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001-es BibID:	BIBFORM017912
Első szerző:	Mészáros T. (Budapest)
Cím:	C1-inhibitor autoantibodies in SLE. / Mészáros T., Füst G., Farkas H., Jakab L., Temesszentandrási G., Nagy G., Kiss E., Gergely P., Zeher M., Griger Z., Czirják L., Hóbor R., Haris A., Polner K., Varga L.
Dátum:	2010
ISSN:	0961-2033
Megjegyzések:	The presence of anti-C1-inhibitor (anti-C1-INH) autoantibodies is a hallmark of acquired C1-inhibitor deficiency. However, only scarce data are available on their prevalence, diagnostic value, and/or significance in systemic lupus erythematosus (SLE). In a multicentre study, we determined the levels of autoantibodies to C1-inhibitor in sera from 202 patients with SLE and 134 healthy controls. Additional clinical and laboratory parameters, such as organ involvement, as well as anti-C1q, anti-double-stranded DNA antibody, erythrocyte sedimentation rate, C-reactive protein, C3 and C4 serum complement levels have been studied in patients. The level of anti-C1-INH IgG was significantly higher (p = 0.034) in SLE patients, than in the controls. A high anti-C1-INH level of > or =0.4 U/ml (mean of controls + 2 SD) was found in 17% of the patients, but in only 4% of the controls (p = 0.0003). The SLEDAI score was significantly higher (p = 0.048) and the duration of SLE was significantly longer (p = 0.0004) among patients with elevated anti-C1-INH levels compared with patients without this autoantibody (median disease duration 8 vs. 17 years, respectively). Anti-C1-INH level was not correlated with any other laboratory parameter or organ manifestation of the disease. These findings indicate that the anti-C1-INH level is higher in SLE patients than in healthy controls and furthermore, the anti-C1-INH level correlates with the duration and activity of the disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Lupus 19 : 5 (2010), p. 634-638. -
További szerzők:	Füst György (Budapest) Farkas H. (Budapest) Jakab Lajos (Budapest) Temesszentandrási G. (Budapest) Nagy G. (Budapest) Kiss Emese (Budapest) Gergely Péter (Budapest) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Czirják László Hóbor Renáta Haris A. (Budapest) Polner Kálmán Varga L. (Budapest)
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001-es BibID:	BIBFORM125984
Első szerző:	Nagy-Vincze Melinda (orvos)
Cím:	High fetal risk in pregnancies of myositis patients : a Hungarian cohort study / Nagy-Vincze Melinda, Szinay Dorottya, Szabó Katalin, Molnár Deliné Sarolta, Balkay László, Béldi Tibor, Griger Zoltán
Dátum:	2024
ISSN:	2813-6934
Megjegyzések:	Background: Several systemic autoimmune rheumatic diseases may affect both fetal and maternal outcomes during pregnancy. However, little information is available regarding pregnancy outcomes in women with idiopathic inflammatory myopathy. Previously published articles stated that the activity of maternal disease may worsen pregnancy outcomes. A former multicenter study suggested that anti-Jo1 antibody positivity and joint involvement could distinguish a more vulnerable group regarding pregnancy complications. Our aim was to identify prognostic factors among clinical symptoms at disease onset and auto-antibody profiles for identifying a high-risk group for poor pregnancy outcome. Methods: The clinical data of the myositis cohort of the Division of Clinical Immunology, University of Debrecen, Hungary, were reviewed retrospectively. IIM diagnoses were made by Bohan and Peter's criteria or European Alliance of Associations for Rheumatology/American College of Rheumatology (EULAR/ACR) criteria. Disease activity was evaluated based on physician opinion. Gynecological definitions were used to evaluate fetal outcomes. Results: Reviewing clinical data of overall 763 patients (542 women and 221 men) revealed that 5.2% of female patients had pregnancies in the same time or after myositis onset. Among these, 71.4% of the mothers suffered from polymyositis (PM) and 28.6% suffered from dermatomyositis (DM). Their mean age at the time of myositis diagnosis was 25.28?years, and the average interval between myositis diagnosis and first pregnancy was 55.4?months. Maternal complications included preeclampsia in one case and pregnancy-induced myositis in 25% of cases. All cases of pregnancy-induced myositis improved after immunosuppressive treatment. Twenty-eight patients reported 60 pregnancies overall, with multiple pregnancies occurring in 57% of cases. Early or late fetal loss was detected in 41.7% of the pregnancies, and stillbirth occurred in 18.3% of deliveries. Although late fetal loss was observed mainly due to placental insufficiency in patients with anti-Jo1 positivity and complications seemed more frequent in PM cases, logistic regression analysis only confirmed that multiple pregnancies could be an independent risk factor for fetal (p?=?0.0112) and interstitial lung disease of maternal complications (p?=?0.02). Conclusion: Internal organ involvement and the number of pregnancies could influence pregnancy outcomes in myositis patients. Patients' family planning should be well organized and counseled by myositis experts. Prospective, multicenter collaborations are needed to precisely identify high-risk groups and state managing guidelines.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk polymyositis dermatomyositis pregnancy outcome miscarriages internal organ involvement
Megjelenés:	Frontiers in Lupus. - 2 (2024), p. 1-7. -
További szerzők:	Szinay Dorottya (1995-) (Orvos) Szabó Katalin (1991-) (orvos) Deliné Molnár Sarolta (1990-) (patológus) Balkay László (1963-) (biofizikus) Béldi Tibor (1994-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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