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1.

001-es BibID:BIBFORM082304
035-os BibID:(Wos)000506895301006
Első szerző:Diószegi Judit (megelőző orvostan és népegészségtan szakorvos)
Cím:Taste and food preferences of the Hungarian Roma population / J. Diószegi, P. Pikó, Z. Kósa, J. Sándor, R. Ádány
Dátum:2019
ISSN:1101-1262
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 29 : Suppl. 4 (2019), p. 118-119. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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2.

001-es BibID:BIBFORM074716
Első szerző:Diószegi Judit (megelőző orvostan és népegészségtan szakorvos)
Cím:Polymorphisms affecting alcohol consumption behaviour in the general Hungarian and Roma populations / J. Diószegi, S. Fiatal, R. Tóth, Á. Moravcsik-Kornyicki, Z. Kósa, J. Sándor, R. Ádány
Dátum:2015
Tárgyszavak:Orvostudományok Egészségtudományok konferenciacikk
Megjelenés:European Journal of Public Health. - 25 : 3 (2015), p. 179-180. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Tóth Réka Moravcsik-Kornyicki Ágota (1986-) (védőnő) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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3.

001-es BibID:BIBFORM105958
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Increased genetic susceptibility of the Hungarian Roma population to venous thrombosis / S. Fiatal, P. Pikó, Z. Kósa, J. Sándor, R. Ádány
Dátum:2017
ISSN:1101-1262
Megjegyzések:Background Studies on Roma populations show the high prevalence of cardiovascular risk factors among them independently from the countries where they live. Sporadic findings suggest that in addition to the environmental/modifiable risk factors genetic susceptibility may also exist behind the high cardiovascular disease morbidity and mortality burden of Roma. Our aim was to define the genetic susceptibility of Hungarian Roma to venous thrombosis by investigating the prevalence of alleles contributing to thrombophilia to a highest extent and compare it to that of the general population. Methods Based on systematic literature review SNPs (N = 48) associated with venous-thrombosis in 32 genes (e.g. F2, F5, F9, F11, F15, FGA, FGB, FGG, CYP4V2, KLKB1, vWF) were selected and analysed in the Hungarian Roma (N = 962) and general (N = 1492) populations. Differences in allele frequencies, as well as genetic risk scores both unweighted (GRS) and weighted (wGRS) were defined for the study groups and compared to estimate the joint effect of SNPs. Results Differences in allele frequencies between the study populations were significant in case of 29 polymorphisms after multiple test correction, and almost all susceptible alleles were more prevalent in the Roma population. Both GRS and wGRS were found significantly higher in Roma than in the general population (GRS: 39.84 5.35 vs. 38.71 5.59, p<0.001; wGRS: 7 1.8 vs. 6.73 1.9, p < 0.01). Only 1.35% of subjects in the Roma population were in the bottom fifth of the wGRS (wGRS 2.5) compared with 2.28% of those in the general population, while 3.62% of the general subjects were in the top fifth of the wGRS (wGRS 9.9) compared with 5.09% of those in the Roma population (p<0.001). Conclusions The Roma population has increased genetic susceptibility to venous thrombosis as it is indicated by higher GRS values in comparison with that for the Hungarian general population.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 27 : suppl3 (2017), p. 31. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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4.

001-es BibID:BIBFORM105956
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Fasting plasma glucose related genetic variants show ethnic variation in Hungarian populations / Sz. Fiatal, P. Pikó, Zs. Kósa, J. Sándor, R. Ádány
Dátum:2017
ISSN:1101-1262
Megjegyzések:Background Elevated fasting glucose (FG) level is a risk factor for diabetes. Meta-analyses of European populations' data identified many loci associated with glucose metabolism, but knowledge on other ethnicities is limited. Consequently, the generalizability of results to non-Europeans remains to be clarified. We addressed the question whether the individual effect of established FG related genetic loci are applicable to the Roma considered to have a South Asian origin. Methods Genotyping of 21 SNPs in 19 genes (among them C2CD4B, CDC123, CDKAL1, CDKN2A/B, FADS1, G6PC2, GCKR, GLIS3, SLC2A2, TCF7L2) was performed in Hungarian populations (General: N = 1411; Roma: N = 576). Single SNP associations (direction and magnitude of the effect on FG level) were estimated by regression models using covariates (age, sex). Data obtained on study populations were compared to formerly published European data and to each other. Individuals on antidiabetic treatment were excluded. Results The beta coefficients for SNPs on the sample of general population were found to be almost (except rs5219, rs174550) identical both in direction and magnitude, indicating that the effect is mostly concordant with the results obtained in large scale studies on Europeans. However, among Roma in case of 5 SNPs (rs10946398, rs340874, rs7034200, rs1111875 and rs174550) the effect direction differed in comparison with European data. The rs174550 variant showed difference in effect direction in both populations compared to data on Europeans. Between study populations in case of 5 SNPs (rs10946398, rs340874, rs7034200, rs1111875, rs5219) the association differed in direction, in addition one out of these variants (rs1111875) differed also in magnitude, pointing out the notable ethnic variation among Hungarians. Conclusions Differences observed in effect direction in case of 5 SNPs indicate that data obtained on European populations can be utilised in genetic risk estimation models for Roma with cautions.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 27 : suppl3 (2017), p. 264. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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5.

001-es BibID:BIBFORM105951
035-os BibID:(WOS)000506895303139
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Disparities in smoking habits in Hungarian Roma and general populations / S. Fiatal, P. Pikó, Z. Kósa, J. Sándor, R. Ádány
Dátum:2019
ISSN:1101-1262
Megjegyzések:Background: Smoking status, dependence and cessation efforts of the disadvantaged Hungarian Roma living in segregated settlements were compared to those of the general population. Methods: Data were collected through survey. Each study group consists of 500 randomly drawn subjects, and are representative of the adult (18-64) general and Roma population, living in two counties of North-East Hungary. Questions on smoking from the European Health Interview Survey were used with some modifications. Prevalence data were analysed according to age strata (18-29, 30-44 and 45-64 years) by chi2 test, and were compared to data from 2003 and 2014. Results: In Roma the proportion of never smokers is much less compared to the general ones (men:27.27% vs.75%, women:38.6% vs.70.75%, p < 0.05). Less Roma reported never smoking in all age compared to 2014, increasing trend can be found in the general population since 2003. Smoking prevalence is higher in Roma in all ages (72.73% vs.20 83%; 68.42% vs.28.42%; 59.02 vs. 32.26%, p < 0.05, respectively). Interestingly, the prevalence of Roma men smokers is decreasing by age, in the general population the trend is the opposite. Heavy smoker status is the highest in 30-44 age group of both populations. Increasing trend of heavy smoking can be detected in the Roma, but the opposite holds for general population compared to 2014. Half of the Roma smoke within 5 minutes after wakeup (50% vs. 36.92%, p < 0.05), smoke hand-rolled cigarettes (68.91%vs 30.77%, p < 0.05), higher proportion of them tried to quit (34.78% vs. 23.38%, p < 0.05) but smaller proportion of them obtained advise on how to quit (48.53% vs.59.09%, p < 0.05). Initiation starts earlier age among them (men: 15.1 vs.16.6, women: 16.2 vs.18.2, p < 0.05). Conclusions: Regular smoking (especially heavy) is much higher in the Roma and decreasing by age compared to the general in all age-groups. The 30-44 age group of Roma mean are exclusively heavy smokers but half of the Roma show effort to quit.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 29 : Suppl4 (2019), p. 388. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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6.

001-es BibID:BIBFORM054074
Első szerző:Kósa Zsigmond (orvos)
Cím:Prevalence of metabolic syndrome among Roma : a comparative health examination survey in Hungary / Zsigmond Kósa, Ágota Moravcsik-Kornyicki, Judit Diószegi, Bayard Roberts, Zoltán Szabó, János Sándor, Róza Ádány
Dátum:2015
ISSN:1101-1262
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Public Health 25 : 2 (2015), p. 299-304. -
További szerzők:Moravcsik-Kornyicki Ágota (1986-) (védőnő) Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) Roberts, Bayard Szabó Zoltán (1973-) (belgyógyász, kardiológus) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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7.

001-es BibID:BIBFORM082082
035-os BibID:(Wos)000506895301005
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Macro- and micro-nutrient intake among Hungarian general and Roma adults / Erand Llanaj, Ferenc Vincze, Zsigmond Kósa, Róza Ádány
Dátum:2019
ISSN:1101-1262
Megjegyzések:Background Few studies have been conducted with reference to dietary intake among adults in Hungary and none among Roma. In this study, we assess dietary intake of both Hungarian general (HG) and Hungarian Roma (HR) adult population and provide an up-to-date preview on highly health-relevant macro- and micro-nutrient intakes and dietary profile of the HG and HR adult population. Methods The study population comprised 797 Hungarian adults (HG: N = 410, response rate=82% and HR: N = 387, response rate=79%), representative in terms of geographic, sex and age distribution with the general population aged 20-64 years, from the 2018 GINOP Complex Health Survey. Energy and selected nutrient intakes were calculated with NutriComp v.3.0, based on a qualitatively validated double 24 hours dietary recall, adopted for the Hungarian population. Results Total daily energy and selected nutrients intake among HG and HR adult subjects are reported. In spite of the presence of diluted underestimation effects, intake of nutrients with high relevance to health (i.e. sugars, sodium, saturated fats, cholesterol, etc.) remains relatively high, while consumption of fibre-rich products and beneficial nutrients appear to be low, particularly among Roma. Considering both health and environmental impact of the diet, animal-based proteins are way over the target value (i.e. 6%E) of the recent EAT-Lancet report. Conclusions Findings provide data on dietary patterns of HG and HR with nutrient-level estimations, highlighting the importance of establishing and integrating Roma nutrition in national surveillance and monitoring systems for key dietary risk factors. Public health strategies to modify current dietary patterns in Hungary are a great opportunity for improving nutrition, health and environmental impact of dietary choices, especially within the current framework of the UN Decade of Action on Nutrition (2016-2025).
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 29 : Suppl.4 (2019), p. 118. -
További szerzők:Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Kósa Zsigmond (1953-) (orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
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8.

001-es BibID:BIBFORM109200
Első szerző:Pikó Péter (biológus)
Cím:Association of HDL subfractions with cardiovascular risk in Hungarian general and Roma populations / P. Pikó, N. A. Werissa, Z. Kosa, J. Sandor, I. Seres, G. Paragh, R. Adany
Dátum:2022
ISSN:1101-1262
Megjegyzések:Background: High-density lipoprotein (HDL) cholesterol levels are inversely associated with cardiovascular risk (CVR). However, HDL cholesterol is not a homogeneous lipid and can be subdivided into subfractions, which are not uniformly associated with CVR. Among Roma populations, the prevalence of reduced HDL cholesterol levels and, consequently, that of cardiovascular diseases is very high. However, it is not known how this reduction affects the different HDL subfractions and whether changes in their representation are associated with changes in CVR. Methods: The study aimed to investigate whether there is a difference in the HDL subfraction profile between the Hungarian general (HG) and Roma populations and to determine the association of the different subfractions with the CVR estimated by the Framingham Risk Score (FRS) and the Systematic COronary Risk Evaluation (SCORE) algorithms. HDL cholesterol was separated using the Lipoprint system, which separates 10 subfractions into three classes: large HDL (HDL-L), medium HDL (HDL-I), and small HDL (HDL-S). Analyses were carried out on samples of 100 control subjects (50 Hungarian general and 50 Roma individuals with normal lipid profiles) and 277 individuals with reduced HDL-C levels. Results: Our results show that Roma has reduced levels of the overall HDL subfraction profile, with significant decreases in HDL-6, and -7. Regardless of the estimation method, elevated levels (in mmol/L) of HDL-1 to 3 and HDL-L were significantly associated with reduced risk. A higher representation (in %) of HDL-1 to 3 subfractions have a significant risk-reducing, while HDL-8 to 10 have a risk-increasing effect estimated by FRS. Conclusions: The results of our study show that levels of CVR protective HDL subfractions are significantly lower in Roma individuals and their reduced levels are associated with increased CVR, suggesting that the distribution of HDL subfractions contributes to the to the overall unfavourable CVR profile of Roma.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 32 : Suppl3 (2022), p. iii467. -
További szerzők:Werissa, Nardos Abebe (1985-) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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9.

001-es BibID:BIBFORM105952
035-os BibID:(WOS)000506895302274
Első szerző:Pikó Péter (biológus)
Cím:Increased risk of Roma for 10-year development of CVDs based on Framingham Risk Score calculation / P. Piko, Sz. Fiatal, Z. Kosa, J. Sandor, R. Adany
Dátum:2019
ISSN:1101-1262
Megjegyzések:Background: Increased mortality and short life expectancy of Roma are well known epidemiological findings which can be partially explained by the high prevalence of cardiovascular risk factors among them. This study assesses the prevalence of the cardiovascular disease (CVD) risk factors (age, sex, systolic blood pressure, smoking and diabetes status, elevated total and reduced high density lipoprotein cholesterol level (HDL-C)) and the estimation of 10-year risk of development of CVD (CVD in general, coronary heart disease (CHD), myocardial infarction (MI) and stroke) and that of death from CHD and CVD based on the Framingham Risk Score (FRS) in case of the Hungarian general (HG) and Roma (HR) populations. Methods: A complex health survey incl. questionnaire based interview, physical examination and laboratory test was carried out in 2018 on the HG and HR populations. The prevalence of different cardiovascular risk factors was defined and FRS was computed and compared between the HG (n = 378) and HR (n = 386) populations. Results: The prevalence of diabetes was significantly higher among Roma females compared to females of general population (17.8% vs. 7.7%; p = 0.001) while the average systolic blood pressure level was less elevated among Roma males (127.9 mmHg vs. 129.4 mmHg; p = 0.020). The prevalence of smoking (males: 63.1% vs. 33.7%; females: 67.6% vs. 31%; p < 0.001) and reduced HDL-C level (males: 40% vs. 25.9%, p = 0.014; females: 55.5% vs. 35.1%, p < 0.001) were significantly higher in both sexes among Roma. The 10-year estimated risk for development of CHD, MI and CVD and the death from CHD was significantly (P < 0.05) higher in both sexes among Roma compared to the general population while the average risk scores for stroke and death from CVD were significantly higher only among Roma men. Conclusions: Our results show that both sexes in the Roma population have a significantly higher risk for 10-year development of CVD compared to the Hungarian general population.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Public Health. - 29 : Suppl4 (2019), p. 321-322. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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10.

001-es BibID:BIBFORM105858
035-os BibID:(WOS)000605268701484
Első szerző:Pikó Péter (biológus)
Cím:Cut-off values of surrogate indices of insulin resistance as risk predictors for metabolic syndrome / P. Pikó, Sz. Fiatal, Zs. Kósa, J. Sándor, R. Ádány
Dátum:2020
ISSN:1101-1262
Megjegyzések:Background: The metabolic syndrome (MS) based on insulin resistance (IR) is a cluster of conditions indicating an increased risk of cardiometabolic diseases. This study aimed to define valid cut-off values for surrogate measures for IR to predicting the risk for the development of MS in the Hungarian general (HG) and Roma (HR) populations. Methods: This study included 397 HG and 368 HR subjects aged 20-64 years from a complex health survey in 2018/2019. Four surrogate measures, namely the homeostasis model assessment-IR (HOMA-IR), McAuley index (McA), TG to HDL-cholesterol ratio (TG/HDL-C) and TG and glucose index (TyG) were calculated for all participants. The cut-off values were determined as the value with the highest Youden index (YI) on the basis of results obtained by receiver operating characteristic (ROC) curve analysis for the development of MS on separate and combined populations. Results: Since no significant difference could be detected between the results obtained on separate populations, cut-off values defined on the combined one are proposed to use for risk prediction. The area under the ROC curve was 0.753 (95%CI: 0.718-0.787) for HOMA-IR, 0.827 (95%CI: 0.797-0.856) for McA, 0.843 (95%CI: 0.814-0.872) for TG/HDL-C ratio and 0.862 (95%CI: 0.835-0.889) for TyG. The cut-off value was 2.32 (sensitivity (sens.) 70.9%; specificity (spec.) 69.0%; YI: 0.399) for HOMA-IR, 5.989 (sens. 69.7%; spec. 82.7%; YI: 0.524) for McA, 1.274 (sens. 73.4; spec. 84.3%; YI: 0.574) for TG/HDL-C ratio and 4.694 (sens. 77.2%; spec. 84.3%; YI: 0.615) for TyG. Concerning the fact, that the TyG has the best indicative power for predicting IR to the estimation of MS risk in both populations the IR/MS prevalence was defined by using TyG and found to be as high as 42.3% and 40.5% in the HG and HR populations, respectively. Conclusions: Based on our results the TyG index could be a useful supplementary method for identifying individuals at risk for MS.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 30 : Suppl5 (2020), p. 299. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor J. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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11.

001-es BibID:BIBFORM105378
Első szerző:Pikó Péter (biológus)
Cím:Genetic factors exist behind the increased risk to reduced HDL-cholesterol level in Roma population / P. Pikó, S. Fiatal, Z. Kósa, J. Sándor, R. Ádány
Dátum:2016
ISSN:1101-1262
Megjegyzések:Contact: adany.roza@sph.unideb.hu Background Roma is the largest ethnic minority in Europe. In our previous study on the prevalence of metabolic syndrome and its components reduced HDL-C level was found significantly more frequent in almost all age groups of the Hungarian Roma compared to the general population (Eur J Public Health 25:299, 2015). This fact in harmony with findings obtained in family and twin studies strongly suggests that plasma level of HDL-C is under genetic control. Our aim was to define whether genetic factors contribute to the higher prevalence of reduced HDL-C level and consequently to the increased susceptibility to atherosclerosis among Roma. Methods SNPs (N = 22) affecting HDL-cholesterol level in genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX were analysed in the Hungarian Roma (N = 757) and general (N = 1787) populations. Genetic risk scores unweighted (GRS) and weighted (wGRS) were calculated and compared within the study populations. In addition the correlation between wGRS and the prevalence of reduced HDL-C level was analysed in both study groups stratified by quintiles. Results Both GRS and wGRS were found significantly higher in Roma than in the general population (GRS: 18.6 3.4 vs. 18.1 3.3, p = 0.001; wGRS: 0.54 0.10 vs. 0.52 0.11, p < 0.001). Only 3% of subjects in the Roma population were in the bottom fifth of the wGRS (wGRS 0.22) compared with 4.8% of those in the general population, while 7% of the Roma subjects were in the top fifth of the wGRS (wGRS 0.7) compared with 3.5% of those in the general population (p = 0.001). Furthermore the prevalence of reduced HDL-C level was significantly higher in the fifth quintile (with the highest genetic load) of the Roma population, than in that of the Hungarian general one (65% vs. 36.3%, p < 0.001). Conclusions The Roma population has increased genetic susceptibility to reduced HDL-C level and consequently to atherosclerosis as it is indicated by higher GRSs values in comparison with that for the general population.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 26 : suppl1 (2016), p. 285. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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12.

001-es BibID:BIBFORM105071
Első szerző:Pikó Péter (biológus)
Cím:Generalisability of effect size estimates for SNPs related to HDL-C obtained on European populations / P. Pikó, S. Fiatal, Z. Kósa, J. Sándor, R. Ádány
Dátum:2017
ISSN:1101-1262
Megjegyzések:Background Large scale association studies that mainly involve European populations identified many genetic loci related to high density lipoprotein cholesterol (HDL-C) levels, the most important indicator of the risk for cardiovascular diseases. Data on non-European populations are just emerging consequently, the generalisability of the association results to non-European populations are pending. We addressed the question whether the individual effect of established HDL-C level related genetic loci are applicable to the Roma population considered to have a South Asian origin. Methods We examined association of 21 SNPs (in genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX) with HDL-C levels by linear regression models using age and sex as covariates. Single SNP associations (direction and magnitude of the effect on HDL-C) were estimated. Analyses were conducted in adults of the Hungarian General (N = 1542) and Hungarian Roma (N = 646) populations. Results The SNPs had small individual effects on HDL-C levels. The beta-coefficients for the general population were found to be identical both in direction and magnitude, indicating that the effect is concordant with large scale studies of European populations obtained previously. Among Roma in case of two SNPs the effect direction, while in case of one SNP the effect size differed in comparison with the general population. Significant associations between SNPs and HDL-C levels were more likely to be seen among general subjects compared to Roma (Roma: 5 SNPs; General: 10 SNPs). The CETP gene variants rs1532624, rs708272 and rs7499892; and the KCTD10 gene rs2338104 variant showed significant associa tions with HDL-C levels consistently in study groups (p < 0.05). Conclusions The patterns of influence of SNPs on HDL-C were consistent across ethnic groups, in large extent, but alteration observed even in effect direction in case of few SNPs indicate that data obtained on European populations can be applied with caution
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 27 : suppl3 (2017), p. 466. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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