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001-es BibID:	BIBFORM073014
Első szerző:	Berta Eszter (belgyógyász)
Cím:	Early stage Graves' disease is uniformly accompanied by orbital immune activity even in patients who fail to develop orbithopathy during follow-up / Eszter Berta, Miklós Bodor, László Galuska, György Paragh, Annamária Erdei, Annamária Gazdag, Bernadett Ujhelyi, Ervin Berényi, Mónika Katkó, Andrea Gazsó, Endre V. Nagy
Dátum:	2018
ISSN:	0947-7349
Megjegyzések:	Purpose. Graves' orbitopathy (GO) is a complication of Graves' disease (GD), the development of which cannot be predicted at the time of diagnosis of GD. Our aims were (i) to test if orbital 99mTc-labelled diethylenetriamine pentaacetic acid single-photon emission computer tomography (DTPA SPECT) can predict development of GO later during the course of the disease and (ii) to study whether orbital immune activity can be detected in GD patients who do not develop GO during follow-up.Methods. Fifty-four orbits of 27 patients with newly diagnosed GD were entered into the case-control study. Individuals showing signs of GO at enrolment were excluded. During the two-year follow up, eye signs were recorded every 3 months. Orbital DTPA uptakes on SPECT images were measured when entering the study and at the end of the follow-up period, or when clinical signs of GO developed, whichever occurred first.Results. During thefollow up, 6 patients (22%) were diagnosed with GO. There was no significant difference between the initial DTPA uptakes of the patients with or without later developing GO (10.45?1.72 MBq/cm vs. 9.18?1.18 MBq/cm3 respectively). However, the DTPA uptakes of both GD groups (ie. with and without GO) were higher than that of the control group (7.45?1.36 MBq/cm3, p<0.05).Conclusions. We have shown that GD is accompanied by moderate orbital immune activity in GD patients without GO, irrespective of later development of GO. Why this orbital autoimmunity remains subclinical in the majority of the cases, and progresses into clinically detectable GO in others, remains unclear.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban pajzsmirigy endokrin orbitopathia
Megjelenés:	Experimental And Clinical Endocrinology & Diabetes. - 126 : 10 (2018), p. 628-631. -
További szerzők:	Bodor Miklós (1969-) (belgyógyász, endokrinológus) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Paragh György (1953-) (belgyógyász) Erdei Annamária (1976-) (belgyógyász) Gazdag Annamária (1979-) (belgyógyász) Ujhelyi Bernadett (1981-) (szemész) Berényi Ervin (1964-) (radiológus) Katkó Mónika (1980-) (biológus) Gazsó Andrea Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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001-es BibID:	BIBFORM131919
035-os BibID:	(scopus)105012975499 (wos)001548867600001
Első szerző:	Galofré, Juan C.
Cím:	Thyroid Hormone Treatment for Hypercholesterolemia in Euthyroid Patients : Results From a European Survey of Thyroid Specialists / Galofré Juan C., Díez Juan J., Attanasio Roberto, Nagy Endre V., Bednarczuk Tomasz, Papini Enrico, Zarkovic Milos, Negro Roberto, Perros Petros, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Berta Eszter, Beleslin Biljana Nedeljkovic, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Burlacu Maria-Cristina, Ciric Jasmina, Fadeyev Valentin, Field Benjamin C. T., Fuhrer Dagmar, Jan Jiskra, Kopp Peter, Krebs Michael, Krsek Michal, Lazúrová Ivica, Luchytskiy Vitaliy, Puga Francisca Marques, McGowan Anne, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Robenshtok Eyal, Rosselet Patrick Olivier, Ruchala Marek, Shepelkevich Alla, Tronko Mykola, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes R., Hegedüs Laszlo
Dátum:	2025
ISSN:	0300-0664
Megjegyzések:	Objective: A relationship among hypothyroidism and lipid disorders is well established. However, current evidence and guidelines donot support the use of thyroid hormones (TH) in euthyroid patients with hyperlipidaemia as potential harms are considerable. ThisEuropean survey investigated the use of TH in euthyroid patients with severe hypercholesterolemia as a complementary treatment.Design: Data were derived from the THESIS (Treatment of Hypothyroidism in Europe by Specialists) project that surveyed THuse. Univariable and multivariable analyses were used to explore associations.Results: Out of 17,232 invitations, 5695 (33.0%) valid responses were received, and of these, 328 (5.8%) stated that TH areindicated in euthyroid patients with severe hypercholesterolemia. Univariable analyses disclosed significant differences andassociations: (a) more non?endocrinologists (8.9%) than endocrinologist (5.4%) used TH (p < 0.001), (b) the number of hypothyroidpatients treated per year was inversely related to use of TH (p = 0.024), (c) members of international endocrine/thyroid societieswere more likely to use TH than non?members (p < 0.001), (d) significant variations by country and geographical region(p < 0.001), and (e) inverse relationship between gross national income per capita (GNIPC) and TH use (p < 0.001). Multivariableanalyses yielded significant associations between use of TH, and male gender, specialty and GNIPC (p < 0.001).Conclusions: This study suggests that a small but noteworthy minority of European thyroid specialists may be using TH to treatof severe hypercholesterolemia in euthyroid patients. If confirmed, this finding highlights the importance of raising awarenessamong thyroid specialists, professional societies, and healthcare providers to ensure adherence to evidence?based practices.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk euthyroidism hypercholesterolemia levothyroxine misuse treatment
Megjelenés:	Clinical Endocrinology. - 2025 (2025), p. 1-8. -
További szerzők:	Díez, Juan J. Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bednarczuk, Tomasz Papini, Enrico Zarkovic, Milos Negro, Roberto Perros, Petros Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Berta Eszter (1980-) (belgyógyász) Beleslin, Biljana Nedeljkovic Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Burlacu, Maria-Cristina Ciric, Jasmina Fadeyev, Valentin Field, Benjamin C. T. Fuhrer, Dagmar Jan, Jiskra Kopp, Peter Krebs, Michael Krsek, Michal Lazúrová, Ivica Luchytskiy, Vitaliy Puga, Francisca Marques McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedüs László
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001-es BibID:	BIBFORM122035
035-os BibID:	(Scopus)85195483644
Első szerző:	Negro, Roberto
Cím:	Use of levothyroxine for euthyroid, thyroid antibody positive women with infertility : analyses of aggregate data from a survey of European thyroid specialists (Treatment of Hypothyroidism in Europe by Specialists : an International Survey) / Roberto Negro, Miloš Žarković, Roberto Attanasio, Endre V. Nagy, Eszter Berta, Miklos Bodor
Dátum:	2024
ISSN:	0300-0664
Megjegyzések:	Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. The aim of the study was to document the use of LT4 by European thyroid specialists in such patients. Design: The data presented derive from Treatment of Hypothyroidism in Europe by Specialists, an International Survey (THESIS), a questionnaire conducted between 2019 and 2021 to document the management of hypothyroidism by European thyroid specialists. Here, we report the aggregate results on the use of LT4 in infertile, euthyroid women with positive TPOAb. Results: A total of 2316/5406 (42.8%) respondents stated that LT4 may be indicated in TPOAb positive euthyroid women with infertility. The proportion of those replying positively to this question varied widely across different countries (median 39.4, range 22.9%-83.7%). In multivariate analyses males (OR: 0.8; CI: 0.7-0.9) and respondents >60 years (OR: 0.7; 0.6-0.8) were the least inclined to consider LT4 for this indication. Conversely, respondents managing many thyroid patients ("weekly" [OR: 1.4; CI: 1.0-1.9], "daily" [OR: 1.8; CI: 1.3-2.4]) and practicing in Eastern Europe (OR: 1.5; CI: 1.3-1.9) were most likely to consider LT4. Conclusions: A remarkably high number of respondents surveyed between 2019 and 2021, would consider LT4 treatment in TPOAb positive euthyroid women with infertility. This view varied widely across countries and correlated with sex, age and workload, potentially influencing patient management. These results raise concerns about potential risks of overtreatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antithyroid antibodies female infertility levothyroxine survey thyroid hormone treatment
Megjelenés:	Clinical Endocrinology. - 101 : 2 (2024), p. 180-190. -
További szerzők:	Zarkovic, Milos Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
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