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1.

001-es BibID:BIBFORM103061
035-os BibID:(WoS)000699490600001 (Scopus)85115891080
Első szerző:Hoang, Anh Cuong
Cím:Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse / Anh Cuong Hoang, Haidong Yu, Tamás Röszer
Dátum:2021
ISSN:2073-4409
Megjegyzések:The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including ?-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adipose tissue
adipogenesis
brown fat
thermogenesis
obesity
Megjelenés:Cells. - 10 : 9 (2021), p. 1-22. -
További szerzők:Yu, Haidong Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:German Research Fund (DFG) RO 4856
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2.

001-es BibID:BIBFORM126066
035-os BibID:(scopus)85208640447 (wos)001351247400001
Első szerző:Radványi Ádám
Cím:Adipose Tissue Macrophages of the Human Fetus / Radványi Ádám, Gyurina Katalin, Rácz Emese, Kovács Ilona, Méhes Gábor, Röszer Tamás
Dátum:2024
ISSN:2073-4409
Megjegyzések:Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. After birth and in adulthood, adipose tissue macrophages (ATMs) are relevant constituents of the fat depots, and they are necessary for physiological adipose tissue development and fat metabolism. In obesity, however, ATMs may induce chronic inflammation leading to insulin resistance, pancreatic beta cell damage and self-immunity. Despite being relevant regulators of adipose tissue development and functioning, it is unknown whether ATMs are present in the fetal adipose tissue, therefore it is elusive whether they may affect the prenatal establishment of fat depots. Here we studied the distribution of ATMs in the human fetus between gestational weeks 17 and 38 and labeled ATMs in the early postnatal life. We found that CD45+/CD14+/CD68+ ATMs infiltrated the fetal adipose tissue from the 17th week of gestation and remained persistent throughout the second and third trimesters. ATMs were phagocytic in the neonate and expressed interleukin-6, along with other pro-inflammatory gene products. These findings show that ATMs colonize the adipose tissue early in gestation, raising the possibility that intrauterine ATM?adipocyte communication may exist, eventually allowing ATMs to affect prenatal adipose tissue development. ? 2024 by the authors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adipose tissue
human development
immunity
macrophages
metabolism
Megjelenés:Cells. - 13 : 21 (2024), p. 1-16. -
További szerzők:Gyurina Katalin (1986-) (tudományos segédmunkatárs) Rácz Emese Kovács Ilona (1965-) (patológus) Méhes Gábor (1966-) (patológus) Röszer Tamás (1979-) (orvos, biológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM123157
035-os BibID:(Scopus)85200941103 (WoS)001286951600001
Első szerző:Röszer Tamás (orvos, biológus)
Cím:MicroRNA Profile of Mouse Adipocyte-Derived Extracellular Vesicles / Tamás Röszer
Dátum:2024
ISSN:2073-4409
Megjegyzések:Abstract: The post-transcriptional control of gene expression is a complex and evolving field in adipocyte biology, with the premise that the delivery of microRNA (miRNA) species to the obese adipose tissue may facilitate weight loss. Cells shed extracellular vesicles (EVs) that may deliver miRNAs as intercellular messengers. However, we know little about the miRNA profile of EVs secreted by adipocytes during postnatal development. Here, we defined the miRNA cargo of EVs secreted by mouse adipocytes in two distinct phases of development: on postnatal day 6, when adipocytes are lipolytic and thermogenic, and on postnatal day 56, when adipocytes have active lipogenesis. EVs were collected from cell culture supernatants, and their miRNA profile was defined by small RNA sequencing. The most abundant miRNA of mouse adipocyte-derived EVs was mmumiR-148a-3p. Adipocyte EVs on postnatal day 6 were hallmarked with mmu-miR-98-5p, and some miRNAs were specific to this developmental stage, such as mmu-miR-466i-5p and 12 novel miRNAs. Adipocytes on postnatal day 56 secreted mmu-miR-365-3p, and 16 miRNAs were specific to this developmental stage. The miRNA cargo of adipocyte EVs targeted gene networks of cell proliferation, insulin signaling, interferon response, thermogenesis, and lipogenesis. We provided here a database of miRNAs secreted by developing mouse adipocytes, which may be a tool for further studies on the regulation of gene networks that control mouse adipocyte development.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
gyermekgyógyászat
elhízás
zsírszövet
Megjelenés:Cells. - 13 : 15 (2024), p. 1-16. -
Pályázati támogatás:NKFI-142939
OTKA
MTA Bolyai Ösztöndíj
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM103104
035-os BibID:(Wos)000443248600019 (Scopus)85063293908
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Understanding the Biology of Self-Renewing Macrophages / Tamás Röszer
Dátum:2018
ISSN:2073-4409
Megjegyzések:Macrophages reside in specific territories in organs, where they contribute to the development, homeostasis, and repair of tissues. Recent work has shown that the size of tissue macrophage populations has an impact on tissue functions and is determined by the balance between replenishment and elimination. Macrophage replenishment is mainly due to self-renewal of macrophages, with a secondary contribution from blood monocytes. Self-renewal is a recently discovered trait of macrophages, which can have a major impact on their physiological functions and hence on the wellbeing of the organism. In this review, I discuss our current understanding of the developmental origin of self-renewing macrophages and the mechanisms used to maintain a physiologically stable macrophage pool.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
macrophage
leukocyte biology
stem cell
proliferation
Megjelenés:Cells. - 7 : 8 (2018), p. 1-21. -
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM103062
035-os BibID:(WoS)000699281300001 (Scopus)85115886588
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Adipose Tissue Immunometabolism and Apoptotic Cell Clearance / Tamás Röszer
Dátum:2021
ISSN:2073-4409
Megjegyzések:The safe removal of apoptotic debris by macrophages-often referred to as efferocytosis-is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte apoptosis is an inflammation-generating process, and the removal of apoptotic adipocytes by so-called adipose tissue macrophages triggers a sequence of events that lead to meta-inflammation and obesity-associated metabolic diseases. Signals that allow apoptotic cells to control macrophage immune functions are complex and involve metabolites released by the apoptotic cells and also metabolites produced by the macrophages during the digestion of apoptotic cell contents. This review provides a concise summary of the adipocyte-derived metabolites that potentially control adipose tissue macrophage immune functions and, hence, may induce or alleviate adipose tissue inflammation.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
apoptosis
obesity
meta-inflammation
immunometabolism
macrophage
M2 macrophage
efferocytosis
phagocytosis
Megjelenés:Cells. - 10 : 9 (2021), p. 1-16. -
Pályázati támogatás:German Research Fund (DFG) RO-4856
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM114971
035-os BibID:(scopus)85175587052 (wos)001085681900001
Első szerző:Varga Kornél Z.
Cím:Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy / Varga Kornél Z., Gyurina Katalin, Radványi Ádám, Pál Tibor, Sasi-Szabó László, Yu Haidong, Felszeghy Enikő, Szabó Tamás, Röszer Tamás
Dátum:2023
ISSN:2073-4409
Megjegyzések:Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a potential proinflammatory signal that causes adipose tissue dysfunction and insulin resistance. Cytosolic DNA activates the stimulator of interferon response genes (STING), a key signal transducer which triggers type I interferon (IFN-I) expression; hence, STING activation is expected to induce IFN-I response and adipocyte dysfunction. However, we show herein that mouse adipocytes had a diminished IFN-I response to STING stimulation by 2·3·-cyclic-GMP-AMP (cGAMP). We also show that cGAMP triggered autophagy in murine and human adipocytes. In turn, STING inhibition reduced autophagosome number, compromised the mitochondrial network and caused inflammation and fat accumulation in adipocytes. STING hence stimulates a process that removes damaged mitochondria, thereby protecting adipocytes from an excessive IFN-I response to mitochondrial DNA efflux. In summary, STING appears to limit inflammation in adipocytes by promoting mitophagy under non-obesogenic conditions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
Megjelenés:Cells. - 12 : 19 (2023), p. 1-17. -
További szerzők:Gyurina Katalin (1986-) (tudományos segédmunkatárs) Radványi Ádám Pál Tibor Sasi Szabó László András (1974-) (sebész) Yu, Haidong Felszeghy Enikő Noémi (1970-) (gyermekgyógyász) Szabó Tamás (1968-) (gyermekgyógyász) Röszer Tamás (1979-) (orvos, biológus)
Pályázati támogatás:142939
OTKA
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Intézményi repozitóriumban (DEA) tárolt változat
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