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001-es BibID:	BIBFORM132287
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate / Al Ashkar Habib, Kharrat Helu Nihad, Kovacs Nora, Fiatal Szilvia, Adany Roza, Piko Peter
Dátum:	2025
ISSN:	1661-6596 1422-0067
Megjegyzések:	Smoking has a well-established impact on cardiovascular health, notably through ele- vated resting heart rate and impaired autonomic regulation?both key risk factors. While nicotine's acute effects are well documented, the influence of smoking-related genetic variants on heart rate (HR) responses remains unclear. This study investigated the asso- ciation between selected smoking-related single nucleotide polymorphisms (SNPs) and HR dynamics following physical exertion. A total of 661 Hungarian adults completed the YMCA 3 min step test, with HR measured at rest, immediately post-exercise, and during recovery at 5 and 10 min. Key indices included post-exercise HR (HRaft), HR change (?HR), maximum HR percentage (HRmax%), and heart rate recovery coefficient (HRR). Genetic analysis focused on nine SNPs previously linked to smoking behaviours, with a composite genetic risk score derived from the three most influential variants (rs2235186, rs4142041, and rs578776). Associations were examined using adjusted linear regression. No significant relationship was found between any individual SNP and resting HR. However, rs2235186, rs4142041, and rs578776 were consistently associated with elevated HRaft, increased ?HR, higher HRmax%, and slower HRR. The genetic risk score showed significant correlations with all post-exercise HR measures, suggesting a cumulative genetic effect. These findings indicate that smoking-related genetic predisposition may influence autonomic cardiovascu- lar responses to physical activity. Although resting HR remains unaffected, specific SNPs are linked to post-exercise HR dynamics and recovery, highlighting the potential value of genetic screening in personalised cardiovascular risk assessment among smokers
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk smoking single nucleotide polymorphisms heart rate recovery cardiovascular risk genetic predisposition YMCA step test genetic risk score
Megjelenés:	International Journal Of Molecular Sciences. - 26 : 18 (2025), p. 1-17. -
További szerzők:	Kharrat Helu, Nihad (1992-) Kovács Nóra (1989-) (népegészségügyi szakember) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP TK2016-78 MTA Hungarian Research Network?HUN-REN (TKCS-2021/32) Egyéb Project No. 135784 - National Research, Development, and Innovation Fund of Hungary Egyéb National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006) Egyéb Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00513/23/5) Egyéb EKÖP-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund Egyéb Stipendium Hugaricum Scholarship Program, provided by the Tempus Public Foundation and the Hungarian Government Egyéb
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001-es BibID:	BIBFORM114683
035-os BibID:	(WoS)001073617500001 (Scopus)85172771410
Első szerző:	Merzah, Mohammed
Cím:	A Transcriptomic Analysis of Smoking-Induced Gene Expression Alterations in Coronary Artery Disease Patients / Mohammed Merzah, Szilárd Póliska, László Balogh, János Sándor, István Szász, Shewaye Natae, Szilvia Fiatal
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Abstract: Smoking is a well established risk factor for coronary artery disease (CAD). Despite this, there have been no previous studies investigating the effects of smoking on blood gene expression in CAD patients. This single-centre cross-sectional study was designed with clearly defined inclusion criteria to address this gap. We conducted a high-throughput approach using next generation sequencing analysis with a single-end sequencing protocol and a read length of 75-cycles. Sixty-one patients with a median age of 67 years (range: 28?88 years) were recruited, and only 44 subjects were included for further analyses. Our investigation revealed 120 differentially expressed genes (DEGs) between smokers and nonsmokers, with a fold change (FC) of ?1.5 and a p-value < 0.05. Among these DEGs, 15 were upregulated and 105 were downregulated. Notably, when applying a more stringent adjusted FC ? 2.0, 31 DEGs (5 upregulated, annotated to immune response pathways, and 26 downregulated, involving oxygen and haem binding or activity, with FDR ? 0.03) remained statistically significant at an alpha level of <0.05. Our results illuminate the molecular mechanisms underlying CAD, fortifying existing epidemiological evidence. Of particular interest is the unexplored overexpression of RCAN3, TRAV4, and JCHAIN genes, which may hold promising implications for the involvement of these genes in CAD among smokers.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk coronary artery disease gene expression smoking NGS RNAseq
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 18 (2023), p. 1-14. -
További szerzők:	Póliska Szilárd (1978-) (biológus) Balogh László (1976-) (kardiológus) Sándor János (1966-) (orvos-epidemiológus) Szász István (1985-) (Ph.D hallgató) Natae, Shewaye (1982-) (PhD hallgató) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
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001-es BibID:	BIBFORM056928
035-os BibID:	(scopus)84920546310 (wos)000348403100064
Első szerző:	Mezei Zoltán András (orvos)
Cím:	Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease / Zoltán A. Mezei, Zsuzsanna Bereczky, Éva Katona, Réka Gindele, Emília Balogh, Szilvia Fiatal, László Balogh, István Czuriga, Róza Ádány, István Édes, László Muszbek
Dátum:	2015
ISSN:	1661-6596 1422-0067
Megjegyzések:	The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, andon FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significantcoronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latterresults in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIIIlevels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban factor XIII (FXIII) factor XIII B subunit (FXIII-B) polymorphism coronary artery disease fibrinogen myocardial infarction risk assessment
Megjelenés:	International Journal of Molecular Sciences. - 16 : 1 (2015), p. 1143-1159. -
További szerzők:	Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Katona Éva (1961-) (klinikai biokémikus) Gindele Réka (1987-) (molekuláris biológus) Balogh Emília (1965-) (kardiológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Balogh László (1976-) (kardiológus) Czuriga István (1948-2018) (kardiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Édes István (1952-) (kardiológus) Muszbek László (1942-) (haematológus, kutató orvos)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Trombózis Kutató Központ KutatócsoportC K113097 OTKA MTA-DE MTA Vascularis Biológia, Thrombosis-Haemostasis Kutatócsoport
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