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001-es BibID:	BIBFORM123485
035-os BibID:	(Scopus)85198701603 (WoS)001270009000001
Első szerző:	Wennrich, Jan-Peer
Cím:	Dactylfungins and Tetralones: Bioactive Metabolites from aNematode-Associated Laburnicola nematophila / Jan-Peer Wennrich, Caren Holzenkamp, Miroslav Kolařík, Wolfgang Maier, Attila Mándi, Tibor Kurtán, Samad Ashrafi, Sherif S. Ebada, Marc Stadler
Dátum:	2024
ISSN:	0163-3864 1520-6025
Megjegyzések:	A chemical investigation of Laburnicola nematophila, isolated from cysts of the plant parasitic nematode Heterodera filipjevi, affored three dactylfungin derivatives (1-3) and three tetralone congeners (4-6). Dactylfungin C (1), laburnicolin (4), and laburnicolenone (5) are previously undescribed natural products. Chemical structures of the isolated compounds were determined based on 1D and 2D NMR spectroscopic analyses together with HR-ESI-MS spectrometry and comparison with data reported in the literature. The relative configurations of compounds 1, 2, and 4-6 were determined based on their ROESY data and analysis of their coupling constants (J values). The absolute configurations of 4-6 were determined through the comparison of their measured and calculated TDDFT-ECD spectra. Compounds 1-3 were active against azole-resistant Aspergillus fumigatus.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 87 : 7 (2024), p. 1860-1871. -
További szerzők:	Holzenkamp, Caren Kolařík, Miroslav Maier, Wolfgang Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Ashrafi, Samad Ebada, Sherif Saeed Stadler, Marc
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM120591
035-os BibID:	(WoS)001189155600001 (Scopus)85188428368
Első szerző:	Wennrich, Jan-Peer
Cím:	Omnipolyphilins A and B : chlorinated Cyclotetrapeptides and Naphtho-α-pyranones from the Plant Nematode-Derived Fungus Polyphilus sieberi / Jan-Peer Wennrich, Sherif S. Ebada, Ellen Sepanian, Caren Holzenkamp, Syeda J. Khalid, Hedda Schrey, Wolfgang Maier, Attila Mándi, Tibor Kurtán, Samad Ashrafi, and Marc Stadler
Dátum:	2024
ISSN:	0021-8561
Megjegyzések:	Chemical exploration for two isolates of the recently described ascomycete species Polyphilussieberi, derived from the eggs of the plant parasitic nematode Heterodera filipjevi, afforded the identification of many compounds that belong to various metabolite families: two previously undescribed chlorinated cyclotetrapeptides, omnipolyphilins A (1) and B (2), one new pyranonaphthoquinone, ventiloquinone P (3), a 6,6 '-binaphto-alpha-pyranone dimer, talaroderxine D (4) in addition to nine known metabolites (5-13) were isolated from this biocontrol candidate. All isolated compounds were characterized by comprehensive 1D, 2D NMR, and HR-ESI-MS analyses. The absolute configurations of the cyclotetrapeptides were determined by a combination of advanced Marfey's method, ROE correlation aided by conformational analysis, and TDDFT-ECD calculations, while ECD calculations, Mosher's method, and experimental ECD spectra were used for ventiloquinone P (3) and talaroderxine D (4). Among the isolated compounds, talaroderxine D (4) showed potent antimicrobial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 mu g mL(-1), respectively. Additionally, promising inhibitory effects on talaroderxine D (4) against the formation of S. aureus biofilms were observed up to a concentration of 0.25 mu g mL(-1). Moreover, ophiocordylongiiside A (10) showed activity against the free-living nematode Caenorhabditis elegans.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk helotiales cyclotetrapeptides naphthopyranones antimicrobial nematicidal
Megjelenés:	Journal of Agricultural and Food Chemistry. - 72 : 13 (2024), p. 6998-7009. -
További szerzők:	Ebada, Sherif Saeed Sepanian, Ellen Holzenkamp, Caren Khalid, Syeda J. Schrey, Hedda Maier, Wolfgang Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Ashrafi, Samad Stadler, Marc
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: