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001-es BibID:	BIBFORM130046
035-os BibID:	(WoS)001495870300001
Első szerző:	Buzgó Lilla (Biológus)
Cím:	High Prevalence of Cefiderocol Resistance Among New Delhi Metallo-β-Lactamase Producing Klebsiella pneumoniae High-Risk Clones in Hungary / Lilla Buzgó, Zsanett Kiss, Dániel Göbhardter, Virág Lesinszki, Erika Ungvári, Zoltán Rádai, Levente Laczkó, Ivelina Damjanova, Gábor Kardos, Ákos Tóth
Dátum:	2025
Megjegyzések:	Background/Objectives: The global spread of carbapenemase-producing K. pneumoniae (CPKP) strains represent a severe public health threat due to very limited choice of antibacterial therapy. Cefiderocol, a novel siderophore-cephalosporin, may represent a new therapeutic option but resistance is increasingly being described. Our aim was to investigate in vitro cefiderocol susceptibility among CPKP strains in Hungary and assess correlations between resistance, carbapenemase types, and clonal lineages. Methods: The study was performed on 420 CPKP strains from 34 Hungarian healthcare institutes (HCIs) submitted to the National Reference Laboratory of Antimicrobial Resistance (March 2021 to April 2023). The disk diffusion method (Liofilchem, Via Scozia, Italy) was used for in vitro cefiderocol susceptibility testing (according to EUCAST guidelines). For molecular epidemiologic investigation, we used whole genome sequencing (Illumina MiSeq, 150 bp paired-end) and pulsed-field gel electrophoresis (PFGE). Carbapenemase gene type was determined by multiplex PCR. Statistical analysis was performed in R (v.4.2.0). Results: Dominant high-risk clones (ST147, ST395, ST258) exhibited regional distribution, with ST147/NDM-1 strains showing the highest cefiderocol resistance (75%). Overall resistance was 65%. Carbapenemase gene types occurred as follows: 35 blaVIM, 53 blaKPC, 57 blaOXA-48-like, 153 blaNDM, and 122 blaOXA-48-like+blaNDM. Cefiderocol resistance rates by carbapenemase type were 20%, 44%, 70%, and 75% in the case of blaVIM, blaOXA-48-like, blaKPC, blaNDM, and blaOXA-48-like+blaNDM. Conclusions: The results show a high prevalence of cefiderocol resistance in CPKP in Hungary, with different rates of resistance in different carbapenemase gene-carrying high-risk clones, highlighting the growing challenge in treating these infections.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk high-risk clones carbapenemase K. pneumoniae resistance cefiderocol
Megjelenés:	Antibiotics. - 14 : 5 (2025), p. 475-491. -
További szerzők:	Kiss Zsanett Göbhardter Dániel Lesinszki Virág Ungvári Erika Rádai Zoltán (1991-) (biológus) Laczkó Levente (1992-) (biológus) Damjanova, Ivelina Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Tóth Ákos
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001-es BibID:	BIBFORM116026
035-os BibID:	(WoS)001108981300001 (Scopus)85175859931
Első szerző:	Nagy József Bálint (molekuláris biológus)
Cím:	Carbapenem-resistant Escherichia coli in Black-headed gulls, the Danube, and human clinical samples : a One Health comparison of contemporary isolates / József Bálint Nagy, Balázs Koleszár, Bernadett Khayer, Eszter Róka, Levente Laczkó, Erika Ungvári, Eszter Kaszab, Krisztina Bali, Krisztián Bányai, Márta Vargha, Ádám Lovas-Kiss, Ákos Tóth, Gábor Kardos
Dátum:	2023
ISSN:	2213-7165
Megjegyzések:	Objectives: Our aim was to characterize and compare contemporary carbapenem-resistant Enterobacterales (CRE) isolates from gulls, the River Danube, and humans in Hungary, Budapest. Methods: Multiresistant Enterobacterales were sought for in 227 gull faecal and 24 Danube water samples from 2019 to 2020. Eosin-methylene blue agar containing 2 mg/L cefotaxime and Colilert-test containing 10 mg/L cefotaxime were used for gull and water samples, respectively. Isolates were characterized by polymerase chain reactions (PCRs); acquired carbapenemase producers were further analysed by whole-genome sequencing, together with 21 Hungarian human CR Escherichia coli (CREc) isolates. Results: Gull and water samples exhibited a CRE prevalence of 7.4% (9/122) and 6.7% (7/105), none and 5/12 water samples yielded CRE from 2019 and 2020, respectively; CRE were found only in samples taken downstream of Budapest. The dominant species was Escherichia coli and the most prevalent carbapenemase was blaNDM-1. High-risk CREc clones were found both in gulls (ST224, ST372, ST744) and the Danube (ST10, ST354, ST410); the closest associations were between ST410 from humans and the Danube, among ST1437 among gulls, and between ST1437 in gulls and the Danube (46, 0, and 22?24 allelic distances, respectively). Direct links between human and gull isolates were not demonstrated. Conclusion: The study demonstrates potential epidemiological links among humans, a river crossing a city, and urbanised birds, suggesting a local transmission network. Water bodies receiving influent wastewater, together with animals using such habitats, may serve as a local reservoir system for CRE, highlighting the importance of One Health in CRE transmission, even in a country with a low CRE prevalence in humans.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antibiotic resistance blaNDM-1 carbapenemase Human-animal interaction ST410 Urbanised birds
Megjelenés:	Journal of Global Antimicrobial Resistance. - 35 (2023), p. 257-261. -
További szerzők:	Koleszár Balázs Khayer Bernadett Róka Eszter (1989-) (gyógyszerész, gyógyszertechnológus) Laczkó Levente (1992-) (biológus) Ungvári Erika Kaszab Eszter (1989-) (biológus) Bali Krisztina Bányai Krisztián (virológus) Vargha Márta (1976-) (biológus/molekuláris biológus) Lovas-Kiss Ádám (1991-) (biológus, botanikus) Tóth Ákos Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM090744
Első szerző:	Petróczki Flóra Mária (élelmiszer-biztonsági és -minőségi mérnök)
Cím:	Occurrence and Characteristics of Staphylococcus aureus in a Hungarian Dairy Farm during a Control Program / Flóra M. Petróczki, Ákos Pásztor, Kata D. Szűcs, Károly Pál, Gábor Kardos, Ervin Albert, Brigitta Horváth, Erika Ungvári, Béla Béri, Ferenc Peles
Dátum:	2021
ISSN:	2076-0817
Megjegyzések:	In this research, our aim was to assess the occurrence of Staphylococcus aureus in a Hungarian large-scale dairy farm during the S. aureus control program conducted in the course of our studies. Furthermore, the phenotypic and genotypic properties of the isolates (type of haemolysis, antibiotic susceptibility, staphylococcal enterotoxin (SE) gene carrying ability and spa type) were determined. S. aureus was detected in all bulk tank milk samples collected during this study. Two different spa types were identified among the 17 strains isolated in the farm. A total of 14 of the 17 studied strains (82%) showed ?-haemolysis on blood agar, 2/17 strains (12%) expressed double zone and 1/17 strains (6%) showed weak ?-haemolysis. All strains were susceptible to most antibiotics tested (cefoxitin, chloramphenicol, clindamycin, erythromycin, gentamicin, tetracycline and trimethoprim/sulphamethoxazole), but all strains were resistant to penicillin G. A total of 11 of the 17 strains (65%) were found to harbour seg, sei, selm, seln, selo genes; 4/17 strains (24%) harboured sei, selm, seln, selo genes and 2/17 strains (11%) harboured sei gene. Since the new SEs/SEls can also cause foodborne outbreaks potentially and all strains were found to be resistant to penicillin G, it is essential to decrease and keep the prevalence of S. aureus low in the dairy farm and the implementation of the S. aureus control program is also highly justified. The results showed that the S. aureus count decreased by the end of our studies, so the control program was proved to be effective.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antibiotic resistance bulk milk enterotoxin microbiology spa typing Staphylococcus aureus
Megjelenés:	Pathogens. - 10 : 2 (2021), p. 1-12. -
További szerzők:	Pásztor Ákos Szűcs Kata Dorina (1992-) (biomérnök, biotechnológus) Pál Károly (1978-) (mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Albert Ervin (1988-) (állatorvos) Horváth Brigitta (1992-) (okleveles táplálkozástudományi szakember, dietetikus) Ungvári Erika Béri Béla (1951-) (agrármérnök) Peles Ferenc (1979-) (mikrobiológia, élelmiszer-mikrobiológia, minőségügy)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00008 EFOP
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