pasic, Mery Petrosyan, Gordana Petrovic, Lidija Pocek, Andrei P. Prodeus, Ismail Reisli, Krista Ress, Nima Rezaei, Yulia A. Rodina, Alexander G. Rumyantsev, Svetlana Sciuca, Anna Sediva, Margit Serban, Svetlana Sharapova, Anna Shcherbina, Brigitta Sitkaustiene, Irina Snimshchikova, Shqipe Spahiu-Konjusha, Miklós Szolnoky, Gabriella Szűcs, Natasa Toplak, Beáta Tóth, Galina Tsyvkina, Irina Tuzankina, Elena Vlasova, Alla Volokha
Dátum:2022
ISSN:1664-3224
Megjegyzések:The J Project (JP) physician education and clinical research collaboration program was started in 2004 and includes by now 32 countries mostly in Eastern and Central Europe (ECE). Until the end of 2021, 344 inborn errors of immunity (IEI)-focused meetings were organized by the JP to raise awareness and facilitate the diagnosis and treatment of patients with IEI. In this study, meeting profiles and major diagnostic and treatment parameters were studied. JP center leaders reported patients' data from 30 countries representing a total population of 506 567 565. Two countries reported patients from JP centers (Konya, Turkey and Cairo University, Egypt). Diagnostic criteria were based on the 2020 update of classification by the IUIS Expert Committee on IEI. The number of JP meetings increased from 6 per year in 2004 and 2005 to 44 and 63 in 2020 and 2021, respectively. The cumulative number of meetings per country varied from 1 to 59 in various countries reflecting partly but not entirely the population of the respective countries. Altogether, 24,879 patients were reported giving an average prevalence of 4.9. Most of the patients had predominantly antibody deficiency (46,32%) followed by patients with combined immunodeficiencies (14.3%). The percentages of patients with bone marrow failure and phenocopies of IEI were less than 1 each. The number of patients was remarkably higher that those reported to the ESID Registry in 13 countries. Immunoglobulin (IgG) substitution was provided to 7,572 patients (5,693 intravenously) and 1,480 patients received hematopoietic stem cell therapy (HSCT). Searching for basic diagnostic parameters revealed the availability of immunochemistry and flow cytometry in 27 and 28 countries, respectively, and targeted gene sequencing and new generation sequencing was available in 21 and 18 countries. The number of IEI centers and experts in the field were 260 and 690, respectively.We found high correlation between the number of IEI centers and patients treated with intravenous IgG (IVIG) (correlation coefficient, cc, 0,916) and with those who were treated with HSCT (cc, 0,905). Similar correlation was found when the number of experts was compared with those treated with HSCT. However, the number of patients treated with subcutaneous Ig (SCIG) only slightly correlated with the number of experts (cc, 0,489) and no correlation was found between the number of centers and patients on SCIG (cc, 0,174).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Immunology. - 13 : 13 (2022), p. 1-14. -
További szerzők:Avcin, Tadej Bahceciler, Nerin Balashov, Dmitry Bata Zsuzsanna Bataneant, Michaela Belevtsev, Michael Bernatowska, Ewa Bidló Judit Blazsó Péter Boisson, Bertrand Bolkov, Mikhail Bondarenko, Anastasia Boyarchuk, Oksana Bundschu, Anna Casanova, Jean-Laurent Chernishova, Liudmyla Ciznar, Peter Csürke Ildikó Erdős Melinda (1975-) (infektológus, gyermekimmunológus) Farkas Henriette Fomina, Daria S. Galal, Nermeen Goda Vera Guner, Sukru Nail Hauser Péter Ilyina, Natalya I. Iremadze, Teona Iritsyan, Sevan Ismaili-Jaha, Vlora Jesenak, Milos Kelecic, Jadranka Keles, Sevgi Kindle, Gerhard Kondratenko, Irina V. Kostyuchenko, Larysa Kovzel, Elena Kriván Gergely Kuli-Lito, Georgina Kumánovics Gábor Kurjane, Natalja Latysheva, Elena A. Latysheva, Tatiana V. Lázár István (1986-) (geográfus) Markelj, Gasper Markovic, Maja Maródi László (1949-) (gyermekgyógyász infektológus, immunológus) Mammadova, Vafa Medvecz Márta Miltner Noémi (1990-) (molekuláris biológus) Mironska, Kristina Modell, Fred Modell, Vicki Mosdósi Bernadett Mukhina, Anna A. Murdjeva, Marianna Műzes Györgyi Nabieva, Umida Nasrullayeva, Gulnara Naumova, Elissaveta Nagy Kálmán Ónozó Beáta Orozbekova, Bubusaira Pac, Malgorzata Pagava, Karaman Pampura, Alexander N. Pasic, Srdjan Petrosyan, Mery Petrovic, Gordana Pocek, Lidija Prodeus, Andrei P. Reisli, Ismail Ress, Krista Rezaei, Nima Rodina, Yulia A. Rumyantsev, Alexander G. Sciuca, Svetlana Sediva, Anna Serban, Margit Sharapova, Svetlana Shcherbina, Anna Sitkaustiene, Brigita Snimshchikova, Irina Spahiu-Konjusha, Shqipe Szolnoky Miklós Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Toplak, Nataŝa Lajszné Tóth Beáta (1978-) (molekuláris biológus) Tsyvkina, Galina Tuzankina, Irina Vlasova, Elena Volokha, Alla
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3.

001-es BibID:BIBFORM121110
035-os BibID:(Scopus)85128197511 (WoS)000780921100001
Első szerző:Aborode, Abdullahi Tunde
Cím:Concern over Nipah virus cases amidst the COVID-19 pandemic in India / Abdullahi T. Aborode, Andrew A. Wireko, Aashna Mehta, Toufik Abdul?Rahman, Esther P. Nansubuga, Mrinmoy Kundu, Manas Pustake, Qasim Mehmood, H. Tillewein
Dátum:2022
ISSN:0146-6615
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
folyóiratcikk
COVID-19
Humans
India
Nipah Virus
Pandemics
SARS-CoV-2
Megjelenés:Journal Of Medical Virology. - 94 : 8 (2022), p. 3488-3490. -
További szerzők:Wireko, Andrew A. Mehta, Aashna Abdul-Rahman, Toufik Nansubuga, Esther Patience Kundu, Mrinmoy Pustake, Manas Mehmood, Qasim Tillewein, H.
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4.

001-es BibID:BIBFORM113272
035-os BibID:(scopus)85142398296 (wos)000888450900001
Első szerző:Aborode, Abdullahi Tunde
Cím:Approaching COVID-19 with epidemiological genomic surveillance and the sustainability of biodiversity informatics in Africa / Abdullahi Tunde Aborode, Helen Huang, Andrew Awuah Wireko, Aashna Mehta, Jacob Kalmanovich, Toufik Abdul-Rahman, Vladyslav Sikora, Aeshah A. Awaji
Dátum:2022
ISSN:0146-6615
Megjegyzések:COVID-19 is an acute respiratory illness caused by Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). The first case was reported in Africa on February 14, 2020 and has surged to 11 million as of July 2022, with 43% and 30% of cases in Southern and Northern Africa. Current epidemiological data demonstrate heterogeneity in transmission and patient outcomes in Africa. However, the burden of infectious diseases such as malaria creates a significant burden on public health resources that are dedicated to COVID-19 surveillance, testing, and vaccination access. Several control measures, such as the SHEF2 model, encompassed Africa's most effective preventive measure. With the help of international collaborations and partnerships, Africa's pandemic preparedness employs effective risk-management strategies to monitor patients at home and build the financial capacity and human resources needed to combat COVID-19 transmission. However, the lack of safe sanitation and inaccessible drinking water, coupled with the financial consequences of lockdowns, makes it challenging to prevent the transmission and contraction of COVID-19. The overwhelming burden on contact tracers due to an already strained healthcare system will hurt epidemiological tracing and swift counter-measures. With the rise in variants, African countries must adopt genomic surveillance and prioritize funding for biodiversity informatics. ? 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Medical Virology. - 95 : 1 (2022), p. 1-5. -
További szerzők:Huang, Helen Wireko, Andrew A. Mehta, Aashna Kalmanovich, Jacob Abdul-Rahman, Toufik Sikora, Vladyslav Awaji, Aeshah A.
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5.

001-es BibID:BIBFORM100939
035-os BibID:(Scopus)85127560068 (WoS)000776869700001
Első szerző:Adácsi Cintia (táplálkozástudományi szakember)
Cím:Microbiological and Toxicological Evaluation of Fermented Forages / Adácsi Cintia, Kovács Szilvia, Pócsi István, Győri Zoltán, Dombrádi Zsuzsanna, Pusztahelyi Tünde
Dátum:2022
ISSN:2077-0472
Megjegyzések:Abstract: Several feed preservation methods can ensure lower mycotoxin contamination levels enter the food life cycle, and a relatively common wet preservation method of forage plant materials is fermentation. This study aimed to characterize the microbiological state and mycotoxin contamination of fermented silages and haylages (corn, alfalfa, rye, and triticale), their main microbiota, and isolation of bacteria with mycotoxin resistance. Bacteria that remain viable throughout the fermentation process and possess high mycotoxin resistance can have a biotechnological benefit. Lactic acid bacteria, primarily found in corn silage, were Lactiplantibacillus plantarum isolates. Meanwhile, a high percentage of alfalfa silage and haylage was characterized by Lactiplantibacillus pentosus. In rye silage and haylage samples, Pediococci were the typical bacteria. Bacterial isolates were characterized by deoxynivalenol and zearalenon resistance. Some of them were sensitive to aflatoxin B1, while ochratoxin A caused 33?86% growth inhibition of the cultures. The mycotoxin resistant organisms are under further research, aiming for mycotoxin elimination in feed.
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
mycotoxin
lactic acid bacteria
spore-forming bacteria
deoxynivalenol
zearalenone
ochratoxin A
aflatoxin B1
silage
haylage
Megjelenés:Agriculture-Basel. - 12 : 3 (2022), p. 1-11. -
További szerzők:Kovács Szilvia (1982-) (biológus) Pócsi István (1961-) (vegyész) Győri Zoltán (1948-) (vegyész) Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Pusztahelyi Tünde (1969-) (biológus, angol-magyar szakfordító)
Pályázati támogatás:018-1.2.1-NKP-2018-00002
Egyéb
019-2.1.13-TÉT_IN-2020-00056
Egyéb
TKP2020-IKA-04 (TP)
Egyéb
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6.

001-es BibID:BIBFORM101339
035-os BibID:(scopus)85127787477 (wos)000786332700001
Első szerző:Ádám Dorottya (molekuláris biológus)
Cím:Opioidergic Signaling : a Neglected, Yet Potentially Important Player in Atopic Dermatitis / Dorottya Ádám, József Arany, Kinga Fanni Tóth, Balázs István Tóth, Attila Gábor Szöllősi, Attila Oláh
Dátum:2022
ISSN:1661-6596 1422-0067
Megjegyzések:Atopic dermatitis (AD) is one of the most common skin diseases, the prevalence of which is es-pecially high among children. Although our understanding about its pathogenesis has substan-tially grown in recent years, and hence, several novel therapeutic targets have been successfully exploited in the management of the disease, we still lack curative treatments for it. Thus, there is an unmet societal demand to identify further details of its pathogenesis to thereby pave the way for novel therapeutic approaches with favorable side effect profiles. It is commonly accepted that dysfunction of the complex cutaneous barrier plays a central role in the development of AD; therefore, the signaling pathways involved in the regulation of this quite complex process are likely to be involved in the pathogenesis of the disease and can provide novel, promising, yet unexplored therapeutic targets. Thus, in the current review, we aim to summarize the available potentially AD-relevant data regarding one such signaling pathway, namely cutaneous opi-oidergic signaling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
atopic dermatitis (AD)
cutaneous barrier
[delta]-opioid receptor (DOR)
inflammation
itch
[delta]-opioid receptor (KOR)
keratinocyte
mast cell
[delta]-opioid receptor (MOR)
nociceptin/orphanin FQ (NOP) receptor
opioid
skin
Megjelenés:International Journal Of Molecular Sciences. - 23 : 8 (2022), p. 4140. -
További szerzők:Arany József (1990-) (klinikai laboratóriumi kutató, vegyész) Tóth Kinga Fanni (1992-) (molekuláris biológus, élettanász) Tóth István Balázs (1978-) (élettanász) Szöllősi Attila Gábor (1982-) (élettanász) Oláh Attila (1984-) (élettanász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00026
GINOP
NKFIH 120187
Egyéb
NKFIH 134235
Egyéb
NKFIH 134725
Egyéb
NKFIH 134993
Egyéb
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
Bolyai János Kutatási Ösztöndíj (BO/00660/21/5)
MTA
Bolyai János Kutatási Ösztöndíj (BO/00905/19/5)
MTA
ÚNKP-21-5-DE-465
Egyéb
ÚNKP-21-5-DE-491
Egyéb
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7.

001-es BibID:BIBFORM121108
035-os BibID:(Scopus)85130246576 (WoS)000799533900001
Első szerző:Adámková, Václava (vegyész)
Cím:Antimicrobial activity of ceftazidime-avibactam and comparators against Pseudomonas aeruginosa and Enterobacterales collected in Croatia, Czech Republic, Hungary, Poland, Latvia and Lithuania : ATLAS Surveillance Program, 2019 / V. Adámková, I. Mareković, J. Szabó, L. Pojnar, S. Billová, S. Horvat Herceg, A. Kuraieva, B. Możejko?Pastewka
Dátum:2022
ISSN:0934-9723
Megjegyzések:Antimicrobial susceptibility of clinical isolates collected from sites in central Europe in 2019 was tested by CLSI broth microdilution method and EUCAST breakpoints. Most active were amikacin, ceftazidime-avibactam and colistin; respectively, susceptibility rates among P. aeruginosa (n = 701) were 89.2%, 92.2% and 99.9%; difficult-to-treat (DTR) isolates, 62.5%, 37.5% and 100%; multidrug-resistant (MDR) isolates, 68.3%, 72.9% and 99.5%; meropenem-resistant (MEM-R), metallo-?-lactamase-negative (MBL-negative) isolates, 72.8%, 78.6% and 100%. Among Enterobacterales (n = 1639), susceptibility to ceftazidime-avibactam, colistin and tigecycline was ? 97.9%; MDR Enterobacterales, 96.8%, 94.4% and 100%, respectively; DTR isolates, ? 76.2% to ceftazidime-avibactam and colistin; MEM-R, MBL-negative isolates, ? 90.0% to ceftazidime-avibactam and colistin.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ceftazidime-avibactam
Pseudomonas aeruginosa
Enterobacterales
Antimicrobial surveillance
ATLAS
Difficult-to-treat
Megjelenés:European Journal Of Clinical Microbiology & Infectious Diseases. - 41 : 6 (2022), p. 989-996. -
További szerzők:Mareković, I. Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Pojnar, L. Billová, Sabina Horvat Herceg, S. Kuraieva, A. Możejko-Pastewka, B.
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8.

001-es BibID:BIBFORM120868
035-os BibID:(Scopus)85119438551 (WOS)000729080200001
Első szerző:Adlam, David
Cím:A Randomized, double-blind, dose ranging clinical trial of intravenous FDY-5301 in acute STEMI patients undergoing primary PCI / David Adlam, Maciej Zarebinski, Neal G. Uren, Pawel Ptaszynski, Keith G. Oldroyd, Shahzad Munir, Azfar Zaman, Hussain Contractor, Róbert Gábor Kiss, István Édes, Joanna Szachniewicz, Gergely Gyorgy Nagy, Mario J. Garcia, János Tomcsanyi, John Irving, Andrew S. P. Sharp, Piotr Musialek, Géza Lupkovics, Cheerag Shirodaria, Joseph B. Selvanayagam, Pauline Quinn, Leong Ng, Mark Roth, Michael A. Insko, Ben Haber, Stephen Hill, Lori Siegel, Simon Tulloch, Keith M. Channon
Dátum:2022
ISSN:0167-5273
Megjegyzések:Background: Ischemia-reperfusion injury remains a major clinical problem in patients with ST-elevation myocardial infarction (STEMI), leading to myocardial damage despite early reperfusion by primary percutaneous coronary intervention (PPCI). There are no effective therapies to limit ischemia-reperfusion injury, which is caused by multiple pathways activated by rapid tissue reoxygenation and the generation of reactive oxygen species (ROS). FDY-5301 contains sodium iodide, a ubiquitous inorganic halide and elemental reducing agent that can act as a catalytic anti-peroxidant. We tested the feasibility, safety and potential utility of FDY-5301 as a treatment to limit ischemia-reperfusion injury, in patients with first-time STEMI undergoing emergency PPCI. Methods: STEMI patients (n = 120, median 62 years) presenting within 12 h of chest pain onset were randomized at 20 PPCI centers, in a double blind Phase 2 clinical trial, to receive FDY-5301 (0.5, 1.0 or 2.0 mg/kg) or placebo prior to reperfusion, to evaluate the feasibility endpoints. Participants underwent continuous ECG monitoring for 14 days after PPCI to address pre-specified cardiac arrhythmia safety end points and cardiac magnetic resonance imaging (MRI) at 72 h and at 3 months to assess exploratory efficacy end points. Results: Intravenous FDY-5301 was delivered before re-opening of the infarct-related artery in 97% participants and increased plasma iodide levels similar to 1000-fold within 2 min. There was no significant increase in the primary safety end point of incidence of cardiac arrhythmias of concern. MRI at 3 months revealed median final infarct sizes in placebo vs. 2.0 mg/kg FDY-5301-treated patients of 14.9% vs. 8.5%, and LV ejection fractions of 53.9% vs. 63.2%, respectively, although the study was not powered to detect statistical significance. In patients receiving FDY-5301, there was a significant reduction in the levels of MPO, MMP2 and NTproBNP after PPCI, but no reduction with placebo. Conclusions: Intravenous FDY-5301, delivered immediately prior to PPCI in acute STEMI, is feasible, safe, and shows potential efficacy. A larger trial is justified to test the effects of FDY-5301 on acute ischemia-reperfusion injury and clinical outcomes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Myocardial infarction
Primary PCI
Reperfusion injury
Megjelenés:International Journal Of Cardiology. - 347 (2022), p. 1-7. -
További szerzők:Zarebinski, Maciej Uren, Neal G. Ptaszynski, Pawel Oldroyd, Keith G. Munir, Shahzad Zaman, Azfar Contractor, Hussain Kiss Róbert Gábor Édes István (1952-) (kardiológus) Szachniewicz, Joanna Nagy Gergely György (1976-) (orvos) Garcia, Mario J. Tomcsányi János Irving, John Sharp, Andrew S. P. Musialek, Piotr Lupkovics Géza Shirodaria, Cheerag Selvanayagam, Joseph B. Quinn, Pauline Ng, Leong Roth, Mark Insko, Michael A. Haber, Ben Hill, Stephen Siegel, Lori Tulloch, Simon Channon, Keith
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9.

001-es BibID:BIBFORM103936
035-os BibID:(WoS)000868254300009 (Scopus)85143055930
Első szerző:Aggarwal, Rohit
Cím:Trial of Intravenous Immune Globulin in Dermatomyositis / Aggarwal Rohit, Charles-Schoeman Christina, Schessl Joachim, Bata-Csörgő Zsuzsanna, Dimachkie Mazen M., Griger Zoltan, Moiseev Sergey, Oddis Chester, Schiopu Elena, Vencovsky Jiri, Beckmann Irene, Clodi Elisabeth, Bugrova Olga, Dankó Katalin, Ernste Floranne, Goyal Namita A., Heuer Marvin, Hudson Marie, Hussain Yessar M., Karam Chafic, Magnolo Nina, Nelson Ronald, Pozur Nataliia, Prystupa Liudmyla, Sárdy Miklós, Valenzuela Guillermo, van der Kooi Anneke J., Vu Tuan, Worm Margitta, Levine Todd, ProDERM Trial Group
Dátum:2022
ISSN:0028-4793
Megjegyzések:Background: Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated. Methods: We conducted a randomized, placebo-controlled trial involving patients with active dermatomyositis. The patients were assigned in a 1:1 ratio to receive IVIG at a dose of 2.0 g per kilogram of body weight or placebo every 4 weeks for 16 weeks. The patients who received placebo and those without confirmed clinical deterioration while receiving IVIG could enter an open-label extension phase for another 24 weeks. The primary end point was a response, defined as a Total Improvement Score (TIS) of at least 20 (indicating at least minimal improvement) at week 16 and no confirmed deterioration up to week 16. The TIS is a weighted composite score reflecting the change in a core set of six measures of myositis activity over time; scores range from 0 to 100, with higher scores indicating greater improvement. Key secondary end points included at least moderate improvement (TIS ?40) and major improvement (TIS ?60), and change in score on the Cutaneous Dermatomyositis Disease Area and Severity Index. Results: A total of 95 patients underwent randomization: 47 patients were assigned to the IVIG group, and 48 to the placebo group. At 16 weeks, 79% of the patients in the IVIG group (37 of 47) and 44% of those in the placebo group (21 of 48) had a TIS of at least 20 (difference, 35 percentage points; 95% confidence interval, 17 to 53; P<0.001). The results with respect to the secondary end points, including at least moderate improvement and major improvement, were generally in the same direction as the results of the primary end-point analysis, except for the change in creatine kinase level (an individual core measure of the TIS), which did not differ meaningfully between the two groups. Over 40 weeks, 282 treatment-related adverse events occurred in the IVIG group, including headache (in 42% of patients), pyrexia (in 19%), and nausea (in 16%). A total of 9 serious adverse events that were considered to be related to IVIG occurred, including 6 thromboembolic events. Conclusions: In this 16-week trial involving adults with dermatomyositis, the percentage of patients with a response of at least minimal improvement based on a composite score of disease activity was significantly greater among those who received IVIG than among those who received placebo. IVIG was associated with adverse events, including thromboembolism. (Funded by Octapharma Pharmazeutika; ProDERM ClinicalTrials.gov number, NCT02728752.).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:New England Journal Of Medicine. - 387 : 14 (2022), p. 1264-1278. -
További szerzők:Charles-Schoeman, Christina Schessl, Joachim Bata-Csörgő Zsuzsanna Dimachkie, Mazen M. Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Moiseev, Sergey Oddis, Chester V. Schiopu, Elena Vencovsky, Jiri Beckmann, Irene Clodi, Elisabeth Bugrova, Olga Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Ernste, Floranne Goyal, Namita A. Heuer, Marvin Hudson, Marie Hussain, Yessar M. Karam, Chafic Magnolo, Nina Nelson, Ronald Pozur, Nataliia Prystupa, Liudmyla Sárdy Miklós Valenzuela, Guillermo van der Kooi, Anneke J. Vu, Tuan Worm, Margitta Levine, Todd ProDERM Trial Group
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM107337
035-os BibID:(scopus)85135370588 (wos)000831208500002
Első szerző:Åkerlund, Cecilia
Cím:Clustering identifies endotypes of traumatic brain injury in an intensive care cohort : a CENTER-TBI study / Ảkerlund Cecilia A. I., Holst Anders, Stocchetti Nino, Steyerberg Ewout W., Menon David K., Ercole Ari, Nelson David W., CENTER-TBI Participants and Investigators
Dátum:2022
ISSN:1364-8535
Megjegyzések:Abstract Background: While the Glasgow coma scale (GCS) is one of the strongest outcome predictors, the current classifcation of traumatic brain injury (TBI) as ♭mild', ♭moderate' or ♭severe' based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization of TBI could identify distinct endotypes and give mechanistic insights. Methods: We developed an unsupervised statistical clustering model based on a mixture of probabilistic graphs for presentation (<24 h) demographic, clinical, physiological, laboratory and imaging data to identify subgroups of TBI patients admitted to the intensive care unit in the CENTER-TBI dataset (N=1,728). A cluster similarity index was used for robust determination of optimal cluster number. Mutual information was used to quantify feature importance and for cluster interpretation. Results: Six stable endotypes were identifed with distinct GCS and composite systemic metabolic stress profles, distinguished by GCS, blood lactate, oxygen saturation, serum creatinine, glucose, base excess, pH, arterial partial pressure of carbon dioxide, and body temperature. Notably, a cluster with ♭moderate' TBI (by traditional classifcation) and deranged metabolic profle, had a worse outcome than a cluster with ♭severe' GCS and a normal metabolic profle. Addition of cluster labels signifcantly improved the prognostic precision of the IMPACT (International Mission for Prognosis and Analysis of Clinical trials in TBI) extended model, for prediction of both unfavourable outcome and mortality (both p<0.001). Conclusions: Six stable and clinically distinct TBI endotypes were identifed by probabilistic unsupervised clustering. In addition to presenting neurology, a profle of biochemical derangement was found to be an important distinguishing feature that was both biologically plausible and associated with outcome. Our work motivates refning current TBI classifcations with factors describing metabolic stress. Such data-driven clusters suggest TBI endotypes that merit investigation to identify bespoke treatment strategies to improve care. Trial registration The core study was registered with ClinicalTrials.gov, number NCT02210221, registered on August 06, 2014, with Resource Identifcation Portal (RRID: SCR_015582)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Traumatic brain injury
Endotypes
Intensive care unit
Critical care
Unsupervised clustering
Machine learning
Megjelenés:Critical Care. - 26 : 1 (2022), p. 1-15. -
További szerzők:Holst, Anders Stocchetti, Nino Steyerberg, Ewout W. Menon, David Krishna Ercole, Ari Nelson, David W. Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM121114
035-os BibID:(Scopus)85130767724 (WoS)000799634800001
Első szerző:Almási Kálmán
Cím:Transanalis műtéti útmutató - második kiadás / Almási Kálmán, Ábrahám Szabolcs, Baracs József, Bursics Attila, Jánó Zoltán, Sztipits Tamás, Szűts Áron, Tóth Dezső, Zaránd Attila, Bánky Balázs
Dátum:2022
ISSN:0030-6002 1788-6120
Megjegyzések:A végbél alsó és középső harmadán kialakuló daganatok sebészetét anatómiai okokból fakadó technikai problémák nehezítik. Az utóbbi években több műtéti megoldás jelent meg a sebészi repertoárban, melyek az alsó és középső harmadi rectumelváltozások megfelelő, biztonságos feltárását és biztonságos műtéti kezelését teszik lehetővé. A következő dolgozat a transanalis endoszkópos technikák jelenlegi szakmai irányelveinek rövid összefoglalása, a technikában jártas hazai szakamberek konszenzusát alapul véve. A tanulmány transanalis excisiónak (TAE) tekint minden olyan műtéti technikát, amely hagyományos sebészi feltárókkal, hagyományos sebészi eszköztárral ?éri el" és távolítja el a rectumelváltozást. (Idesoroljuk az oldalablakos vagy végablakos anoszkópok segítségével végzett ?nyílt" eljárásokat is.) Transanalis endoszkópos műtétnek (TAM) definiálunk minden, operációs anoszkópon vagy rektoszkópon keresztül, pneumorectum-képzés segítségével, laparoszkópos műtéti eszköztárral végzett, rectumon belüli beavatkozást [1]. (Idesoroljuk a TEM-, TEO- és TAMIS-műtéteket.) A flexibilis endoszkóppal végzett transanalis beavatkozások (EMR és ESD) külön kategóriát jelentenek, ezekkel a tanulmány részletesen nem foglalkozik. A jelen felújított Útmutató célja az első (2019. évi) verzió megjelenése óta e forrongó témában megjelent szakirodalmi ismeretek integrálása és interpretálása, ezáltal a megfogalmazott ajánlások naprakésszé tétele.
Tárgyszavak:Orvostudományok Klinikai orvostudományok gyakorlati útmutató
folyóiratcikk
Megjelenés:Orvosi Hetilap. - 163 : Suppl_1 (2022), p. 3-19. -
További szerzők:Ábrahám Szabolcs Baracs József Bursics Attila Jánó Zoltán Sztipits Tamás Szűts Áron Tóth Dezső (1972-) (sebész, onkológus) Zaránd Attila Bánky Balázs
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM119940
035-os BibID:(Scopus)85139561280 (WoS)000872550600001
Első szerző:Al-Tammemi, Ala'a B. (PhD hallgató)
Cím:A qualitative exploration of university students` perspectives on distance education in Jordan : an application of Moore`s theory of transactional distance / Ala`a B. Al-Tammemi, Rana Nheili, Chiamaka H. Jibuaku, Dua`a Al Tamimi, Musheer A. Aljaberi, Moawiah Khatatbeh, Muna Barakat, Hindya O. Al-Maqableh, Hussam N. Fakhouri
Dátum:2022
ISSN:2504-284X
Megjegyzések:The current study aimed at exploring university students' perspectives on the emergency distance education strategy that was implemented during the COVID-19 crisis in Jordan, one of the countries in the Eastern Mediterranean Region. Utilizing a qualitative design supported by Moore's theory of transactional distance, a total of 17 semi-structured interviews were conducted with university students of various study levels and disciplines. Data were inductively analyzed using thematic analysis as suggested by Braun and Clarke. Seven themes have emerged, including, (i) students' psychological response to the sudden transition in educational process, (ii) students' digital preparedness, equality, and digital communication, (iii) students' and teachers' technical competencies and technostress, (iv) student?student and student?teacher interpersonal communication, (v) quality and quantity of learning materials, (vi) students' assignments, examinations, and non-reliable evaluation methods, and (vii) opportunities with positive impact of distance learning. The study findings provide evidence that the sudden transition from traditional on-campus to online distance education was significantly challenging in many aspects and was not a pleasant experience for many participants. Various factors under the jurisdiction of academic institutions and decision-makers are considered main contributing factors to the students' educational experiences amid the pandemic crisis. Therefore, better planning and more sustainable utilization of educational resources have paramount importance in providing a high-quality education. Additionally, more dedicated efforts in terms of equitable, reliable, and credible evaluation systems should be considered in Jordan's distance education strategy.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
digital preparedness
Jordan
COVID-19
qualitative
distance education
Moore's theory
transactional distance
Megjelenés:Frontiers in Education. - 7 (2022), p. 1-12. -
További szerzők:Nheili, Rana Jibuaku, Chiamaka H. Al Tamimi, Dua'a Aljaberi, Musheer A. Khatatbeh, Moawiah Barakat, Muna Al-Maqableh, Hindya O. Fakhouri, Hussam N.
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Intézményi repozitóriumban (DEA) tárolt változat
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