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1.
001-es BibID:
BIBFORM019249
Első szerző:
Gézsi András
Cím:
Accelerated clearance alone explains ultra-large multimers in von Willebrand disease Vicenza / A. Gézsi, U. Budde, I. Deák, E. Nagy, A. Mohl, Á. Schlammadinger, Z. Boda, T. Masszi, J. E. Sadler, I. Bodó
Dátum:
2010
Megjegyzések:
von Willebrand disease (VWD) Vicenza is characterized by low plasma von Willebrand factor (VWF) levels, the presence of ultra-large (UL) VWF multimersand less prominent satellite bands on multimer gels, and the heterozygous amino acid substitution R1205H in the VWFgene. The pathogenesis of VWD Vicenza has been elusive.Accelerated clearance is implicated as a cause of low VWF level. Objectives: We addressed the question, whether the presence of ultra-large multimers is a cause, or a result of accelerated VWF clearance, or whether it is an unrelated phenomenon. Patients/methods: We studied the detailed phenotype of three Hungarian patients with VWD Vicenza, expressed the mutant VWFR1205H in 293T cells and developed a mathematical model to simulate VWF synthesis and catabolism. Results: We found that the half-life of VWF after DDAVP was approximately one tenth of that after the administration of Haemate P, a source of exogenous wild-type (WT) VWF (0.81 ? 0.2 vs. 7.25 ? 2.38 h). An analysis of recombinant mutant VWF-R1205H showed that the biosynthesis and multimer structure ofWT and mutant VWF were indistinguishable. A mathematical model of the complex interplay of VWF synthesis, clearance and cleavageshowed that decreasing VWF half-life to one-tenth of normalreproduced all features of VWD Vicenza including low VWFlevel, ultra-large multimers and a decrease of satellite band intensity. Conclusion: We conclude that accelerated clearance alone may explain all features of VWD Vicenza.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
clearance
von Willebrand disease
von Willebrand factor
Megjelenés:
Journal of Thrombosis and Haemostasis. - 8 : 6 (2010), p. 1273-1280. -
További szerzők:
Budde, U.
Deák Ivett
Nagy E.
Mohl, A.
Schlammadinger Ágota (1971-) (belgyógyász, haematológus)
Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
Masszi Tamás
Sadler, J. E.
Bodó I.
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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Saját polcon:
2.
001-es BibID:
BIBFORM034335
Első szerző:
Mohl, A.
Cím:
Common large partial VWF gene deletion does not cause alloantibody formation in the Hungarian type 3 von Willebrand disease population / Mohl A., Boda Z., Jager R., Losonczy H., Marosi A., Masszi T., Nagy E., Nemes L., Obser T., Oyen F., Radványi G., Schlammadinger Á., Szélessy Zs., Várkonyi A., Vezendy K., Vilimi B., Schneppenheim R., Bodó I.
Dátum:
2011
ISSN:
1538-7933
Megjegyzések:
BACKGROUND: Type 3 von Willebrand disease (VWD) is an autosomal recessive bleeding disorder, characterized by virtually undetectable plasma von Willebrand factor (VWF) and consequently reduced plasma factor VIII levels. Genetic mutations responsible for type 3 VWD are very heterogeneous, scattered throughout the VWF gene and show high variability among different populations. METHODS: Twenty-five severe VWD patients were studied by direct sequencing of the 51 coding exons of the VWF gene. The total number of VWD type 3 families in Hungary is 24, of which 23 were investigated. RESULTS: Fifteen novel mutations were identified in 31 alleles, five being nonsense mutations (p.Q1238X, p.Q1898X, p.Q1931X, p.S2505X and p.S2568X), four small deletions and insertions resulting in frame shifts (c.1992insC, c.3622delT, c.5315insGA and c.7333delG), one a large partial deletion (delExon1-3) of the 5'-region, four candidate missense mutations (p.C35R, p.R81G, p.C295S, p.C623T) and one a candidate splice site mutation (c.1730-10C>A). Six previously described mutations were detected in 17 alleles, including the repeatedly found c.2435delC, p.R1659X and p.R1853X. Only one patient developed alloantibodies to VWF, carrying a homozygous c.3622delT. CONCLUSION: We report the genetic background of the entire Hungarian type 3 VWD population. A large novel deletion, most probably due to a founder effect, seems to be unique to Hungarian type 3 VWD patients with high allele frequency. In contrast to previous reports, none of the five patients homozygous for the large partial deletion developed inhibitors to VWF. This discrepancy raises the possibility of selection bias in some of the reports.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
genetic defect
type 3
von Willebrand disease
Megjelenés:
Journal Of Thrombosis And Haemostasis. - 9 : 5 (2011), p. 945-952. -
További szerzők:
Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
Jáger Rita
Losonczy Hajna
Marosi A.
Masszi Tamás
Nagy E.
Nemes László
Obser, T.
Oyen, F.
Radványi Gáspár
Schlammadinger Ágota (1971-) (belgyógyász, haematológus)
Szélessy Zs.
Várkonyi Ágnes
Vezendy K.
Vilimi B.
Schneppenheim, Reinhard
Bodó I.
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM035991
Első szerző:
Réti Marienn
Cím:
Complement activation in thrombotic thrombocytopenic purpura / Réti M., Farkas P., Csuka D., Rázsó K., Schlammadinger Á., Udvardy M. L., Madách K., Domján G., Bereczki C., Reusz G. S., Szabó A. J., Prohászka Z.
Dátum:
2012
ISSN:
1538-7933
Megjegyzések:
Ultra-large von Willebrand factor and deficiency of its cleaving protease are important factors in the events leading to thrombotic microangiopathy; however, the mechanisms involved are only partly understood. Whereas pathological activation of the alternative complement pathway is linked to atypical hemolytic uremic syndrome, the role of complement activation in thrombotic thrombocytopenic purpura (TTP) is unknown. The aim of this study was to investigate whether signs of complement activation are characteristic of TTP. PATIENTS AND METHODS: Twenty-three patients with TTP (18 women, median age 38 years) and 17 healthy controls (13 women, median age 38 years) were included. Complement parameters (C3, Factors H, I, B and total alternative pathway activity) together with complement activation fragments (C3a) or complexes (C1rs-INH, C3bBbP, sC5b9) were measured by ELISA or RID. ADAMTS13 activity and anti-ADAMTS13 inhibitory antibodies were measured by the VWF-FRET73 assay. RESULTS: Increased levels of C3a, and SC5b9 were observed in TTP during acute episodes, as compared with healthy controls. Decreased complement C3 levels indicative of complement consumption occurred in 15% of acute TTP patients. Significant decrease of complement activation products C3a and SC5b9 was observed during plasma exchange (PEX). The sustained presence of anti-ADAMTS13 inhibitory antibodies in complete remission was associated with increased complement activation.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
ADAMTS13 inhibitor
complement activation
TTP
Megjelenés:
Journal Of Thrombosis And Haemostasis. - 10 : 5 (2012), p. 791-798. -
További szerzők:
Farkas P.
Csuka D.
Molnárné Rázsó Katalin (1966-) (belgyógyász, haematológus, klinikai onkológus)
Schlammadinger Ágota (1971-) (belgyógyász, haematológus)
Udvardy Miklós László (1977-) (orvos, tudományos segédmunkatárs)
Madách Krisztina
Domján Gyula
Bereczki Csaba
Reusz György
Szabó A. J.
Prohászka Zoltán
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Intézményi repozitóriumban (DEA) tárolt változat
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