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001-es BibID:BIBFORM118990
035-os BibID:(Scopus)85189475993 (WoS)001190999100001
Első szerző:Attanasio, Roberto
Cím:Patients' persistent symptoms, clinician demographics and geo-economic factors are associated with choice of therapy for hypothyroidism by European thyroid specialists : The "THESIS"* collaboration (*Treatment of Hypothyroidism in Europe by Specialists, an International Survey) / Roberto Attanasio, Miloš Žarković, Enrico Papini, Endre Vezekenyi Nagy, Roberto Negro, Petros Perros, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Tomasz Bednarczuk, Biljana Beleslin, Eszter Berta, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Camille Buffet, Maria-Cristina Burlacu, Jasmina Ciric, Juan J. Díez, Harald Dobnig, Valentin V. Fadeyev, Benjamin C. T. Field, Eric Fliers, Dagmar Führer, Juan Carlos Galofré, Tommi Hakala, Jan Jiskra, Peter A. Kopp, Michael Krebs, Michal Kršek, Martin Kuzma, Mikael Lantz, Ivica Lazúrová, Laurence Leenhardt, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Catalina Poiana, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Kamilla Ryom Riis, Alla Shepelkevich, Mykola D. Tronko, David Unuane, Irfan Vardarli, W. Edward Visser, Andromachi Vryonidou, Younes Ramazan Younes, Laszlo Hegedus
Dátum:2024
ISSN:1050-7256
Megjegyzések:Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting treatment choices of European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, and geo-economic factors relate to treatment choices. Methods. 17,247 thyroid specialists from 28 countries were invited to participate in an online questionnaire survey. The survey included respondent demographic data and treatment choices for hypothyroid patients with persistent symptoms. Geo-economic data for each country were included in the analyses. Results. The response rate was 32.9% (6,058 respondents out of 17,247 invitees). Levothyroxine (LT4) was the initial treatment preferred by the majority (98.3%). Persistent symptoms despite normal serum thyrotropin (TSH) while receiving LT4 treatment were reported to affect up to 10.0% of patients by 75.4% of respondents, while 28.4% reported an increasing such trend in the past five years. The principal explanations offered for patients' persistent symptoms were psychosocial factors (77.1%), comorbidities (69.2%), and unrealistic patient expectations (61.0%). Combination treatment with LT4 + liothyronine (LT3) was chosen by 40.0% of respondents for patients who complained of persistent symptoms despite a normal TSH. This option was selected more frequently by female thyroid specialists, with high-volume practice, working in countries with high gross national income per capita. Conclusions. The perception of patients' dissatisfaction reported by physicians seems lower than that described by hypothyroid patients in previous surveys. LT4+LT3 treatment is used frequently by thyroid specialists in Europe for persistent hypothyroid-like symptoms even if they generally attribute such symptoms to non-endocrine causes and despite the evidence of non-superiority of the combined over the LT4 therapy. Pressure by dissatisfied patients on their physicians for LT3-containing treatments is a likely explanation. The association of the therapeutic choices with the clinician demographic characteristics and geo-economic factors in Europe is a novel information and requires further investigation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
quality of life
geoeconomics
survey
hypothyroidism
levothyroxine
triiodothyronine
Megjelenés:Thyroid. - 34 : 4 (2024), p. 429-441. -
További szerzők:Zarkovic, Milos Papini, Enrico Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Perros, Petros Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Marques Puga, Francisca McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Ryom Riis, Kamilla Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedüs László
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2.

001-es BibID:BIBFORM133292
Első szerző:Bednarczuk, Tomasz
Cím:Use of thyroid hormones in euthyroid patients with unexplained fatigue : analyses of aggregate data from European national surveys of professional endocrine society members / Bednarczuk Tomasz, Sugier Aleksandra, Attanasio Roberto, Nagy Endre V., Negro Roberto, Papini Enrico, Zarkovic Milos, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Nedeljkovic Beleslin Biljana, Berta Eszter, Bodor Miklos, Borissova Anna M., Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Cohen Chagit A., Ciric Jasmina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Führer-Sakel Dagmar, Frlich Jacob S., Galofré Juan C., Hakala Tommi, Jiskra Jan, Kopp Peter A., Krebs Michael, Krsek Michal, Kuzma Martin, Lazúrová Ivica, Leenhardt Laurence, Ludgate Stephen, Luchytskiy Vitaliy, McGowan Anne, Melo Miguel, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan A., Peric Bozidar, Planck Tereza, Poiana Catalina, Puga Francisca M., Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla R., Shepelkevich Alla, Tronko Mykola D., Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Yurenya Elena, Perros Petros, Hegedüs Laszlo
Dátum:2025
ISSN:1664-2392
Megjegyzések:Background: Managing patients with fatigue is a clinical challenge. Because fatigue is often reported in hypothyroidism, thyroid hormone (TH) therapy may sometimes be incorrectly considered for biochemically euthyroid individuals. This study aimed to evaluate the prevalence and determinants of this practice in different European countries. Methods: We analyzed aggregate data from the THESIS (Treatment of Hypothyroidism in Europe by Specialists: an International Survey) online survey. We analyzed responses from 5,695 members of 28 national endocrine/thyroid societies' specialists to the statement:"Thyroid hormones may be indicated in biochemically euthyroid patients with unexplained fatigue" . Results: Overall, 7.5% (426/5695) of respondents indicated that TH therapy might be considered for euthyroid patients with unexplained fatigue. The proportion of positive responses varied widely across different countries (between 1.1% in Switzerland and 29.3% in Serbia; p=2 ?10-16) and regions (between 4.7% in Western Europe and 8.7% in Western Asia or 8.8% in Eastern Europe; p=0.004). TH were more frequently prescribed for unexplained fatigue by male respondents (Odds Ratio, OR 1.45, 95% CI 1.18-1.78) and physicians practicing in private practice (OR 1.27, 95% CI 1.02-1.58), and less frequently by endocrinologists (OR 0.62, 95% CI 0.46-0.83). Conclusion: A small, yet not negligible percentage of European thyroid-focused physicians consider using TH for euthyroid patients with unexplained fatigue, with signi cant variations based on geographic, demographic, and practice- related factors. Using levothyroxine and/or liothyronine in such cases lacks evidence and may partially contribute to the concerning overuse of TH therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
euthyroidism
fatigue
levothyroxine
thyroid hormone
survey
Megjelenés:Frontiers in Endocrinology. - 16 (2025), p. 1-11. -
További szerzők:Sugier, Aleksandra Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Zarkovic, Milos Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Nedeljkovic-Beleslin, Biljana Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Cohen, Chagit Adler Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Frlich, Jacob Stampe Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lazúrová, Ivica Leenhardt, Laurence Ludgate, Stephen Luchytskiy, Vitaliy McGowan, Anne Melo, Miguel Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Puga, Francisca Marques Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Perros, Petros Hegedüs László
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3.

001-es BibID:BIBFORM131919
035-os BibID:(scopus)105012975499 (wos)001548867600001
Első szerző:Galofré, Juan C.
Cím:Thyroid Hormone Treatment for Hypercholesterolemia in Euthyroid Patients : Results From a European Survey of Thyroid Specialists / Galofré Juan C., Díez Juan J., Attanasio Roberto, Nagy Endre V., Bednarczuk Tomasz, Papini Enrico, Zarkovic Milos, Negro Roberto, Perros Petros, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Berta Eszter, Beleslin Biljana Nedeljkovic, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Burlacu Maria-Cristina, Ciric Jasmina, Fadeyev Valentin, Field Benjamin C. T., Fuhrer Dagmar, Jan Jiskra, Kopp Peter, Krebs Michael, Krsek Michal, Lazúrová Ivica, Luchytskiy Vitaliy, Puga Francisca Marques, McGowan Anne, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Robenshtok Eyal, Rosselet Patrick Olivier, Ruchala Marek, Shepelkevich Alla, Tronko Mykola, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes R., Hegedüs Laszlo
Dátum:2025
ISSN:0300-0664
Megjegyzések:Objective: A relationship among hypothyroidism and lipid disorders is well established. However, current evidence and guidelines donot support the use of thyroid hormones (TH) in euthyroid patients with hyperlipidaemia as potential harms are considerable. ThisEuropean survey investigated the use of TH in euthyroid patients with severe hypercholesterolemia as a complementary treatment.Design: Data were derived from the THESIS (Treatment of Hypothyroidism in Europe by Specialists) project that surveyed THuse. Univariable and multivariable analyses were used to explore associations.Results: Out of 17,232 invitations, 5695 (33.0%) valid responses were received, and of these, 328 (5.8%) stated that TH areindicated in euthyroid patients with severe hypercholesterolemia. Univariable analyses disclosed significant differences andassociations: (a) more non?endocrinologists (8.9%) than endocrinologist (5.4%) used TH (p < 0.001), (b) the number of hypothyroidpatients treated per year was inversely related to use of TH (p = 0.024), (c) members of international endocrine/thyroid societieswere more likely to use TH than non?members (p < 0.001), (d) significant variations by country and geographical region(p < 0.001), and (e) inverse relationship between gross national income per capita (GNIPC) and TH use (p < 0.001). Multivariableanalyses yielded significant associations between use of TH, and male gender, specialty and GNIPC (p < 0.001).Conclusions: This study suggests that a small but noteworthy minority of European thyroid specialists may be using TH to treatof severe hypercholesterolemia in euthyroid patients. If confirmed, this finding highlights the importance of raising awarenessamong thyroid specialists, professional societies, and healthcare providers to ensure adherence to evidence?based practices.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
euthyroidism
hypercholesterolemia
levothyroxine
misuse
treatment
Megjelenés:Clinical Endocrinology. - 2025 (2025), p. 1-8. -
További szerzők:Díez, Juan J. Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bednarczuk, Tomasz Papini, Enrico Zarkovic, Milos Negro, Roberto Perros, Petros Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Berta Eszter (1980-) (belgyógyász) Beleslin, Biljana Nedeljkovic Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Burlacu, Maria-Cristina Ciric, Jasmina Fadeyev, Valentin Field, Benjamin C. T. Fuhrer, Dagmar Jan, Jiskra Kopp, Peter Krebs, Michael Krsek, Michal Lazúrová, Ivica Luchytskiy, Vitaliy Puga, Francisca Marques McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedüs László
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM133291
035-os BibID:(scopus)105018499975 (wos)001588705800001
Első szerző:Ludgate, Stephen
Cím:The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members / Ludgate Stephen, McGowan Anne, Moran Carla, Attanasio Roberto, Zarkovic Milos, Nagy Endre Vezekenyi, Negro Roberto, Papini Enrico, Adler Cohen Chagit, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Beleslin Biljana Nedeljkovic, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jamina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Führer-Sakel Dagmar, Galofré Juan Carlos, Hakala Tommi, Jiskra Jan, Kopp Peter A., Krebs Michael, Krsek Michal, Kuzma Martin, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, Melo Miguel, Metso Saara, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Poiana Catalina, Marques Puga Francisca, Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Tronko Mykola D., Frlich Jacob Stampe, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Yurenya Elena, Perros Petros, Hegedüs Laszlo
Dátum:2025
ISSN:1664-2392
Megjegyzések:Purpose: Treatment-resistant depression (TRD) is most commonly de ned as depression that has not responded to two different pharmacological agents used for an adequate period of time. We explored the views of European specialists via survey, regarding the use of thyroid hormone (TH) in euthyroid patients with TRD as part of♭Treatment of Hypothyroidism in Europe by Specialists: An International Survey' (THESIS). Methods: The question"Thyroid hormones may be indicated in biochemically euthyroid patients with treatment resistant depression" was posed to specialists from 28 countries. Results: 5695 valid responses were received following 17,232 invitations (33.0% response rate; 65% female, 90% endocrinologists). 348 (6.1%) stated that TH may be indicated in biochemically euthyroid patients with TRD. This view was more common in males (p<0.01), respondents who saw ?100 patients with hypothyroidism per year (p<0.01), respondents who worked in private practice (p=0.05) and respondents who were not members of international specialist associations (p=0.05). Geographical variation existed with respondents in Eastern Europe signi cantly more likely to use TH in TRD (p<0.01). Linear regression showed a statistically signi cant reduction in the use of TH for TRD with increasing gross national income (F-statistic=7.35, CI -0.15 - -0.02, p=0.01). T H i n T R D w a s r e c o m m e n d e d i n p s y c h i a t r y g u i d e l i n e s b u t n o t endocrinology guidelines. Conclusion: While there is limited evidence for their use, over 6% of respondents stated that TH may be indicated in TRD. Due to the risk of iatrogenic thyrotoxicosis and increased morbidity the use of TH should be addressed in relevant endocrinology guidelines and consensus should be reached between specialties.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
TRD (treatment-resistant depression)
thyroid
thyroid hormone
liothyroinine levothyroxine
Megjelenés:Frontiers in Endocrinology. - 16 (2025), p. 1-14. -
További szerzők:McGowan, Anne Moran, Carla Attanasio, Roberto Zarkovic, Milos Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Adler Cohen, Chagit Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Melo, Miguel Metso, Saara Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Marques Puga, Francisca Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Frlich, Jacob Stampe Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Perros, Petros Hegedüs László
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM124557
035-os BibID:(scopus)85202766336 (wos)001303223800001
Első szerző:Papini, Enrico
Cím:Thyroid hormones for euthyroid patients with simple goiter growing over time : a survey of European thyroid specialists / Papini Enrico, Attanasio Roberto, Zarkovic Milos, Nagy Endre Vezekenyi, Negro Roberto, Perros Petros, Galofré Juan Carlos, Cohen Chagit Adler, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Beleslin Biljana Nedeljkovic, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jasmina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Führer-Sakel Dagmar, Hakala Tommi, Jiskra Jan, Kopp Peter Andreas, Krebs Michael, Krsek Michal, Lantz Mikael, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, Puga Francisca Marques, McGowan Anne, Melo Miguel, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Robenshtok Eyal, Rosselet Patrick Olivier, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Tronko Mykola, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Hegedüs Laszlo
Dátum:2025
ISSN:0969-711X 1559-0100
Megjegyzések:Background Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. Purpose To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. Methods Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. Results The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41?50, 51?60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03?1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33?0.48), Northern Europe (OR 0.28, 95% CI 0.22?0.36) and Western Asia (OR 0.16, 95% CI 0.11?0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. Conclusions Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Survey
Goiter
Thyroid hormone
Levothyroxine
TSH-suppressive therapy
Megjelenés:Endocrine. - 87 : 1 (2025), p. 262-272. -
További szerzők:Attanasio, Roberto Zarkovic, Milos Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Perros, Petros Galofré, Juan C. Cohen, Chagit Adler Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Führer, Dagmar Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Puga, Francisca Marques McGowan, Anne Melo, Miguel Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedűs László
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM100389
035-os BibID:(WoS)000716258500001 (Scopus)85118614351
Első szerző:Paschou, Stavroula A.
Cím:Use of thyroid hormones in hypothyroid and euthyroid patients : a 2020 THESIS questionnaire survey of members of the Hellenic Endocrine Society / Stavroula A. Paschou, Maria Alevizaki Roberto Attanasio, Laszlo Hegedüs, Endre V. Nagy, Enrico Papini, Petros Perros, Andromachi Vryonidou
Dátum:2022
ISSN:1109-3099 2520-8721
Megjegyzések:Purpose: To investigate current practices of specialists in the use of thyroid hormone preparations in Greece as part of an ongoing international survey, namely THESIS-Treatment of Hypothyroidism in Europe by Specialists: an International Survey. Methods: An electronic link leading to an anonymized questionnaire was sent to all (n = 837) members of the Hellenic Endocrine Society. Results: In total, 501 respondents participated in the survey, though only part of the questionnaire was filled in by some participants. A total of 88.2% were endocrinologists and 57.9% worked in private practice. Levothyroxine (LT4) was the first-line choice (98.6%) for the treatment of hypothyroid patients. In total, 70.2% preferred LT4 soft-gel capsules for patients reporting intolerance to various foods. Soft-gel capsules were the preferred LT4 formulation for patients on generic LT4 and with unexplained poor biochemical control of hypothyroidism (66.3%) or inability to take LT4 fasted and separate from food/drink (68.3%). It was found that 48.4% would never use combined LT4 + LT3. However, 25% would use combination therapy for a short period in patients recovering from protracted hypothyroidism or in patients with normal serum TSH but persistent symptoms. Concerning euthyroid individuals, 31.9% considered treatment with thyroid hormones in infertile females with positive thyroid antibodies and 24.4% in patients with growing goiter. Selenium or iodine supplementation was used occasionally, mostly in patients with coexisting autoimmune thyroiditis. Conclusions: LT4 tablets are the treatment of choice for hypothyroidism in Greece. Several conditions may lead to various other practices, some of which deviate from current evidence-based guidelines and need more scrutiny.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Hormones. - 21 : 1 (2022), p. 103-111. -
További szerzők:Alevizaki, Maria Attanasio, Roberto Hegedüs László Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Perros, Petros Vryonidou, Andromachi
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