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001-es BibID:BIBFORM125172
035-os BibID:(scopus)85207507392 (WOS)001341961400001
Első szerző:Berta Eszter (belgyógyász)
Cím:Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto's Thyroiditis on Levothyroxine Substitution / Berta Eszter, Halmi Sándor, Molnár István, Hutkai Dávid, Csiha Sára, Bhattoa Harjit Pal, Lőrincz Hajnalka, Somodi Sándor, Katkó Mónika, Harangi Mariann, Paragh György, Nagy Endre V., Bodor Miklós
Dátum:2024
ISSN:2218-1989
Megjegyzések:Background/Objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto's thyroiditis (HT). Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay. Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4?148.3) pg/mL vs. 131.9 (44.8?236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy. Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
thyroid
fibroblast growth factor 21
FGF21
Hashimoto's thyroiditis
levothyroxine
hyperlipidemia
hypothyroidism
Megjelenés:Metabolites. - 14 : 10 (2024), p. 1-10. -
További szerzők:Halmi Sándor (1986-) (belgyógyász) Molnár István (1991-) (belgyógyász) Hutkai Dávid (1990-) (belgyógyász, nefrológus) Csiha Sára (1985-) (Biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Lőrincz Hajnalka (1986-) (biológus) Somodi Sándor (1977-) (belgyógyász) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
Pályázati támogatás:K142273
OTKA
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2.

001-es BibID:BIBFORM112354
035-os BibID:(WoS)001003354300001 (Scopus)85161358752
Első szerző:Csiha Sára (Biológus)
Cím:Advanced glycation end products and their soluble receptor (sRAGE) in patients with Hashimoto's thyroiditis on levothyroxine substitution / Sára Csiha, István Molnár, Sándor Halmi, Dávid Hutkai, Hajnalka Lőrincz, Sándor Somodi, Mónika Katkó, Mariann Harangi, György Paragh, Endre V. Nagy, Eszter Berta, Miklós Bodor
Dátum:2023
ISSN:1664-2392
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Endocrinology. - 14 (2023), p. 1-9. -
További szerzők:Molnár István (1991-) (belgyógyász) Halmi Sándor (1986-) (belgyógyász) Hutkai Dávid (1990-) (belgyógyász, nefrológus) Lőrincz Hajnalka (1986-) (biológus) Somodi Sándor (1977-) (belgyógyász) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
Pályázati támogatás:K142273
OTKA
ÚNKP-21-4.2
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM105694
Első szerző:Csiha Sára (Biológus)
Cím:Association of chemerin and serum advanced glycation end products in patients with autoimmune thyroiditis / Bak-Csiha Sara, Halmi Sandor, Hutkai David, Molnar Istvan, Katko Monika, Lőrincz Hajnalka, Harangi Mariann, Paragh Gyorgy, Nagy Endre, Bodor Miklos, Berta Eszter
Dátum:2022
ISSN:1479-6848
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Endocrine Abstracts. - 81 (2022), p. EP400. -
További szerzők:Halmi Sándor (1986-) (belgyógyász) Hutkai Dávid (1990-) (belgyógyász, nefrológus) Molnár István (1991-) (belgyógyász) Katkó Mónika (1980-) (biológus) Lőrincz Hajnalka (1986-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Berta Eszter (1980-) (belgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM103912
Első szerző:Lengyel Inez (belgyógyász)
Cím:Characterization of fetuin-A levels in patients with autoimmune thyroid disease / Lengyel I., Halmi S., Lőrincz H., Bak-Csiha S., Katkó M., Harangi M., Nagy E. V., Paragh G., Bodor M., Berta E.
Dátum:2022
ISSN:0021-9150
Megjegyzések:Background and Aims : Hypothyroidism leads to atherogenic lipid profile and might increase the cardiovascular risk of patients. Fetuin-A is a hepatokine with a regulatory role on mineralization, metabolism and the cardiovascular system. Fetuin-A is increased in obesity-linked diseases Methods: In our study we investigated the association between thyroid hormone levels, the components of lipid metabolism, anthropometrical parameters and fetuin-A. We enrolled eighty-six patients (7 men, 79 women, mean age 43?13 years, median BMI 25.3 (23.4-30.5) kg/m2) from the Endocrine outpatient clinic of the Department of Medicine, Debrecen. Our patients had autoimmune thyroid disease; their thyroid hormone status varied from hypo- to hyperthyroidism. Serum fetuin-A concentrations were determined with enzyme-linked immunosorbent assay (ELISA). Thyroid hormone levels and lipid parameters were measured by routine laboratory methods. Results: Median serum fetuin-A level was 929.7 (822.0 ? 1038.3) mg/L, LDL-C was 3.2 (2.6-3.8) mmol/l, HDL-C was 1.5 (1.3-1.8), triglyceride was 0.84 (0.49-1.45) mmol/l, while mean total cholesterol level was 5.3?1.1 mmol/l. Mean fT3 and fT4 were 4.67?0.67 and 17.8?3.6 pmol/l, respectively. Significant positive correlation was found between fT3 and fetuin-A levels. There was a significant negative correlation between ApoB100, total cholesterol and fT3. Significant negative correlation was found between TSH and log triglyceride. Among patients receiving levothyroxine substitution, a correlation between CRP and fT3 was present. Conclusions: The significant correlation between fetuin-A and fT3 levels might indicate a regulatory effect of fT3 on metabolism. However, further clinical investigations are needed to clarify the effect of thyroid status on hepatokine levels.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
autoimmune thyroid disease
fetuin-A
hepatokine
Hypothyroidism
atherosclerosis
lipid metabolism
Megjelenés:Atherosclerosis. - 355 (2022), p. e247-e248. -
További szerzők:Halmi Sándor (1986-) (belgyógyász) Lőrincz Hajnalka (1986-) (biológus) Csiha Sára (1985-) (Biológus) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Berta Eszter (1980-) (belgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM133290
Első szerző:Ratku Balázs (mentőtiszt)
Cím:Alterations of lipoprotein subfractions in GH-deficient adults / Balázs Ratku, Hajnalka Lőrincz, Sára Csiha, Lajos Bíró, Annamária Erdei, Eszter Berta, Dóra Ujvárosy, Miklós Bodor, Endre V. Nagy, Zoltán Szabó, Mariann Harangi, Sándor Somodi
Dátum:2025
ISSN:1664-2392
Megjegyzések:Introduction: Dyslipidemia is a common complication of adult growth hormone de ciency (AGHD) and considered an important contributor to increased mortality. Previous studies mainly focused on quantitative assessment of lipoproteins, but lipoprotein subfractions and their relationship with insulin-like growth factor 1 (IGF-1) have not been explored. Purpose: To perform a comprehensive evaluation of lipoprotein subfractions and measuring apolipoprotein L1 (apoL1), sphingosine 1-phosphate (S1P) and apolipoprotein M (apoM) in AGHD. Materials and methods: 11 GH-substituted (GHS) patients, 9 GH-unsubstituted (GHU) patients and 37 controls were included in the study. Lipoprotein subfractions were separated by the Lipoprint system. ApoL1, apoM and S1P were determined by ELISA. In the GHS patients GH-replacement was discontinued for 2 months. Measurements were performed before GH- discontinuation, at the end of the 2-month GH-withdrawal, and 1 month after reinstituting GH-replacement. Results: Standard lipid parameters, apoM and apoL levels were not different between the groups. GHU patients demonstrated lower apolipoprotein A1 compared to controls (p=0.02) and higher apolipoprotein B100 compared to GHS (p=0.02). GHU and GHS showed higher S1P levels compared to controls (p=0.04 and p=0.01, respectively). Both GHU and GHS patients also presented higher percentage of intermediate-density lipoprotein (IDL) compared to controls (p=0.03 and p=0.01, respectively). Mean LDL size was lower in GHU compared to GHS (p=0.04). Percentage of intermediate HDL was lower in GHU and GHS compared to controls (p<0.001 and p<0.01, respectively). GHU demonstrated higher percentage of small HDL than controls (p<0.001). Overall, log10IGF-1 correlated positively with the percentage of large HDL (r=0.27; p=0.04) and intermediate HDL (r=0.38; p<0.01) and negatively with the percentage of small HDL (r=-0.46; p<0.01). Log10IGF-1 was the best predictor of small HDL (standardized b=-0.46; p<0.001) in overall subjects. In the GH-withdrawal study, the amount of HDL-6 increased with GH-withdrawal (p=0.03) and the percentage of IDL increased with reinstitution (p=0.05). Conclusion: Despite no changes in standard lipid parameters, considerable alterations of lipoprotein subfractions were revealed in GH-de cient adults indicating that lipoprotein subfraction analysis may allow for a more precise cardiovascular risk assessment in AGHD. Associations between HDL subfractions and Log10IGF-1 demonstrate a novel insight into the role of GH in lipid metabolism.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adult growth hormone de ciency
dyslipidemia
high-density lipoprotein
ipoprotein subfractions
sphingosine 1-phosphate
insulin-like growth factor 1
Megjelenés:Frontiers in Endocrinology. - 16 (2025), p. 1-14. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Csiha Sára (1985-) (Biológus) Biró Lajos Erdei Annamária (1976-) (belgyógyász) Berta Eszter (1980-) (belgyógyász) Ujvárosy Dóra (1985-) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM118422
035-os BibID:(WoS)001165227400001 (Scopus)85185245598
Első szerző:Ratku Balázs (mentőtiszt)
Cím:Serum afamin and its implications in adult growth hormone deficiency : a prospective GH-withdrawal study / Balázs Ratku, Hajnalka Lőrincz, Sára Csiha, Veronika Sebestyén, Eszter Berta, Miklós Bodor, Endre V. Nagy, Zoltán Szabó, Mariann Harangi, Sándor Somodi
Dátum:2024
ISSN:1664-2392
Megjegyzések:Introduction: Adult growth hormone deficiency (AGHD) is associated with a high prevalence of metabolic syndrome (MS), which contributes to the unfavorable cardiovascular risk profile in these patients. Insulin like growth factor-1 (IGF-1) is a widely used biomarker, however it does not always reflect the cardiometabolic risk and has a poor relationship with clinical efficacy endpoints. Consequently, there is an unmet need for biomarkers to monitor responses to GH-replacement. Afamin is a hormone-like glycoprotein, expressed in the liver. Higher afamin levels are strongly associated with MS and insulin resistance (IR). Although both MS and IR are very common in AGHD, afamin has not been investigated in these patients. Purpose: To investigate afamin as a potential biomarker in patients with AGHD. Materials and methods: Participants included 20 AGHD patients (11 GH-substituted and 9 GH-unsubstituted) and 37 healthy controls. Subjects underwent routine laboratory examinations, anthropometric measurements, body composition analysis using multi-frequency bioelectrical impedance analysis (InBody720) and measurement of serum afamin concentrations. In GH-substituted subjects, GH-substitution was withdrawn for 2 months. Measurements were carried out right before GH-withdrawal, at the end of the 2-month withdrawal period, and 1 month after reinstituting GH-replacement therapy (GHRT). Results: GH-unsubstituted patients demonstrated higher afamin levels compared to controls (p=0.03). Afamin positively correlated with skeletal muscle mass, bone mineral content, total body water, extracellular- and intracellular water content, insulin (all, p<0.01), HOMA-IR (p=0.01) and C-peptide (p=0.03) levels in AGHD but not in healthy controls. In GH-substituted patients 2-month of GH-withdrawal caused significant changes in body composition, including decreased fat-free mass, skeletal muscle mass, total body water, and intracellular water content (all, p<0.01); but these changes almost fully recovered 1 month after reinstituting GHRT. Unexpectedly, afamin levels decreased after GH-withdrawal (p=0.03) and increased with reinstitution (p<0.01). Changes of afamin levels during GH-withdrawal positively correlated with changes of HOMA-IR (r=0.80; p<0.01) and changes of insulin (r=0.71; p=0.02). Conclusion: Higher afamin levels in unsubstituted AGHD patients might indicate severe metabolic dysregulation. Significant changes accompanying GH-withdrawal and reinstitution, along with strong correlations with measures of IR, suggest that afamin could be a promising biomarker to monitor GHRT-associated changes of insulin sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adult growth hormone deficiency
growth hormone withdrawal
afamin
body composition
insulin sensitivity
biomarker
Megjelenés:Frontiers in Endocrinology. - 15 (2024), p. 1-13. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Csiha Sára (1985-) (Biológus) Borbásné Sebestyén Veronika (1990-) (biofizikus) Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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