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1.

001-es BibID:BIBFORM075755
035-os BibID:(WoS)000458773000011 (Scopus)85058002826
Első szerző:Fernández, Javier
Cím:Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with ACLF across Europe / Javier Fernández, Verónica Prado, Jonel Trebicka, Alex Amoros, Thierry Gustot, Reiner Wiest, Carme Deulofeu, Elisabet Garcia, Juan Acevedo, Valentin Fuhrmann, François Durand, Cristina Sánchez, Maria Papp, Paolo Caraceni, Victor Vargas, Rafael Bañares, Salvatore Piano, Martin Janicko, Agustin Albillos, Carlo Alessandria, German Soriano, Tania M. Welzel, Wim Laleman, Alexander Gerbes, Andrea De Gottardi, Manuela Merli, Minneke Coenraad, Faouzi Saliba, Marco Pavesi, Rajiv Jalan, Pere Ginès, Paolo Angeli, Vicente Arroyo, the European Foundation for the Study of Chronic Liver Failure (EF Clif)
Dátum:2019
ISSN:0168-8278
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Hepatology. - 70 : 3 (2019), p. 398-411. -
További szerzők:Prado, Verónica Trebica, Jonel Amoros, Alex Gustot, Thierry Wiest, Reiner Deulofeu, Carme Garcia, Elisabet Acevedo, Juan Fuhrmann, Valentin Durand, François Sánchez, Cristina Papp Mária (1975-) (belgyógyász, gasztroenterológus) Caraceni, Paolo Vargas, Victor Bañares, Rafael Piano, Salvatore Janicko, Martin Albillos, Agustin Alessandria, Carlo Soriano, German Welzel, Tania M. Laleman, Wim Gerbes, Alexander Gottardi, Andrea De Merli, Manuela Coenraad, Minneke Saliba, Faouzi Pavesi, Marco Jalan, Rajiv Ginès, Pere Angeli, Paolo Arroyo, Vicente The European Foundation for the Study of Chronic Liver Failure (EF Clif)
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2.

001-es BibID:BIBFORM132974
Első szerző:Ma, Ann
Cím:Real-world Use of Terlipressin in Cirrhosis and Acute Kidney Injury : Frequent Use Beyond Hepatorenal Syndrome / Ma Ann T., Juanola Adria, Patidar Kavish R., Barone Anna, Incicco Simone, Kulkarni Anand V., Verma Nipun, Lange Christian M., Xie Qing, Alessandria Carlo, Cerda Reyes Eira, Maiwall Rakhi, Kim Jeong Han, Marciano Sebastián, Farias Alberto Queiroz, Toledo Claudio, Nardelli Silvia, Vorobioff Julio D., Roblero Juan Pablo, Thévenot Thierry, Papp Maria, Maan Raoel, Solé Cristina, Cordova-Gallardo Jacqueline, Simonetto Douglas A., Fouad Yasser, Balcar Lorenz, Raevens Sarah, Nabilou Puria, Caraceni Paolo, Merli Manuela, Presa José, Laleman Wim, Krag Aleksander, Bruns Tony, Pereira Gustavo, Mattos Angelo Z., Arab Juan Pablo, Wentworth Brian, Abdelkader Nadia Abdelaaty, Wong Yu Jun, Kim Sung-Eun, Roux Olivier, Takkenberg R. Bart, Galante Antonio, Goncalves Luciana Lofego, Pyrsopoulos Nikolaos T., Pérez Hernández José Luis, Asrani Sumeet K., Torre Aldo, Díaz-Ferrer Javier, Orman Eric S., Perricone Giovanni, Gadano Adrian, Ivashkin Vladimir, Fassio Eduardo, Marino Mónica, Vargas Victor, Rabinowich Liane, Montes Pedro, Mohammed Abdulsemed, Carrera Enrique, Cabrera María Cecilia, Girala Marcos, Samant Hrishikesh, Madaleno Joao, Kim W. Ray, Ferreira Carlos Noronha, Allegretti Andrew S., Sarin Shiv K., Gines Pere, Angeli Paolo, Sola Elsa, Piano Salvatore, International Club of Ascites GLOBAL AKI team
Dátum:2026
ISSN:1542-3565 1542-7714
Megjegyzések:BACKGROUND & AIMS: Terlipressin is indicated to treat hepatorenal syndrome (HRS)-acute kidney injury (AKI) but is likely used outside this primary indication in clinical practice. We aimed to investigate realworld practice patterns on the use of terlipressin in AKI in cirrhosis. METHODS: International prospective study including patients hospitalized for decompensated cirrhosis. This was a subgroup analysis of patients who received terlipressin to treat AKI. Primary outcome was AKI resolution. Secondary outcomes were respiratory failure and 28-day mortality. RESULTS: Among 1456 patients with AKI, 243 (17%) received terlipressin. Terlipressin was predominantly administered as a continuous infusion (75%). The AKI phenotype was HRS-AKI in 50%, acute tubular necrosis (ATN) in 17%, hypovolemic in 25%, and other in 8%. AKI resolution occurred in 49% of the patients, and was lowest in ATN (29%), followed by HRS-AKI (51%) and hypovolemic (63%). ATN was independently associated with lack of AKI resolution (odds ratio, 2.77; 95% confidence interval, 1.24?6.54; P ? .02). De novo respiratory failure occurred in 20% of patients. There were no significant differences in the amount of albumin received nor acute-on-chronic liver failure grade between those who did and did not develop respiratory failure. The presence of pneumonia independently predicted respiratory failure (odds ratio, 7.80; 95% confidence interval, 2.43?26.95; P < .001). Mortality rate at 28 days was 36%; ATN and hospital-acquired AKI independently predicted 28-day mortality. CONCLUSIONS: Terlipressin is often used for treatment of AKI outside its primary indication of HRS-AKI. Compared with patients with HRS-AKI, response to terlipressin is significantly lower in patients with ATN, in whom the risks may outweigh the benefits. Respiratory failure is common but does not seem to be driven by the amount of albumin received nor acute-on-chronic liver failure grade.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Hepatorenal Syndrome
Mortality
Respiratory Failure
Vasoconstrictor
Megjelenés:Clinical Gastroenterology and Hepatology. - 24 : 4 (2026), p. 1079-1091. -
További szerzők:Juanola, Adria Patidar, Kavish R. Barone, Anna Incicco, Simone Kulkarni, Anand V. Verma, Nipun Lange, Christian M. Xie, Qing Alessandria, Carlo Cerda, Eira Maiwall, Rakhi Kim, Jeonghan Marciano, Sebastian Farias, Alberto Queiroz Toledo, Claudio Nardelli, Silvia Vorobioff, Julio D. Roblero, Juan Pablo Thevenot, Thierry Papp Mária (1975-) (belgyógyász, gasztroenterológus) Maan, Raoel Sole, Cristina Cordova-Gallardo, Jacqueline Simonetto, Douglas A. Fouad, Yasser Balcar, Lorenz Raevens, Sarah Nabilou, Puria Caraceni, Paolo Merli, Manuela Presa, José Laleman, Wim Krag, Aleksander Bruns, Tony Pereira, Gustavo Mattos, Angelo Z. Arab, Juan Pablo Wentworth, Brian Abdelkader, Nadia Abdelaaty Wong, Yu Jun Kim, Sung-Eun Roux, Olivier Takkenberg, Bart Galante, Antonio Goncalves, Luciana Lofego Pyrsopoulos, Nikolaos T. Pérez Hernández, José Luis Asrani, Sumeet K. Torre, Aldo Díaz-Ferrer, Javier Orman, Eric S. Perricone, Giovanni Gadano, Adrian Ivashkin, Vladimir Fassio, Eduardo Marino, Monica Vargas, Victor Rabinowich, Liane Montes, Pedro Mohammed, Abdulsemed Carrera, Enrique Cabrera, María Cecilia Girala, Marcos Samant, Hrishikesh Madaleno, João Kim, W. Ray Ferreira, Carlos Noronha Allegretti, Andrew S. Sarin, Shiv K. Ginès, Pere Angeli, Paolo Solà, Elsa Piano, Salvatore International Club of Ascites GLOBAL AKI team
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3.

001-es BibID:BIBFORM126904
035-os BibID:(scopus)105002128353 (wos)001470060400001
Első szerző:Patidar, Kavish R.
Cím:Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis : the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study / Kavish R. Patidar, Ann Ma, Adrià Juanola, Anna Barone, Simone Incicco, Anand V. Kulkarni, José Luis Pérez Hernández, Brian Wentworth, Sumeet K. Asrani, Carlo Alessandria, Nadia Abdelaaty Abdelkader, Yu Jun Wong, Qing Xie, Nikolaos T. Pyrsopoulos, Sung-Eun Kim, Yasser Fouad, Aldo Torre, Eira Cerda, Javier Diaz Ferrer, Rakhi Maiwall, Douglas A. Simonetto, Maria Papp, Eric S. Orman, Giovanni Perricone, Cristina Solé, Christian M. Lange, Alberto Queiroz Farias, Adrian Gadano, Paolo Caraceni, Thierry Thevenot, Nipun Verma Jeong Han Kim, Julio D. Vorobioff, Jacqueline Cordova-Gallardo, Vladimir Ivashkin, Juan Pablo Roblero, Raoel Maan, Claudio Toledo, Stefania Gioia, Eduardo Fassio, Monica Marino, Puria Nabilou, Victor Vargas, Manuela Merli, Luciana Lofego Goncalves, Liane Rabinowich, Aleksander Krag, Lorenz Balcar, Pedro Montes, Angelo Z. Mattos, Tony Bruns, Abdulsemed Mohammed, Wim Laleman, Enrique Carrera, María Cecilia Cabrera, Marcos Girala, Hrishikesh Samant, Sarah Raevens, Joao Madaleno, Ray W. Kim, Juan Pablo Arab, José Presa, Carlos Noronha Ferreira, Antonio Galante, Andrew S. Allegretti, Bart Takkenberg, Sebastian Marciano, Shiv. K. Sarin, François Durand, Pere Gines, Paolo Angeli, Elsa Solà, Salvatore Piano, International Club of Ascites GLOBAL AKI team
Dátum:2025
Megjegyzések:SUMMARY Background: Acute kidney injury (AKI) is a serious complication of cirrhosis. A systematic characterization of AKI occurring in cirrhosis patients across different regions of the world is yet missing. This prospective intercontinental cohort study aimed to assess global differences in the characteristics, management and outcomes of AKI in hospitalized patients with cirrhosis. Methods: In this prospective observational cohort study, patients older than 18 years who were hospitalized for decompensated cirrhosis were enrolled from July 1st 2022 to May 31st 2023 at 65 centers across 5 continents. We captured AKI prevalence, stage, phenotype [hypovolemic, hepatorenal syndrome (HRS-AKI), acute tubular necrosis (ATN) and others] and details on AKI management and clinical course. Universal health coverage (UHC) index was also collected. The primary outcome was 28-day mortality. Multivariable models which included demographic variables, cirrhosis etiology, cirrhosis severity, AKI severity, AKI management variables, and UHC were used to analyze the independent association of each outcome with the variables of interest. This study is complete and registered with Clinicaltrials.gov, NCT05387811. Findings: Among 3,821 enrolled patients with decompensated cirrhosis [N=2,467 (64?6%) men and N=1,354 (35?4%) women], 1,456 (38?1%) had AKI [N=943 (64?7%) men and N=513 (35?3%) women]. Patients presented with similar AKI stages globally, but patients from North America and Asia had higher MELD-Na score at presentation and peak AKI stage. Overall, hypovolemic AKI was the most common phenotype (N=858, 58?9%), followed by HRS-AKI (N=253, 17?4%) and ATN (N=216, 14?8%). The prevalence of HRS-AKI was similar across regions (p=0.28), but ATN was more frequent in Asia (p<0?001). Additionally, regional differences in the management of AKI (use of albumin, vasopressors and handling diuretics) were found. AKI resolved in 59?2% (N=862) of cases. Overall, 22?8% (N=333) of patients with AKI died at 28-days. On multivariable analysis, age, female sex, white blood cells, presence of ascites, presence of hepatic encephalopathy, serum albumin, MELD-Na, hospital-acquired AKI, and lower UHC index countries were independently associated with an increased risk of 28-day mortality. Interpretation: This study found important regional differences in AKI severity, phenotype, management and outcomes. Healthcare coverage remains the most important driver of survival in patients with cirrhosis and AKI. Funding: European Association Study for the Study of The Liver Registry Grant, Italian Society of Internal Medicine
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
AKI
acute kidney injury
cirrhosis
Megjelenés:Lancet Gastroenterology & Hepatology. - 10 (2025), p. 418-430. -
További szerzők:Ma, Ann Juanola, Adria Barone, Anna Incicco, Simone Kulkarni, Anand V. Hernández, José Luis Pérez Wentworth, Brian Asrani, Sumeet K. Carlo, Alessandria Abdelaaty Abdelkader, Nadia Wong, Yu Jun Xie, Qing Pyrsopoulos, Nikolaos T. Kim, Sung-Eun Fouad, Yasser Torre, Aldo Cerda, Eira Ferrer, Javier Diaz Maiwall, Rakhi Simonetto, Douglas A. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Orman, Eric S. Perricone, Giovanni Sole, Cristina Lange, Christian M. Farias, Alberto Queiroz Gadano, Adrian Caraceni, Paolo Thevenot, Thierry Han Kim, Nipun Verma Jeong Vorobioff, Julio D. Cordova-Gallardo, Jacqueline Ivashkin, Vladimir Roblero, Juan Pablo Maan, Raoel Toledo, Claudio Gioia, Stefania Fassio, Eduardo Marino, Monica Nabilou, Puria Vargas, Victor Merli, Manuela Goncalves, Luciana Lofego Rabinowich, Liane Krag, Aleksander Balcar, Lorenz Montes, Pedro Mattos, Angelo Z. Bruns, Tony Mohammed, Abdulsemed Laleman, Wim Carrera, Enrique Cabrera, María Cecilia Girala, Marcos Samant, Hrishikesh Raevens, Sarah Madaleno, João Kim, Ray W. Arab, Juan Pablo Presa, José Ferreira, Carlos Noronha Galante, Antonio Allegretti, Andrew S. Takkenberg, Bart Marciano, Sebastian Sarin, Shiv K. Durand, François Ginès, Pere Angeli, Paolo Solà, Elsa Piano, Salvatore International Club of Ascites GLOBAL AKI team
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4.

001-es BibID:BIBFORM088130
035-os BibID:(WoS)000640696100013 (Scopus)85101877901
Első szerző:Trebica, Jonel
Cím:PREDICT identifies Precipitating Events Associated with Clinical Course of Acutely Decompensated Cirrhosis / Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Ushcner, Christian Jansen, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Banares, Peter Jarcuska, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, Debbie Shawcross, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Karen V. Danielsen, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, Jose Presa Ramos, Cristina Sole, German Soriano, Andrea de Gottardi, Henning Groenbaek Faouzi, Saliba Trautwein, Christian Haluk, Tarik Kani, Sven Francque, Stephen Ryder, Pierre Nahon, Manuel Romero Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Michael Praktiknjo, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, William Bernal, Ferran Aquilar, Joan Claria, Paolo Ponzo, Zsuzsanna Vitalis, Giacomo Zaccherini, Boglarka Balogh, Alexander Gerbes, Victor Vargas, Carlo Alessandria, Mauro Bernardi, Pere Gines, Richard Moreau, Paolo Angeli, Rajiv Jalan, Vicente Arroyo
Dátum:2021
ISSN:0168-8278
Megjegyzések:ABSTRACT Introduction: Acute decompensation (AD) of cirrhosis may present without acute-onchronic liver failure (ACLF) (AD-No ACLF), or with ACLF-phenotype (AD-ACLF) defined by organ failure(s). Precipitating events may induce AD. This multicenter,prospective, observational PREDICT Study (NCT03056612) analyzes and characterizes the precipitants leading to both AD-phenotypes. Patients and Methods: The PREDICT study included 1273 non-electively hospitalized patients with AD (No-ACLF=1071; ACLF=202). Medical history, clinical and laboratory data were carefully collected at enrolment and during 90-days follow up, focused on the characteristics of precipitants, specifically induction of organ dysfunction/failure and/or systemic inflammation, chronology, intensity, and relationship to outcome in both AD phenotypes. Results: Among different clinical events, four distinct events were precipitants consistently related to AD, including proven bacterial infections, severe alcoholic hepatitis, gastrointestinal (GI) bleeding with shock and toxic encephalopathy. Among patients in the AD-No ACLF cohort and the AD-ACLF cohort with precipitants (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Interestingly, in both AD-phenotypes, proven bacterial infections and severe alcoholic hepatitis had a similar association withsurvival, and the number of precipitants was associated with significantly increased 90-day mortality, in paralleled by surrogates of systemic inflammation confirming a valid definition of precipitating events. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with lower ACLF development rate and higher 90-day survival. Conclusions: This study identified precipitating events that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
chronic liver disease
non-elective admission
acute complications
outcome
risk factors
Megjelenés:Journal of Hepatology. - 74 : 5 (2021), p. 1097-1108. -
További szerzők:Fernández, Javier Papp Mária (1975-) (belgyógyász, gasztroenterológus) Caraceni, Paolo Laleman, Wim Gambino, Carmine Giovo, Ilaria Uschner, Frank Erhard Jansen, Christian Jimenez, Cesar Mookerjee, Rajeshwar Gustot, Thierry Albillos, Agustin Bañares, Rafael Jarcuska, Peter Steib, Christian Reiberger, Thomas Acevedo, Juan Gatti, Pietro Shawcross, Debbie Zeuzem, Stefan Zipprich, Alexander Piano, Salvatore Berg, Thomas Bruns, Tony Danielsen, Karen V. Coenraad, Minneke Merli, Manuela Stauber Rudolf Zoller, Heinz Ramos, José Sole, Cristina Soriano, German Gottardi, Andrea De Faouzi, Henning Groenbaek Trautwein, Saliba Haluk, Christian Kani, Tarik Francque, Sven Ryder, Stephen Nahon, Pierre Gomez, Manuel Romero Vlierberghe, Hans Van Francoz, Claire Manns, Michael P. Garcia, Elisabet Tufoni, Manuel Amoros, Alex Pavesi, Marco Sánchez, Cristina Praktiknjo, Michael Curto, Anna Pitarch, Carla Putignano, Antonella Moreno, Esau Bernal, William Aquilar, Ferran Claria, Joan Ponzo, Paolo Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Zaccherini, Giacomo Balogh Boglárka (1993-) (belgyógyász) Gerbes, Alexander Vargas, Victor Alessandria, Carlo Bernardi, Mauro Ginès, Pere Moreau, Richard Angeli, Paolo Jalan, Rajiv Arroyo, Vicente
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5.

001-es BibID:BIBFORM086407
035-os BibID:(WoS)000572079900019 (Scopus)85088972261
Első szerző:Trebica, Jonel
Cím:The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology / Jonel Trebicka, Javier Fernandez, Papp Mária, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Uschner, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Banares, Martin Janicko, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, William Bernal, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Lise Lotte Gluud, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, Ana Cristino, Cristina Sole, Germán Soriano, Andrea de Gottardi, Henning Groenbaek, Faouzi Saliba, Christian Trautwein, Osman Cavit Özdogan, Francque Sven, Stephen Ryder, Pierre Nahon, Manuel Romero-Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, Debbie Showcross, Ferran Aguilar, Joan Claria, Paolo Ponzo, Christian Jansen, Vitális Zsuzsanna, Giacomo Zaccherini, Balogh Boglárka, Victor Vargas, Sara Montagnese, Carlo Alessandria, Mauro Bernardi, Pere Gines, Rajiv Jalan, Richard Moreau, Paolo Angeli, Vicente Arroyo
Dátum:2020
ISSN:0168-8278
Megjegyzések:Background/Aims:Acute decompensation (AD) of cirrhosis is defined by the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, i nfection or any combination of these, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF), while their absence defines AD. We designed the PREDICT study, a European, prospective, observational study, to characterize the clinical course of AD and predict ACLF . Methods:A total of 1071 patients with AD were enrolled to collect detailed pre-specified information on the 3-month period prior to enrollment, and clinical and laboratory data at enrollment. Patients were then closely followed-up for 3 months. The 12-month outcomes (liver transplantation, and death) were also recorded. Results:Three groups of patients were identified: Pre-ACLF patients (n=218), who developed ACLF and had 3-month and 1-year mortality rates of 53.7% and 67.4%, respectively. Unstable decompensated cirrhosis (UDC) patients (n = 233) required ?1 readmission but not developing ACLF and had 21.0% and 35.6% mortality rates. Stable decompensated cirrhosis (SDC) patients (n = 620) who were neither readmitted, nor developed ACLF and showed a 1-year mortality of only 9.5%. The 3 groups differed significantly in the grade and course of systemic inflammation (high-grade at enrollment with aggravation during follow-up in pre-ACLF; low-grade at enrollment with subsequent steady-course in UDC; and low-grade at enrollment with subsequent improvement in the SDC) and prevalence of surrogates of severe portal hypertension throughout the study (high in UDC versus low in pre-ACLF and SDC). Conclusions:Acute decompensation without ACLF is a heterogeneous condition with three different clinical courses and two major pathophysiological mechanisms: systemic inflammation and portal hypertension. Prediction of ACLF development remains a major future task.(ClinicalTrials.gov number, NCT03056612)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Chronic liver disease
non-elective admission
acute complications
Outcome
Risk factors
Megjelenés:Journal of Hepatology. - 73 (2020), p. 842-854. -
További szerzők:Fernández, Javier Papp Mária (1975-) (belgyógyász, gasztroenterológus) Caraceni, Paolo Laleman, Wim Gambino, Carmine Giovo, Ilaria Uschner, Frank Erhard Jimenez, Cesar Mookerjee, Rajeshwar Gustot, Thierry Albillos, Agustin Bañares, Rafael Janicko, Martin Steib, Christian Reiberger, Thomas Acevedo, Juan Gatti, Pietro Bernal, William Zeuzem, Stefan Zipprich, Alexander Piano, Salvatore Berg, Thomas Bruns, Tony Gluud, Lise Lotte Coenraad, Minneke Merli, Manuela Stauber Rudolf Zoller, Heinz Cristino, Ana Sole, Cristina Soriano, German Gottardi, Andrea De Groenbaek, Henning Saliba, Faouzi Trautwein, Christian Özdogan, Osman Cavit Sven, Francque Ryder, Stephen Nahon, Pierre Romero-Gomez, Manuel Vlierberghe, Hans Van Francoz, Claire Manns, Michael P. Garcia, Elisabet Tufoni, Manuel Amoros, Alex Pavesi, Marco Sánchez, Cristina Curto, Anna Pitarch, Carla Putignano, Antonella Moreno, Esau Showcross, Debbie Aguilar, Ferran Claria, Joan Ponzo, Paolo Jansen, Christian Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Zaccherini, Giacomo Balogh Boglárka (1993-) (belgyógyász) Vargas, Victor Montagnese, Sara Alessandria, Carlo Bernardi, Mauro Ginès, Pere Jalan, Rajiv Moreau, Richard Angeli, Paolo Arroyo, Vicente
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6.

001-es BibID:BIBFORM107811
035-os BibID:(Scopus)85160261108 (WoS)000941419200001
Első szerző:Weiss, Emmanuel
Cím:Sympathetic nervous activation, mitochondrial dysfunction, and outcome in acutely decompensated cirrhosis : the metabolomic prognostic models (CLIF-C MET) / Emmanuel Weiss, Carlos De La PeNa-Ramirez, Ferran Aguilar, Juan-José Lozano, Cristina Sánchez, Patricia Sierra, Pedro Izquierdo-Bueno, Juan Manuel Diaz, FranCois Fenaille, Florence Castelli, Thierry Gustot, Wim Laleman, Agustín Albillos, Carlo Alessandria, Marco Domenicali, Paolo Caraceni, Salvatore Piano, Faouzi Saliba, Stefan Zeuzem, Alexander Gerbes, Julia Wendom, Christian Jansen, Wenyi Gu, Maria Papp, Rajeshwar P. Mookerjee, Carmine Gambino, Cesar Jiménez, Ilaria Giovo, Giacomo Zaccherini, Manuela Merli, Antonella Putignano, Frank Erhard Uschner, Thomas Berg, Tony Bruns, Christian Trautwein, Alexander Zipprich, Rafael BaNares, José Presa, Joan Genesca, Victor Vargas, Javier Fernández, Mauro Bernardi, Paolo Angeli, Rajiv Jalan, Joan Claria, Christophe Junot, Richard Moreau, Jonel Trebicka, Vicente Arroyo, Canonic And Predict 22 Study Investigators
Dátum:2023
ISSN:0017-5749
Megjegyzések:ABSTRACT BACKGROUND AND AIMS. Current prognostic scores of patients with acutely decompensated cirrhosis (AD), particularly those with ACLF, underestimate the risk of mortality. This is probably because systemic inflammation (SI), the major driver of AD/ACLF, is not reflected in the scores. SI induces metabolic changes which impair delivery of the necessary energy for the immune reaction. This investigation aimed to identify metabolites associated with short-term (28-day) death and to design metabolomic prognostic models. METHODS. Two prospective multi-center large cohorts from Europe for investigating ACLF and development of ACLF, CANONIC (discovery, n=831) and PREDICT validation, n=851) were explored by untargeted serum metabolomics to identify and validate metabolites which could allow improved prognostic modelling. RESULTS. Three prognostic metabolites strongly associated with death were selected to build the models. 4-hydroxy-3-methoxyphenylglycol sulphate is a norepinephrine derivate, which may derive from the brainstem response to systemic inflammation. Additionally, galacturonic acid and hexanoylcarnitine are associated with mitochondrial dysfunction. Model 1 included only these three prognostic metabolites and age. Model 2 was built around 4-hydroxy-3-methoxyphenylglycol sulphate, hexanoylcarnitine, bilirubin, INR, and age. In the discovery cohort, both models were more accurate in predicting death within 7, 14 and 28 days after admission compared to MELDNa score (C-index: 0.9267, 0.9002 and 0.8424, and 0.9369, 0.9206 and 0.8529, with model 1 and model 2, respectively). Similar results were found in the validation cohort (C-index: 0.9399, 0.8339 and 0.7912, and 0.9471, 0.8566 and 0.8101, with model 1 and model 2, respectively). Also, in ACLF, model 1 and model 2 outperformed MELDNa after 7, 14 25 and 28 days after admission for prediction of mortality.CONCLUSIONS. Models including metabolites (CLIF-C MET) reflecting SI, mitochondrial dysfunction and sympathetic system activation are better predictors of short-term mortality than scores based only on organ dysfunction (e.g., MELDNa), especially in patients with ACLF.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Gut. - 72 : 8 (2023), p. 1581-1591. -
További szerzők:de la Pena-Ramirez, Carlos Aguilar, Ferran Lozano, Juan-José Sánchez, Cristina Sierra, Patricia Izquierdo-Bueno, Pedro Diaz, Juan Manuel Fenaille, Francois Castelli, Florence Gustot, Thierry Laleman, Wim Albillos, Agustin Alessandria, Carlo Domenicali, Marco Caraceni, Paolo Piano, Salvatore Saliba, Faouzi Zeuzem, Stefan Gerbes, Alexander Wendom, Julia Jansen, Christian Gu, Wenyi Papp Mária (1975-) (belgyógyász, gasztroenterológus) Mookerjee, Rajeshwar P. Gambino, Carmine Jimenez, Cesar Giovo, Ilaria Zaccherini, Giacomo Merli, Manuela Putignano, Antonella Uschner, Frank Erhard Berg, Thomas Bruns, Tony Trautwein, Christian Zipprich, Alexander Bañares, Rafael Presa, José Genesca, Joan Vargas, Victor Fernández, Javier Bernardi, Mauro Angeli, Paolo Jalan, Rajiv Claria, Joan Junot, Christophe Moreau, Richard Trebica, Jonel Arroyo, Vicente CANONIC and PREDICT 22 study investigators
Internet cím:DOI
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