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001-es BibID:	BIBFORM131428
Első szerző:	Barkóczi Alexandra (orvos)
Cím:	Metastasis and angiogenesis : preclinical PET study on hepatocellular carcinoma (He/De) tumor models / Barkóczi Alexandra, Képes Zita, Szabó Judit P., Dienes Renáta Adél, Károlyi Péter Kálmán, Papp Tamás, Kálmán-Szabó Ibolya, Sass Tamás, Opposits Gábor, Kertész István, Hajdu István, Trencsényi György, Deák Ádám
Dátum:	2025
ISSN:	0928-0987
Megjegyzések:	The use of animal models to study tumorigenesis and metastatic spread seems crucial to discover novel diagnostic and therapeutic targets that inhibit tumor development and progression. In this study a preclinical metastasis model of hepatocellular carcinoma (He/De) was established to explore metastases formation and related angiogenic processes using positron emission tomography (PET) and angiogenesis specific radiopharmaceuticals. Approximately 8?1 days after the subrenal capsule assaybased generation of the primary, secondary and tertiary transplanted metastatic He/De tumors in Fischer344 rats, we used [18F]FDG, [68Ga]Ga-NOTA-c(NGR) and [68Ga]Ga-NODAGA-[c(RGD)]2 for the in vivo PET imaging of tumor development and angiogenesis. [18F]FDG displayed the highest level of radioactivity among all investigated tracers. This pattern was consistent across all neoplastic lesions in each of the three transplantations. Comparing the two 68Ga-labelled probes, the NGR compound showed significantly higher accumulation in the subrenally growing primary/secondary/tertiary He/De tumors (p?0.05) and related parathymic lymph node metastases (PTLNs, p?0.01) that could indicate higher expression level for aminopeptidase N/CD13 than for RGD-binding ?v?3 integrin. Progressive increase in the [18F]FDG, [68Ga]Ga-NOTA-c(NGR) and [68Ga]Ga-NODAGA-[c(RGD)]2 uptakes of both the subrenally growing He/De tumors and the PTLNs during the serial transplantations may imply increasing aggressivity. Overall, the currently developed experimental system provides a feasible platform for further investigation of metastatic spread.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk angiogenesis [68Ga]Ga-NOTA-c(NGR) [68Ga]Ga-NODAGA-[c(RGD)]2 hepatocellular carcinoma (He/De) metastasis positron emission tomography (PET)
Megjelenés:	European Journal Of Pharmaceutical Sciences. - 212 (2025), p. 1-11. -
További szerzők:	Képes Zita (1991-) (orvos) Péli-Szabó Judit (1977-) (vegyész) Dienes Renáta Adél Károlyi Péter Kálmán Papp Tamás (1987-) (orvos) Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Sass Tamás (1989-) (sebész szakorvos) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Kertész István (1966-) (vegyész) Hajdu István (1981-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Deák Ádám (1974-) (állatorvos)
Pályázati támogatás:	KDP-2021 program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund Egyéb
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001-es BibID:	BIBFORM105131
035-os BibID:	(WOS)000887335500001 (Scopus)85142823505
Első szerző:	Képes Zita (orvos)
Cím:	In Vivo Preclinical Assessment of β-Amyloid-Affine [11C]C-PIB Accumulation in Aluminium-Induced Alzheimer's Disease-Resembling Hypercholesterinaemic Rat Model / Zita Képes, Alexandra Barkóczi, Judit P. Szabó, Ibolya Kálmán-Szabó, Viktória Arató, István Jószai, Ádám Deák, István Kertész, István Hajdu, György Trencsényi
Dátum:	2022
ISSN:	1422-0067
Megjegyzések:	Aluminum (Al) excess and hypercholesterinaemia are established risks of Alzheimer's disease (AD). The aim of this study was to establish an AD-resembling hypercholesterinaemic animal model?with the involvement of 8 week and 48 week-old Fischer-344 rats?by Al administration for the safe and rapid verification of ? -amyloid-targeted positron emission tomography (PET) radiopharmaceuticals. Measurement of lipid parameters and ? -amyloid?affine [11C]C-Pittsburgh Compound B ([11C]C-PIB) PET examinations were performed. Compared with the control, the significantly elevated cholesterol and LDL levels of the rats receiving the cholesterol-rich diet support the development of hypercholesterinaemia (p?0.01). In the older cohort, a notably increased age-related radiopharmaceutical accumulation was registered compared to in the young (p?0.05; p?0.01). A monotherapy-induced slight elevation of mean standardised uptake values (SUVmean) was statistically not significant; however, adult rats administered a combined diet expressed remarkable SUVmean increment compared to the adult control (SUVmean: from 0.78?0.16 to 1.99?0.28). One and two months after restoration to normal diet, the cerebral [11C]C-PIB accumulation of AD-mimicking animals decreased by half and a third, respectively, to the baseline value. The proposed in vivo Al-induced AD-resembling animal system seems to be adequate for the understanding of AD neuropathology and future drug testing and radiopharmaceutical development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 23 (2022), p. 1-14. -
További szerzők:	Barkóczi Alexandra (1994-) (orvos) Péli-Szabó Judit (1977-) (vegyész) Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Arató Viktória Zsófia (1989-) (gyógyszerész) Jószai István (1978-) (vegyész) Deák Ádám (1974-) (állatorvos) Kertész István (1966-) (vegyész) Hajdu István (1981-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus)
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001-es BibID:	BIBFORM104375
035-os BibID:	(WOS)000881332000001 (Scopus)85141644328
Első szerző:	Képes Zita (orvos)
Cím:	In Vivo Assessments of Mesoblastic Nephroma (Ne/De) and Myelomonoblastic Leukaemia (My1/De) Tumour Development in Hypercholesterolemia Rat Models / Zita Képes, Alexandra Barkóczi, Judit P. Szabó, Ibolya Kálmán-Szabó, Viktória Arató, Ildikó Garai, Péter Árkosy, István Jószai, Ádám Deák, István Kertész, István Hajdu, György Trencsényi
Dátum:	2022
ISSN:	1422-0067
Megjegyzések:	Given the rising prevalence of lipid metabolic disorders and malignant diseases, we aimed to establish an in vivo hypercholesterinaemic tumour-bearing rat model for the induction and assessment of these conditions. A normal standard CRLT/N, 2 (baseline),- or 4 (2 + 2, pretreated)-week-long butter and cholesterol rich (BCR) diet was applied to mesoblastic nephroma (Ne/De) and myelomonoblastic leukaemia (My1/De) tumour-bearing and healthy control Long-Evans and Fischer 344 rats. The beginning of chow administration started in parallel with tumour induction and the 2 weeks of pre-transplantation in the baseline and pretreated groups, respectively. Fourteen days post-inoculation, the measurement of lipid parameters and [F-18]F-FDG PET/MRI examinations was executed. The comparable lipid status of baseline healthy and tumorous rats proves that regardless of tumour presence, BCR-based hypercholesterolemia was achieved. A higher tumour mass among pretreated tumorous animals was found when compared to the control groups (p < 0.05, p < 0.01). Further, a visually greater [F-18]F-FDG accumulation was observed in pretreated BCR tumorous animals; however, the quantitative data (SUVmean: 9.86 +/- 0.98, 9.68 +/- 1.24; SUVmax: 19.63 +/- 1.20; 17.56 +/- 3.21 for Ne/De and My1/De, respectively) were not statistically significantly different from those of the CRLT/N tumorous rats (SUVmean: 8.40 +/- 1.42, 7.22 +/- 1.06 and SUVmax: 15.99 +/- 2.22, 12.46 +/- 1.96 for control Ne/De and My1/De, respectively). Our model seems to be appropriate for simultaneously investigating hypercholesterolemia and cancer in the same rat.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk butter and cholesterol-rich (BCR) diet [18F]F-FDG PET/MRI hypercholesterolemia lipids myelomonoblastic leukaemia (My1/De) mesoblastic nephroma (Ne/De) standardised uptake value (SUV)
Megjelenés:	International Journal Of Molecular Sciences. - 23 : 21 (2022), p. 1-16. -
További szerzők:	Barkóczi Alexandra (1994-) (orvos) Péli-Szabó Judit (1977-) (vegyész) Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Arató Viktória Zsófia (1989-) (gyógyszerész) Garai Ildikó (1966-) (radiológus) Árkosy Péter (1962-) (általános sebész, mellkassebész) Jószai István (1978-) (vegyész) Deák Ádám (1974-) (állatorvos) Kertész István (1966-) (vegyész) Hajdu István (1981-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP K119552 NKFIH TKP2020-NKA-04 Egyéb
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