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001-es BibID:	BIBFORM127925
035-os BibID:	(scopus)85214498718 (WoS)001394987300001
Első szerző:	Parvaneh, Shahram
Cím:	Chemoresistance in Pancreatic Cancer : the Role of Adipose-Derived Mesenchymal Stem Cells and Key Resistance Genes / Parvaneh Shahram, Miklós Vanda, Páhi Zoltán Gábor, Szűcs Diána, Monostori Tamás, Póliska Szilárd, Venglovecz Viktória, Pankotai Tibor, Kemény Lajos, Veréb Zoltán
Dátum:	2025
ISSN:	1661-6596 1422-0067
Megjegyzések:	Abstract: Drug resistance is a significant challenge in pancreatic ductal adenocarcinoma (PDAC), where stromal elements such as adipose-derived mesenchymal stem cells (ASCs) contribute to a chemoresistant tumor microenvironment (TME). This study explored the effects of oxaliplatin (OXP) and 5-fluorouracil (5-FU) on PDAC cells (Capan-1) and ASCs to investigate the mechanisms of chemoresistance. While OXP and 5-FU reduced Capan- 1 viability in a dose- and time-dependent manner, ASCs demonstrated high resistance, maintaining > 90% viability even at cytotoxic doses. Transcriptomic analyses revealed OXP-induced transcriptional reprogramming in ASCs, with over 7000 differentially expressed genes, highlighting the pathways related to DNA damage response, cell cycle regulation, and stress-related signaling. In contrast, 5-FU elicited limited transcriptional changes, affecting only 192 genes. Cytokine proteome profiling revealed that OXP-treated ASCs significantly influenced the tumor microenvironment by promoting immune evasion (via IL-4, GM-CSF, IP-10, and GRO?) and driving extracellular matrix remodeling (through EMMPRIN and DPPIV). In contrast, 5-FU induced comparatively weaker effects, primarily limited to hypoxia-related pathways. Although OXP reduced angiogenic factors, it paradoxically activated pro-survival pathways, thereby enhancing ASC-mediated tumor support. These findings underscore ASCs as modulators of chemoresistance via secretome alterations and stress adaptation. Therefore, future strategies should prioritize the precise targeting of tumor cells while also focusing on the development of personalized treatments to achieve durable therapeutic responses in PDAC.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk pancreatic cancer Capan-1 adipose-derived mesenchymal stem cell (ASC) protein array transcriptome oxaliplatin 5-fluorouracil
Megjelenés:	International Journal Of Molecular Sciences. - 26 : 1 (2025), p. 390-417. -
További szerzők:	Miklós Vanda Páhi Zoltán Gábor Szűcs Diána Monostori Tamás Póliska Szilárd (1978-) (biológus) Venglovecz Viktória Pankotai Tibor Kemény Lajos V. (bőrgyógyász Szeged) Veréb Zoltán
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM121379
035-os BibID:	(Scopus)85189970497 (WOS)001199617500001
Első szerző:	Szűcs Diána
Cím:	Licensing effects of inflammatory factors and TLR ligands on the regenerative capacity of adipose-derived mesenchymal stem cells / Diána Szűcs, Tamás Monostori, Vanda Miklós, Zoltán G. Páhi, Szilárd Póliska, Lajos Kemény, Zoltán Veréb
Dátum:	2024
ISSN:	2296-634X
Megjegyzések:	Introduction: Adipose tissue-derived mesenchymal stem cells are promising contributors to regenerative medicine, exhibiting the ability to regenerate tissues and modulate the immune system, which is particularly beneficial for addressing chronic inflammatory ulcers and wounds. Despite their inherent capabilities, research suggests that pretreatment amplifies therapeutic effectiveness.Methods: Our experimental design exposed adipose-derived mesenchymal stem cells to six inflammatory factors for 24 h. We subsequently evaluated gene expression and proteome profile alterations and observed the wound closure rate post-treatment.Results: Specific pretreatments, such as IL-1 beta, notably demonstrated an accelerated wound-healing process. Analysis of gene and protein expression profiles revealed alterations in pathways associated with tissue regeneration.Discussion: This suggests that licensed cells exhibit potentially higher therapeutic efficiency than untreated cells, shedding light on optimizing regenerative strategies using adipose tissue-derived stem cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adipose-derived mesenchymal stem cells immune system inflammation licensing regenerative medicine
Megjelenés:	Frontiers in Cell and Developmental Biology. - 12 (2024), p. 1-15. -
További szerzők:	Monostori Tamás Miklós Vanda Páhi Zoltán Gábor Póliska Szilárd (1978-) (biológus) Kemény Lajos Veréb Zoltán
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM116204
035-os BibID:	(Scopus)85167596616 (WOS)001046691600001
Első szerző:	Szűcs Diána
Cím:	Effect of Inflammatory Microenvironment on the Regenerative Capacity of Adipose-Derived Mesenchymal Stem Cells / Szűcs Diána, Miklós Vanda, Monostori Tamás, Guba Melinda, Kun-Varga Anikó, Póliska Szilárd, Kis Erika, Bende Balázs, Kemény Lajos, Veréb Zoltán
Dátum:	2023
ISSN:	2073-4409
Megjegyzések:	Adipose-derived mesenchymal stem cells are increasingly being used in regenerative medicine as cell therapy targets, including in the treatment of burns and ulcers. The regenerative potential of AD-MSCs and some of their immunological properties are known from in vitro studies; however, in clinical applications, cells are used in non-ideal conditions and can behave differently in inflammatory environments, affecting the efficacy and outcome of therapy. Our aim was to investigate and map the pathways that the inflammatory microenvironment can induce in these cells. High-throughput gene expression assays were performed on AD-MSCs activated with LPS and TNF?. Analysis of RNA-Seq data showed that control, LPS-treated and TNF?-treated samples exhibited distinct gene expression patterns. LPS treatment increased the expression of 926 genes and decreased the expression of 770 genes involved in cell division, DNA repair, the cell cycle, and several metabolic processes. TNF? treatment increased the expression of 174 genes and decreased the expression of 383 genes, which are related to cell division, the immune response, cell proliferation, and differentiation. We also map the biological pathways by further investigating the most altered genes using the Gene Ontology and KEGG databases. Secreted cytokines, which are important in the immunological response, were also examined at the protein level, and a functional assay was performed to assess wound healing. Activated AD-MSC increased the secretion of IL-6, IL-8 and CXCL-10, and also the closure of wounds. AD-MSCs presented accelerated wound healing under inflammation conditions, suggesting that we could use this cell in clinical application.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adipose-derived mesenchymal stem cells inflammation lipopolysaccharide regenerative medicine tumor necrosis factor
Megjelenés:	Cells. - 12 : 15 (2023), p. 1-19. -
További szerzők:	Miklós Vanda Monostori Tamás Guba Melinda Kun-Varga Anikó Póliska Szilárd (1978-) (biológus) Kis Erika (Szeged) Bende Balázs Kemény Lajos V. (bőrgyógyász Szeged) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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