Találati lista | Tudóstér

001-es BibID:	BIBFORM122179
Első szerző:	Gashew, Mequanint (Phd student)
Cím:	The effect of mtor and related signaling pathway on ageing in birds / Mequanint Gashew, Achenef, Adam Lendvai, Levente Czegledi
Dátum:	2024
Megjegyzések:	An organism's lifespan is governed by the mechanistic target of rapamycin (mTOR) and insulin-like insulin growth factor signaling (IIS) pathways. This review seeks to explore the influence of mTOR and its related signaling pathways on the ageing process in avian species. In birds, this pathway plays a crucial role in regulating physiological effects, longevity, and the ageing phenomenon. Both rapamycin and dietary restrictions have demonstrated the ability to inhibit mTOR, leading to an extension of the maximum lifespan in model organisms. Ageing is charac-terized by a gradual decline in physiological function, impacting overall performance, increa-sing susceptibility to death, and diminishing life expectancy. Addressing this issue through mTOR inhibition via dietary restriction and rapamycin administration, as observed in model organisms, presents a potential solution. Despite similarities, a physiological paradox exists between mammals and birds. Additionally, it is reasonable to infer significant differences in the physiological systems of birds compared to mammals. Variations in how sexes allocate resour-ces to different aspects of reproduction can contribute to differences in longevity and ageing, driven by trade-offs in life history. Despite the limited research conducted on birds ageing, the potential impact of mTOR modulation through interventions remains an intriguing area for furt-her exploration.
ISBN:	978-963-306-980-6
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok előadáskivonat könyvrészlet ageing mTOR birds
Megjelenés:	21st Wellmann International Scientific Conference Book of abstracts / felelős kiadó Edit Mikó, szerk. Ingrid Melinda Gyalai, Szilárd Czóbel. - p. 34. -
További szerzők:	Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: