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001-es BibID:	BIBFORM060757
Első szerző:	Szabó Tamás (gyermekgyógyász)
Cím:	Regulation of TRPC6 ion channels in podocytes : implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases / T. Szabó, L. Ambrus, N. Zákány, Gy. Balla, T. Bíró
Dátum:	2015
ISSN:	0231-424X 1588-2683
Megjegyzések:	The glomerular filtration barrier is a highly specialized tri-layer structure with unique functional properties. Podocyte dysfunction and cytoskeletal disorganization leads to disruption of the slit diaphragma, and proteinuria. Inflammatory diseases involving the kidney as well as inherited podocytopathies or diabetic nephropathy cause injury of the podocyte network. Focal segmental glomerulosclerosis (FSGS) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children. Several causative genes have been identified in the pathogenesis of FSGS. Mutations of the transient receptor potential canonical-6 (TRPC6), a non-selective cation channel that is directly activated by diacylglycerol (DAG), cause a particularly aggressive form of FSGS. Angiotensin II, acting through its AT1 receptor, plays a critical role in generation of proteinuria and progression of kidney injury in a number of kidney diseases, including FSGS. Mounting evidence suggest the central role of TRPC6 and perhaps other TRPC channels in the pathogenesis of FSGS as well as of acquired forms of proteinuria such as diabetic nephropathy or hypertension. Identification of signaling pathways downstream of TRPC6 may provide novel targets for the treatment of proteinuria and prevent progression of podocyte injury.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban proteinuric disease focal segmental glomerulosclerosis (FSGS) TRPC6 diabetic nephropathy angiotensin II podocyte
Megjelenés:	Acta Physiologica Hungarica 102 : 3 (2015), p. 241-251. -
További szerzők:	Ambrus Lídia (1986-) (élettanász) Zákány Nóra Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Gyermekgyógyászat Kutatócsoport PD-76065 OTKA
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001-es BibID:	BIBFORM072830
035-os BibID:	(WOS)000439136200018 (Scopus)85046719619
Első szerző:	Zákány Nóra
Cím:	Endocannabinoid tone regulates human sebocyte biology / Nóra Zákány, Attila Oláh, Arnold Markovics, Erika Takács, Andrea Aranyász, Simon Nicolussi, Fabiana Piscitelli, Marco Allarà, Ágnes Pór, Ilona Kovács, Christos C. Zouboulis, Jürg Gertsch, Vincenzo Di Marzo, Tamás Bíró, Tamás Szabó
Dátum:	2018
ISSN:	0022-202X 1523-1747
Megjegyzések:	We have previously shown that i) endocannabinoids (eCB; e.g. anandamide [AEA]) are involved in the maintenance of homeostatic sebaceous lipid production (SLP) in human sebaceous glands (SG); and ii) eCB treatment dramatically increases SLP. Here, we aimed to investigate the expression of the major eCB synthesizing and degrading enzymes, and to study the effects of eCB uptake inhibitors on human SZ95 sebocytes, thus exploring the role of the putative eCB membrane transporter (EMT), which has been hypothesized to facilitate the cellular uptake and subsequent degradation of eCBs.We found that the major eCB synthesizing (NAPE-PLD, DAGL? and -?) and degrading (FAAH, MAGL) enzymes are expressed in SZ95 sebocytes, and also in SGs (except for DAGL?, whose staining was dubious in histological preparations). Interestingly, eCB uptake-inhibition with VDM11 induced a moderate increase in SLP, and also elevated the levels of various eCBs and related acylethanolamides. Finally, we found that VDM11 was able to interfere with the pro-inflammatory action of the Toll-like receptor 4 activator lipopolysaccharide.Collectively, our data suggest that inhibition of eCB uptake exerts anti-inflammatory actions and elevates both SLP and eCB levels; thus, these inhibitors might be beneficial in cutaneous inflammatory conditions accompanied by dry skin.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk xylitol
Megjelenés:	Journal of Investigative Dermatology. - 138 : 8 (2018), p. 1699-1706. -
További szerzők:	Oláh Attila (1984-) (élettanász) Markovics Arnold (1988-) (molekuláris biológus) Takács Erika (1987-) (biológus) Aranyász Andrea Nicolussi, Simon Piscitelli, Fabiana Allarà, Marco Pór Ágnes Kovács Ilona (1965-) (patológus) Zouboulis, Christos C. (1960-) (bőrgyógyász) Gertsch, Jürg Di Marzo, Vincenzo Bíró Tamás (1968-) (élettanász) Szabó Tamás (1968-) (gyermekgyógyász)
Pályázati támogatás:	Lendület LP2011-003/2015 MTA GINOP-2.3.2-15-2016-00015 GINOP TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP 120552 OTKA 121360 OTKA 125055 OTKA
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