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1.

001-es BibID:BIBFORM041186
Első szerző:Burch, Henry B.
Cím:Immunodetection of manganese superoxide dismutase in cultured human retroocular fibroblasts using sera directed against the thyrotropin receptor / Burch, H. B., Barnes, S., Nagy, E. V., Sellitti, D., Burman, K. D., Bahn, R. S., Lahiri, S.
Dátum:1998
ISSN:0391-4097
Megjegyzések:The identification of antigenic targets in the retroocular autoimmune response of Graves' ophthalmopathy is likely to increase our understanding of mechanisms underlying this disorder. While a number of putative autoantigens have been identified on the basis of molecular weight or cell of origin, a determination of the significance of these antigens is contingent upon an identification of the amino acid sequence. Our group has previously identified immunoreactive retroocular fibroblast (ROF) proteins recognized by thyrotropin receptor (hTSH-R) antisera (anti-p1), at molecular weights of 95, 71, 41, and 14-25 kDa. In the present study, proteins detected by anti-p1 and visualized by Ponceau staining were isolated and processed for microsequencing. Ponceau staining revealed dense bands at molecular weights of 14 and 23 kDa, and a weak band at 41 kDa. N-terminal sequencing was performed on the prominent band at approximately 23 kDa, showing it to be manganese superoxide dismutase (MnSOD), a mitochondrial enzyme responsible for protection against oxygen free radical-associated cellular damage. Sequence comparison of MnSOD to the hTSH-R peptide, p1, revealed a linear segment of amino acid homology. Preincubation of anti-p1 with p1 blocked immunodetection of the 23 kDa band corresponding to MnSOD, and immunoprecipitation of ROF protein using anti-pi yielded protein recognized by anti-MnSOD. Autoimmunity against human recombinant MnSOD was further assessed by ELISA. Patients with Graves' disease (n = 53) had significantly higher ELISA indices than normal control subjects (n = 29), while patients with Hashimoto's thyroiditis had intermediate values. These results document MnSOD autoantibodies in patients with Graves' disease and suggest that this may result from an immune cross-reactivity between MnSOD and the TSH-receptor.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Endocrinological Investigation. - 21 : 1 (1998), p. 48-55. -
További szerzők:Barnes, Stephen Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Sellitti, D. Burman, Kenneth D. Bahn, R. S. Lahiri, Susanta
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2.

001-es BibID:BIBFORM122079
035-os BibID:(scopus)85196034108 (wos)001248305800001
Első szerző:Galofré, Juan C.
Cím:Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration / J. C. Galofré, J. J. Díez, R. Attanasio, E. V. Nagy, R. Negro, E. Papini, P. Perros, M. Zarkovic, E. Akarsu, M. Alevizaki, G. Ayvaz, T. Bednarczuk, B. N. Beleslin, E. Berta, M. Bodor, A. M. Borissova, M. Boyanov, C. Buffet, Maria-Cristina Burlacu, H. Dobnig, V. Fadeyev, B. C. T. Field, E. Fliers, D. Führer, T. Hakala, J. Jiskra, P. Kopp, M. Krebs, M. Krsek, M. Kuzma, M. Lantz, I. Lazúrová, L. Leenhardt, V. Luchytskiy, F. M. Puga, A. McGowan, S. Metso, C. Moran, T. Morgunova, D. A. Niculescu, B. Peric, T. Planck, C. Poiana, E. Robenshtok, P. O. Rosselet, M. Ruchala, K. R. Riis, A. Shepelkevich, M. Tronko, D. Unuane, I. Vardarli, W. E. Visser, M. Vryonidou, Y. R. Younes, L. Hegedüs
Dátum:2025
ISSN:0391-4097
Megjegyzések:Purpose The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as refected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European thyroid specialists. Methods Specialists from 28 countries were invited to a survey via professional organisations. The relevant question was whether "Thyroid hormones may be indicated in biochemically euthyroid patients with obesity resistant to lifestyle interventions". Results Of 17,232 invitations 5695 responses were received (33% valid response rate; 65% women; 90% endocrinologists). Of these, 290 (5.1%) stated that TH may be indicated as treatment for obesity in euthyroid patients. This view was commoner among non-endocrinologists (8.7% vs. 4.7%, p<0.01), private practice (6.5% vs. 4.5%, p<0.01), and varied geographically (Eastern Europe, 7.3%; Southern Europe, 4.8%; Western Europe, 2.7%; and Northern Europe, 2.5%). Respondents from Northern and Western Europe were less likely to use TH than those from Eastern Europe (p<0.01). Gross national income (GNI) correlated inversely with this view (OR 0.97, CI: 0.96?0.97; p<0.001). Having national guidelines on hypothyroidism correlated negatively with treating obesity with TH (OR 0.71, CI: 0.55?0.91). Conclusions Despite the lack of evidence, and contrary to guidelines' recommendations, about 5% of respondents stated that TH may be indicated as a treatment for obesity in euthyroid patients resistant to life-style interventions. This opinion was associated with (i) respondent characteristics: being non-endocrinologist, working in private practice, treating a small number of hypothyroid patients annually and (ii) national characteristics: prevalence of obesity, Eastern Europe, low GNI and lack of national hypothyroidism guidelines.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
hypothyroidism
levothyroxine
survey
Megjelenés:Journal of Endocrinological Investigation. - 48 : 1 (2025), p. 201-212. -
További szerzők:Díez, Juan J. Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Perros, Petros Zarkovic, Milos Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Puga, Francisca Marques McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, M. Younes, Younes Ramazan Hegedüs László
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3.

001-es BibID:BIBFORM054227
Első szerző:Gazdag Annamária (belgyógyász)
Cím:Aortic stiffness and left ventricular function in patients with differentiated thyroid cancer / A. Gazdag, E. V. Nagy, A. Erdei, M. Bodor, E. Berta, Z. Szabo, Z. Jenei
Dátum:2015
ISSN:0391-4097
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aortic stiffness
Cardiovascular risk
Differentiated thyroid cancer
Subclinical hyperthyroidism
Megjelenés:Journal of Endocrinological Investigation 38 : 2 (2015), p. 133-142. -
További szerzők:Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Erdei Annamária (1976-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Berta Eszter (1980-) (belgyógyász) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Jenei Zoltán (1968-) (belgyógyász)
Pályázati támogatás:TÁMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
K105733
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM041178
Első szerző:Mengistu, M.
Cím:TSH receptor gene expression in retroocular fibroblasts / Mengistu, M., Lukes, Y. G., Nagy, V. E., Burch, H. B., Carr, F. E., Lahiri, S., Burman, K. D.
Dátum:1994
ISSN:0391-4097
Megjegyzések:RNA was isolated from fibroblasts from the retroocular area, from endomysial fibroblasts obtained from orbital lateral rectus muscle, and from abdominal skin fibroblasts. The RNA was reverse transcribed into cDNA which was then used as a template for PCR with primers encompassing a portion (nucleotides 989-1235) of the extra-cellular domain of the human TSH receptor (hTSH-R). A definite 247 BP product was detected from fibroblast RNA by ethidium bromide staining, and was confirmed by hybridization with labelled hTSH-R cDNA. The product had homology with the known TSH-R cDNA. These studies indicate that human fibroblasts can express hTSH-R, and they suggest that a cross reactive immunologic response between anti-hTSH-R and these fibroblast TSH receptors may play a role in the genesis of Graves' ophthalmopathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Endocrinological Investigation. - 17 : 6 (1994), p. 437-441. -
További szerzők:Lukes, Yvonne G. Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Burch, Henry B. Carr, Frances E. Lahiri, Susanta Burman, Kenneth D.
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5.

001-es BibID:BIBFORM041290
035-os BibID:PMID:7901266
Első szerző:Nagy Endre V. (belgyógyász, endokrinológus)
Cím:Immunogenicity of a unique region of the human thyrotropin receptor / E. V. Nagy, H. B. Burch, Y. G. Lukes, F. E. Carr, S. Kosugi, L. D. Kohn, K. D. Burman
Dátum:1993
ISSN:0391-4097
Megjegyzések:Clarifying the role of the TSH receptor protein in the autoimmune process may be the key to understanding the development of Graves' disease. In the present study we used a 16 amino acid peptide of the human TSH receptor (hTSHR) to immunize rabbits. A comparable, but theoretically less immunogenic, peptide was injected into other rabbits. The antibody response against these and other peptides, as well as against solubilized human thyroid membrane (TM) and guinea pig fat cell membrane (GPF) proteins, was tested using ELISA and Western blots. The GPF and TM binding pattern of rabbits' sera was compared to that of Graves' patients' sera. We have identified an area of antigenic cross-reactivity between GPF and TM; a 63 kD protein was present in both GPF and TM, and this protein uniformly bound IgG-s of the rabbits' postimmunization sera and one of eight Graves' patient's serum. We have shown that i) a theoretically immunogenic 16 amino acid peptide was indeed highly immunogenic in rabbits, ii) antibodies binding to GPF and TM were detected after immunization, and iii) the peak of thyroid stimulating immunoglobulin activity of sera was followed by a transient elevation of serum triiodothyronine levels. Further studies investigating the immunogenic epitopes of the hTSHR as well as characterizing the 63 kD protein are indicated.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Journal of Endocrinological Investigation. - 16 : 7 (1993), p. 485-493. -
További szerzők:Burch, Henry B. Lukes, Yvonne G. Carr, Frances E. Kosugi, S. Kohn, L. D. Burman, Kenneth D.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM100393
Első szerző:Riis, Kamilla Ryom
Cím:Use of thyroid hormones in hypothyroid and euthyroid patients : a 2020 THESIS questionnaire survey of members of the Danish Endocrine Society / Riis K. R., Frølich J. S., Hegedüs L., Negro R., Attanasio R., Nagy E. V., Papini E., Perros P., Bonnema S. J.
Dátum:2021
ISSN:1720-8386
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Endocrinological Investigation. - 44 : 11 (2021), p. 2435-2444. -
További szerzők:Frølich, J. S. Hegedüs László Negro, Roberto Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Perros, Petros Bonnema, S. J.
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7.

001-es BibID:BIBFORM023976
Első szerző:Sámson L.
Cím:Addition of chlorine during water purification reduces iodine content of drinking water and contributes to iodine deficiency / Samson L., Czegeny I., Mezosi E., Erdei A., Bodor M., Cseke B., Burman K. D., Nagy E. V.
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Endocrinological Investigation. - 35 : 1 (2011), p. 21-24. -
További szerzők:Czégény Ildikó Mezősi Emese Erdei Annamária (1976-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Cseke Béla (1974-) (belgyógyász, endokrinológus) Burman, Kenneth D. Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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