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001-es BibID:	BIBFORM082847
035-os BibID:	(WoS)000514755200024 (Scopus)85076853630
Első szerző:	Kuti Dániel
Cím:	Gastrointestinal (non-systemic) antibiotic rifaximin differentially affects chronic stress-induced changes in colon microbiome and gut permeability without effect on behavior / Kuti D., Winkler Z., Horváth K., Juhász B., Paholcsek M.á, Stágel A.á, Gulyás G., Czeglédi L., Ferenczi S., Kovács K. J.
Dátum:	2020
ISSN:	0889-1591
Megjegyzések:	Chronic stress is often accompanied by gastrointestinal symptoms, which might be due to stress-induced shift ofgut microbiome to pathogenic bacteria. It has been hypothesized that stress alters gut permeability and results inmild endotoxemia which exaggerates HPA activity and contributes to anxiety and depression. To reveal therelationship between microbiome composition, stress-induced gastrointestinal functions and behavior, wetreated chronically stressed mice with non-absorbable antibiotic, rifaximin. The"two hits"stress paradigm wasused, where newborn mice were separated from their mothers for 3 h daily as early life adversity (maternalseparation, MS) and exposed to 4 weeks chronic variable stress (CVS) as adults. 16S rRNA based analysis of gutmicrobiome revealed increases ofBacteroidetesandProteobacteriaand more specifically, Clostridium species inchronically stressed animals. In mice exposed to MS + CVS, we found extenuation of colonic mucosa, increasedbacterial translocation to mesenteric lymph node, elevation of plasma LPS levels and infiltration of F4/80 po-sitive macrophages into the colon lamina propria. Chronically stressed mice displayed behavioral signs of an-xiety-like behavior and neophobia. Rifaximin treatment decreased Clostridium concentration, gut permeabilityand LPS plasma concentration and increased colonic expression of tight junction proteins (TJP1, TJP2) andoccludin. However, these beneficial effects of rifaximin in chronically stressed mice was not accompanied bypositive changes in behavior. Our results suggest that non-absorbable antibiotic treatment alleviates stress-in-duced local pathologies, however, does not affect stress-induced behavior.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Brain Behavior And Immunity. - 84 (2020), p. 218-228. -
További szerzők:	Winkler-Ferenczi Zsuzsanna Horváth Krisztina Juhász Balázs Paholcsek Melinda (1984-) (molekuláris biológus, genetikus) Stágel Anikó (agrár) Gulyás Gabriella (1985-) (agrár) Czeglédi Levente (1977-) (agrármérnök) Ferenczi Szilamér (1977-) (biológus) Kovács Krisztina J.
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM116373
035-os BibID:	(cikkazonosító)e0290310 (WoS)001051745900088 (Scopus)85168299624
Első szerző:	Pesti-Asbóth Georgina (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Monitoring physiological processes of fast-growing broilers during the whole life cycle : Changes of redox-homeostasis effected to trassulfuration pathway predicting the development of non-alcoholic fatty liver disease / Georgina Pesti-Asbóth, Endre Szilágyi, Piroska Bíróné Molnár, János Oláh, László Babinszky, Levente Czeglédi, Zoltán Cziáky, Melinda Paholcsek, László Stündl, Judit Remenyik
Dátum:	2023
ISSN:	1932-6203
Megjegyzések:	In the broiler industry, the average daily gain and feed conversion ratio are extremely favorable, but the birds are beginning to approach the maximum of their genetic capacity. However, as a consequence of strong genetic selection, the occurrence of certain metabolic diseases, such as myopathies, ascites, sudden cardiac death and tibial dyschondroplasia, is increasing. These metabolic diseases can greatly affect the health status and welfare of birds, as well as the quality of meat. The main goal of this study was to investigate the changes in the main parameters of redox homeostasis during the rearing (1-42 days of age) of broilers with high genetic capacity, such as the concentrations of malondialdehyde, vitamin C, vitamin E, and reduced glutathione, the activities of glutathione peroxidase and glutathione reductase, and the inhibition rate of superoxide dismutase. Damage to the transsulfuration pathway during growth and the reason for changes in the level of homocysteine were investigated. Further, the parameters that can characterize the biochemical changes occurring in the birds were examined. Our study is the first characterize plasma albumin saturation. A method was developed to measure the levels of other small molecule thiol components of plasma. Changes in redox homeostasis induce increases in the concentrations of tumor necrosis factor alpha and inflammatory interleukins interleukin 2, interleukin 6 and interleukin 8 in broilers reared according to current large-scale husbandry technology and feeding protocols. A significant difference in all parameters tested was observed on the 21st day. The concentrations of cytokines and homocysteine increased, while the concentrations of glutathione and cysteine in the plasma decreased. Our findings suggest that observed changes in the abovementioned biochemical indices have a negative effect on poultry health.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Animals Chickens Glutathione Homeostasis Non-alcoholic Fatty Liver Disease Oxidation-Reduction Physiological Phenomena
Megjelenés:	Plos One. - 18 : 8 (2023), p. 1-28. -
További szerzők:	Szilágyi Endre (1986-) Bíróné Molnár Piroska (1970-) (biokémia) Oláh János (1976-) (állattenyésztés) Babinszky László (1950-) (agrár) Czeglédi Levente (1977-) (agrármérnök) Cziáky Zoltán Paholcsek Melinda (1984-) (molekuláris biológus, genetikus) Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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