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001-es BibID:	BIBFORM068611
Első szerző:	Jakab Éva
Cím:	Standardizing 25-hydroxyvitamin D data from the HunMen cohort / E. Jakab, E. Kalina, Z. Petho, Z. Pap, A. Balogh, W. B. Grant, H. P. Bhattoa
Dátum:	2017
ISSN:	0937-941X
Megjegyzések:	Summary Standardization of 25-hydroxyvitamin D (25OHD)values is still a challenge.We propose standardization by correctionof the measured 25OHD values using the linear regressionbias from the National Institute of Standards andTechnology (NIST) ♭total' target values reported by VitaminD External Quality Assessment Scheme (DEQAS). Our approachcould perhaps be a practical solution to the anomalysurrounding non-standardized 25OHD values.Introduction Standardization of 25OHD values is still a challenge.We propose standardization by correction of the measured25OHD values using the linear regression equation derivedfrom the analysis of relationship between total 25OHDvalues measured by the methodology used by the laboratoryand the NIST total target values (TV) reported by the DEQASfor all 5 of the DEQAS samples in a given survey.Methods We applied our approach to standardize total25OHD values of the HunMen cohort.Results All 206 samples for the HunMen cohort were evaluatedusing the automated Liaison DiaSorin total 25OHDchemiluminescence immunoassay (CLIA). The timing ofthese measurements coincided with that of the October 2015DEQAS survey using samples 481 to 485. Following standardization,the mean total 25OHD changed from 53 to62 nmol/L and the prevalence of hypovitaminosis D(<75 nmol/L) decreased significantly from 84 to 72%.Conclusion A simple approach readily applicable at the routinediagnostic laboratory could perhaps be a practical solutionto the anomaly surrounding non-standardized 25OHD values
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 25-Hydroxyvitamin D DEQAS HunMen Standardization
Megjelenés:	Osteoporosis International. - 28 : 5 (2017), p. 1653-1657. -
További szerzők:	Kalina Edit (1971-) (laboratóriumi analitikus) Pethő Zsófia (1981-) (reumatológus, immunológus) Pap Zoltán Domokos (1973-) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM134193
035-os BibID:	(scopus)105024456285 (wos)001636258300001
Első szerző:	Rácz Szilvia (molekulársi biológus)
Cím:	Exploring Vitamin D Trends Through Big Data Analysis / Szilvia Racz, Miklos Emri, Ervin Berenyi, Laszlo Horvath, Bela E. Toth, Sandor Barath, Edit Kalina, Luca Jozsa, Amrit Pal Bhattoa-Buzas, William B. Grant, Harjit Pal Bhattoa
Dátum:	2025
ISSN:	2072-6643
Megjegyzések:	Background/Objectives: Big data analysis has revolutionized medical research, making it possible to analyze vast amounts of data and gain valuable insights that were previously impossible to obtain. Our knowledge of the characteristics of vitamin D sufficiency is primarily based on data from a limited number of observations, generally spanning a few years at most. Methods: Here at the Medical Faculty of the University of Debrecen, the big data approach has allowed us to analyze trends in vitamin D status using nearly 60,000 25-hydroxyvitamin D (25(OH)D) concentration results from 2000 onwards. Results: Apart from analyzing the well-known phenomenon of seasonality in 25(OH)D concentration, we observed a trend in test requests, which increased from a few hundred in 2000 to almost 10,000 in 2020. Of particular interest is the change in the gender gap in test requests. In previous years, test requests were primarily from women, but by the end of the analysis period, a significant number of requests were from men as well. Since the data set includes all age groups, we analyzed 25(OH)D concentration for incremental age sets of five years, from a few months to 100 years old. The prevalence of vitamin D insufficiency (<75 nmol/L) was clearly demarcated among various years of observation, age groups, sexes, and seasons. Our data was particularly valuable for analyzing the effect of the methodology used for 25(OH)D determination. Three different methodologies were used during the study period, and clear, statistically significant bias was observed. Conclusions: Our results clearly demonstrate the effect of the methodology used to determine 25(OH)D concentrations on vitamin D status, explicitly highlighting the urgent need to standardize the various platforms used to measure this important analyte and its consequences for public health.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 25-hydroxyvitamin D big data methodology seasonal variations age gender vitamin D
Megjelenés:	Nutrients. - 17 (2025), p. 1-16. -
További szerzők:	Emri Miklós (1962-) (fizikus) Berényi Ervin (1964-) (radiológus) Horváth László (1973-) (gyógyszerész) Tóth E. Béla (1960-) (orvos) Baráth Sándor (1977-) (biológus) Kalina Edit (1971-) (laboratóriumi analitikus) Józsa Luca Bhattoa-Buzas, Amrit Pal Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Pályázati támogatás:	TKP2021-NKTA-34 Egyéb
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