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001-es BibID:	BIBFORM134822
035-os BibID:	(scopus)105014476813 (wos)001559455600001
Első szerző:	Che, Weng Ian
Cím:	Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region / Che Weng Ian, Öberg Sysojev Anton, Zhu Catherine, Patasova Karina, International Lymphoma Epidemiology Consortium (InterLymph), IMACS Myositis Genetics Scientific Interest Group (MYOGEN), Smedby Karin E., Lundberg Ingrid E., Westerlind Helga, Holmqvist Marie
Dátum:	2025
ISSN:	2056-5933
Megjegyzések:	Objectives: To estimate shared genetic susceptibility between major subtypes of idiopathic inflammatory myopathies (IIM) and B cell lymphomas. Methods: We paired summary statistics from genome-wide association studies (GWASs) of diffuse large B cell lymphoma, follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and marginal zone lymphoma with those of dermatomyositis (DM) and polymyositis (PM) from a GWAS and an ImmunoChip study. We estimated local genetic correlation (rg) for each disease pair using local analysis of (co)variant association (Bonferroni-corrected p value<0.05) and identified genetic variants jointly associated with both diseases using pleiotropy-informed false discovery rate (conjunctional false discovery rate <0.05). Functional mapping and annotation analyses were also performed. Results: We identified significant rg (ranging from -0.50 to 0.84) across 16 loci, with half located in the human leucocyte antigen (HLA) region, for the disease pairs of IIM and B cell lymphoma subtypes. Furthermore, jointly associated single-nucleotide polymorphisms were predominantly found in the HLA region. Specifically, all disease pairs showed shared genetic susceptibility in the HLA class I regions, while additional correlations in class III and class II regions were specific to DM and PM disease pairs, respectively. For some non-HLA loci with significant rg, functional analyses revealed immune-related responses potentially overlapping between DM and FL, DM and CLL, and PM and CLL. Conclusion: We revealed that DM and PM share genetic susceptibility with common B cell lymphoma subtypes in both immune-related loci and loci with unclear biological functions. These novel findings improve our understanding of the pathological link between IIM and B cell lymphomas.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Dermatomyositis Epidemiology Hematology Polymorphism, Genetic Polymyositis.
Megjelenés:	RMD Open. - 11 : 3 (2025), p. 1-12. -
További szerzők:	Öberg Sysojev, Anton Zhu, Catherine Patasova, Karina Smedby, Karin E. Lundberg, Ingrid Westerlind, Helga Holmqvist, Marie Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) International Lymphoma Epidemiology Consortium (InterLymph) IMACS Myositis Genetics Scientific Interest Group (MYOGEN)
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001-es BibID:	BIBFORM123875
035-os BibID:	(Scopus)85201771588 (WoS)001308121100001
Első szerző:	Espinosa-Ortega, Fabricio
Cím:	Autoantibodies and damage in patients with idiopathic inflammatory myopathies : a longitudinal multicenter study from the MYONET international network / Espinosa-Ortega Fabricio, Lodin Karin, Dastmalchi Maryam, Vencovsky Jiri, Diederichsen Louise P., Shinjo Samuel Katsuyuki, Danieli Maria Giovanna, Selva-O'Callaghan Albert, de Visser Marianne, Griger Zoltan, Ceribelli Angela, Gómez-Martin Diana, Andersson Helena, Mercado Mónica Vázquez-Del, Chinoy Hector, Lilleker James B., New Paul, Krogh Niels S., Lundberg Ingrid E., Alexanderson Helene, MYONET Registry Study Group
Dátum:	2024
ISSN:	0049-0172
Megjegyzések:	Objective To study the trajectories of changes in damage over time and explore associations with autoantibody defined subgroups using a large international cohort of patients with idiopathic inflammatory myopathies (IIM). Methods Data from the MYONET registry, including patients who were tested for autoantibodies and had at least one assessment of damage using the Myositis Damage Index (MDI), were analyzed. Patients were sub-grouped according to their autoantibody profiles (myositis-specific, myositis-associated, or seronegative). The index date was defined as the time point for the first registered MDI assessment. The longitudinal trajectories of damage with autoantibody status as the main predictor were analyzed using linear mixed models. Results A total of 757 adult patients were included in this study. Each year of disease duration since diagnosis had an estimated MDI score increase of 0.16 units for the seronegative group (reference). Compared with the seronegative group as reference, patients with dermatomyositis-specific autoantibodies developed less damage per year of follow-up since diagnosis (average 0.08 less score, P = 0.04), whereas patients with anti-PM/Scl autoantibodies developed more damage per year of follow-up since diagnosis (average 0.28 higher score, P = 0.03) independent of sex and age at diagnosis. The seronegative subgroup and the immune-mediated necrotizing myopathy autoantibody subgroup had the strongest correlation between severity of muscle damage and HAQ-DI scores at five years of follow-up, rho=0.84, P < 0.001 and rho=0.72, P < 0.001, respectively. Conclusion Our study is the first to describe patterns and trajectories of change in damage over time in relation to autoantibody defined subgroups in a large international multicenter cohort of patients with IIM. Patients with anti-PM/Scl scored a greater extent of damage, whereas patients with dermatomyositis-specific antibodies had less damage than seronegative patients. Severity in muscle damage had moderate to strong correlation with functional disability among the IMNM and seronegative subgroups with lower correlations for the other subgroups. These findings suggest that autoantibodies may be useful predictors of long-term damage.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Autoantibodies Dermatomyositis Inflammatory myopathies Organ damage Myositis
Megjelenés:	Seminars In Arthritis And Rheumatism. - 68 (2024), p. 1-10.-
További szerzők:	Lodin, Karin Dastmalchi, Maryam Vencovsky, Jiri Diederichsen, Louise Pyndt Shinjo, Samuel Katsuyuki Danieli, Maria Giovanna Selva-O'Callaghan, Albert de Visser, Marianne Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Ceribelli, Angela Gómez-Martin, Diana Andersson, Helena Mercado, Mónica Vázquez-Del Chinoy, Hector Lilleker, James B. New, Paul Krogh, Niels Steen Lundberg, Ingrid Alexanderson, Helene MYONET Registry
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001-es BibID:	BIBFORM115334
035-os BibID:	(WoS)001078071300001 (Scopus)85200360861
Első szerző:	Hum, Ryan Malcolm
Cím:	Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry / Hum Ryan Malcolm, Lilleker James B., Lamb Janine A., Oldroyd Alexander G. S., Wang Guochun, Wedderburn Lucy R., Diederichsen Louise P., Schmidt Jens, Danieli Maria Giovanna, Oakley Paula, Griger Zoltan, Nguyen Thi Phuong Thuy, Kodishala Chanakya, Vazquez-Del Mercado Monica, Andersson Helena, De Paepe Boel, De Bleecker Jan L., Maurer Britta, McCann Liza, Pipitone Nicolo, McHugh Neil, New Robert Paul, Ollier William E., Krogh Niels Steen, Vencovsky Jiri, Lundberg Ingrid E., Chinoy Hector, MYONET Registry
Dátum:	2024
ISSN:	1462-0324 1462-0332
Megjegyzések:	Objectives: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations, and malignancy, between adults with anti-synthetase syndrome (ASyS) and dermatomyositis (DM). Methods: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1?/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V sign, erythroderma, and/or periorbital rash). Results: In total 1,054 patients were included (DM, n = 405; ASyS, n = 649). In ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease, and cardiac involvement differentiated ASyS-DMskin from DM (all p< 0.001), whereas higher frequency of any of four DM-type rashes: heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%) differentiated DM from ASyS-DMskin (all p< 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both p< 0.001). Conclusion: DM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antisynthetase syndrome MYONET Raynaud's phenomenon cutaneous dermatomyositis epidemiology extramuscular malignancy rashes skin
Megjelenés:	Rheumatology. - 63 : 8 (2024), p. 2093-2100. -
További szerzők:	Lilleker, James B. Lamb, Janine A. Oldroyd, Alexander Wang, Guochun Wedderburn, Lucy R. Diederichsen, Louise Pyndt Schmidt, Jens Danieli, Maria Giovanna Oakley, Paula Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nguyen, Thi Le Phuong Kodishala, Chanakya Vazquez-Del Mercado, Monica Andersson, Helena De Paepe, Boel De Bleecker, Jan Maurer, Britta McCann, Liza J. Pipitone, Nicolo McHugh, Neil New, Robert Paul Ollier, William E. Krogh, Niels Steen Vencovsky, Jiri Lundberg, Ingrid Chinoy, Hector MYONET Registry
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001-es BibID:	BIBFORM117991
035-os BibID:	(scopus)85184773277
Első szerző:	Lodin, Karin
Cím:	Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : a longitudinal study / Lodin Karin, Espinosa-Ortega Fabricio, Dastmalchi Maryam, Vencovsky Jiri, Andersson Helena, Chinoy Hector, Lilleker James B., Shinjo Samuel Katsuyuki, Maurer Britta, Griger Zoltan, Ceribelli Angela, Torres-Ruiz Jiram, Mercado Mónica Vázquez-Del, Leonard Dag, Alexanderson Helene, Lundberg Ingrid E.
Dátum:	2024
ISSN:	0049-0172
Megjegyzések:	Aim : To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM). Methods : PGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analysed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function. Results : PGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity. Conclusion : Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Idiopathic inflammatory myopathies myositis patient reported outcome measures inflammation
Megjelenés:	Seminars In Arthritis And Rheumatism. - 65 (2024), p. 1-10. -
További szerzők:	Espinosa-Ortega, Fabricio Dastmalchi, Maryam Vencovsky, Jiri Andersson, Helena Chinoy, Hector Lilleker, James B. Shinjo, Samuel Katsuyuki Maurer, Britta Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Ceribelli, Angela Torres-Ruiz, Jiram Mercado, Mónica Vázquez-Del Leonard, Dag Alexanderson, Helene Lundberg, Ingrid
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