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001-es BibID:	BIBFORM034135
035-os BibID:	PMID:22410174
Első szerző:	Szekanecz Éva (onkológus szakorvos)
Cím:	Malignancies associated with systemic sclerosis / Éva Szekanecz, Szilvia Szamosi, Ágnes Horváth, Ágnes Németh, Balázs Juhász, János Szántó, Gabriella Szücs, Zoltán Szekanecz
Dátum:	2012
ISSN:	1568-9972
Megjegyzések:	The outcome of systemic sclerosis (SSc) has become more favorable during the past years. Respiratory failure or renal crisis became less frequent, therefore more attention should be paid to long-term comorbidities, such as malignancies secondary to scleroderma. The incidence of malignant lymphoproliferative diseases, as well as that of solid tumors are higher in a number of rheumatic diseases including SSc. Some cytotoxic agents, primarily cyclophosphamide used in the treatment of SSc, as well as exposure to chemicals or smoking may further increase cancer risk. We also present malignancies in 218 scleroderma patients undergoing follow-up in our department were assessed for secondary malignancies. Although the number of SSc patients with tumor is relatively small, we compared our cohort to the Health for All Hungarian database and calculated standard incidence ratios (SIR). We identified 11 cases of malignancy in 10 SSc patients (4.6%). One patient had two types of tumor: breast cancer before the onset of SSc and later malignant lymphoma. Half of SSc patients with cancer belonged to the diffuse cutaneous (dcSSc) subtype. The mean age at onset of SSc was 54.6years, while that at the diagnosis of malignancy was 61.5years. The mean disease duration of scleroderma at the time of cancer diagnosis was 6.6years. Five patients died, 4 due to the underlying malignancy. Among the five surviving patients, the mean survival time was 4.9years. Altogether 3 patients had non-Hodgkin's lymphoma, 2 had bronchial cancer, 2 had breast cancer, one had leiomyosarcoma of the leg, one had esophageal cancer, one had cervix cancer and one had skin cancer. In comparison to the Health for All database, the overall SIR of all malignancies in SSc was 1.07 (CI: 0.82-1.38) varying between 5.8 and 52.4 in different tumor types. Only one cancer patient received cyclophosphamide therapy. In conclusion, secondary tumors including lung, skin and breast cancer, as well as lymphomas are more common in SSc than in the general population. The adequate treatment and follow-up of scleroderma patients may help us to lower the risk of malignancies secondary to SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Autoimmunity Reviews 11 : 12 (2012), p. 852-855. -
További szerzők:	Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Horváth Ágnes (1985-) (reumatológus) Németh Ágnes Juhász Balázs (1973-) (orvos, onkológus) Szántó János (1949-) (onkológus szakorvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM067625
Első szerző:	Szentpétery Ágnes (reumatológus)
Cím:	Effects of targeted therapies on the bone in arthritides / Ágnes Szentpétery, Ágnes Horváth, Katalin Gulyás, Zsófia Pethö, Harjit Pal Bhattoa, Sándor Szántó, Gabriella Szücs, Oliver FitzGerald, Georg Schett, Zoltán Szekanecz
Dátum:	2017
ISSN:	1568-9972
Megjegyzések:	Inflammatory arthritides, such as rheumatoid arthritis (RA) and spondyloarthritides (SpA) have been associated with both localized bone resorption and/or formation, and generalized osteoporosis. Systemic inflammation may be the major driver for bone loss in arthritis. In RA and peripheral SpA the RANK-RANKL-OPG network is involved in bone resorption, while in axial SpA the Wnt-?-catenin axis and its inhibitors (DKK-1, sclerostin) are the most relevant. Targeted therapies including biologics and small molecule tyrosine kinase inhibitors may interfere with inflammatory bone metabolism. Most of these compounds are able to slow down radiographic progression and osteoporosis in arthritides. In very early cases of non-radiological SpA, there may be a window of opportunity allowing to prevent syndesmophyte formation. The inability of targeted therapies to increase the production of DKK-1 and sclerostin may explain the lack of efficacy of TNF inhibitors to halt syndesmophyte formation in SpA. Further clinical trials are needed to better understand the bone effects of targeted therapies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Biologics Bone loss DKK-1 Erosion JAK inhibitors Osteoporosis Osteoprotegerin RANKL Rheumatoid arthritis Sclerostin Spondyloarthritis Syndesmophyte
Megjelenés:	Autoimmunity Reviews 16 : 3 (2017), p. 313-320. -
További szerzők:	Horváth Ágnes (1985-) (reumatológus) Gulyás Katalin (reumatológus) Pethő Zsófia (1981-) (reumatológus, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) FitzGerald, Oliver Schett, Georg Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:	K 105073 OTKA TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP
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