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1.

001-es BibID:BIBFORM061948
Első szerző:Bodoki Levente (PhD hallgató)
Cím:Inclusion body myositis - a case based clinicopathological update / Bodoki Levente, Nagy-Vincze Melinda, Griger Zoltán, Csonka Tamás, Murnyák Balázs, Kurucz Andrea, Dankó Katalin, Hortobágyi Tibor
Dátum:2014
ISSN:1895-1058 1644-3640
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Central European Journal of Medicine. - 9 : 1 (2014), p. 80-85. -
További szerzők:Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csonka Tamás (1984-) (pathológus) Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Kurucz Andrea (1984-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Hortobágyi Tibor (1965-) (patológus)
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2.

001-es BibID:BIBFORM129305
Első szerző:Kozák Márk (neurológus)
Cím:Prevalence of Elevated CK Levels, Myositis-Specific and Myositis-Associated Antibodies, Myositis, and Other Neuromuscular Diseases in Myasthenia Gravis Patients : Experience from an Eastern European Tertiary Center / Márk Kozák, Edina Kovács, Melinda Nagy-Vincze, Attila Tóth, Judit Boczán
Dátum:2025
ISSN:2077-0383
Megjegyzések:Myasthenia gravis (MG) and idiopathic inflammatory myopathy (IIM) are autoimmune diseases that affect the musculoskeletal system. The association of the two diseases is rare. Their management is different, so it is important to recognize the concomitant presentation. Methods: In this cross-sectional study, we study the presence of CK elevation, myositis-specific and myositis-associated antibodies (MSA/MAA), and vitamin D levels in a cohort of 101 MG patients. Electromyography, limb magnetic resonance imaging (MRI), and, in some cases, muscle biopsy were performed when IIM was suspected. We reviewed the patients' medical records to access the results of these tests if they had been performed previously. Results: CK elevation was detected in 10 patients (9.9%). We identified one case of anti-Jo-1 antibody-positive polymyositis and two cases of possible myositis. MSA/MAA antibodies were not found in the patients with high CK levels, except for the one with anti-Jo-1-positive IIM. One patient with elevated CK levels had an overlapping muscular dystrophy. MSA/MAA antibodies were detected in 19 patients (18.8%). A total of 37% had high-titer antibodies and concomitant systemic autoimmune diseases, while 63% had low-titer antibodies, most of whom had no systemic autoimmune disease. Low serum vitamin D levels were found in 67.3% of patients. Comparison of myasthenia gravis composite (MGC) scores between patients with low and normal vitamin D levels did not show a statistically significant difference. Conclusions: Our results may raise awareness among neuromuscular specialists caring for MG patients of the possibility of associated myositis or other neuromuscular diseases and the need to assess vitamin D levels. Although deficiency was frequent, its impact on MG severity remains unclear, necessitating further investigation into its immunological relevance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
myasthenia gravis
myositis
idiopathic inflammatory myopathy (IIM)
elevated CK levels
MSA
MAA
vitamin D
Megjelenés:Journal of Clinical Medicine. - 14 : 7 (2025), p. 1-13. -
További szerzők:Kovács Edina (1983-) (neurológus) Nagy-Vincze Melinda (1985-) (orvos) Tóth Attila (1971-) (biológus) Boczán Judit (1972-) (neurológus)
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3.

001-es BibID:BIBFORM047187
035-os BibID:PMID:22732951
Első szerző:Labirua-Iturburu, Ane
Cím:Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome : clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature / Ane Labirua-Iturburu, Albert Selva-O'Callaghan, Melinda Vincze, Katalin Dankó, Jiri Vencovsky, Benjamin Fisher, Peter Charles, Maryam Dastmalchi, Ingrid E. Lundberg
Dátum:2012
ISSN:0025-7974
Megjegyzések:Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases. This multicenter study of patients positive for anti-PL-7, identified between 1984 and 2011, derives from the EUMYONET cohort. Clinical and serologic data were obtained by retrospective laboratory and medical record review, and statistical analyses were performed with chi-squared and Fisher exact tests. Eighteen patients, 15 women, were anti-PL-7 antibody positive. Median follow-up was 5.25 years (interquartile range, 2.8-10.7 yr), and 4 patients died. All patients had myositis (12 polymyositis, 5 dermatomyositis, and 1 amyopathic dermatomyositis), 10 (55.6%) had interstitial lung disease, and 9 (50%) had pericardial effusion. Occupational exposure to organic/inorganic particles was more frequent in patients with interstitial lung disease than in the remaining patients (5 of 10 vs. 1 of 7; p = 0.152), although the difference was not significant. Concurrent autoantibodies against Ro60 and Ro52 were seen in 8 of 14 (57%) patients studied. In the literature review the most common manifestations of anti-PL-7 antisynthetase syndrome were interstitial lung disease (77%), myositis (75%), and arthritis (56%). As in other subsets of the antisynthetase syndrome, myositis and interstitial lung disease are common features of the anti-PL-7 antisynthetase syndrome. In addition, we can add pericarditis as a possible manifestation related to anti-PL-7 antibodies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medicine 91 : 4 (2012), p. 206-211. -
További szerzők:Selva-O'Callaghan, Albert Nagy-Vincze Melinda (1985-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Vencovsky, Jiri Fisher, Benjamin Charles, Peter Dastmalchi, Maryam Lundberg, Ingrid
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4.

001-es BibID:BIBFORM061954
Első szerző:Murnyák Balázs (molekuláris biológus, genetikus)
Cím:Inclusion body myositis : pathomechanism and lessons from genetics / Balázs Murnyák, Levente Bodoki, Melinda Vincze, Zoltán Griger, Tamás Csonka, Rita Szepesi, Andrea Kurucz, Katalin Dankó, Tibor Hortobágyi
Dátum:2015
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Open Medicine 10 (2015), p. 188-193. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csonka Tamás (1984-) (pathológus) Szepesi Rita (1975-) (neurológus) Kurucz Andrea (1984-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Hortobágyi Tibor (1965-) (patológus)
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5.

001-es BibID:BIBFORM132071
035-os BibID:(Scopus)105014423937 (WoS)001557797100001
Első szerző:Ranjbar, Yasamin
Cím:The Way Back from Tetraplegia or, Rare Neurological Manifestations of Eosinophil Granulomatosis with Polyangiitis / Ranjbar Yasamin, Árokszállási Tamás, Szinay Dorottya, Nagy Edit B., Tarr Tünde, Nagy-Vincze Melinda
Dátum:2025
ISSN:2077-0383
Megjegyzések:Central nervous system (CNS) involvement is an extremely rare manifestation in eosinophilic granulomatosis with polyangiitis (EGPA), associated with a poor prognosis. Here we present a case of 50-year-old female patient with long-term asthma treatment who presented initially with extreme eosinophilia (56%) and severe progressive ascending paresis, similar to Guillain?Barré syndrome, leading to tetraplegia. After navigating through diagnostic mazes, the diagnosis of EGPA was established based on eosinophilia, myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, asthma, eosinophil granulomatosis in the gastrointestinal tract, and severe peripheral nervous system involvement, complicated with rare central nervous granulomas and ischemia. With combined immunosuppressive and immunomodulatory treatment including high-dose corticosteroids, rituximab and intravenous immunoglobulin along with symptomatic treatment and planned rehabilitation over 6 months, our patient recovered gradually from tetraplegia and adverse events such as severe infections and osteoporotic fractures. Now, from a 2-year perspective, we can conclude a successful treatment leading to decrease in all of her symptoms. Due to persistent eosinophilia after steroid tapering, she was switched to mepolizumab maintenance treatment and demonstrated continuous improvement of motor and sensory functions. Thanks to periodically repeated rehabilitation, she became self-sufficient and returned to her previous job. Our case highlights that EGPA patients should be treated in a center of expertise due to the rarity of the disease and complexity of diagnosis and treatment. Careful multidisciplinary cooperation, the huge effort of the patient, and a supportive environment can show a way back from immune-mediated tetraplegia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
eosinophil granulomatosis with polyangiitis
central nervous system
tetraplegia
individualized treatment
Megjelenés:Journal of Clinical Medicine. - 14 : 16 (2025), p. 1-8. -
További szerzők:Árokszállási Tamás (1988-) (neurológus) Szinay Dorottya (1995-) (Orvos) Nagy Edit B. Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Nagy-Vincze Melinda (1985-) (orvos)
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6.

001-es BibID:BIBFORM129928
035-os BibID:(WoS)001496704400001 (Scopus)105006669489
Első szerző:Szinay Dorottya (Orvos)
Cím:Assessment of Efficacy and Safety of Lipid-Lowering Treatment and Its Importance in Risk Assessment and Prevention in a Hungarian Myositis Cohort / Dorottya Szinay, Katalin Szabó, Henrik Molnár, Tibor Béldi, Viktor Bencs, Hajnalka Lőrincz, Mariann Harangi, Zoltán Griger, Melinda Nagy-Vincze
Dátum:2025
ISSN:2077-0383
Megjegyzések:Background: Idiopathic inflammatory myopathies (IIMs), also known as myositis, are systemic autoimmune diseases characterized by chronic inflammation affecting the skin, muscles, and internal organs. Besides traditional risk factors and immune-mediated myocarditis, continuous activity of the immune system increases cardiovascular disease (CVD) risk, meaning that cardiovascular events are the leading causes of mortality in IIM patients. Statins are the most widely used lipid-lowering therapies, which reduce cardiovascular risk, but the fear of adverse muscular events inhibits the frequency of use. Methods: Our aim was to assess the CVD risk in a myositis cohort using the SCORE2 prediction system, carotid artery Doppler ultrasound measurement, and biomarkers; recommend individual lipid-lowering treatment; and follow the efficacy and adverse events of therapy in a 6-month treatment period. Results: The study population (80 IIM patients) was a middle-aged, female-dominant myositis cohort with an average disease duration of 9 years and low median global disease activity. Based on the SCORE2 evaluation, 78.8% of patients had medium/high CVD risk, while 73.13% had asymptomatic carotid plaque. After 6 months of adequate lipid-lowering therapy, 37.5% of patients reached a lower CVD risk category, the biomarker levels of atherosclerosis significantly decreased, and no progression in carotid plaques was detected. None of the patients reported an adverse muscular event or IIM relapse. Conclusions: Our findings proved that the CVD risk of patients with myositis is high, but carefully applied lipid-lowering treatment is the key to effective risk reduction. Risk stratification and the recommendation of preventive treatment are the responsibility of the treating physician.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
idiopathic inflammatory myopathies
cardiovascular disease risk
statin
efficacy
Megjelenés:Journal of Clinical Medicine. - 14 : 10 (2025), p. 1-18. -
További szerzők:Szabó Katalin (1991-) (orvos) Molnár Henrik Béldi Tibor (1994-) (orvos) Bencs Viktor (1995-) (orvos) Lőrincz Hajnalka (1986-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy-Vincze Melinda (1985-) (orvos)
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7.

001-es BibID:BIBFORM111641
035-os BibID:(scopus)85160027968
Első szerző:Vincze Anett (orvos)
Cím:Pruritogenic molecules in the skin of patients with dermatomyositis / Vincze Anett, Herczeg-Lisztes Erika, Szabó Katalin, Béldi Tibor Gábor, Nagy-Vincze Melinda, Pór Ágnes, Varga József, Dankó Katalin, Biró Tamás, Tóth Balázs István, Griger Zoltán
Dátum:2023
ISSN:2296-858X
Megjegyzések:Introduction: Pruritus is a common excruciating symptom in systemic autoimmune diseases such as dermatomyositis (DM) but the pathogenesis is not fully understood. We intended to investigate the targeted expression analysis of candidate molecules involved in the development of pruritus in lesional vs. non-lesional skin samples of patients affected with active DM. We looked for correlations between the investigated pruriceptive signaling molecules, disease activity, and itching sensation of DM patients. Methods: Interleukins (IL-33 and IL-6), tumor necrosis factor ? (TNF-?), peroxisome proliferator-activated receptor ? (PPAR-?), and ion channels belonging to the transient receptor potential (TRP) family were analyzed. The expression of TNF-?, PPAR-?, IL-33, IL-6, and TRP channels in lesional DM skin was evaluated by RT-qPCR and immunohistochemistry and was compared with non-lesional DM skin samples. Pruritus, disease activity, and damage of DM were evaluated by the 5-D itch scale and Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), respectively. Statistical analysis was performed with IBM SPSS 28 software. Results: A total of 17 active DM patients participated in the study. We could show that the itching score was positively correlated with the CDASI activity score (Kendall's tau-b = 0.571; p = 0.003). TNF-? gene expression was significantly higher in lesional DM skin than in non-lesional DM skin (p = 0.009) and differed in the subgroups of patients with different itch intensities (p = 0.038). The mRNA expression of lesional IL-6 correlated positively with 5-D itch and CDASI activity score (Kendall's tau-b = 0.585; p = 0.008 and 0.45; p = 0.013, respectively). TRPV4 expressions were positively correlated with CDASI damage score (Kendall's tau-b = 0.626; p < 0.001), but the mRNA expressions of the TRP family, PPAR-?, IL-6, and IL-33 were not different in lesional and non-lesional samples. Immunohistochemistry analysis did not find significant alterations in the expressions of TNF-?, PPAR-?, IL-6, and IL-33 in lesional and non-lesional regions. Discussion: Our results argue that cutaneous disease activity, TNF-?, and IL-6 might play a central role in DM-associated itch, while TRPV4 plays a central role in tissue regeneration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dermatomyositis
inflammatory myopathies
itch
pruritus
TRP channels
TNF-α
IL-6
Megjelenés:Frontiers in Medicine. - 10 (2023), p. 1168359. -
További szerzők:Lisztes Erika (1986-) (élettanász) Szabó Katalin (1991-) (orvos) Béldi Tibor (1994-) (orvos) Nagy-Vincze Melinda (1985-) (orvos) Pór Ágnes Varga József (1955-) (fizikus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Bíró Tamás (1968-) (élettanász) Tóth István Balázs (1978-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:134791
OTKA
120187
OTKA
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
Bolyai János Kutatási Ösztöndíj
Egyéb
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8.

001-es BibID:BIBFORM081379
Első szerző:Zilahi Erika (molekuláris biológus)
Cím:Dysregulated expression profile of myomiRs in the skeletal muscle of patients with polymyositis / Erika Zilahi, Zsuzsanna Adamecz, Levente Bodoki, Zoltán Griger, Szilárd Póliska, Melinda Nagy-Vincze, Katalin Dankó
Dátum:2019
Megjegyzések:MicroRNA (miRNA) research has intensively developed over the past decade. Characterization of dysregulated miRNA expression profiles could give a better understanding of the development of pathological conditions and clinical disorders, such as autoimmune diseases with polygenic etiology, including idiopathic inflammatory myopathies (IIMs). IIMs are a group of rare autoimmune disorders characterized by skeletal weakness and inflammation. Polymyositis (PM) is one of the conditions of autoimmune myopathies with proximal skeletal muscle weakness. A novel group of miRNAs, known as myomiRs are described as striated muscle-specific or muscle-enriched miRNAs. They are involved in myoblast proliferation/differentiation as well as muscle regeneration. To determine the role of myomiRs in the development and progression of PM, we performed an initial skeletal muscle miRNA profiling using microarray technique at diagnosis. The aim of the study was to examine myomiRs expression profile in patients with PM in order to remark the association between the dysregulated myomiRs' expression and the development of the disease. As a results of microarray investigation, most of the myomiRs showed altered expression patterns in the muscle samples of PM patients compared to controls. These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
autoimmune disease
microarray
myomiRs
polymyositis
Megjelenés:The Journal of the International Federation of Clinical Chemistry and Laboratory Medicine. - 30 : 2 (2019), p. 237-245. -
További szerzők:Adamecz Zsuzsanna Bodoki Levente (1986-) (PhD hallgató) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Póliska Szilárd (1978-) (biológus) Nagy-Vincze Melinda (1985-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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