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001-es BibID:	BIBFORM102081
035-os BibID:	(WoS)000809980800001 (Scopus)85130822695
Első szerző:	Kövér Ágnes (szociológus)
Cím:	A Comprehensive Investigation into the Distribution of Circulating B Cell Subsets in the Third Trimester of Pregnancy / Ágnes Kövér, Rudolf Lampé, Krisztina Szabó, Tünde Tarr, Gábor Papp
Dátum:	2022
ISSN:	2077-0383
Megjegyzések:	Maternal B cells play a crucial role in the development and maintenance of pregnancy, due to their humoral activities and regulatory functions. In the study, we investigated the alterations in the distributions of naïve and memory B cell subsets, as well as regulatory B (Breg) cells, in the third trimester of pregnancy. Peripheral blood from 14 healthy pregnant women in the third trimester and 7 healthy non-pregnant women was collected and examined for the frequencies of B cell subsets, including IgD+CD27? naïve, IgD+CD27+ un-switched memory, IgD?CD27+ switched memory, CD38intCD24int mature?naïve, CD38?CD24hi primarily memory and CD38hiCD24hi transitional B cells by flow cytometry. Breg cell subsets were also characterized based on the expression of CD5, CD1d and IL-10. In pregnant women, the proportions of un-switched memory and transitional B cells were significantly decreased. Additionally, the frequencies of both CD5+CD1d+ Breg and IL-10-producing B10 cells were decreased in pregnancy. Changes in the distribution of transitional B cells as well as Breg cells may be crucial contributors for the development of altered maternal immune responses and tolerance needed for the maintenance of normal pregnancy in the third trimester.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Clinical Medicine. - 11 : 11 (2022), p. 1-11. -
További szerzők:	Lampé Rudolf (1983-) (szülész-nőgyógyász) Szabó Krisztina (1987-) (Molekuláris biológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász)
Pályázati támogatás:	K 124177 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM124149
035-os BibID:	(Scopus)85205047254 (WoS)001326252500001
Első szerző:	Orosz Mónika (Szülész-nőgyógyász)
Cím:	Endocrine Characteristics and Obstetric Outcomes of PCOS Patients with Successful IVF and Non-IVF Pregnancies / Orosz Mónika, Borics Fanni, Rátonyi Dávid, Krasznai Zoárd Tibor, Vida Beáta, Herman Tünde, Csehely Szilvia, Jakab Attila, Lukács Luca, Lampé Rudolf, Deli Tamás
Dátum:	2024
ISSN:	2077-0383
Megjegyzések:	Background/Objective: Infertility affects an estimated 40?50% of women with polycystic ovary syndrome (PCOS), the leading cause of anovulatory infertility, but only a small proportion of the patients require in vitro fertilization (IVF) therapy. Both PCOS and IVF are associated with an increased risk of obstetric complications. To compare preconception endocrine profiles and symptoms, as well as obstetric outcomes of PCOS patients who achieved successful pregnancies with and without IVF treatment. Methods: A single-center retrospective cohort study was conducted. Data spanning from 2012 to 2019 were compiled from patients with PCOS who visited the Gynecologic Endocrinology Unit and the Infertility Unit at the Department of Obstetrics and Gynecology, University of Debrecen. Patients diagnosed with PCOS who had had at least one successful delivery beyond the 23rd gestational week at the department were eligible for inclusion in the study. Results: Fifteen percent of the 206 pregnancies leading to successful deliveries of 232 newborns in our cohort conceived with IVF. A one year increase in the maternal age increased the odds of being in the IVF group by 22% (OR: 1.222, 95% confidence interval, CI: 1.11?1.35, p < 0.001). Baseline DHEAS and androstenedione levels were significantly lower in the IVF group as compared to the non-IVF group: 1 ?mol/L increase in the DHEAS level decreased the odds of being in the IVF group by 18% (OR: 0.82, 95% CI: 0.66?1.01, p = 0.06), and 1 ?g/L increase in the serum androstenedione concentration decreased the same odds by 42% (OR: 0.58, 95% CI: 0.33?1.02, p = 0.056). DHEAS levels <6.5 ?mol/L had an OR 3.86 (95% CI 1.10?13.50, p = 0.04) and LH/FSH ratio <1.3 had an OR 3.58 (95% CI 1.18?10.81, p = 0.03) for being in the IVF group. The birth weight (3069 ? 683 g vs. 3362 ? 638 g, p = 0.02) and the gestational age (37.23 ? 2.55 vs. 38.54 ? 2.28 weeks, p = 0.004) were significantly lower in the IVF group, but in the singleton subgroups, no significant differences could be found. Birth weight percentiles showed no significant difference in either subgroup. In the IVF group, both preterm delivery (29% vs. 8.3%, OR 4.53, 95% CI 1.75?11.70, p = 0.002; singleton subgroup: 17.4% vs. 6.3%, OR 3.12, 95% CI 0.89?10.92, p = 0.07) and cesarean section (71% vs. 43.2%, OR 3.22, 95% CI 1.40?7.40, p = 0.006; singleton subgroup: 65.2% vs. 42.4%, OR 2.55, 95% CI 1.02?6.35, p = 0.04) were more frequent than in the non-IVF group. Gestational diabetes and preeclampsia were not significantly different in the IVF and non-IVF groups. Conclusions: In PCOS patients with successful pregnancies, those who conceive with IVF seem to be different in their baseline hormone levels and symptoms from the non-IVF group. Adverse obstetric outcomes are more common in the IVF group, and some of these differences persist when adjusting for singleton pregnancies and maternal age, too.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk polycystic ovary syndrome pregnancy complications in vitro fertilization pre-pregnancy hormone levels obstetric outcomes androgen levels
Megjelenés:	Journal of Clinical Medicine. - 13 : 18 (2024), p. 1-13. -
További szerzők:	Borics Fanni (1995-) (orvos) Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Vida Beáta (1994-) (szülész-nőgyógyász) Herman Tünde (1979-) (orvos) Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Lukács Luca (1995-) (hallgató) Lampé Rudolf (1983-) (szülész-nőgyógyász) Deli Tamás (1979-) (szülész-nőgyógyász, endokrinológus szakorvos)
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