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001-es BibID:	BIBFORM122040
Első szerző:	Sztanek Ferenc (orvos)
Cím:	New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes-Beyond and within GLP-1 Receptor Agonists / Sztanek Ferenc, Tóth László Imre, Pető Attila, Hernyák Marcell, Diószegi Ágnes, Harangi Mariann
Dátum:	2024
ISSN:	2227-9059
Megjegyzések:	Guidelines for the management of obesity and type 2 diabetes (T2DM) emphasize the importance of lifestyle changes, including a reduced-calorie diet and increased physical activity. However, for many people, these changes can be difficult to maintain over the long term. Medication options are already available to treat obesity, which can help reduce appetite and/or reduce caloric intake. Incretin-based peptides exert their effect through G-protein-coupled receptors, the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and glucagon peptide hormones are important regulators of insulin secretion and energy metabolism. Understanding the role of intercellular signaling pathways and inflammatory processes is essential for the development of effective pharmacological agents in obesity. GLP-1 receptor agonists have been successfully used, but it is assumed that their effectiveness may be limited by desensitization and downregulation of the target receptor. A growing number of new agents acting on incretin hormones are becoming available for everyday clinical practice, including oral GLP-1 receptor agonists, the dual GLP-1/GIP receptor agonist tirzepatide, and other dual and triple GLP-1/GIP/glucagon receptor agonists, which may show further significant therapeutic potential. This narrative review summarizes the therapeutic effects of different incretin hormones and presents future prospects in the treatment of T2DM and obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk G-protein-coupled receptors GLP-1 receptor agonist GIP receptor agonist glucagon receptor agonist obesity type 2 diabetes
Megjelenés:	Biomedicines. - 12 : 6 (2024), p. 1-22. -
További szerzők:	Tóth László (1997-) (orvos) Pető Attila (1990-) (általános orvos) Hernyák Marcell Diószegi Ágnes (1987-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	142273 OTKA TKP2021-EGA-18 Egyéb Eötvös Loránd Research Network 11003 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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