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001-es BibID:	BIBFORM016873
Első szerző:	Cai, You-Sheng
Cím:	Palmarumycins BG1-BG7 and Preussomerin BG1 : Establishment of Their Absolute Configurations Using Theoretical Calculations of Electronic Circular Dichroism Spectra / You-Sheng Cai, Tibor Kurtán, Ze-Hong Miao, Attila Mándi, István Komáromi, Hai-Li Liu, Jian Ding, Yue-Wei Guo
Dátum:	2011
Megjegyzések:	Palmarumycins BG1-BG7 (1-7), seven new compounds related to palmarumycins, were isolated from the aerial parts of Bruguiera gymnorrhiza as well as a new preussomerin derivative BG1 (8). The structures of these compounds were determined mainly by the analysis of their NMR and MS data, and their relative configurations were assigned on the basis of their 3JH,H coupling constants. Compounds 4 and 7 have a sulfate group that is unprecedented amongmembers of spirodioxynaphthalene-type natural products. The absolute configurations of 1-8 were determined by TDDFT CD calculations of the solution conformers. Compound 5 displayed inhibitory activity against HL 60 and MCF-7 cell lines.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Organic Chemistry. - 76 : 6 (2011), p. 1821-1830. -
További szerzők:	Kurtán Tibor (1973-) (vegyész, angol szakfordító) Miao, Ze-Hong Mándi Attila (1981-) (vegyész, német szakfordító) Komáromi István (1957-) (vegyész, molekuláris biológus, biokémikus) Liu, Hai-Li Ding, Jian Guo, Yue-Wei
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM013694
Első szerző:	Gong, Jing-Xu
Cím:	Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities / Jing-Xu Gong, Ze-Hong Miao, Li-Gong Yao, Jian Ding, Tibor Kurtán, Yue-Wei Guo
Dátum:	2010
ISSN:	0936-5214
Megjegyzések:	The stereoselective synthesis of methyl spongoate, a naturally occurring new steroid derivative with an unusual C-20 methoxycarbonyl group and potent antitumor activities, was achieved starting from the commercially available pregnenolone acetate in 11% overall yield.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban steroids methyl spongoate stereoselective synthesis diastereoselective alkylation cytotoxicity
Megjelenés:	Synlett. - 2010 : 3 (2010), p. 480-482. -
További szerzők:	Miao, Ze-Hong Yao, Li-Gong Ding, Jian Kurtán Tibor (1973-) (vegyész, angol szakfordító) Guo, Yue-Wei
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM004097
Első szerző:	Zhang, Wen
Cím:	Structural and Stereochemical Studies of alpha-Methylene-gamma-lactone-Bearing Cembrane Diterpenoids from a South China Sea Soft Coral Lobophytum crassum / Wen Zhang, Karsten Krohn, Jian Ding, Ze-Hong Miao, Xiu-Hong Zhou, Si-Han Chen, Gennaro Pescitelli, Piero Salvadori, Tibor Kurtán, Yue-Wei Guo
Dátum:	2008
Megjegyzések:	Levelező szerző Yue-Wei Guo, e-mail: ywguo@mail.shcnc.ac.cn Four new alpha-methylene-gamma-lactone-bearing cembranoids, 20-acetylsinularolide B (6), presinularolide B (7), 3-dehydroxylpresinularolide B (8), and 3-dehydroxyl-20-acetylpresinularolide B (9), together with five known analogues, sinularolides B-E (1-4) and 20-acetylsinularolide C (5), were isolated from a South China Sea soft coral Lobophytum crassum. Their structures and relative stereochemistry were established by a combination of detailed spectroscopic data analysis and chemical correlations. The structures of 1-9 were further confirmed by an X-ray diffraction study on a single crystal of sinularolide B (1). The absolute configurations of sinularolide B (1) and presinularolide B (7) were determined by a novel solid-state CD/TDDFT approach and by a modified Mosher's method, respectively. This study also revealed that the coupling constant between the lactonic methine protons (3J1,2) varies considerably with different functional groups on the cembrane ring and that the determination of the stereochemistry of lactone ring fusion based on this coupling constant is risky. In a bioassay, sinularolides B and C (1 and 2) and new cembranoids 7 and 8 showed in Vitro cytotoxicity against the tumor cell lines A-549 and P-388.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Natural Products. - 71 : 6 (2008), p. 961-966. -
További szerzők:	Krohn, Karsten Ding, Jian Miao, Ze-Hong Zhou, Xiu-Hong Chen, Si-Han Pescitelli, Gennaro (1972-) (vegyész) Salvadori, Piero Guo, Yue-Wei Kurtán Tibor (1973-) (vegyész, angol szakfordító)
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM061786
035-os BibID:	(Scopus)84952649991 (WoS)000367193900004
Cím:	Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. / Ren-Yong Huang, Wen-Ting Chen, Tibor Kurtán, Attila Mándi, Jian Ding, Jia Li, Xu-Wen Li, Yue-Wei Guo
Dátum:	2016
ISSN:	1756-8919 1756-8927
Megjegyzések:	Background: Nudibranchs are slug-like invertebrates, well known as rich sources of biologically active secondary metabolites with highly chemical diversity and complexity. The production of such interesting metabolites was possibly inflenced by their diet relationship with sponges such as Xestospongia. Results: Our continuous investigation of South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. led to the isolation of two new and eight known metabolites (1-10). The absolute confiurations were determined by time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) method and by the comparison of ECD spectra. In bioassays, 1-4 and 7 showed strong NF-?B inhibitory activity, 4-6 exhibited considerable cytotoxicity against A549 and HL-60 tumor cell lines. Conclusion: Five unusual isoquinolinequinones (3, 7-10) were discovered from both two animals, further confimed their predator-prey relationship. Preliminary bioassay results and structure-activity relationship studies suggested that several isolated compounds were potential to be drug leads.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban epimer NF-[kappa]B signaling pathway TDDFT ECD tetrahydroisoquinolinequinone
Megjelenés:	Future Medicinal Chemistry. - 8 : 1 (2016), p. 17-27. -
További szerzők:	Huang, Ren-Yong Chen, Wen-Ting Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Ding, Jian Li, Jia Li, Xu-Wen Guo, Yue-Wei
Pályázati támogatás:	K105871 OTKA NIIFI 10038 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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