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001-es BibID:	BIBFORM122416
035-os BibID:	(scopus)85196431091
Első szerző:	Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:	Exposure to volatile organic compounds in offices and in residential and educational buildings in the European Union between 2010 and 2023 : A systematic review and health risk assessment / Pál László, Lovas Szabolcs, McKee Martin, Diószegi Judit, Kovács Nóra, Szűcs Sándor
Dátum:	2024
ISSN:	0048-9697
Megjegyzések:	Chronic exposure to indoor volatile organic compounds (VOCs) can result in several adverse effects including cancers. We review reports of levels of VOCs in offices and in residential and educational buildings in the member states of the European Union (EU) published between 2010 and 2023. We use these data to assess the risk to population health by estimating lifetime exposure to indoor VOCs and resulting non-cancer and cancer risks and, from that, the burden of cancer attributable to VOC exposure and associated economic losses. Our systematic review identified 1783 articles, of which 184 were examined in detail, with 58 yielding relevant data. After combining data on VOC concentrations separately for EU countries and building types, non-cancer and cancer risks were assessed in terms of hazard quotient and lifetime excess cancer risk (LECR) using probabilistic Monte Carlo Simulations. The LECR was used to estimate disability adjusted life years (DALYs) from VOC-related cancers and associated costs. We find that the LECR associated with formaldehyde exposure was above the acceptable risk level (ARL) in France and Germany and that of from exposure to benzene was also above the ARL in Spanish females. The sum of DALYs and related costs/1,000,000 population/year from exposure to acetaldehyde, benzene, formaldehyde, tetrachloroethylene, and trichloroethylene were 4.02 and ?41,010, respectively, in France, those from exposure to acetaldehyde, benzene, carbon tetrachloride, formaldehyde, and trichloroethylene were 3.91 and ?39,590 in Germany, and those from exposure to benzene were 0.1 and ?1030 in Spain. Taken as a whole, these findings show that indoor exposure to VOCs remains a public health concern in the EU. Although the EU has set limits for certain VOCs, further measures are needed to restrict the use of these chemicals in consumer products.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Science Of The Total Environment. - 945 (2024), p. 1-16. -
További szerzők:	Lovas Szabolcs (1989-) (tudományos segédmunkatárs) McKee, Martin Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos) Kovács Nóra (1989-) (népegészségügyi szakember) Szűcs Sándor (1958-) (biokémikus, vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103564
035-os BibID:	(WoS)000863090700018 (Scopus)85137072456
Első szerző:	Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:	Health and economic gain attributable to the introduction of the World Health Organization's drinking water standard on arsenic level in Hungary : a nationwide retrospective study on cancer occurrence and ischemic heart disease mortality / Pál László, Jenei Tibor, McKee Martin, Kovács Nóra, Vargha Márta, Bufa-Dőrr Zsuzsanna, Muhollari Teuta, Bujdosó Marozsán Orsolya, Sándor János, Szűcs Sándor
Dátum:	2022
ISSN:	0048-9697
Megjegyzések:	The World Health Organization (WHO) estimates that 140 million individuals are at risk from consumption of drinking water containing arsenic at concentrations above the WHO guideline value of 10 ?g/l. Arsenic mitigation is considered to be the most effective way to prevent arsenic related diseases. After joining the European Union, Hungary implemented a Drinking Water Quality Improvement Programme (DWQIP) to reduce levels of arsenic in drinking water below the WHO guideline value. But what impact did this have on health? We estimated the change in lifetime excess skin, lung, and bladder cancer risks and mortality from ischaemic heart disease (IHD) associated with chronic arsenic intake among those exposed before (2004?2007) and after (2014?2017) the implementation of DWQIP. A populationbased risk assessment approach was used to assess lifetime excess cancer risk applying two scenarios for lung and bladder cancers. The economic benefits of the DWQIP were estimated by the combination of cost of illness and value per statistical life methods. Compared to the period before the DWQIP, its implementation was associated with a significant reduction in arsenic in drinking water [median: 3.0 ?g/l interquartile range (IQR): 1.5?12.0 ?g/l to median: 2.15 ?g/l IQR: 1.0?5.79 ?g/l]. The two scenarios were estimated to be associated with 225.2 and 35.9 fewer cancer cases each year. The number of annually prevented IHD deaths was estimated to be 88.9. It was estimated that the benefits of the DWQIP will outweigh its costs. We conclude that reducing arsenic levels in drinking water to 10.0 ?g/l resulted in significant health and economic benefits. Our study goes beyond the existing research, offering both new insights into the impact of arsenic mitigation and providing a methodological template for similar studies in the many parts of the world that have yet to reduce arsenic exposure.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Arsenic exposure WHO drinking water standard Arsenic mitigation Cancer risk assessment Mortality from ischemic heart disease Public health and economic benefits
Megjelenés:	Science Of The Total Environment. - 851 (2022), p. 1-11. -
További szerzők:	Jenei Tibor (1963-) (programtervező informatikus) McKee, Martin Kovács Nóra (1989-) (népegészségügyi szakember) Vargha Márta (1976-) (biológus/molekuláris biológus) Bufa-Dőrr Zsuzsanna Muhollari, Teuta Bujdosó Orsolya (1992-) (népegészségügyi szakember) Sándor János (1966-) (orvos-epidemiológus) Szűcs Sándor (1958-) (biokémikus, vegyész)
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