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001-es BibID:	BIBFORM118990
035-os BibID:	(Scopus)85189475993 (WoS)001190999100001
Első szerző:	Attanasio, Roberto
Cím:	Patients' persistent symptoms, clinician demographics and geo-economic factors are associated with choice of therapy for hypothyroidism by European thyroid specialists : The "THESIS"* collaboration (*Treatment of Hypothyroidism in Europe by Specialists, an International Survey) / Roberto Attanasio, Miloš Žarković, Enrico Papini, Endre Vezekenyi Nagy, Roberto Negro, Petros Perros, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Tomasz Bednarczuk, Biljana Beleslin, Eszter Berta, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Camille Buffet, Maria-Cristina Burlacu, Jasmina Ciric, Juan J. Díez, Harald Dobnig, Valentin V. Fadeyev, Benjamin C. T. Field, Eric Fliers, Dagmar Führer, Juan Carlos Galofré, Tommi Hakala, Jan Jiskra, Peter A. Kopp, Michael Krebs, Michal Kršek, Martin Kuzma, Mikael Lantz, Ivica Lazúrová, Laurence Leenhardt, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Catalina Poiana, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Kamilla Ryom Riis, Alla Shepelkevich, Mykola D. Tronko, David Unuane, Irfan Vardarli, W. Edward Visser, Andromachi Vryonidou, Younes Ramazan Younes, Laszlo Hegedus
Dátum:	2024
ISSN:	1050-7256
Megjegyzések:	Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting treatment choices of European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, and geo-economic factors relate to treatment choices. Methods. 17,247 thyroid specialists from 28 countries were invited to participate in an online questionnaire survey. The survey included respondent demographic data and treatment choices for hypothyroid patients with persistent symptoms. Geo-economic data for each country were included in the analyses. Results. The response rate was 32.9% (6,058 respondents out of 17,247 invitees). Levothyroxine (LT4) was the initial treatment preferred by the majority (98.3%). Persistent symptoms despite normal serum thyrotropin (TSH) while receiving LT4 treatment were reported to affect up to 10.0% of patients by 75.4% of respondents, while 28.4% reported an increasing such trend in the past five years. The principal explanations offered for patients' persistent symptoms were psychosocial factors (77.1%), comorbidities (69.2%), and unrealistic patient expectations (61.0%). Combination treatment with LT4 + liothyronine (LT3) was chosen by 40.0% of respondents for patients who complained of persistent symptoms despite a normal TSH. This option was selected more frequently by female thyroid specialists, with high-volume practice, working in countries with high gross national income per capita. Conclusions. The perception of patients' dissatisfaction reported by physicians seems lower than that described by hypothyroid patients in previous surveys. LT4+LT3 treatment is used frequently by thyroid specialists in Europe for persistent hypothyroid-like symptoms even if they generally attribute such symptoms to non-endocrine causes and despite the evidence of non-superiority of the combined over the LT4 therapy. Pressure by dissatisfied patients on their physicians for LT3-containing treatments is a likely explanation. The association of the therapeutic choices with the clinician demographic characteristics and geo-economic factors in Europe is a novel information and requires further investigation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk quality of life geoeconomics survey hypothyroidism levothyroxine triiodothyronine
Megjelenés:	Thyroid. - 34 : 4 (2024), p. 429-441. -
További szerzők:	Zarkovic, Milos Papini, Enrico Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Perros, Petros Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lantz, Mikael Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Marques Puga, Francisca McGowan, Anne Metso, Saara Moran, Carla Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Ryom Riis, Kamilla Shepelkevich, Alla P. Tronko, Mykola D. Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Hegedüs László
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001-es BibID:	BIBFORM133291
035-os BibID:	(scopus)105018499975 (wos)001588705800001
Első szerző:	Ludgate, Stephen
Cím:	The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members / Ludgate Stephen, McGowan Anne, Moran Carla, Attanasio Roberto, Zarkovic Milos, Nagy Endre Vezekenyi, Negro Roberto, Papini Enrico, Adler Cohen Chagit, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Bednarczuk Tomasz, Beleslin Biljana Nedeljkovic, Berta Eszter, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Buffet Camille, Burlacu Maria-Cristina, Ciric Jamina, Díez Juan J., Dobnig Harald, Fadeyev Valentin, Field Benjamin C. T., Fliers Eric, Führer-Sakel Dagmar, Galofré Juan Carlos, Hakala Tommi, Jiskra Jan, Kopp Peter A., Krebs Michael, Krsek Michal, Kuzma Martin, Lazúrová Ivica, Leenhardt Laurence, Luchytskiy Vitaliy, Melo Miguel, Metso Saara, Morgunova Tatyana, Niculescu Dan Alexandru, Peric Bozidar, Planck Tereza, Poiana Catalina, Marques Puga Francisca, Robenshtok Eyal, Rosselet Patrick, Ruchala Marek, Riis Kamilla Ryom, Shepelkevich Alla, Tronko Mykola D., Frlich Jacob Stampe, Unuane David, Vardarli Irfan, Visser W. Edward, Vryonidou Andromachi, Younes Younes Ramazan, Yurenya Elena, Perros Petros, Hegedüs Laszlo
Dátum:	2025
ISSN:	1664-2392
Megjegyzések:	Purpose: Treatment-resistant depression (TRD) is most commonly de ned as depression that has not responded to two different pharmacological agents used for an adequate period of time. We explored the views of European specialists via survey, regarding the use of thyroid hormone (TH) in euthyroid patients with TRD as part of♭Treatment of Hypothyroidism in Europe by Specialists: An International Survey' (THESIS). Methods: The question"Thyroid hormones may be indicated in biochemically euthyroid patients with treatment resistant depression" was posed to specialists from 28 countries. Results: 5695 valid responses were received following 17,232 invitations (33.0% response rate; 65% female, 90% endocrinologists). 348 (6.1%) stated that TH may be indicated in biochemically euthyroid patients with TRD. This view was more common in males (p<0.01), respondents who saw ?100 patients with hypothyroidism per year (p<0.01), respondents who worked in private practice (p=0.05) and respondents who were not members of international specialist associations (p=0.05). Geographical variation existed with respondents in Eastern Europe signi cantly more likely to use TH in TRD (p<0.01). Linear regression showed a statistically signi cant reduction in the use of TH for TRD with increasing gross national income (F-statistic=7.35, CI -0.15 - -0.02, p=0.01). T H i n T R D w a s r e c o m m e n d e d i n p s y c h i a t r y g u i d e l i n e s b u t n o t endocrinology guidelines. Conclusion: While there is limited evidence for their use, over 6% of respondents stated that TH may be indicated in TRD. Due to the risk of iatrogenic thyrotoxicosis and increased morbidity the use of TH should be addressed in relevant endocrinology guidelines and consensus should be reached between specialties.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk TRD (treatment-resistant depression) thyroid thyroid hormone liothyroinine levothyroxine
Megjelenés:	Frontiers in Endocrinology. - 16 (2025), p. 1-14. -
További szerzők:	McGowan, Anne Moran, Carla Attanasio, Roberto Zarkovic, Milos Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Negro, Roberto Papini, Enrico Adler Cohen, Chagit Akarsu, Ersin Alevizaki, Maria Ayvaz, Goksun Bednarczuk, Tomasz Beleslin, Biljana Nedeljkovic Berta Eszter (1980-) (belgyógyász) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Borissova, Anna-Maria I. Boyanov, Mihail A. Buffet, Camille Burlacu, Maria-Cristina Ciric, Jasmina Díez, Juan J. Dobnig, Harald Fadeyev, Valentin Field, Benjamin C. T. Fliers, Eric Führer, Dagmar Galofré, Juan C. Hakala, Tommi Jiskra, Jan Kopp, Peter Krebs, Michael Krsek, Michal Kuzma, Martin Lazúrová, Ivica Leenhardt, Laurence Luchytskiy, Vitaliy Melo, Miguel Metso, Saara Morgunova, Tatyana Niculescu, Dan Alexandru Peric, Bozidar Planck, Tereza Poiana, Catalina Marques Puga, Francisca Robenshtok, Eyal Rosselet, Patrick Ruchaa, Marek Riis, Kamilla Ryom Shepelkevich, Alla P. Tronko, Mykola D. Frlich, Jacob Stampe Unuane, David Vardarli, Irfan Visser, W. Edward Vryonidou, Andromachi Younes, Younes Ramazan Yurenya, Elena V. Perros, Petros Hegedüs László
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