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001-es BibID:BIBFORM135213
Első szerző:Chatterjee, Anoushka
Cím:Assessment of health risks from exposure to indoor volatile organic compounds in European educational buildings / Anoushka Chatterjee, László Pál, Szabolcs Lovas, Martin McKee, Judit Diószegi, Nóra Kovács, Sándor Szűcs
Dátum:2026
ISSN:2045-2322
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - [Epub ahead of print] (2026). -
További szerzők:Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Lovas Szabolcs (1989-) (tudományos segédmunkatárs) McKee, Martin Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) Kovács Nóra (1989-) (népegészségügyi szakember) Szűcs Sándor (1958-) (biokémikus, vegyész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM125229
035-os BibID:(scopus)85208218158 (wos)001355558900001
Első szerző:Lovas Szabolcs (tudományos segédmunkatárs)
Cím:Dataset on concentrations of volatile organic compounds in indoor environments of offices, educational and residential buildings in the European Union between 2010 and 2023 / Lovas Szabolcs, Pál László, Kovács Nóra, Diószegi Judit, McKee Martin, Szűcs Sándor
Dátum:2024
ISSN:2352-3409
Megjegyzések:Indoor air pollutants, such as volatile organic compounds (VOCs), include a range of hazardous substances that can accumulate in the indoor environments. As individuals spend 80-90% of their daily time indoors, chronic exposure to VOCs has been recognised as an important public health concern. Therefore, measuring the concentration of indoor air pollutants is essential for improving indoor air quality and thereby reducing the associated burden of disease. Our objective was to generate a dataset on concentrations of VOCs measured in offices and in educational and residential buildings in the member states of the European Union between 2010 and 2023. Data were collected by means of systematic literature searches, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search was carried out in PubMed, Web of Science, and Scopus databases. In addition to data on VOC levels, information on types of buildings, seasons when the measurements were performed, heating and ventilation systems, humidity and temperature at the sampling points, and methods used for sampling and analysis was collected. The dataset contains information on 18 VOCs and total volatile organic compounds (TVOC) from 101 original research papers. It consists of 19 worksheets, each with 46 columns, and the number of rows varies depending on the number of articles per VOC/TVOC, ranging from 11 to 576 rows. This dataset will be of use to public health professionals interested in using systematically collected data on VOC levels and corresponding reference concentrations to estimate the health risks associated with exposure to VOCs.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Data in Brief. - 57 (2024), p. 1-18. -
További szerzők:Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Kovács Nóra (1989-) (népegészségügyi szakember) Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) McKee, Martin Szűcs Sándor (1958-) (biokémikus, vegyész)
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3.

001-es BibID:BIBFORM123817
Első szerző:Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:Indoor air pollution from volatile organic compounds in residential buildings in the European Union between 2010 and 2023 / Pál L., Lovas S., McKee M., Diószegi J., Kovács N., Szűcs S.
Dátum:2024
ISSN:0378-4274
Megjegyzések:Long-term exposure to volatile organic compounds (VOCs) in indoor environments can lead to diverse adverse effects including damage to the central nervous system and cancer. This study summarises data on levels of 16 VOCs in residential buildings in the member states of the European Union (EU) reported between 2010 and 2023. We obtained data on VOC concentrations by means of systematic literature search- es in PubMed, Scopus and Web of Science databases. 1390 articles were identified, of which 112 were reviewed, with 33 yielding relevant data. We used these data to compare indoor levels of VOCs reported in the literature searches with their reference concentrations (RFC). The data extracted from each study were used to determine the concentration distribution for each VOC separately. The resulting concentration dis- tributions were grouped by country, then weighted by the number of buildings studied and combined by VOCs using probabilistic Monte Carlo simulations. We show that the concentration of acetaldehyde in Romania (median: 68.6 ?g/m3 , 1st and 99th percentiles: 16.1?362.3 ?g/ m3), benzene in Cyprus (median: 3.43 ?g/m3 , 1st and 99th percentiles: 0.2?44.5 ?g/m3) and formaldehyde in Romania (median: 89.4 ?g/m3 , 1st and 99 th percentiles: 8.8?247.1 ?g/m3) reached above their RFC of 100, 30, and 100 ?g/m3, respectively. In addition, we demonstrated that the level of trichloroethylene in France (median: 0.4 ?g/m3 , 1st and 99 th percentiles: 0.004?24.1 ?g/m3), Germany (median: 0.08 ?g/ m3 , 1st and 99 th percentiles: 0.02?1.9 ?g/m3), and Lithuania (median: 6.9 ?g/m3 , 1st and 99 th percentiles: 3.8?11.9 ?g/m 3), and xylenes in Lithuania (median: 1.1 ?g/m3 , 1st and 99 th percentiles: 0.5?177.6 ?g/ m3) and Portugal (median: 3.8 ?g/m3 , 1st and 99th percentiles: 0.6?39.4 ?g/m3) were above their limit value of 2 and 100 ?g/m3, respectively. Our research reveals that residential exposure to VOCs continues to be a public health concern in the EU. Although the EU has implemented limits for the emission of certain VOCs, further measures are necessary to limit the use of these chemicals in household products.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Toxicology Letters. - 399 (2024), p. S321. -
További szerzők:Lovas Szabolcs (1989-) (tudományos segédmunkatárs) McKee, Martin Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) Kovács Nóra (1989-) (népegészségügyi szakember) Szűcs Sándor (1958-) (biokémikus, vegyész)
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4.

001-es BibID:BIBFORM122416
035-os BibID:(scopus)85196431091
Első szerző:Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:Exposure to volatile organic compounds in offices and in residential and educational buildings in the European Union between 2010 and 2023 : A systematic review and health risk assessment / Pál László, Lovas Szabolcs, McKee Martin, Diószegi Judit, Kovács Nóra, Szűcs Sándor
Dátum:2024
ISSN:0048-9697
Megjegyzések:Chronic exposure to indoor volatile organic compounds (VOCs) can result in several adverse effects including cancers. We review reports of levels of VOCs in offices and in residential and educational buildings in the member states of the European Union (EU) published between 2010 and 2023. We use these data to assess the risk to population health by estimating lifetime exposure to indoor VOCs and resulting non-cancer and cancer risks and, from that, the burden of cancer attributable to VOC exposure and associated economic losses. Our systematic review identified 1783 articles, of which 184 were examined in detail, with 58 yielding relevant data. After combining data on VOC concentrations separately for EU countries and building types, non-cancer and cancer risks were assessed in terms of hazard quotient and lifetime excess cancer risk (LECR) using probabilistic Monte Carlo Simulations. The LECR was used to estimate disability adjusted life years (DALYs) from VOC-related cancers and associated costs. We find that the LECR associated with formaldehyde exposure was above the acceptable risk level (ARL) in France and Germany and that of from exposure to benzene was also above the ARL in Spanish females. The sum of DALYs and related costs/1,000,000 population/year from exposure to acetaldehyde, benzene, formaldehyde, tetrachloroethylene, and trichloroethylene were 4.02 and ?41,010, respectively, in France, those from exposure to acetaldehyde, benzene, carbon tetrachloride, formaldehyde, and trichloroethylene were 3.91 and ?39,590 in Germany, and those from exposure to benzene were 0.1 and ?1030 in Spain. Taken as a whole, these findings show that indoor exposure to VOCs remains a public health concern in the EU. Although the EU has set limits for certain VOCs, further measures are needed to restrict the use of these chemicals in consumer products.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Science Of The Total Environment. - 945 (2024), p. 1-16. -
További szerzők:Lovas Szabolcs (1989-) (tudományos segédmunkatárs) McKee, Martin Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) Kovács Nóra (1989-) (népegészségügyi szakember) Szűcs Sándor (1958-) (biokémikus, vegyész)
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5.

001-es BibID:BIBFORM103564
035-os BibID:(WoS)000863090700018 (Scopus)85137072456
Első szerző:Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:Health and economic gain attributable to the introduction of the World Health Organization's drinking water standard on arsenic level in Hungary : a nationwide retrospective study on cancer occurrence and ischemic heart disease mortality / Pál László, Jenei Tibor, McKee Martin, Kovács Nóra, Vargha Márta, Bufa-Dőrr Zsuzsanna, Muhollari Teuta, Bujdosó Marozsán Orsolya, Sándor János, Szűcs Sándor
Dátum:2022
ISSN:0048-9697
Megjegyzések:The World Health Organization (WHO) estimates that 140 million individuals are at risk from consumption of drinking water containing arsenic at concentrations above the WHO guideline value of 10 ?g/l. Arsenic mitigation is considered to be the most effective way to prevent arsenic related diseases. After joining the European Union, Hungary implemented a Drinking Water Quality Improvement Programme (DWQIP) to reduce levels of arsenic in drinking water below the WHO guideline value. But what impact did this have on health? We estimated the change in lifetime excess skin, lung, and bladder cancer risks and mortality from ischaemic heart disease (IHD) associated with chronic arsenic intake among those exposed before (2004?2007) and after (2014?2017) the implementation of DWQIP. A populationbased risk assessment approach was used to assess lifetime excess cancer risk applying two scenarios for lung and bladder cancers. The economic benefits of the DWQIP were estimated by the combination of cost of illness and value per statistical life methods. Compared to the period before the DWQIP, its implementation was associated with a significant reduction in arsenic in drinking water [median: 3.0 ?g/l interquartile range (IQR): 1.5?12.0 ?g/l to median: 2.15 ?g/l IQR: 1.0?5.79 ?g/l]. The two scenarios were estimated to be associated with 225.2 and 35.9 fewer cancer cases each year. The number of annually prevented IHD deaths was estimated to be 88.9. It was estimated that the benefits of the DWQIP will outweigh its costs. We conclude that reducing arsenic levels in drinking water to 10.0 ?g/l resulted in significant health and economic benefits. Our study goes beyond the existing research, offering both new insights into the impact of arsenic mitigation and providing a methodological template for similar studies in the many parts of the world that have yet to reduce arsenic exposure.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Arsenic exposure
WHO drinking water standard
Arsenic mitigation
Cancer risk assessment
Mortality from ischemic heart disease
Public health and economic benefits
Megjelenés:Science Of The Total Environment. - 851 (2022), p. 1-11. -
További szerzők:Jenei Tibor (1963-) (programtervező informatikus) McKee, Martin Kovács Nóra (1989-) (népegészségügyi szakember) Vargha Márta (1976-) (biológus/molekuláris biológus) Bufa-Dőrr Zsuzsanna Muhollari, Teuta Bujdosó Orsolya (1992-) (népegészségügyi szakember) Sándor János (1966-) (orvos-epidemiológus) Szűcs Sándor (1958-) (biokémikus, vegyész)
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6.

001-es BibID:BIBFORM132222
Első szerző:Pikó Péter (biológus)
Cím:Effect of smoking and its exposure on the HDL subfraction profile / Pikó Péter, Al Ashkar Habib, Helu Nihad Kharrat, Kovács Nóra, Pál László, Szücs Sándor, Seres Ildikó, Paragh György, Ádány Róza
Dátum:2025
ISSN:0021-9150
Megjegyzések:Background and Aims: Smoking is a preventable risk factor for cardiovascular disease (CVD) and other non-communicable diseases. Studies have shown that smoking reduces high-density lipoprotein cholesterol (HDL-C) and increases triacylglycerol (TG) levels, thereby increasing the risk of developing atherosclerosis. The aim of the present study was to investigate the effects of smoking and smoking exposure on lipidomic profiles (total cholesterol (TC), HDL-C, TG, LDL, apoA-I, and apoB-100), focusing on HDL subfractions, in 137 nonsmokers and 177 smokers from the Hungarian population. Methods: The HDL was separated using the Lipoprint HDL? system, which identifies ten subfractions (HDL-1? 10) and three subclasses: large (HDL-L), intermediate (HDL-I), and small (HDL-S). Four outcome variables were used to assess smoking exposure: current smoking status, number of cigarettes per day (CPD), duration of smoking (DoS), and heaviness of smoking index (HSI). Multivariate linear regression and receiver operating characteristic (ROC) curve analysis were used, and p-values adjusted by the Benjamini-Hochberg method <0.05 were considered significant. Results: Smoking and its exposures significantly reduced HDL-C and apoA-I levels, while increasing the TG levels and the TG/HDL-C and apoA-I/apoB-100 ratios. Significant reductions in concentrations were observed between smoking and HDL-2 to HDL-8, and between CPD and HDL-3 to HDL-9 and all subclasses. Similarly, significant reductions were observed between DoS and HDL-4 to HDL-7 andHDL-I, and between HSI and HDL-3 to HDL-10 and HDL-I to HDL-S. Despite the quantitative changes, smoking did not significantly modify the distribution of the subfractions and subclasses. Conclusions: Our results confirm that smoking adversely alters the lipid profile and significantly reduces the levels of almost all HDL subfractions , especially HDL 5,-6 and-7 and HDL-I, thereby accelerating the development of atherosclerosis.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Atherosclerosis. - 407 : Suppl. (2025), p. 56-57. -
További szerzők:Al Ashkar, Habib (1998-) (népegészségügyi szakember) Helu, Nihad Kharrat (1992-) (PhD hallgató) Kovács Nóra (1989-) (népegészségügyi szakember) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Szűcs Sándor (1958-) (biokémikus, vegyész) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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