Találati lista | Tudóstér

001-es BibID:	BIBFORM124142
035-os BibID:	(Scopus)85205266079 (WoS)001323447400001
Első szerző:	Debreczeni-Máté Zsanett
Cím:	Value of 11C-Methionine PET Imaging in High-Grade Gliomas : a Narrative Review / Debreczeni-Máté Zsanett, Freihat Omar, Törő Imre, Simon Mihály, Kovács Árpád, Sipos David
Dátum:	2024
ISSN:	2072-6694
Megjegyzések:	11 C-Methionine (MET) is a widely utilized amino acid tracer in positron emission tomography (PET) imaging of primary brain tumors. 11C-MET PET offers valuable insights for tumor classification, facilitates treatment planning, and aids in monitoring therapeutic response. Its tracer properties allow better delineation of the active tumor volume, even in regions that show no contrast enhancement on conventional magnetic resonance imaging (MRI). This review focuses on the role of MET-PET in brain glioma imaging. The introduction provides a brief clinical overview of the problems of high-grade and recurrent gliomas. It discusses glioma management, radiotherapy planning, and the difficulties of imaging after chemoradiotherapy (pseudoprogression or radionecrosis). The mechanism of MET-PET is described. Additionally, the review encompasses the application of MET-PET in the context of primary gliomas, addressing its diagnostic precision, utility in tumor classification, prognostic value, and role in guiding biopsy procedures and radiotherapy planning.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 11C-MET hybrid imaging PET/CT multimodal imaging glioma high-grade glioma
Megjelenés:	Cancers. - 16 : 18 (2024), p. 1-11.-
További szerzők:	Freihat, Omar Törő Imre (1900-1993) (anatómus, biológus) Simon Mihály (1981-) (Fizikus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Sipos Dávid
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM100238
035-os BibID:	(WoS)000755032500001 (Scopus)85124104299
Első szerző:	Freihat, Omar
Cím:	Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) / Freihat Omar, Zoltán Tóth, Pinter Tamas, Kedves András, Sipos Dávid, Repa Imre, Kovács Árpád, Zsolt Cselik
Dátum:	2022
ISSN:	2072-6694
Megjegyzések:	Background: This study aimed to assess the association of 18F-Fluorodeoxyglucose positronemission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors. Methods: We retrospectively analyzed primary tumors in 71 patients with proven HNC. Primary tumor radiological parameters: DWI and FDG, as well as pathological characteristics were analyzed. Spearman correlation coefficient was used to assess the correlation between DWI and FDG parameters, ANOVA or Kruskal?Wallis, independent sample t-test, Mann?Whitney test, and multiple regression were performed on the clinicopathological features that may affect the 18F- FDG and apparent-diffusion coefficient (ADC) of the tumor. Results: No significant correlations were observed between DWI and any of the 18F-FDG parameters (p > 0.05). SUVmax correlated with N-stages (p = 0.023), TLG and MTV correlated with T-stages (p = 0.006 and p = 0.001), and ADC correlated with tumor grades (p = 0.05). SUVmax was able to differentiate between N+ and N? groups (p = 0.004). Conclusions: Our results revealed a non-significant correlation between the FDG-PET and ADC-MR parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cancers. - 14 : 3 (2022), p. 1-12. -
További szerzők:	Tóth Zoltán Pintér Tamás Kedves András Sipos Dávid Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Cselik Zsolt
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM126430
035-os BibID:	(scopus)85214508705 (wos)001393399900001
Első szerző:	Sipos Dávid
Cím:	Glioblastoma : Clinical Presentation, Multidisciplinary Management, and Long-Term Outcomes / Sipos David, Raposa Bence L., Freihat Omar, Simon Mihály, Mekis Nejc, Cornacchione Patrizia, Kovács Árpád
Dátum:	2025
ISSN:	2072-6694
Megjegyzések:	Abstract: Glioblastoma, the most common and aggressive primary brain tumor in adults, presents a formidable challenge due to its rapid progression, treatment resistance, and poor survival outcomes. Standard care typically involves maximal safe surgical resection, followed by fractionated external beam radiation therapy and concurrent temozolomide chemotherapy. Despite these interventions, median survival remains approximately 12-15 months, with a five-year survival rate below 10%. Prognosis is influenced by factors such as patient age, molecular characteristics, and the extent of resection. Patients with IDH-mutant tumors or methylated MGMT promoters generally have improved survival, while recurrent glioblastoma is associated with a median survival of only six months, as therapies in these cases are often palliative. Innovative treatments, including TTFields, add incremental survival benefits, extending median survival to around 20.9 months for eligible patients. Symptom management?addressing seizures, headaches, and neurological deficits-alongside psychological support for patients and caregivers is essential to enhance quality of life. Emerging targeted therapies and immunotherapies, though still limited in efficacy, show promise as part of an evolving treatment landscape. Continued research and clinical trials remain crucial to developing more effective treatments. This multidisciplinary approach, incorporating diagnostics, personalized therapy, and supportive care, aims to improve outcomes and provides a hopeful foundation for advancing glioblastoma management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk glioblastoma prognosis treatment survival outcome
Megjelenés:	Cancers. - 17 : 1 (2025), p. 1-17. -
További szerzők:	Raposa Bence Freihat, Omar Simon Mihály Mekis, Nejc Cornacchione, Patrizia Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: