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001-es BibID:	BIBFORM134641
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	Association of physical activity domains and intensity with acute heart rate response to exercise / Al Ashkar H., Kovács N., Veres-Balajti I., Ádány R., Pikó P.
Dátum:	2025
ISSN:	1101-1262
Megjegyzések:	Background The positive association between physical activity (PA) and heart rate (HR) related cardiovascular (CV) fitness and CV risk is well established, but it is less well known how the type and intensity of PA have influence on the efficacy of the risk reduction. The aim of the present study was to investigate the association between CV fitness and three intensity categories of PA in four domains in the Hungarian population. Methods Data for our study were obtained from a cross-sectional survey (n?=?665) conducted in Hungary in 2018. Individual PA was assessed using the IPAQ long form and expressed as the metabolic equivalent of task minutes per week for light, moderate and vigorous activities for total and each domain (work, transport, domestic and gardening - dom. & gard., leisure-time - LTPA). CV fitness was assessed using the YMCA 3-minute step test, with HR measured at rest (HRrest) and immediately after exercise (HRaft) and their difference (?HR) was calculated. Multiple regression analysis was used for the statistical analyses. Results Total PA (B=-0.001; p?<?0.001), its vigorous (B=-0.001; p?=?0.001) and moderate (B=-0.001; p?<?0.001) intensity forms, and LTPA (B=-0.002; p?<?0.001) showed a significant association with both HRaft and ?HR, whereas dom. & gard. domain (B=-0.001; p?=?0.010) is only significantly associated with ?HR. Vigorous intensity form of dom. & gard. (B=-0.002; p?=?0.006) and moderate intensity form of LTPA (B=-0.004; p?<?0.001) showed individually significant associations with HRaft but not with ?HR. Transport by bicycle was the only form of PA that showed a significant association with both HRaft (B=-0.004; p?<?0.001) and ?HR (B=-0.003; p?=?<0.001). Conclusions Based on our results, among the domains of PA, dom. & gard. and LTPA, both moderate and vigorous intensity forms, as well as the use of bicycles for transport showed the strongest association with favourable CV fitness, and their promotion in public health interventions is recommended. Key messages ??Recommendations should consider that not all forms of physical activity significantly improve individual cardiovascular fitness. ??Interventions targeting the improvement of cardiovascular fitness should improve physical activity in leisure time and the use of bicycles for transport.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 35 : Supplement 4 (2025), p. iv705-iv706. -
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
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001-es BibID:	BIBFORM132164
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	Association of HDL-C and its subfraction profile with heart rate response to exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Seres Ildikó, Paragh György, Ádány Róza, Pikó Péter
Dátum:	2025
ISSN:	0021-9150
Megjegyzések:	Background and Aims: High-density lipoproteins (HDL) are a heterogeneous group of plasma molecules that can be divided into subfractions based on their characteristics. Although HDL subfractions vary widely in size, density, and function, their association with cardiovascular outcomes remains complex and partly unknown. Heart rate response to physical activity (HRR) is a well-known indicator of individual cardiovascular fitness. The present study aimed to investigate the association between HRR and HDL subfraction profile in 304 individuals from the Hungarian population. Methods: HDL was divided into ten subfractions using the Lipoprint HDL? system. The YMCA 3-minute step test was used to assess the individual HRR by measuring the heart rate at four-time points: before the exercise (resting HR - HRrest), immediately (HRexe), 5 minutes (HR5min) and 10 minutes (HR10min) after exercise. In addition, acute HRR (?HR) was calculated (HRexe-HRrest). Multiple linear regression was used to examine the association between HDL subfraction profile and HRR. Results: The distribution of HDL-3 (BHRexe=-1.26, p =0.020; BHR5min=-0.70, p=0.048; B?HR=-1.21, p=0.035), HDL-4 (BHRexe=-1.86, p=0.040; BHR5min=-0.92, p=0.048; B?HR=-1.88, p=0.030), and HDL-5 (BHRexe=-3.34, p=0.017; BHR5min=-1.84, p=0.041; B?HR=-3.32, p=0.037) showed a significant negative association, whereas HDL-7 (BHRexe=2.64, p=0.025; BHR5min=1.37, p=0.045; B?HR=2.41, p=0.034), HDL-8 (BHRexe=2.87, p =0.030; BHR5min=1.70, p=0.035; B?HR=2.48, p=0.035), HDL-9 (BHRexe=3.10, p =0.010; BHR5min=2.18, p=0.013; B?HR=3.04, p=0.045), and HDL-10 (BHRexe=0.95, p =0.035; BHR5min=0.67, p=0.020; B?HR=0.71, p=0.049) were positively associated with HRR. However, there was no significant change in the concentration of HDL-C and its subfractions in mmol/L in relation to HRR. Conclusions: Our results suggest that a more optimal (smaller) heart rate change in response to physical activity is associated with a more favourable distribution of the HDL subfraction profile, i.e. a significant increase in the proportion of smaller HDL subfractions and a decrease in the proportion of larger subfractions. In contrast, no significant quantitative changes were observed in HDL-C and its subfractions.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk HDL Cardiovascular risk heart rate response to exercise HDL-C subfraction profile Cardiorespiratory fitness Lipid profile
Megjelenés:	Atherosclerosis. - 407 : Suppl. (2025), p. 57. -
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
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001-es BibID:	BIBFORM123542
035-os BibID:	(Scopus)85202750993 (WoS)001307359100001
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	Association of CETP Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Ádány Róza, Pikó Péter
Dátum:	2024
ISSN:	1661-6596 1422-0067
Megjegyzések:	Polymorphisms in the cholesteryl ester transfer protein (CETP) gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of CETP gene polymorphisms on AHRR. Our analysis examines the association of five single nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene with AHRR in 607 people from the Hungarian population. Individual AHRR in the present study was assessed using the YMCA 3-min step test and was estimated as the difference between resting and post-exercise heart rate, i.e., delta heart rate (Delta HR). To exclude the direct confounding effect of the CETP gene on the lipid profile, adjustments for TG and HDL-C levels, next to conventional risk factors, were applied in the statistical analyses. Among the examined five SNPs, two showed a significant association with lower Delta HR (rs1532624-C-dominant: B = -8.41, p < 0.001; rs708272-G(dominant): B = -8.33, p < 0.001) and reduced the risk of adverse AHRR (rs1532624-C-dominant: OR = 0.44, p = 0.004; rs708272-G(dominant): OR = 0.43, p = 0.003). Among the ten haplotypes, two showed significant association with lower Delta HR (H3-CAGCA: B = -6.81, p = 0.003; H9-CGGCG: B = -14.64, p = 0.015) and lower risk of adverse AHRR (H3-CAGCA: OR = 0.58, p = 0.040; H9-CGGCG: OR = 0.05, p = 0.009) compared to the reference haplotype (H1-AGACG). Our study is the first to report a significant association between CETP gene polymorphisms and AHRR. It also confirms that the association of the CETP gene with cardiovascular risk is mediated by changes in heart rate in response to physical activity, in addition to its effect on lipid profile.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cardiovascular risk haplotype acute heart rate response cholesteryl ester transfer protein genomics
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 16 (2024), p. 1-10.-
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP TK2016-78 MTA Hungarian Research Network-HUN-REN (TKCS-2021/32) Egyéb National Research, Development, and Innovation Fund of Hungary K_20 programme Egyéb National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006) Egyéb ÚNKP-23-5-DE-494 Egyéb Janos Bolyai Research Scholarship (BO/00513/23/5) MTA
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001-es BibID:	BIBFORM119418
035-os BibID:	(Scopus)85189091222 (WoS)001193452500001
Első szerző:	Pikó Péter (biológus)
Cím:	Genetic Background of Acute Heart Rate Response to Exercise / Péter Pikó, Habib Al Ashkar, Nóra Kovács, Ilona Veres-Balajti, Róza Ádány
Dátum:	2024
ISSN:	1422-0067
Megjegyzések:	The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (?HR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ?HR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ?HR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ?HR (B = ?2.51, 95% CI: ?3.46??1.76; p = 2.99 ? 10?9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23?143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acute heart rate response cardiorespiratory fitness YMCA 3 min step test optimised polygenic score single nucleotide polymorphism leisure-time physical activity
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 6 (2024), p. 1-12. -
További szerzők:	Al Ashkar, Habib (1998-) (népegészségügyi szakember) Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP TK2016-78 MTA TKCS-2021/32 Egyéb 135784 OTKA National Research, Development, and Innovation Office (NKFIH) RRF-2.3.1-21-2022-00006 Egyéb ÚNKP-23-5-DE-494 Egyéb BO/00513/23/5 MTA
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