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001-es BibID:	BIBFORM132985
035-os BibID:	(scopus)105021339733 (wos)001609436000001
Első szerző:	Pös, Ondrej (biológus)
Cím:	Breath biopsy biomarkers : cell-free nucleic acids in exhaled breath condensate / Pös Ondrej, Styk Jakub, Kubanova Monika, Bokorova Silvia, Buglyo Gergely, Soltesz Beata, Lukasz Peter, Benes Vladimir, Repiska Vanda, Nagy Balint, Szemes Tomas
Dátum:	2025
ISSN:	2296-858X
Megjegyzések:	Exhaled breath condensate (EBC) has emerged as a promising, organ-specific biofluid for non-invasive molecular diagnostics. While breath analysis has traditionally focused on volatile organic compounds (VOCs), recent advances have shifted attention toward non-volatile constituents, particularly cell-free nucleic acids (cfNAs) such as genomic DNA, mitochondrial DNA, mRNA, miRNA, long non-coding RNA, and microbial genetic material. These molecules reflect the respiratory tract biology and can serve as biomarkers for a range of clinical conditions, including lung cancer, obstructive lung diseases, infections, and potentially even systemic disorders. This review summarizes the current knowledge on cfNAs in EBC, highlighting technical challenges in sample collection and nucleic acid extraction. We provide a comparison of EBC collection devices, discuss optimization strategies for nucleic acid recovery, and examine emerging applications such as early cancer detection, treatment monitoring, infection diagnostics, and endotyping of chronic airway diseases. The feasibility of at-home EBC sampling with portable collection devices offers additional advantages, potentially overcoming logistical and psychological barriers that often delay clinical care. Although limitations remain, including low cfNA yield and lack of standardization, ongoing innovation in sampling and molecular techniques is rapidly expanding the translational potential of breath biopsy. With further development, EBC-based cfNA profiling may complement blood-based liquid biopsies and, in specific contexts such as lung cancer, provide additional organ-specific information.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk breath biopsy exhaled breath condensate (EBC) cell-free nucleic acids lung cancer biomarkers liquid biopsy obstructive lung diseases
Megjelenés:	Frontiers in Medicine. - 12 (2025), p. 1-11. -
További szerzők:	Styk, Jakub Kubanova, Monika Bokorova, Silvia Buglyó Gergely (1980-) (genetikus) Soltész Beáta (1987-) (molekuláris biológus) Lukasz, Peter Benes, Vladimir Repiska Vanda Nagy Bálint (1956-) (molekuláris genetikus) Szemes, Tomas (1980-) (biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM102993
035-os BibID:	(WOS)000839249500001 (Scopus)85136586949
Első szerző:	Styk, Jakub
Cím:	Extracellular Nucleic Acids in the Diagnosis and Progression of Colorectal Cancer / Styk Jakub, Buglyó Gergely, Pös Ondrej, Csók Ádám, Soltész Beáta, Lukasz Peter, Repiská Vanda, Nagy Bálint, Szemes Tomás
Dátum:	2022
ISSN:	2072-6694
Megjegyzések:	Colorectal cancer (CRC) is the 3rd most common malignant neoplasm worldwide, with more than two million new cases diagnosed yearly. Despite increasing efforts in screening, many cases are still diagnosed at a late stage, when mortality is high. This paper briefly reviews known genetic causes of CRC (distinguishing between sporadic and familial forms) and discusses potential and confirmed nucleic acid biomarkers obtainable from liquid biopsies, classified by their molecular features, focusing on clinical relevance. We comment on advantageous aspects such as better patient compliance due to blood sampling being minimally invasive, the possibility to monitor mutation characteristics of sporadic and hereditary CRC in a disease showing genetic heterogeneity, and using up- or down-regulated circulating RNA markers to reveal metastasis or disease recurrence. Current difficulties and thoughts on some possible future directions are also discussed. We explore current evidence in the field pointing towards the introduction of personalized CRC management.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk colorectal cancer liquid biopsy cell-free nucleic acids biomarkers non-invasive diagnosis
Megjelenés:	Cancers. - 14 : 15 (2022), p. 1-20. -
További szerzők:	Buglyó Gergely (1980-) (genetikus) Pös, Ondrej (1990-) (biológus) Csók Ádám (1994-) (biológus) Soltész Beáta (1987-) (molekuláris biológus) Lukasz, Peter Repiská, Vanda Nagy Bálint (1956-) (molekuláris genetikus) Szemes, Tomas (1980-) (biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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