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001-es BibID:	BIBFORM120663
035-os BibID:	(WoS)001206952400001 (Scopus)85191051777
Első szerző:	Kovács Fruzsina (molekuláris biológus, biotechnológus)
Cím:	Epidemiology, clinical characteristics, outcome and biofilm forming properties in candidaemia : a single-centre retrospective 4-year analysis from Hungary / Fruzsina Kovács, Noémi Balla, Aliz Bozó, Andrea Harmath, Ágnes Jakab, Zoltán Tóth, Fruzsina Nagy, László Majoros, Renátó Kovács
Dátum:	2024
ISSN:	0933-7407
Megjegyzések:	Background: Candidaemia is a life-threatening disease that is associated with high mortality, especially in intensive care units (ICUs). The number of comprehensive studies dealing with the epidemiologic characteristics of biofilm-related properties is limited. Objective: This study evaluated the clinical characteristics of candidaemia, to assess the biofilm-forming properties of isolates, and to identify the risk factors of mortality. Patients and Methods: A total of 149 candidaemia episodes from the University of Debrecen, Clinical Centre, between January 2020 and December 2023 were inves- tigated retrospectively. The susceptibility of Candida isolates to fluconazole, ampho- tericin B, anidulafungin, caspofungin, and micafungin was evaluated and compared to the susceptibility of 1-day-old biofilms. Multivariate logistic regression analysis was applied to identify the independent predictors of 30-day mortality rate. Results: The most common Candida species was Candida albicans (41%), followed by C. parapsilosis (20%), C. glabrata (14%), C. tropicalis (13%), rare Candida species (7%), and C. krusei (5%). Sixty-six percent of Candida isolates were biofilm formers and 44% had high metabolic activity. The 30-day mortality rate was 52%, which was higher in ICUs (65%). The logistic regression analysis revealed several factors significantly influencing mortality including ICU admission (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.17?8.04, p = 0.025), fluconazole treatment (OR 4.12, 95% CI 1.62?11.42, p = .004), and pneumonia (OR 0.261, 95% CI 0.1?0.67, p = .006). Conclusions: This comprehensive analysis supports the better characterisation of candidaemia in healthcare settings, which ultimately may reduce mortality among patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk biofilm bloodstream infections Candida Hungary intensive care unit mortality
Megjelenés:	Mycoses. - 67 : 4 (2024), p. 1-12. -
További szerzők:	Balla Noémi (1998-) (mikrobiológus) Bozó Aliz (1984-) (biológus) Harmath Andrea Jakab Ágnes (1987-) (biológus) Tóth Zoltán (1990-) (molekuláris biológus) Nagy Fruzsina (1991-) (molekuláris biológus) Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Kovács Renátó László (1987-) (molekuláris biológus)
Pályázati támogatás:	FK138462 OTKA UNKP-23-5-DE-480 Egyéb Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00127/21/8) MTA
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