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001-es BibID:	BIBFORM132070
Első szerző:	Diószegi Ágnes (belgyógyász)
Cím:	Assessment of Serum Endocan Levels and Their Associations with Arterial Stiffness Parameters in Young Patients with Systemic Lupus Erythematosus / Diószegi Ágnes, Lőrincz Hajnalka, Kaáli Eszter, Csiha Sára, Kaluha Judit, Varga Éva, Páll Dénes, Tarr Tünde, Harangi Mariann
Dátum:	2025
ISSN:	2077-0383
Megjegyzések:	Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder associated with premature atherosclerosis and vascular impairment. However, the role of endocan, a biomarker of glycocalyx injury, is not completely clarified in the detection of vascular damage. Therefore, our aim was to investigate serum endocan in comparison with conventional inflammatory markers, arterial stiffness parameters, and carotid ultrasound findings in a cohort of young patients with SLE. Methods: We enrolled 47 clinically active young SLE patients (40 females and 7 males) in the study. Arterial stiffness indicated by augmentation index and pulse wave velocity (PWV) was measured by arteriography. Brachial artery flow-mediated dilatation and common carotid intima-media thickness were detected by ultrasonography. The serum concentrations of endocan, IL-6, MPO, MCP-1, MMP-3, -7, and -9, as well as TNF?, were measured by an enzyme-linked immunosorbent assay (ELISA). Results: We found significant negative correlations between serum endocan and both CH50 and C3. Serum endocan was higher in active SLE patients compared to inactive patients, however, the difference was not statistically significant (241.4 (183?295) vs. 200.3 (167?278) pg/mL; p = 0.313). Serum TNF? and hsCRP significantly correlated with PWV. However, we did not detect significant correlations between vascular diagnostic tests and serum endocan levels. Conclusions: Based on our results, serum endocan is associated with disease activity; however, further studies are needed to clarify the value of serum endocan in the cardiovascular risk estimation of SLE patients. Measurement of serum endocan, as well as the routine assessment of arterial stiffness parameters, should be integrated into the comprehensive management plans of young patients with SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endocan tumor necrosis factor-alpha C-reactive protein atherosclerosis systemic lupus erythematosus arterial stiffness pulse wave velocity
Megjelenés:	Journal of Clinical Medicine. - 14 : 17 (2025), p. 1-16. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Kaáli Eszter Csiha Sára (1985-) (Biológus) Kaluha Judit (1987-) (orvos) Varga Éva (1982-) (belgyógyász) Páll Dénes (1967-) (belgyógyász, kardiológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	OTKA - 142273 OTKA TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM109052
035-os BibID:	(Scopus)85151113623 (WoS)000953989400001
Első szerző:	Diószegi Ágnes (belgyógyász)
Cím:	Role of Altered Metabolism of Triglyceride-Rich Lipoprotein Particles in the Development of Vascular Dysfunction in Systemic Lupus Erythematosus / Diószegi Ágnes, Lőrincz Hajnalka, Kaáli Eszter, Soltész Pál, Perge Bianka, Varga Éva, Harangi Mariann, Tarr Tünde
Dátum:	2023
ISSN:	2218-273X
Megjegyzések:	Background: Impaired lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis in systemic lupus erythematosus (SLE). We aimed to evaluate the lipid profile, inflammatory markers, and vascular diagnostic tests in active SLE patients to clarify the association between dyslipidemia and early vascular damage. Patients and Methods: 51 clinically active SLE patients and 41 age- and gender-matched control subjects were enrolled in the study. Lipoprotein subfractions were detected by Lipoprint. Brachial artery flow-mediated dilation and common carotid intima-media thickness were detected by ultrasonography. Arterial stiffness indicated by augmentation index (Aix) and pulse wave velocity was measured by arteriography. Results: We found significantly higher Aix, higher VLDL ratio, plasma triglyceride, ApoB100, and small HDL, as well as lower HDL-C, large HDL, and ApoA1 in patients with SLE. There was a significant positive correlation of Aix with triglyceride, VLDL, IDL-C, IDL-B, and LDL1. A backward stepwise multiple regression analysis showed IDL-C subfraction to be the best predictor of Aix. Conclusions: Our results indicate that in young patients with SLE, triglyceride-rich lipoproteins influence vascular function detected by Aix. These parameters may be assessed and integrated into the management plan for screening cardiovascular risk in patients with SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic lupus erythematosus carotid intima-media thickness augmentation index flow-mediated dilation triglyceride very low-density lipoprotein intermediate-density lipoprotein triglyceride-rich lipoproteins
Megjelenés:	Biomolecules. - 13 : 3 (2023), p. 1-13. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Kaáli Eszter Soltész Pál (1961-) (belgyógyász, kardiológus) Perge Bianka (1990-) (belgyógyász) Varga Éva (1982-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus)
Pályázati támogatás:	Tématerületi Kiválósági Program Egyéb K142273 NKFIH TKP2021-EGA-18 Egyéb TKP2021-EGA Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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