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001-es BibID:BIBFORM122885
035-os BibID:(Scopus)85195564954 (WoS)001241583300001
Első szerző:Szajewska, Hania
Cím:Early diet and the risk of coeliac disease. An update 2024 position paper by the ESPGHAN special interest group on coeliac disease / Hania Szajewska, Raanan Shamir, Renata Auricchio, Anna Chmielewska, Jernej Dolinsek, Laura Kivelä, Sibylle Koletzko, Ilma R. Korponay-Szabo, Elin M. Hård Af Segerstad, M. Luisa Mearin, Caroline Meijer-Boekel, Carmen Ribes Konickx, Alfonso Rodriguez-Herrera, Ketil Stordal, Riccardo Troncone, Margreet Wessels
Dátum:2024
ISSN:0277-2116
Megjegyzések:This position paper by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Coeliac Disease (SIG-CD) presents an update to the 2016 recommendations concerning early diet and the risk of coeliac disease (CD). This update adheres to the policy that mandates reviewing guidelines every 5 years, particularly when new data emerge. The 2024 statements and recommendations are essentially similar to the 2016 recommendations. Breastfeeding, whether any amount, exclusive, or of any duration, does not reduce the risk of developing CD. Introducing gluten into an infant's diet at any time between completed 4 months (?17 weeks) and 12 months of age does not affect the cumulative incidence of CD, although earlier introduction may lead to earlier seroconversion and CD. In observational studies involving cohorts with a known risk for CD, consuming a high amount of gluten compared to a low amount during weaning and in the subsequent childhood years-specifically the first 2-3 years, and even up to 5 years in some studies-was associated with an increased risk for CD. However, the specific optimal amounts of gluten consumption remain undetermined due to insufficient evidence on safe thresholds, and the impact of restricting gluten in the diet of healthy children of unknown risk for CD is unknown. Thus, any recommendation on the gluten amount is currently unjustifiable for the general population and infants with known HLA risk types. There is no specific guidance on the type of gluten-containing foods to be introduced at weaning.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coeliac disease risk
gluten amount
gluten introduction
infant feeding
infant nutrition
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 79 (2024), p. 438-445. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Auricchio, Renata Chmielewska, Anna Dolinśek, Jernej Kivelä, Laura Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Af Segerstad, Elin M. Hård Mearin, Maria Luisa Meijer-Boekel, Caroline Konickx, Carmen Ribes Rodriguez-Herrera, Alfonso Størdal, Ketil Troncone, Riccardo Wessels, Margreet
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001-es BibID:BIBFORM109151
035-os BibID:(scopus)85143485531 (wos)000888150500001
Első szerző:Szajewska, Hania
Cím:Systematic review : early feeding practices and the risk of coeliac disease. A 2022 update and revision / Szajewska Hania, Shamir Raanan, Strózyk Agata, Chmielewska Anna, Zalewski Bartomiej M., Auricchio Renata, Koletzko Sibylle, Korponay-Szabo Ilma R., Mearin M. Luisa, Meijer Caroline, Ribes-Koninckx Carmen, Troncone Riccardo, PreventCD project group
Dátum:2023
ISSN:0269-2813 1365-2036
Megjegyzések:Background: The effects of early feeding practices on the risk of coeliac disease (CD) remain debated. Aims: To update evidence on these practices on the risk of CD and/or CD-related autoimmunity (CDA), defined as anti-transglutaminase or anti-endomysial antibody positivity METHODS: We searched MEDLINE, EMBASE and the Cochrane Library to May 2022 for randomised controlled trials (RCTs) and observational studies. Results: We included 36 publications (30 studies). In the population at genetic risk of developing CD (HLA DQ2/DQ8-positive), exclusive or any breastfeeding and longer breastfeeding duration did not reduce the risk of developing CD/CDA during childhood. While a meta-analysis of four case-control studies showed a decreased risk for CD when gluten was introduced during breastfeeding, this was not shown in RCTs and cohort studies. Age at gluten introduction was not associated with cumulative CD/CDA risk, although two RCTs suggested that earlier gluten introduction was associated with earlier CDA appearance. Evidence from six observational studies suggests that consumption of a higher amount of gluten at weaning and/or thereafter may increase CD risk. There is insufficient evidence to determine the amount of gluten associated with an increased CD/CDA risk. Regarding whether infant feeding practices modulate the risk conferred by different HLA genotypes results were inconsistent. Conclusions: For the population at genetic risk of CD, breastfeeding and age at gluten introduction have no effect on its cumulative incidence during childhood. There is some evidence for an effect of the amount of gluten consumed at weaning and/or thereafter on CD/CDA risk.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
celiac disease
infant fedding
Megjelenés:Alimentary Pharmacology & Therapeutics. - 57 : 1 (2023), p. 8-22. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Stróżyk, Agata Chmielewska, Anna Zalewski, Bartomiej Auricchio, Renata Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Ribes-Koninckx, Carmen Troncone, Riccardo PreventCD Group
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3.

001-es BibID:BIBFORM100890
035-os BibID:(WoS)000770907500001 (Scopus)85125956936
Első szerző:Szajewska, Hania
Cím:Early Feeding Practices and Celiac Disease Prevention : protocol for an Updated and Revised Systematic Review and Meta-Analysis / Szajewska Hania, Shamir Raanan, Chmielewska Anna, Strózyk Agata, Zalewski Bartomiej, Auricchio Renata, Koletzko Sibylle, Korponay-Szabo Ilma, Mearin Luisa, Meijer Caroline, Ribes-Koninckx Carmen, Troncone Riccardo, PREVENTCD Study Group
Dátum:2022
ISSN:2072-6643
Megjegyzések:Uncertainty remains in regard to when, how, and in what form gluten should be introduced into the diet, particularly of infants genetically predisposed to developing celiac disease (CD). MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials databases will be searched from inception. Randomized controlled trials (RCTs) and observational studies (cohort, case-control, or cross-sectional studies) investigating the association between early feeding practices and the risk of CD and/or CD autoimmunity will be included. In prospective studies, participants will be infants regardless of the risk of developing CD. For retrospective studies, participants will be children or adults with CD or presenting with positive serology indicative of CD. Interventions will be gluten-containing products of any type. Exposures will be breastfeeding and/or the introduction of gluten-containing products of any type. In control groups, there will be no exposure, different degrees of exposure (partial vs. exclusive breastfeeding, different amounts of gluten, etc.), or a placebo. The primary outcome measure will be CD or CD autoimmunity (i.e., anti-transglutaminase or anti-endomysial antibodies). At least two reviewers will independently assess the risk of bias using a validated risk assessment tool depending on study design. Disagreements will be resolved by discussion to achieve a consensus with the involvement of one or more additional reviewers if required. If appropriate, data will be pooled. If not, a narrative synthesis will be performed. The findings will be submitted to a peer-reviewed journal.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
nutrition
feeding
infants
children
celiac sprue
breastfeeding
Megjelenés:Nutrients. - 14 : 5 (2022), p. 1-7. -
További szerzők:Shamir, Raanan (gyermekgyógyász) Chmielewska, Anna Stróżyk, Agata Zalewski, Bartomiej Auricchio, Renata Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Meijer, Caroline R. Ribes-Koninckx, Carmen Troncone, Riccardo PreventCD Group
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4.

001-es BibID:BIBFORM056540
Első szerző:Vriezinga, Sabine Lisa
Cím:Randomized feeding intervention in infants at high risk for celiac disease / S. L. Vriezinga, R. Auricchio, E. Bravi, G. Castillejo, A. Chmielewska, P. Crespo Escobar, S. Kolaček, S. Koletzko, I. R. Korponay-Szabo, E. Mummert, I. Polanco, H. Putter, C. Ribes-Koninckx, R. Shamir, H. Szajewska, K. Werkstetter, L. Greco, J. Gyimesi, C. Hartman, C. Hogen Esch, E. Hopman, A. Ivarsson, T. Koltai, F. Koning, E. Martinez-Ojinaga, C. te Marvelde, A. Mocic Pavic, J. Romanos, E. Stoopman, V. Villanacci, C. Wijmenga, R. Troncone, M. L. Mearin
Dátum:2014
ISSN:0028-4793
Megjegyzések:BACKGROUND A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS We performed a multicenter, randomized, double-blind, placebo-controlled dietaryintervention study involving 944 children who were positive for HLA-DQ2 or HLADQ8 and had at least one first-degree relative with celiac disease. From 16 to 24 weeks of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received placebo. Anti-transglutaminase type 2 and antigliadin antibodies were periodically measured. The primary outcome was the frequency of biopsy-confirmed celiac disease at 3 years of age. RESULTS Celiac disease was confirmed by means of biopsies in 77 children. To avoid underestimation of the frequency of celiac disease, 3 additional children who received a diagnosis of celiac disease according to the 2012 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria (without having undergone biopsies) were included in the analyses (80 children; median age, 2.8 years; 59% were girls). The cumulative incidence of celiac disease among patients 3 years of age was 5.2% (95% confidence interval [CI], 3.6 to 6.8), with similar rates in the gluten group and the placebo group (5.9% [95% CI, 3.7 to 8.1] and 4.5% [95% CI, 2.5 to 6.5], respectively; hazard ratio in the gluten group, 1.23; 95% CI, 0.79 to 1.91). Rates of elevated levels of anti-transglutaminase type 2 and antigliadin antibodies were also similar in the two study groups (7.0% [95% CI, 4.7 to 9.4] in the gluten group and 5.7% [95% CI, 3.5 to 7.9] in the placebo group; hazard ratio, 1.14; 95% CI, 0.76 to 1.73). Breast-feeding, regardless of whether it was exclusive or whether it was ongoing during gluten introduction, did not significantly influence the development of celiac disease or the effect of the intervention. CONCLUSIONS As compared with placebo, the introduction of small quantities of gluten at 16 to 24 weeks of age did not reduce the risk of celiac disease by 3 years of age in this group of high-risk children. (Funded by the European Commission and others; PreventCD Current Controlled Trials number, ISRCTN74582487.)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:New England Journal Of Medicine 371 : 14 (2014), p. 1304-1315. -
További szerzők:Auricchio, Renata Bravi, Enzo (biológus) Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Chmielewska, Anna Crespo-Escobar, Paula Kolaček, Sanja Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mummert, Eckart Polanco, Isabel Putter, Hein Ribes-Koninckx, Carmen Shamir, Raanan (gyermekgyógyász) Szajewska, Hania (gyermekgyógyász) Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Greco, Luigi Gyimesi Judit Hartman, Corina Hogen Esch, Caroline Hopman, Erica Ivarsson, Anneli Koltai Tünde Koning, Frits Martinez-Ojinaga, Eva Marvelde, Chantal te Pavic, Ana Romanos, Jihane Stoopman, Els Villanacci, Vincenzo Wijmenga, Cisca Troncone, Riccardo Mearin, Maria Luisa
Pályázati támogatás:TÁMOP-2.2.11/1/KONV-2012-0023
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101788
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