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001-es BibID:	BIBFORM133292
Első szerző:	Bednarczuk, Tomasz
Cím:	Use of thyroid hormones in euthyroid patients with unexplained fatigue : analyses of aggregate data from European national surveys of professional endocrine society members / Bednarczuk Tomasz, Sugier Aleksandra, Attanasio Roberto, Nagy Endre V., Negro Roberto, Papini Enrico, Zarkovic Milos, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Nedeljkovic Beleslin Biljana, Berta Eszter, Bodor Miklos, Borissova Anna M., Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Cohen Chagit A., Ciric Jasmina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Führer-Sakel Dagmar, Frlich Jacob S., Galofré Juan C., Hakala Tommi, Jiskra Jan, Kopp Peter A., Krebs Michael, Krsek Michal, Kuzma Martin, Lazúrová Ivica, Leenhardt Laurence, Ludgate Stephen, Luchytskiy Vitaliy, McGowan Anne, Melo Miguel, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan A., Peric Bozidar, Planck Tereza, Poiana Catalina, Puga Francisca M., Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla R., Shepelkevich Alla, Tronko Mykola D., Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Yurenya Elena, Perros Petros, Hegedüs Laszlo
Dátum:	2025
ISSN:	1664-2392
Megjegyzések:	Background: Managing patients with fatigue is a clinical challenge. Because fatigue is often reported in hypothyroidism, thyroid hormone (TH) therapy may sometimes be incorrectly considered for biochemically euthyroid individuals. This study aimed to evaluate the prevalence and determinants of this practice in different European countries. Methods: We analyzed aggregate data from the THESIS (Treatment of Hypothyroidism in Europe by Specialists: an International Survey) online survey. We analyzed responses from 5,695 members of 28 national endocrine/thyroid societies' specialists to the statement:"Thyroid hormones may be indicated in biochemically euthyroid patients with unexplained fatigue" . Results: Overall, 7.5% (426/5695) of respondents indicated that TH therapy might be considered for euthyroid patients with unexplained fatigue. The proportion of positive responses varied widely across different countries (between 1.1% in Switzerland and 29.3% in Serbia; p=2 ?10-16) and regions (between 4.7% in Western Europe and 8.7% in Western Asia or 8.8% in Eastern Europe; p=0.004). TH were more frequently prescribed for unexplained fatigue by male respondents (Odds Ratio, OR 1.45, 95% CI 1.18-1.78) and physicians practicing in private practice (OR 1.27, 95% CI 1.02-1.58), and less frequently by endocrinologists (OR 0.62, 95% CI 0.46-0.83). Conclusion: A small, yet not negligible percentage of European thyroid-focused physicians consider using TH for euthyroid patients with unexplained fatigue, with signi cant variations based on geographic, demographic, and practice- related factors. Using levothyroxine and/or liothyronine in such cases lacks evidence and may partially contribute to the concerning overuse of TH therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk euthyroidism fatigue levothyroxine thyroid hormone survey
Megjelenés:	Frontiers in Endocrinology. - 16 (2025), p. 1-11. -
További szerzők:	Sugier, Aleksandra Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Zarkovic, Milos Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Nedeljkovic-Beleslin, Biljana Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Cohen, Chagit Adler Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Frlich, Jacob Stampe Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lazúrová, Ivica Leenhardt, Laurence Ludgate, Stephen Luchytskiy, Vitaliy McGowan, Anne Melo, Miguel Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Puga, Francisca Marques Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Perros, Petros Hegedüs László
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001-es BibID:	BIBFORM133291
035-os BibID:	(scopus)105018499975 (wos)001588705800001
Első szerző:	Ludgate, Stephen
Cím:	The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members / Ludgate Stephen, McGowan Anne, Moran Carla, Attanasio Roberto, Zarkovic Milos, Nagy Endre Vezekenyi, Negro Roberto, Papini Enrico, Adler Cohen Chagit, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Beleslin Biljana Nedeljkovic, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jamina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Führer-Sakel Dagmar, Galofré Juan Carlos, Hakala Tommi, Jiskra Jan, Kopp Peter A., Krebs Michael, Krsek Michal, Kuzma Martin, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, Melo Miguel, Metso Saara, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Poiana Catalina, Marques Puga Francisca, Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Tronko Mykola D., Frlich Jacob Stampe, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Yurenya Elena, Perros Petros, Hegedüs Laszlo
Dátum:	2025
ISSN:	1664-2392
Megjegyzések:	Purpose: Treatment-resistant depression (TRD) is most commonly de ned as depression that has not responded to two different pharmacological agents used for an adequate period of time. We explored the views of European specialists via survey, regarding the use of thyroid hormone (TH) in euthyroid patients with TRD as part of♭Treatment of Hypothyroidism in Europe by Specialists: An International Survey' (THESIS). Methods: The question"Thyroid hormones may be indicated in biochemically euthyroid patients with treatment resistant depression" was posed to specialists from 28 countries. Results: 5695 valid responses were received following 17,232 invitations (33.0% response rate; 65% female, 90% endocrinologists). 348 (6.1%) stated that TH may be indicated in biochemically euthyroid patients with TRD. This view was more common in males (p<0.01), respondents who saw ?100 patients with hypothyroidism per year (p<0.01), respondents who worked in private practice (p=0.05) and respondents who were not members of international specialist associations (p=0.05). Geographical variation existed with respondents in Eastern Europe signi cantly more likely to use TH in TRD (p<0.01). Linear regression showed a statistically signi cant reduction in the use of TH for TRD with increasing gross national income (F-statistic=7.35, CI -0.15 - -0.02, p=0.01). T H i n T R D w a s r e c o m m e n d e d i n p s y c h i a t r y g u i d e l i n e s b u t n o t endocrinology guidelines. Conclusion: While there is limited evidence for their use, over 6% of respondents stated that TH may be indicated in TRD. Due to the risk of iatrogenic thyrotoxicosis and increased morbidity the use of TH should be addressed in relevant endocrinology guidelines and consensus should be reached between specialties.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk TRD (treatment-resistant depression) thyroid thyroid hormone liothyroinine levothyroxine
Megjelenés:	Frontiers in Endocrinology. - 16 (2025), p. 1-14. -
További szerzők:	McGowan, Anne Moran, Carla Attanasio, Roberto Zarkovic, Milos Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Adler Cohen, Chagit Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Melo, Miguel Metso, Saara Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Marques Puga, Francisca Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Frlich, Jacob Stampe Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Perros, Petros Hegedüs László
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001-es BibID:	BIBFORM124557
035-os BibID:	(scopus)85202766336 (wos)001303223800001
Első szerző:	Papini, Enrico
Cím:	Thyroid hormones for euthyroid patients with simple goiter growing over time : a survey of European thyroid specialists / Papini Enrico, Attanasio Roberto, Zarkovic Milos, Nagy Endre Vezekenyi, Negro Roberto, Perros Petros, Galofré Juan Carlos, Cohen Chagit Adler, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Beleslin Biljana Nedeljkovic, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jasmina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Führer-Sakel Dagmar, Hakala Tommi, Jiskra Jan, Kopp Peter Andreas, Krebs Michael, Krsek Michal, Lantz Mikael, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, Puga Francisca Marques, McGowan Anne, Melo Miguel, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Robenshtok Eyal, Rosselet Patrick Olivier, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Tronko Mykola, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Hegedüs Laszlo
Dátum:	2025
ISSN:	0969-711X 1559-0100
Megjegyzések:	Background Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. Purpose To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. Methods Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. Results The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41?50, 51?60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03?1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33?0.48), Northern Europe (OR 0.28, 95% CI 0.22?0.36) and Western Asia (OR 0.16, 95% CI 0.11?0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. Conclusions Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Survey Goiter Thyroid hormone Levothyroxine TSH-suppressive therapy
Megjelenés:	Endocrine. - 87 : 1 (2025), p. 262-272. -
További szerzők:	Attanasio, Roberto Zarkovic, Milos Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Perros, Petros Galofré, Juan C. Cohen, Chagit Adler Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Führer, Dagmar Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Puga, Francisca Marques McGowan, Anne Melo, Miguel Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedűs László
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001-es BibID:	BIBFORM115997
035-os BibID:	(Scopus)85177456203
Első szerző:	Zarkovic, Milos
Cím:	Characteristics of specialists treating hypothyroid patients : the "THESIS" collaborative / Zarkovic Milos, Attanasio Roberto, Nagy Endre V., Negro Roberto, Papini Enrico, Perros Petros, Cohen Chagit Adler, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jasmina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Frlich Jacob Stampe, Führer Dagmar, Galofré Juan Carlos, Hakala Tommi, Jiskra Jan, Kopp Peter, Krebs Michael, Krsek Michal, Kuzma Martin, Lantz Mikael, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, McGowan Anne, Melo Miguel, Metso Saara, Moran Carla, Morgunova Tatyana, Mykola Tronko, Beleslin Biljana Nedeljkovic, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Poiana Catalina, Puga Francisca Marques, Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Unuane David, Vardarli Irfan, Visser W. Edward, Vrionidou Andromachi, Younes Younes R., Yurenya Elena, Hegedüs Laszlo
Dátum:	2023
ISSN:	1664-2392
Megjegyzések:	Introduction: Thyroid specialists influence how hypothyroid patients are treated, including patients managed in primary care. Given that physician characteristics influence patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods: Thyroid specialists from 28 countries were invited to respond to a questionnaire, Treatment of Hypothyroidism in Europe by Specialists: an International Survey (THESIS). Geographic regions were defined according to the United Nations Statistics Division. The national economic status was estimated using World Bank data on the gross national income per capita (GNI per capita). Results: 5,695 valid responses were received (response rate 33?0%). The mean age was 49 years, and 65?0% were female. The proportion of female respondents was lowest in Northern (45?6%) and highest in Eastern Europe (77?2%) (p <0?001). Respondent work volume, university affiliation and private practice differed significantly between countries (p<0?001). Age and GNI per capita were correlated inversely with the proportion of female respondents (p<0?01). GNI per capita was inversely related to the proportion of respondents working exclusively in private practice (p<0?011) and the proportion of respondents who treated >100 patients annually (p<0?01). Discussion: THESIS has demonstrated differences in characteristics of thyroid specialists at national and regional levels, strongly associated with GNI per capita. Hypothyroid patients in middle-income countries are more likely to encounter female thyroid specialists working in private practice, with a high workload, compared to high-income countries. Whether these differences influence the quality of care and patient satisfaction is unknown, but merits further study.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Endocrinology. - 14 : 24 (2023), p. 1-11. -
További szerzők:	Attanasio, Roberto Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Perros, Petros Cohen, Chagit Adler Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Frlich, Jacob Stampe Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy McGowan, Anne Melo, Miguel Metso, Saara Moran, Carla Morgunova, Tatyana Mykola, Tronko Beleslin, Biljana Nedeljkovic Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Puga, Francisca Marques Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Unuane, David Vardarli, Irfan Visser, W. Edward Vrionidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Hegedüs László
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