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001-es BibID:	BIBFORM135454
035-os BibID:	(scopus)105015493172 (wos)001568845400001
Első szerző:	Perros, Petros
Cím:	Knowledge gaps about the diagnosis and treatment of hypothyroidism : an international patient survey / Perros Petros, Poots Alan, Nagy Endre Vezekenyi, Papini Enrico, Hay Harriet, Abad-Madronero Juan, Tallett Amy, Lakwijk Petrus, Hegedüs Laszlo
Dátum:	2025
ISSN:	1664-2392
Megjegyzések:	Introduction: Over-diagnosis and over-treatment of hypothyroidism is a growing concern. The role of patient knowledge has not been previously investigated. The aim was to explore patient knowledge in relation to diagnosis and treatment of hypothyroidism. Methods: Cross-sectional, international online survey. Participants were people with treated hypothyroidism amounting to 3421 valid respondents from 68 countries. A questionnaire was used, which included knowledge statements about hypothyroidism relating to recommendations by international guidelines. The principal knowledge statement was "A patient with a normal thyroid blood test does not need to be treated with thyroid hormones (even if they have positive thyroid antibodies and symptoms)", and participants were asked to classify it as "false", "true", or "don't know". Responses were divided into corresponding groups: "Incorrect", "Correct", and "Unsure". Associations of groups with respondent characteristics and patient reported outcomes were investigated. Responses to a further seven knowledge statements explored ampliative knowledge about hypothyroidism. Results: With regards to the principal knowledge statement, "Correct", "Incorrect" and "Unsure" comprised 15.3%, 50.7% and 34.0% of responses to the respectively. "Incorrect" respondents were more likely than expected to live in the United Kingdom, have Hashimoto's thyroiditis, have a recent low self-reported serum thyrotropin, be treated with liothyronine-containing medication, and use social media and the internet for hypothyroidism-related information daily. "Incorrect" responses were associated with dissatisfaction, poor perceived control of symptoms and negative impact of hypothyroidism on everyday activities. The proportion of "Incorrect" responses for seven other knowledge statements ranged between 1.8-34.9%. Discussion: Incorrect responses to the principal knowledge statement were common in this sample of people with hypothyroidism, and associated with several demographic variables and adverse patient outcomes. Our findings suggest that knowledge gaps about the significance of symptoms in relation to the diagnosis and treatment of hypothyroidism may be important in driving over-diagnosis and over-treatment. The high number of "Unsure" respondents suggests that patient education may be an effective intervention.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hypothyroidism knowledge misconception misinformation questionnaire survey
Megjelenés:	Frontiers in Endocrinology. - 16 (2025), p. 1-12. -
További szerzők:	Poots, Alan J. Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Hay, Harriet Alexandra Abad-Madronero, Juan Tallett, Amy Johanna Lakwijk, Petrus Hegedüs László
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001-es BibID:	BIBFORM119085
035-os BibID:	(WoS)000979722700001 (Scopus)85163178290
Első szerző:	Perros, Petros
Cím:	Hypothyroidism and Somatization : results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey / Petros Perros, Endre Vezekenyi Nagy, Enrico Papini, Christina Maria Van Der Feltz-Cornelis, Anthony Peter Weetman, Harriet Alexandra Hay, Juan Abad-Madroñero, Amy Johanna Tallett, Megan Bilas, Peter Lakwijk, Alan J. Poots, Laszlo Hegedűs
Dátum:	2023
ISSN:	1050-7256
Megjegyzések:	Background: Between 10% and 15% of hypothyroid patients experience persistent symptoms despite achieving biochemical euthyroidism. Unexplained persistent symptoms can be a sign of somatization. This is associated with distress and high health care resource use and can be classified as somatic symptom disorder (SSD). Prevalence rates for SSD differ depending on classification criteria and how they are ascertained, varying between 4% and 25%. As this has not been studied in hypothyroid patients before, the aim of this study was to document somatization in people with hypothyroidism and to explore associations with other patient charac- teristics and outcomes. Methods: Online, multinational cross-sectional survey of individuals with self-reported, treated hypothyroid- ism, which included the validated Patient Health Questionnaire-15 (PHQ-15) for assessment of somatization. Chi-squared tests with the Bonferroni correction were used to explore outcomes for respondents with a PHQ-15 score œ10 (probable somatic symptom disorder [pSSD]) versus a PHQ-15 score <10 (absence of SSD). Results: A total of 3915 responses were received, 3516 of which contained the valid PHQ-15 data (89.8%). The median score was 11.3 (range 0?30 [confidence interval 10.9?11.3]). The prevalence of pSSD was 58.6%. Associations were found between pSSD and young age ( p < 0.001), women ( p < 0.001), not working ( p < 0.001), having below average household income ( p < 0.001), being treated with levothyroxine (LT4) (rather than combination of LT4 and L-triiodothyronine [LT3], LT3 alone, or desiccated thyroid extract) ( p < 0.001), expression of the view that the thyroid medication taken did not control the symptoms of hypo- thyroidism well ( p < 0.001), and with number of comorbidities ( p < 0.001). pSSD was associated with re- spondent attribution of most PHQ-15 symptoms to the hypothyroidism or its treatment ( p < 0.001), dissatisfaction with care and treatment of hypothyroidism ( p < 0.001), a negative impact of hypothyroidism on daily living ( p < 0.001), and with anxiety and low mood/depression ( p < 0.001). Conclusions: This study demonstrates a high prevalence of pSSD among people with hypothyroidism and associations between pSSD and negative patient outcomes, including a tendency to attribute persistent symp- toms to hypothyroidism or its treatment. SSD may be an important determinant of dissatisfaction with treatment and care among some hypothyroid patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hypothyroidism somatization questionnaire survey levothyroxine L-triiodothyronine
Megjelenés:	Thyroid. - 33 : 8 (2023), p. 927-939. -
További szerzők:	Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Feltz-Cornelis, Christina Maria Van Der Weetman, Anthony Peter Hay, Harriet Alexandra Abad-Madronero, Juan Tallett, Amy Johanna Bilas, Megan Lakwijk, Peter Poots, Alan J. Hegedüs László
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM105771
035-os BibID:	(scopus)85140857010 (wos)000862864000001
Első szerző:	Perros, Petros
Cím:	The Impact of Hypothyroidism on Satisfaction with Care and Treatment and Everyday Living : Results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey / Perros Petros, Hegedüs Laszlo, Nagy Endre Vezekenyi, Papini Enrico, Hay Harriet Alexandra, Abad-Madronero Juan, Tallett Amy Johanna, Bilas Megan, Lakwijk Peter, Poots Alan J.
Dátum:	2022
ISSN:	1050-7256
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Thyroid. - 32 : 10 (2022), p. 1158-1168. -
További szerzők:	Hegedüs László Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Hay, Harriet Alexandra Abad-Madronero, Juan Tallett, Amy Johanna Bilas, Megan Lakwijk, Peter Poots, Alan J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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